UniProtKB - P50572 (GBRR1_RAT)
Gamma-aminobutyric acid receptor subunit rho-1
Gabrr1
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- GABA-A receptor activity Source: InterPro
- GABA receptor activity Source: RGD
- identical protein binding Source: RGD
- ligand-gated ion channel activity involved in regulation of presynaptic membrane potential Source: RGD
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: RGD
- protein domain specific binding Source: RGD
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: RGD
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
- visual perception Source: RGD
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-RNO-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit rho-1Alternative name(s): GABA(A) receptor subunit rho-1 GABA(C) receptor |
Gene namesi | Name:Gabrr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61900, Gabrr1 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: RGD
- glutamatergic synapse Source: RGD
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 282 | ExtracellularCuratedAdd BLAST | 261 | |
Transmembranei | 283 – 306 | HelicalCuratedAdd BLAST | 24 | |
Transmembranei | 310 – 332 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 344 – 366 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 367 – 458 | CytoplasmicCuratedAdd BLAST | 92 | |
Transmembranei | 459 – 480 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000000487 | 22 – 480 | Gamma-aminobutyric acid receptor subunit rho-1Add BLAST | 459 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 199 ↔ 213 | By similarity | ||
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P50572 |
PTM databases
GlyGeni | P50572, 3 sites |
iPTMneti | P50572 |
PhosphoSitePlusi | P50572 |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Interacts with SQSTM1.
1 PublicationGO - Molecular functioni
- identical protein binding Source: RGD
- protein domain specific binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010172 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 67 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 60 | Basic and acidic residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
InParanoidi | P50572 |
PhylomeDBi | P50572 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008058, GABAAa_rho1_rcpt IPR008057, GABAAa_rho_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01670, GABAARRHO PR01671, GABAARRHO1 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLAVRNMKFG IFLLWWGWVL AAESTVHWPG REVHEPSKKG SRPQRQRRGA
60 70 80 90 100
HDDAHKQGSP ILKRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV
110 120 130 140 150
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSTN NLSMTFDGRL
160 170 180 190 200
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN
210 220 230 240 250
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL
260 270 280 290 300
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
310 320 330 340 350
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW
360 370 380 390 400
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS
410 420 430 440 450
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK SQRGSYVSMR
460 470 480
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LPA8 | F1LPA8_RAT | GABA(C) receptor | Gabrr1 | 480 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21070 mRNA Translation: AAA87730.1 Different initiation. X95579 mRNA Translation: CAA64832.1 Different initiation. |
Genome annotation databases
Ensembli | ENSRNOT00000010172; ENSRNOP00000010172; ENSRNOG00000007603 |
UCSCi | RGD:61900, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21070 mRNA Translation: AAA87730.1 Different initiation. X95579 mRNA Translation: CAA64832.1 Different initiation. |
3D structure databases
AlphaFoldDBi | P50572 |
SMRi | P50572 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010172 |
Chemistry databases
GuidetoPHARMACOLOGYi | 420 |
PTM databases
GlyGeni | P50572, 3 sites |
iPTMneti | P50572 |
PhosphoSitePlusi | P50572 |
Proteomic databases
PaxDbi | P50572 |
Genome annotation databases
Ensembli | ENSRNOT00000010172; ENSRNOP00000010172; ENSRNOG00000007603 |
UCSCi | RGD:61900, rat |
Organism-specific databases
RGDi | 61900, Gabrr1 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
InParanoidi | P50572 |
PhylomeDBi | P50572 |
Enzyme and pathway databases
Reactomei | R-RNO-977443, GABA receptor activation |
Miscellaneous databases
PROi | PR:P50572 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008058, GABAAa_rho1_rcpt IPR008057, GABAAa_rho_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01670, GABAARRHO PR01671, GABAARRHO1 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRR1_RAT | |
Accessioni | P50572Primary (citable) accession number: P50572 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families