TUB

Functionⁱ

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.By similarity1 Publication

GO - Molecular functionⁱ

phosphatidylinositol binding Source: GO_Central
protein-containing complex binding
Source: MGI
Inferred from direct assayⁱ
- 20889716

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phagocytosis, recognition Source: Ensembl
photoreceptor cell maintenance Source: Ensembl
positive regulation of phagocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 19837063
protein localization to photoreceptor outer segment Source: GO_Central
receptor localization to non-motile cilium Source: GO_Central
response to hormone Source: Ensembl
retina development in camera-type eye Source: Ensembl
sensory perception of sound Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Phagocytosis, Sensory transduction

Biological process

Phagocytosis, Sensory transduction

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tubby protein homolog
Gene namesⁱ	Name:TUB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166402.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12406 TUB
MIMⁱ	601197 gene
neXtProtⁱ	NX_P50607

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Retinal dystrophy and obesity (RDOB)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy.

Keywords - Diseaseⁱ

Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7275
MalaCards human disease database More...MalaCardsⁱ	TUB
MIMⁱ	616188 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000166402
Orphanetⁱ	791 Retinitis pigmentosa
PharmGKBⁱ	PA37070

Polymorphism and mutation databases

BioMutaⁱ	TUB
DMDMⁱ	1717821

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186463	1 – 506	Tubby protein homologAdd BLAST		506

Proteomic databases

EPDⁱ	P50607
PaxDbⁱ	P50607
PeptideAtlas More...PeptideAtlasⁱ	P50607
PRIDEⁱ	P50607
ProteomicsDBⁱ	56256 56257 [P50607-2]

PTM databases

iPTMnetⁱ	P50607
PhosphoSitePlusⁱ	P50607

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166402 Expressed in 182 organ(s), highest expression level in substantia nigra pars reticulata
CleanExⁱ	HS_TUB
ExpressionAtlasⁱ	P50607 baseline and differential
Genevisibleⁱ	P50607 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017997 HPA049019

HPAⁱ

HPA017997
HPA049019

Interactionⁱ

Subunit structureⁱ

Interacts with GNAQ. Interacts with TULP1.By similarity

Protein-protein interaction databases

BioGridⁱ	113126, 5 interactors
STRINGⁱ	9606.ENSP00000305426

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	251 – 255	Combined sources	5
Beta strandⁱ	265 – 272	Combined sources	8
Helixⁱ	276 – 278	Combined sources	3
Beta strandⁱ	283 – 289	Combined sources	7
Beta strandⁱ	295 – 303	Combined sources	9
Beta strandⁱ	311 – 316	Combined sources	6
Helixⁱ	318 – 322	Combined sources	5
Beta strandⁱ	329 – 334	Combined sources	6
Beta strandⁱ	338 – 348	Combined sources	11
Turnⁱ	355 – 357	Combined sources	3
Beta strandⁱ	358 – 363	Combined sources	6
Beta strandⁱ	366 – 372	Combined sources	7
Beta strandⁱ	385 – 390	Combined sources	6
Helixⁱ	406 – 408	Combined sources	3
Helixⁱ	410 – 415	Combined sources	6
Beta strandⁱ	421 – 427	Combined sources	7
Beta strandⁱ	431 – 433	Combined sources	3
Turnⁱ	434 – 437	Combined sources	4
Beta strandⁱ	438 – 440	Combined sources	3
Beta strandⁱ	455 – 459	Combined sources	5
Beta strandⁱ	467 – 474	Combined sources	8
Beta strandⁱ	477 – 482	Combined sources	6
Helixⁱ	488 – 500	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P50607
SMRⁱ	P50607
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P50607

EvolutionaryTraceⁱ

P50607

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	197 – 204	Asp/Glu-rich		8
Compositional biasⁱ	206 – 210	Poly-Ser		5

Sequence similaritiesⁱ

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2502 Eukaryota ENOG410XQFT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00610000085970
HOGENOMⁱ	HOG000016044
HOVERGENⁱ	HBG018010
InParanoidⁱ	P50607
OMAⁱ	FQIIHGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04TF
PhylomeDBⁱ	P50607
TreeFamⁱ	TF314076

Family and domain databases

Gene3Dⁱ	3.20.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR025659 Tubby-like_C IPR000007 Tubby_C IPR018066 Tubby_C_CS IPR005398 Tubby_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01167 Tub, 1 hit PF16322 Tub_N, 1 hit
PRINTSⁱ	PR01573 SUPERTUBBY PR01574 TUBBYPROTEIN
SUPFAMⁱ	SSF54518 SSF54518, 1 hit
PROSITEⁱ	View protein in PROSITE PS01200 TUB_1, 1 hit PS01201 TUB_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: P50607-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSKPHSDWI PYSVLDDEGR NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA 
        60         70         80         90        100
NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQLGATR 
       110        120        130        140        150
PTAPASAKRT KAAATAGGQG GAARKEKKGK HKGTSGPAAL AEDKSEAQGP 
       160        170        180        190        200
VQILTVGQSD HAQDAGETAA GGGERPSGQD LRATMQRKGI SSSMSFDEDE 
       210        220        230        240        250
EDEEENSSSS SQLNSNTRPS SATSRKSVRE AASAPSPTAP EQPVDVEVQD 
       260        270        280        290        300
LEEFALRPAP QGITIKCRIT RDKKGMDRGM YPTYFLHLDR EDGKKVFLLA 
       310        320        330        340        350
GRKRKKSKTS NYLISVDPTD LSRGGDSYIG KLRSNLMGTK FTVYDNGVNP 
       360        370        380        390        400
QKASSSTLES GTLRQELAAV CYETNVLGFK GPRKMSVIVP GMNMVHERVS 
       410        420        430        440        450
IRPRNEHETL LARWQNKNTE SIIELQNKTP VWNDDTQSYV LNFHGRVTQA 
       460        470        480        490        500
SVKNFQIIHG NDPDYIVMQF GRVAEDVFTM DYNYPLCALQ AFAIALSSFD 

