UniProtKB - P50607 (TUB_HUMAN)
Tubby protein homolog
TUB
Functioni
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).
Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
By similarity1 PublicationGO - Molecular functioni
- G protein-coupled receptor binding Source: MGI
- intraciliary transport particle A binding Source: MGI
- protein-containing complex binding Source: MGI
GO - Biological processi
- intraciliary transport Source: MGI
- phagocytosis, recognition Source: Ensembl
- photoreceptor cell maintenance Source: Ensembl
- positive regulation of phagocytosis Source: UniProtKB
- protein localization to cilium Source: GO_Central
- protein localization to photoreceptor outer segment Source: Ensembl
- receptor localization to non-motile cilium Source: Ensembl
- regulation of G protein-coupled receptor signaling pathway Source: Ensembl
- response to stimulus Source: UniProtKB-KW
- retina development in camera-type eye Source: Ensembl
- sensory perception of sound Source: Ensembl
Keywordsi
Biological process | Phagocytosis, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | P50607 |
SignaLinki | P50607 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubby protein homolog |
Gene namesi | Name:TUB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12406, TUB |
MIMi | 601197, gene |
neXtProti | NX_P50607 |
VEuPathDBi | HostDB:ENSG00000166402 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Extracellular region or secreted
- Secreted By similarity
Nucleus
- Nucleus By similarity
Note: Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).By similarity
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, Nucleus, SecretedPathology & Biotechi
Involvement in diseasei
Retinal dystrophy and obesity (RDOB)1 Publication
Keywords - Diseasei
ObesityOrganism-specific databases
DisGeNETi | 7275 |
MalaCardsi | TUB |
MIMi | 616188, phenotype |
OpenTargetsi | ENSG00000166402 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA37070 |
Miscellaneous databases
Pharosi | P50607, Tbio |
Chemistry databases
DrugBanki | DB02028, (1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)] |
Genetic variation databases
BioMutai | TUB |
DMDMi | 1717821 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186463 | 1 – 506 | Tubby protein homologAdd BLAST | 506 |
Proteomic databases
jPOSTi | P50607 |
MassIVEi | P50607 |
PaxDbi | P50607 |
PeptideAtlasi | P50607 |
PRIDEi | P50607 |
ProteomicsDBi | 56256 [P50607-1] 56257 [P50607-2] |
PTM databases
iPTMneti | P50607 |
PhosphoSitePlusi | P50607 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166402, Expressed in substantia nigra pars reticulata and 201 other tissues |
ExpressionAtlasi | P50607, baseline and differential |
Genevisiblei | P50607, HS |
Organism-specific databases
HPAi | ENSG00000166402, Tissue enhanced (brain, retina) |
Interactioni
Subunit structurei
Interacts with GNAQ.
Interacts with TULP1.
By similarityGO - Molecular functioni
- G protein-coupled receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 113126, 23 interactors |
IntActi | P50607, 2 interactors |
STRINGi | 9606.ENSP00000305426 |
Miscellaneous databases
RNActi | P50607, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P50607 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P50607 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 244 | DisorderedSequence analysisAdd BLAST | 209 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 69 – 100 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 208 – 231 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000158372 |
HOGENOMi | CLU_028236_1_1_1 |
InParanoidi | P50607 |
OMAi | HKGTGGP |
OrthoDBi | 1445357at2759 |
PhylomeDBi | P50607 |
TreeFami | TF314076 |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit PS01201, TUB_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSKPHSDWI PYSVLDDEGR NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA
60 70 80 90 100
NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQLGATR
110 120 130 140 150
PTAPASAKRT KAAATAGGQG GAARKEKKGK HKGTSGPAAL AEDKSEAQGP
160 170 180 190 200
VQILTVGQSD HAQDAGETAA GGGERPSGQD LRATMQRKGI SSSMSFDEDE
210 220 230 240 250
EDEEENSSSS SQLNSNTRPS SATSRKSVRE AASAPSPTAP EQPVDVEVQD
260 270 280 290 300
