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Protein

Fibromodulin

Gene

Fmod

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibromodulin
Short name:
FM
Alternative name(s):
Collagen-binding 59 kDa protein
Keratan sulfate proteoglycan fibromodulin
Short name:
KSPG fibromodulin
Gene namesi
Name:Fmod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1328364 Fmod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000003274019 – 376FibromodulinAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei20SulfotyrosineBy similarity1
Modified residuei38SulfotyrosineBy similarity1
Modified residuei53SulfotyrosineBy similarity1
Modified residuei55SulfotyrosineBy similarity1
Modified residuei63SulfotyrosineBy similarity1
Modified residuei65SulfotyrosineBy similarity1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi166N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi201N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi291N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Disulfide bondi334 ↔ 367By similarity
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Binds keratan sulfate chains.By similarity
Sulfated on tyrosine residue(s).Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP50608
PeptideAtlasiP50608
PRIDEiP50608

PTM databases

iPTMnetiP50608
PhosphoSitePlusiP50608

Expressioni

Tissue specificityi

Highest levels observed in knee epiphysis, in calvarial and diaphyseal bone, in nasal and costal cartilage, in the eye, and in bladder. In mature knee joint it is mostly present in the proliferating zone of growth plate. It is also observed in ligaments, especially at insertion sites, in the junction between meniscus and joint capsule, in the perimysium of skeletal muscle and in the periosteum.

Developmental stagei

Highest levels between 5 days and 1 month of age. Thereafter, the expression of declined to a level of approx. 35% of maximum, and remained constant throughout the rest of the observation period.

Gene expression databases

BgeeiENSMUSG00000041559 Expressed in 290 organ(s), highest expression level in vault of skull
CleanExiMM_FMOD
ExpressionAtlasiP50608 baseline and differential
GenevisibleiP50608 MM

Interactioni

Subunit structurei

Binds to type I and type II collagen.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035489

Structurei

3D structure databases

ProteinModelPortaliP50608
SMRiP50608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 105LRRNTAdd BLAST39
Repeati106 – 127LRR 1Add BLAST22
Repeati130 – 151LRR 2Add BLAST22
Repeati156 – 176LRR 3Add BLAST21
Repeati177 – 198LRR 4Add BLAST22
Repeati201 – 222LRR 5Add BLAST22
Repeati224 – 245LRR 6Add BLAST22
Repeati246 – 266LRR 7Add BLAST21
Repeati269 – 289LRR 8Add BLAST21
Repeati294 – 315LRR 9Add BLAST22
Repeati316 – 335LRR 10Add BLAST20
Repeati344 – 367LRR 11Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 73Poly-Pro6
Compositional biasi76 – 92Cys-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOVERGENiHBG108061
InParanoidiP50608
KOiK08121
OMAiDEDPHWW
OrthoDBiEOG091G0A3V
PhylomeDBiP50608
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR027215 Fibromodulin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PANTHERiPTHR24373:SF127 PTHR24373:SF127, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P50608-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQWASVLLLA GLCSLSQGQY DEDSHWWIQY LRNQQSTYYD PYDPYPYEPS
60 70 80 90 100
EPYPYGVEEG PAYAYGAPPP PEPRDCPQEC DCPPNFPTAM YCDNRNLKYL
110 120 130 140 150
PFVPSRMKYV YFQNNQISAI QEGVFDNATG LLWVALHGNQ ITSDKVGRKV
160 170 180 190 200
FSKLRHLERL YLDHNNLTRM PGPLPRSLRE LHLDHNQISR VPNNALEGLE
210 220 230 240 250
NLTALYLHHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD GLPSALEQLY
260 270 280 290 300
LEHNNVYTVP DSYFRGSPKL LYVRLSHNSL TNNGLATNTF NSSSLLELDL
310 320 330 340 350
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVM NFSKLQVLRL
360 370
DGNEIKRSAM PVDAPLCLRL ANLIEI
Length:376
Mass (Da):43,055
Last modified:October 1, 1996 - v1
Checksum:i45A9EDDB0BADA85B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX60E0CX60_MOUSE
Fibromodulin
Fmod
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94998 mRNA Translation: CAA64454.1
BC064779 mRNA Translation: AAH64779.1
CCDSiCCDS15301.1
RefSeqiNP_067330.1, NM_021355.3
UniGeneiMm.287146

Genome annotation databases

EnsembliENSMUST00000048183; ENSMUSP00000035489; ENSMUSG00000041559
GeneIDi14264
KEGGimmu:14264
UCSCiuc007crd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94998 mRNA Translation: CAA64454.1
BC064779 mRNA Translation: AAH64779.1
CCDSiCCDS15301.1
RefSeqiNP_067330.1, NM_021355.3
UniGeneiMm.287146

3D structure databases

ProteinModelPortaliP50608
SMRiP50608
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035489

PTM databases

iPTMnetiP50608
PhosphoSitePlusiP50608

Proteomic databases

PaxDbiP50608
PeptideAtlasiP50608
PRIDEiP50608

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048183; ENSMUSP00000035489; ENSMUSG00000041559
GeneIDi14264
KEGGimmu:14264
UCSCiuc007crd.1 mouse

Organism-specific databases

CTDi2331
MGIiMGI:1328364 Fmod

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOVERGENiHBG108061
InParanoidiP50608
KOiK08121
OMAiDEDPHWW
OrthoDBiEOG091G0A3V
PhylomeDBiP50608
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Miscellaneous databases

PROiPR:P50608
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041559 Expressed in 290 organ(s), highest expression level in vault of skull
CleanExiMM_FMOD
ExpressionAtlasiP50608 baseline and differential
GenevisibleiP50608 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR027215 Fibromodulin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PANTHERiPTHR24373:SF127 PTHR24373:SF127, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFMOD_MOUSE
AccessioniPrimary (citable) accession number: P50608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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