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Protein

Protein BTG3

Gene

Btg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

GO - Biological processi

  • negative regulation of cell proliferation Source: GO_Central
  • negative regulation of mitotic cell cycle Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG3
Alternative name(s):
Abundant in neuroepithelium area protein
BTG family member 3
Protein Tob5
Gene namesi
Name:Btg3
Synonyms:Ana, Tob5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 16, Chromosome 17

Organism-specific databases

MGIiMGI:109532 Btg3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438081 – 252Protein BTG3Add BLAST252

Proteomic databases

PaxDbiP50615
PRIDEiP50615

PTM databases

PhosphoSitePlusiP50615

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000022863 Expressed in 89 organ(s), highest expression level in retina
CleanExiMM_BTG3
ExpressionAtlasiP50615 baseline and differential
GenevisibleiP50615 MM

Interactioni

Protein-protein interaction databases

DIPiDIP-61989N
IntActiP50615, 1 interactor
STRINGi10090.ENSMUSP00000053997

Structurei

3D structure databases

ProteinModelPortaliP50615
SMRiP50615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Ser6

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiP50615
KOiK14443
OMAiNNEFIVA
OrthoDBiEOG091G0U1P
PhylomeDBiP50615
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P50615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK
60 70 80 90 100
PSKGQAYRCI RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE
110 120 130 140 150
VCCRYGEKNN AFIVASFENE DENKDEISKK VSRALDKVTS DYHSGSSSSD
160 170 180 190 200
EDTSKEVDVK PSSVAATPSP VYQISELIFP PLPMWHPLPR KKPGMYRGSG
210 220 230 240 250
HQTHYPPPVP FAYPNPGRKN KPFRPIPVTW VPPPGMHCDR NHWINPHMLA

PH
Length:252
Mass (Da):28,983
Last modified:October 1, 1996 - v1
Checksum:i15C4F8EFFF3B4A24
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1M9D3Z1M9_MOUSE
Protein BTG3
Btg3
137Annotation score:
A0A338P787A0A338P787_MOUSE
Protein BTG3
Btg3
152Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72000 mRNA Translation: CAA96519.1
D83745 mRNA Translation: BAA29058.1
BC012705 mRNA Translation: AAH12705.1
CCDSiCCDS28277.1
RefSeqiNP_001284676.1, NM_001297747.1
NP_033900.1, NM_009770.3
UniGeneiMm.392910

Genome annotation databases

EnsembliENSMUST00000023570; ENSMUSP00000023570; ENSMUSG00000022863
ENSMUST00000061681; ENSMUSP00000053997; ENSMUSG00000044645
GeneIDi12228
KEGGimmu:12228
UCSCiuc007zsp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72000 mRNA Translation: CAA96519.1
D83745 mRNA Translation: BAA29058.1
BC012705 mRNA Translation: AAH12705.1
CCDSiCCDS28277.1
RefSeqiNP_001284676.1, NM_001297747.1
NP_033900.1, NM_009770.3
UniGeneiMm.392910

3D structure databases

ProteinModelPortaliP50615
SMRiP50615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61989N
IntActiP50615, 1 interactor
STRINGi10090.ENSMUSP00000053997

PTM databases

PhosphoSitePlusiP50615

Proteomic databases

PaxDbiP50615
PRIDEiP50615

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023570; ENSMUSP00000023570; ENSMUSG00000022863
ENSMUST00000061681; ENSMUSP00000053997; ENSMUSG00000044645
GeneIDi12228
KEGGimmu:12228
UCSCiuc007zsp.2 mouse

Organism-specific databases

CTDi10950
MGIiMGI:109532 Btg3

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiP50615
KOiK14443
OMAiNNEFIVA
OrthoDBiEOG091G0U1P
PhylomeDBiP50615
TreeFamiTF105272

Miscellaneous databases

PROiPR:P50615
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022863 Expressed in 89 organ(s), highest expression level in retina
CleanExiMM_BTG3
ExpressionAtlasiP50615 baseline and differential
GenevisibleiP50615 MM

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTG3_MOUSE
AccessioniPrimary (citable) accession number: P50615
Secondary accession number(s): Q62328
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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