LEEFALRPAP QGITIKCRIT RDKKGMDRGM YPTYFLHLDR EDGKKVFLLA
310 320 330 340 350
GRKRKKSKTS NYLISVDPTD LSRGGDSYIG KLRSNLMGTK FTVYDNGVNP
360 370 380 390 400
QKASSSTLES GTLRQELAAV CYETNVLGFK GPRKMSVIVP GMNMVHERVS
410 420 430 440 450
IRPRNEHETL LARWQNKNTE SIIELQNKTP VWNDDTQSYV LNFHGRVTQA
460 470 480 490 500
SVKNFQIIHG NDPDYIVMQF GRVAEDVFTM DYNYPLCALQ AFAIALSSFD
SKLACE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PQR4 | E9PQR4_HUMAN | Tubby-like protein | TUB | 512 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023030 | 1 – 13 | MTSKP…WIPYS → MGARTPLPSFWVSFFAETGI LFPGGTPWPMGSQHSKQHRK PGPLKRGHRRDRRTTRRKYW KEGREIAR in isoform 2. 2 PublicationsAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U54644 mRNA Translation: AAB53494.1 U82467 mRNA Translation: AAB53699.1 CH471064 Genomic DNA Translation: EAW68634.1 BC075031 mRNA Translation: AAH75031.1 BC075032 mRNA Translation: AAH75032.1 |
CCDSi | CCDS7786.1 [P50607-2] CCDS7787.1 [P50607-1] |
RefSeqi | NP_003311.2, NM_003320.4 [P50607-2] NP_813977.1, NM_177972.2 [P50607-1] |
Genome annotation databases
Ensembli | ENST00000299506; ENSP00000299506; ENSG00000166402 ENST00000305253; ENSP00000305426; ENSG00000166402 [P50607-2] |
GeneIDi | 7275 |
KEGGi | hsa:7275 |
MANE-Selecti | ENST00000299506.3; ENSP00000299506.3; NM_177972.3; NP_813977.1 |
UCSCi | uc001mfy.4, human [P50607-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U54644 mRNA Translation: AAB53494.1 U82467 mRNA Translation: AAB53699.1 CH471064 Genomic DNA Translation: EAW68634.1 BC075031 mRNA Translation: AAH75031.1 BC075032 mRNA Translation: AAH75032.1 |
CCDSi | CCDS7786.1 [P50607-2] CCDS7787.1 [P50607-1] |
RefSeqi | NP_003311.2, NM_003320.4 [P50607-2] NP_813977.1, NM_177972.2 [P50607-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S31 | X-ray | 2.70 | A | 234-506 | [»] | |
SMRi | P50607 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113126, 23 interactors |
IntActi | P50607, 2 interactors |
STRINGi | 9606.ENSP00000305426 |
Chemistry databases
DrugBanki | DB02028, (1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)] |
PTM databases
iPTMneti | P50607 |
PhosphoSitePlusi | P50607 |
Genetic variation databases
BioMutai | TUB |
DMDMi | 1717821 |
Proteomic databases
jPOSTi | P50607 |
MassIVEi | P50607 |
PaxDbi | P50607 |
PeptideAtlasi | P50607 |
PRIDEi | P50607 |
ProteomicsDBi | 56256 [P50607-1] 56257 [P50607-2] |
Protocols and materials databases
Antibodypediai | 11439, 89 antibodies from 25 providers |
DNASUi | 7275 |
Genome annotation databases
Ensembli | ENST00000299506; ENSP00000299506; ENSG00000166402 ENST00000305253; ENSP00000305426; ENSG00000166402 [P50607-2] |
GeneIDi | 7275 |
KEGGi | hsa:7275 |
MANE-Selecti | ENST00000299506.3; ENSP00000299506.3; NM_177972.3; NP_813977.1 |
UCSCi | uc001mfy.4, human [P50607-1] |
Organism-specific databases
CTDi | 7275 |
DisGeNETi | 7275 |
GeneCardsi | TUB |
HGNCi | HGNC:12406, TUB |
HPAi | ENSG00000166402, Tissue enhanced (brain, retina) |
MalaCardsi | TUB |
MIMi | 601197, gene 616188, phenotype |
neXtProti | NX_P50607 |
OpenTargetsi | ENSG00000166402 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA37070 |
VEuPathDBi | HostDB:ENSG00000166402 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000158372 |
HOGENOMi | CLU_028236_1_1_1 |
InParanoidi | P50607 |
OMAi | HKGTGGP |
OrthoDBi | 1445357at2759 |
PhylomeDBi | P50607 |
TreeFami | TF314076 |
Enzyme and pathway databases
PathwayCommonsi | P50607 |
SignaLinki | P50607 |
Miscellaneous databases
BioGRID-ORCSi | 7275, 14 hits in 1065 CRISPR screens |
ChiTaRSi | TUB, human |
EvolutionaryTracei | P50607 |
GeneWikii | TUB_(gene) |
GenomeRNAii | 7275 |
Pharosi | P50607, Tbio |
PROi | PR:P50607 |
RNActi | P50607, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166402, Expressed in substantia nigra pars reticulata and 201 other tissues |
ExpressionAtlasi | P50607, baseline and differential |
Genevisiblei | P50607, HS |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit PS01201, TUB_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TUB_HUMAN | |
Accessioni | P50607Primary (citable) accession number: P50607 Secondary accession number(s): D3DQU4, O00293, Q6B007 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families