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Entry version 117 (29 Sep 2021)
Sequence version 2 (01 Nov 1997)
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Protein

Flagellar hook protein FlgE

Gene

flgE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A flexible structure which links the flagellar filament to the drive apparatus in the basal body. Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility. Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.

Miscellaneous

The N-terminal amino acid sequence was from strain CCUG 951; the DNA sequence was from strain CCUG 17874. Disruption and subcellular localization experiments were performed for both strains. The apparent pI for the hook protein was 5.1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP0870-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellar hook protein FlgE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:flgE
Ordered Locus Names:HP_0870
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Bacterial flagellum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001808281 – 718Flagellar hook protein FlgEAdd BLAST718

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50610

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3456N

Protein interaction database and analysis system

More...
IntActi
P50610, 6 interactors

Molecular INTeraction database

More...
MINTi
P50610

STRING: functional protein association networks

More...
STRINGi
85962.C694_04455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50610

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1749, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAFRYRY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50610

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.98.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011491, Falgellar_hook_FlgE
IPR037058, Falgellar_hook_FlgE_sf
IPR001444, Flag_bb_rod_N
IPR020013, Flagellar_FlgE/F/G
IPR010810, Flagellin_hook_IN_motif
IPR010930, Flg_bb/hook_C_dom
IPR037925, FlgE/F/G-like
IPR012835, FlgE_epsilon

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07559, FlaE, 1 hit
PF07196, Flagellin_IN, 1 hit
PF00460, Flg_bb_rod, 1 hit
PF06429, Flg_bbr_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117143, SSF117143, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02489, flgE_epsilon, 1 hit
TIGR03506, FlgEFG_subfam, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRSLWSGVN GMQAHQIALD IESNNIANVN TTGFKYSRAS FVDMLSQVKL
60 70 80 90 100
IATAPYKNGL AGQNDFSVGL GVGVDATTKI FSQGNIQNTD VKTDLAIQGD
110 120 130 140 150
GFFIISPDRG ITRNFTRDGE FLFDSQGSLV TTGGLVVQGW VRNGSDTGNK
160 170 180 190 200
GSDTDALKVD NTGPLENIRI DPGMVMPARA SNRISMRANL NAGRHADQTA
210 220 230 240 250
AIFALDSSAK TPSDGINPVY DSGTNLAQVA EDMGSLCNED GDALLLNENQ
260 270 280 290 300
GIWVSYKSAK MVKDILPSAE NSTLELNGVK ISFTNDSAVS RTSSLVAAKN
310 320 330 340 350
AINAVKSQTG IEAYLDGKQL RLENTNELDG DEKLKNIVVT QAGTGAFANF
360 370 380 390 400
LDGDKDVTAF KYSYTHSISP NADIGQFRTT EDLRALIQHD ANIVKDPSLA
410 420 430 440 450
DNYQDSAASI GVSVNQYGMF EINNKDNKNV IKENLNIFVS GYSSDSVTNN
460 470 480 490 500
VLFKNAMKGL NTASLIEGGA SASSSKFTHA THATSIDVID SLGTKHAMRI
510 520 530 540 550
EFYRSGGAEW NFRVIVPEPG ELVGGSAARP NVFEGGRLHF NNDGSLAGMN
560 570 580 590 600
PPLLQFDPKN GADAPQRINL AFGSSGSFDG LTSVDKISET YAIEQNGYQA
610 620 630 640 650
GDLMDVRFDS DGVLLGAFSN GRTLALAQVA LANFANDAGL QALGGNVFSQ
660 670 680 690 700
TGNSGQALIG AANTGRRGSI SGSKLESSNV DLSRSLTNLI VVQRGFQANS
710
KAVTTSDQIL NTLLNLKQ
Length:718
Mass (Da):76,207
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF36EB60684AD1333
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106S → N in AAA92803 (PubMed:7891557).Curated1
Sequence conflicti237C → Y in AAA92803 (PubMed:7891557).Curated1
Sequence conflicti259A → P in AAA92803 (PubMed:7891557).Curated1
Sequence conflicti373 – 374DI → NS in AAA92803 (PubMed:7891557).Curated2
Sequence conflicti413 – 414SV → TI in AAA92803 (PubMed:7891557).Curated2
Sequence conflicti509E → D in AAA92803 (PubMed:7891557).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09549 Genomic DNA Translation: AAA92803.1
AE000511 Genomic DNA Translation: AAD07911.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F64628

NCBI Reference Sequences

More...
RefSeqi
NP_207664.1, NC_000915.1
WP_000946389.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD07911; AAD07911; HP_0870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP0870

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.924

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09549 Genomic DNA Translation: AAA92803.1
AE000511 Genomic DNA Translation: AAD07911.1
PIRiF64628
RefSeqiNP_207664.1, NC_000915.1
WP_000946389.1, NC_018939.1

3D structure databases

SMRiP50610
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3456N
IntActiP50610, 6 interactors
MINTiP50610
STRINGi85962.C694_04455

Proteomic databases

PaxDbiP50610

Genome annotation databases

EnsemblBacteriaiAAD07911; AAD07911; HP_0870
KEGGihpy:HP0870
PATRICifig|85962.47.peg.924

Phylogenomic databases

eggNOGiCOG1749, Bacteria
OMAiTAFRYRY
PhylomeDBiP50610

Enzyme and pathway databases

BioCyciHPY:HP0870-MONOMER

Family and domain databases

Gene3Di2.60.98.20, 1 hit
InterProiView protein in InterPro
IPR011491, Falgellar_hook_FlgE
IPR037058, Falgellar_hook_FlgE_sf
IPR001444, Flag_bb_rod_N
IPR020013, Flagellar_FlgE/F/G
IPR010810, Flagellin_hook_IN_motif
IPR010930, Flg_bb/hook_C_dom
IPR037925, FlgE/F/G-like
IPR012835, FlgE_epsilon
PfamiView protein in Pfam
PF07559, FlaE, 1 hit
PF07196, Flagellin_IN, 1 hit
PF00460, Flg_bb_rod, 1 hit
PF06429, Flg_bbr_C, 1 hit
SUPFAMiSSF117143, SSF117143, 2 hits
TIGRFAMsiTIGR02489, flgE_epsilon, 1 hit
TIGR03506, FlgEFG_subfam, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLGE_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50610
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: September 29, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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