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Protein

Tumor necrosis factor ligand superfamily member 10

Gene

TNFSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi230Zinc; shared with trimeric partnerCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB
  • signaling receptor binding Source: ProtInc
  • TRAIL binding Source: Ensembl
  • tumor necrosis factor receptor binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75158 TRAIL signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P50591

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 10
Alternative name(s):
Apo-2 ligand
Short name:
Apo-2L
TNF-related apoptosis-inducing ligand
Short name:
Protein TRAIL
CD_antigen: CD253
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFSF10
Synonyms:APO2L, TRAIL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121858.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11925 TNFSF10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603598 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 281ExtracellularSequence analysisAdd BLAST243

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8743

Open Targets

More...
OpenTargetsi
ENSG00000121858

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36618

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5813

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFSF10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1730015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001855031 – 281Tumor necrosis factor ligand superfamily member 10Add BLAST281

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by PKDCC/VLK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P50591

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50591

PeptideAtlas

More...
PeptideAtlasi
P50591

PRoteomics IDEntifications database

More...
PRIDEi
P50591

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56254
56255 [P50591-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50591

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P50591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widespread; most predominant in spleen, lung and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121858 Expressed in 224 organ(s), highest expression level in epithelium of bronchus

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFSF10

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P50591 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50591 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054938

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114280, 22 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P50591

Database of interacting proteins

More...
DIPi
DIP-6230N

Protein interaction database and analysis system

More...
IntActi
P50591, 18 interactors

Molecular INTeraction database

More...
MINTi
P50591

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000241261

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P50591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P50591

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50591

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P50591

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIX7 Eukaryota
ENOG410YS4F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063443

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133003

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059007

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50591

KEGG Orthology (KO)

More...
KOi
K04721

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTCVLIL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F3S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50591

TreeFam database of animal gene trees

More...
TreeFami
TF332169

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00184 TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR017355 TNF_ligand_10/11
IPR008983 Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00229 TNF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038013 TNF10_TNF11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00207 TNF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P50591-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS
60 70 80 90 100
KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI
110 120 130 140 150
STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK
160 170 180 190 200
INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT
210 220 230 240 250
KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL
260 270 280
KENDRIFVSV TNEHLIDMDH EASFFGAFLV G
Length:281
Mass (Da):32,509
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDAAAF78DAAB2F6D
GO
Isoform 2 (identifier: P50591-2) [UniParc]FASTAAdd to basket
Also known as: TRAIL-short, TRAIL-s

The sequence of this isoform differs from the canonical sequence as follows:
     91-101: MILRTSEETIS → TPRMKRLWAAK
     102-281: Missing.

Note: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).
Show »
Length:101
Mass (Da):11,746
Checksum:i205B6BA004A7C104
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C246H7C246_HUMAN
Tumor necrosis factor ligand superf...
TNFSF10
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05258433V → I. Corresponds to variant dbSNP:rs6763816Ensembl.1
Natural variantiVAR_05258547D → E. Corresponds to variant dbSNP:rs16845759Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04350791 – 101MILRTSEETIS → TPRMKRLWAAK in isoform 2. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_043508102 – 281Missing in isoform 2. 3 PublicationsAdd BLAST180

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37518 mRNA Translation: AAC50332.1
U57059 mRNA Translation: AAB01233.1
DQ848564 mRNA Translation: ABI24016.1
EU183231 mRNA Translation: ABW24658.1
AK296085 mRNA Translation: BAG58840.1
AC007919 Genomic DNA No translation available.
AC016938 Genomic DNA No translation available.
BC032722 mRNA Translation: AAH32722.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3219.1 [P50591-1]
CCDS54680.1 [P50591-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001177871.1, NM_001190942.1 [P50591-2]
NP_003801.1, NM_003810.3 [P50591-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.478275

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000241261; ENSP00000241261; ENSG00000121858 [P50591-1]
ENST00000420541; ENSP00000389931; ENSG00000121858 [P50591-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8743

UCSC genome browser

More...
UCSCi
uc003fie.4 human [P50591-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37518 mRNA Translation: AAC50332.1
U57059 mRNA Translation: AAB01233.1
DQ848564 mRNA Translation: ABI24016.1
EU183231 mRNA Translation: ABW24658.1
AK296085 mRNA Translation: BAG58840.1
AC007919 Genomic DNA No translation available.
AC016938 Genomic DNA No translation available.
BC032722 mRNA Translation: AAH32722.1
CCDSiCCDS3219.1 [P50591-1]
CCDS54680.1 [P50591-2]
RefSeqiNP_001177871.1, NM_001190942.1 [P50591-2]
NP_003801.1, NM_003810.3 [P50591-1]
UniGeneiHs.478275

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0GX-ray2.40A/B/D114-281[»]
1D2QX-ray2.80A/B114-281[»]
1D4VX-ray2.20B119-281[»]
1DG6X-ray1.30A91-281[»]
1DU3X-ray2.20D/E/F/J/K/L114-281[»]
4N90X-ray3.30A/B/C114-281[»]
5CIRX-ray3.00A/B/D114-281[»]
ProteinModelPortaliP50591
SMRiP50591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114280, 22 interactors
CORUMiP50591
DIPiDIP-6230N
IntActiP50591, 18 interactors
MINTiP50591
STRINGi9606.ENSP00000241261

Chemistry databases

BindingDBiP50591
ChEMBLiCHEMBL5813

PTM databases

iPTMnetiP50591
PhosphoSitePlusiP50591

Polymorphism and mutation databases

BioMutaiTNFSF10
DMDMi1730015

Proteomic databases

EPDiP50591
PaxDbiP50591
PeptideAtlasiP50591
PRIDEiP50591
ProteomicsDBi56254
56255 [P50591-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8743
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241261; ENSP00000241261; ENSG00000121858 [P50591-1]
ENST00000420541; ENSP00000389931; ENSG00000121858 [P50591-2]
GeneIDi8743
KEGGihsa:8743
UCSCiuc003fie.4 human [P50591-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8743
DisGeNETi8743
EuPathDBiHostDB:ENSG00000121858.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TNFSF10
HGNCiHGNC:11925 TNFSF10
HPAiHPA054938
MIMi603598 gene
neXtProtiNX_P50591
OpenTargetsiENSG00000121858
PharmGKBiPA36618

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIX7 Eukaryota
ENOG410YS4F LUCA
GeneTreeiENSGT00530000063443
HOGENOMiHOG000133003
HOVERGENiHBG059007
InParanoidiP50591
KOiK04721
OMAiQTCVLIL
OrthoDBiEOG091G0F3S
PhylomeDBiP50591
TreeFamiTF332169

Enzyme and pathway databases

ReactomeiR-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75158 TRAIL signaling
SIGNORiP50591

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNFSF10 human
EvolutionaryTraceiP50591

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRAIL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8743

Protein Ontology

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PROi
PR:P50591

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121858 Expressed in 224 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_TNFSF10
ExpressionAtlasiP50591 baseline and differential
GenevisibleiP50591 HS

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR017355 TNF_ligand_10/11
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF038013 TNF10_TNF11, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNF10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50591
Secondary accession number(s): A1Y9B3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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