SKLACE

Length:506

Mass (Da):55,651

Last modified:October 1, 1996 - v1

Checksum:ⁱB2A7D230795346C3

GO

Isoform 2 (identifier: P50607-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-13: MTSKPHSDWIPYS → MGARTPLPSF...YWKEGREIAR

« Hide

        10         20         30         40         50
MGARTPLPSF WVSFFAETGI LFPGGTPWPM GSQHSKQHRK PGPLKRGHRR 
        60         70         80         90        100
DRRTTRRKYW KEGREIARVL DDEGRNLRQQ KLDRQRALLE QKQKKKRQEP 
       110        120        130        140        150
LMVQANADGR PRSRRARQSE EQAPLVESYL SSSGSTSYQV QEADSLASVQ 
       160        170        180        190        200
LGATRPTAPA SAKRTKAAAT AGGQGGAARK EKKGKHKGTS GPAALAEDKS 
       210        220        230        240        250
EAQGPVQILT VGQSDHAQDA GETAAGGGER PSGQDLRATM QRKGISSSMS 
       260        270        280        290        300
FDEDEEDEEE NSSSSSQLNS NTRPSSATSR KSVREAASAP SPTAPEQPVD 
       310        320        330        340        350
VEVQDLEEFA LRPAPQGITI KCRITRDKKG MDRGMYPTYF LHLDREDGKK 
       360        370        380        390        400
VFLLAGRKRK KSKTSNYLIS VDPTDLSRGG DSYIGKLRSN LMGTKFTVYD 
       410        420        430        440        450
NGVNPQKASS STLESGTLRQ ELAAVCYETN VLGFKGPRKM SVIVPGMNMV 
       460        470        480        490        500
HERVSIRPRN EHETLLARWQ NKNTESIIEL QNKTPVWNDD TQSYVLNFHG 
       510        520        530        540        550
RVTQASVKNF QIIHGNDPDY IVMQFGRVAE DVFTMDYNYP LCALQAFAIA 
       560 
LSSFDSKLAC E

Show »

Length:561

Mass (Da):62,091

Checksum:ⁱ1ADCBB761A60F6A6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	E9PQR4	E9PQR4_HUMAN		Tubby-like protein Tubby-like protein	TUB	512	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023030	1 – 13	MTSKP…WIPYS → MGARTPLPSFWVSFFAETGI LFPGGTPWPMGSQHSKQHRK PGPLKRGHRRDRRTTRRKYW KEGREIAR in isoform 2. 2 PublicationsAdd BLAST		13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U54644 mRNA Translation: AAB53494.1 U82467 mRNA Translation: AAB53699.1 CH471064 Genomic DNA Translation: EAW68634.1 BC075031 mRNA Translation: AAH75031.1 BC075032 mRNA Translation: AAH75032.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7786.1 [P50607-2] CCDS7787.1 [P50607-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003311.2, NM_003320.4 [P50607-2] NP_813977.1, NM_177972.2 [P50607-1]
UniGeneⁱ	Hs.568986 Hs.733193

Genome annotation databases

Ensemblⁱ	ENST00000299506; ENSP00000299506; ENSG00000166402 [P50607-1] ENST00000305253; ENSP00000305426; ENSG00000166402 [P50607-2]
GeneIDⁱ	7275
KEGGⁱ	hsa:7275
UCSC genome browser More...UCSCⁱ	uc001mfy.4 human [P50607-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50607	Tubby-like protein		PANTR		506	UniRef100_P50607
Tubby-like protein		PANPA		506

Protein	Similar proteins		Species	Score	Length	Source
P50607	Tubby protein	)	MOUSE		505	UniRef90_P50586
Tubby protein homolog		RAT		505
Tubby-like protein		ODORO		617
Tubby-like protein		MUSPF		593
Tubby homolog (Mouse) (Fragment)		NEOVI		297
+170

Protein	Similar proteins		Species	Score	Length	Source
P50607	Tubby protein	)	MOUSE		505	UniRef50_P50586
Tubby protein homolog		RAT		505
Tubby-like protein		ODORO		617
Tubby-like protein		MUSPF		593
Tubby homolog (Mouse) (Fragment)		NEOVI		297
+526

Entry informationⁱ

Entry nameⁱ	TUB_HUMAN
Accessionⁱ	P50607Primary (citable) accession number: P50607 Secondary accession number(s): D3DQU4, O00293, Q6B007
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50607 (TUB_HUMAN)

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Tubby protein homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Extracellular region or secreted

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