UniProtKB - P50573 (GBRR3_RAT)
Protein
Gamma-aminobutyric acid receptor subunit rho-3
Gene
Gabrr3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- extracellular ligand-gated ion channel activity Source: InterPro
- neurotransmitter receptor activity Source: GO_Central
- protein domain specific binding Source: RGD
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-RNO-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit rho-3Alternative name(s): GABA(A) receptor subunit rho-3 GABA(C) receptor |
Gene namesi | Name:Gabrr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621564, Gabrr3 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 264 | ExtracellularCuratedAdd BLAST | 243 | |
Transmembranei | 265 – 288 | HelicalCuratedAdd BLAST | 24 | |
Transmembranei | 292 – 314 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 326 – 348 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 349 – 442 | CytoplasmicCuratedAdd BLAST | 94 | |
Transmembranei | 443 – 464 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000000491 | 22 – 464 | Gamma-aminobutyric acid receptor subunit rho-3Add BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 123 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 181 ↔ 195 | By similarity | ||
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P50573 |
PRIDEi | P50573 |
PTM databases
GlyGeni | P50573, 2 sites |
PhosphoSitePlusi | P50573 |
Expressioni
Tissue specificityi
Retina.
Gene expression databases
Bgeei | ENSRNOG00000001679, Expressed in liver and 17 other tissues |
Genevisiblei | P50573, RN |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Forms a ternary complex with SQSTM1 and PRKCZ.
GO - Molecular functioni
- protein domain specific binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 251384, 1 interactor |
CORUMi | P50573 |
STRINGi | 10116.ENSRNOP00000002281 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 445 | Interaction with SQSTM11 PublicationAdd BLAST | 102 |
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000159906 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P50573 |
OMAi | SSTGWYY |
OrthoDBi | 480926at2759 |
PhylomeDBi | P50573 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P50573-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLAFWLAFF TYTWITLMLD ASAVKEPHQQ CLSSPKQTRI RETRMRKDDL
60 70 80 90 100
TKVWPLKREQ LLHIEDHDFS TRPGFGGSPV PVGIDVQVES IDSISEVNMD
110 120 130 140 150
FTMTFYLRHY WKDERLSFPS TTNKSMTFDR RLIQKIWVPD IFFVHSKRSF
160 170 180 190 200
IHDTTVENIM LRVHPDGNVL FSLRITVSAM CFMDFSRFPL DTQNCSLELE
210 220 230 240 250
SYAYNEEDLM LYWKHGNKSL NTEEHISLSQ FFIEEFSASS GLAFYSSTGW
260 270 280 290 300
YYRLFINFVL RRHIFFFVLQ TYFPAMLMVM LSWVSFWIDR RAVPARVSLG
310 320 330 340 350
ITTVLTMSTI VTGVSASMPQ VSYVKAVDVY MWVSSLFVFL SVIEYAAVNY
360 370 380 390 400
LTTVEEWKQL NRRGKISGMY NIDAVQAMAF DGCYHDGETD VDQTSFFLHS
410 420 430 440 450
EEDSMRTKFT GSPCADSSQI KRKSLGGNVG RIILENNHVI DTYSRIVFPV
460
VYIIFNLFYW GIYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50671 mRNA Translation: BAA09322.1 |
PIRi | S65756 |
RefSeqi | NP_620252.1, NM_138897.1 |
Genome annotation databases
Ensembli | ENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679 |
GeneIDi | 192258 |
KEGGi | rno:192258 |
UCSCi | RGD:621564, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50671 mRNA Translation: BAA09322.1 |
PIRi | S65756 |
RefSeqi | NP_620252.1, NM_138897.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 251384, 1 interactor |
CORUMi | P50573 |
STRINGi | 10116.ENSRNOP00000002281 |
PTM databases
GlyGeni | P50573, 2 sites |
PhosphoSitePlusi | P50573 |
Proteomic databases
PaxDbi | P50573 |
PRIDEi | P50573 |
Genome annotation databases
Ensembli | ENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679 |
GeneIDi | 192258 |
KEGGi | rno:192258 |
UCSCi | RGD:621564, rat |
Organism-specific databases
CTDi | 200959 |
RGDi | 621564, Gabrr3 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000159906 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P50573 |
OMAi | SSTGWYY |
OrthoDBi | 480926at2759 |
PhylomeDBi | P50573 |
TreeFami | TF315453 |
Enzyme and pathway databases
Reactomei | R-RNO-977443, GABA receptor activation |
Miscellaneous databases
PROi | PR:P50573 |
Gene expression databases
Bgeei | ENSRNOG00000001679, Expressed in liver and 17 other tissues |
Genevisiblei | P50573, RN |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRR3_RAT | |
Accessioni | P50573Primary (citable) accession number: P50573 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families