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UniProtKB - P50570 (DYN2_HUMAN)

Protein

Dynamin-2

Gene

DNM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).By similarity1 Publication

Miscellaneous

Overexpression of CNM- and CMT-related DNM2 mutants in COS7 cells, whatever the mutated domain, led to a reduction in clathrin-mediated receptor endocytosis associated with MAPK ERK-1 and ERK-2 impairment. The membrane trafficking impairment process may represent a common pathophysiological pathway in the autosomal forms of CNM DNM2-CMT neuropathy.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 46GTPBy similarity9
Nucleotide bindingi205 – 211GTPBy similarity7
Nucleotide bindingi236 – 239GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • D2 dopamine receptor binding Source: Ensembl
  • enzyme binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB
  • microtubule binding Source: GO_Central
  • nitric-oxide synthase binding Source: Ensembl
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: Ensembl
  • protein-containing complex binding Source: Ensembl
  • protein kinase binding Source: Ensembl
  • SH3 domain binding Source: UniProtKB
  • WW domain binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis, Phagocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.5.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-203641 NOSTRIN mediated eNOS trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-437239 Recycling pathway of L1
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P50570

SIGNOR Signaling Network Open Resource

More...SIGNORi		P50570

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P50570 Curated

Transport Classification Database

More...TCDBi		1.R.1.1.1 the membrane contact site (mcs) family
8.A.34.1.4 the endophilin (endophilin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin-2 (EC:3.6.5.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNM2
Synonyms:DYN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000079805.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:2974 DNM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602378 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P50570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, centronuclear, 1 (CNM1)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
See also OMIM:160150
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031962368E → K in CNM1. 2 PublicationsCorresponds to variant dbSNP:rs121909092EnsemblClinVar.1
Natural variantiVAR_068365368E → Q in CNM1. 1 Publication1
Natural variantiVAR_031963369R → Q in CNM1. 1 PublicationCorresponds to variant dbSNP:rs121909089EnsemblClinVar.1
Natural variantiVAR_031964369R → W in CNM1; reduced association with the centrosome. 1 PublicationCorresponds to variant dbSNP:rs121909090EnsemblClinVar.1
Natural variantiVAR_031965465R → W in CNM1; reduced association with the centrosome; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 3 PublicationsCorresponds to variant dbSNP:rs121909091EnsemblClinVar.1
Natural variantiVAR_068366522R → C in CNM1. 1 Publication1
Natural variantiVAR_068367522R → H in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783595EnsemblClinVar.1
Natural variantiVAR_068368523R → G in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783596EnsemblClinVar.1
Natural variantiVAR_068369560E → K in CNM1. 1 PublicationCorresponds to variant dbSNP:rs879254086EnsemblClinVar.1
Natural variantiVAR_068370618A → D in CNM1. 1 Publication1
Natural variantiVAR_039041618A → T in CNM1; severe. 2 Publications1
Natural variantiVAR_039042619S → L in CNM1; severe. 2 PublicationsCorresponds to variant dbSNP:rs121909095EnsemblClinVar.1
Natural variantiVAR_039043619S → W in CNM1; severe. 1 PublicationCorresponds to variant dbSNP:rs121909095EnsemblClinVar.1
Natural variantiVAR_068371621L → P in CNM1; centronuclear myopathy with cataracts. 1 PublicationCorresponds to variant dbSNP:rs587783597EnsemblClinVar.1
Natural variantiVAR_039044625Missing in CNM1; severe; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 Publications1
Natural variantiVAR_068372627P → H in CNM1. 1 Publication1
Natural variantiVAR_068373627P → R in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783598EnsemblClinVar.1
Natural variantiVAR_062576650E → K in CNM1; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 1 Publication1
Lethal congenital contracture syndrome 5 (LCCS5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.
See also OMIM:615368
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070163379F → V in LCCS5; hypomorphic mutation impacting on endocytosis. 1 PublicationCorresponds to variant dbSNP:rs397514735EnsemblClinVar.1
Charcot-Marie-Tooth disease, dominant, intermediate type, B (CMTDIB)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type B is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
See also OMIM:606482
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031966555 – 557Missing in CMTDIB; may affect binding to vesicles and membranes in favor of binding to microtubules; may affect receptor-mediated endocytosis. 1 Publication3
Natural variantiVAR_031967562K → E in CMTDIB; with neutropenia; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 PublicationsCorresponds to variant dbSNP:rs121909088EnsemblClinVar.1
Natural variantiVAR_070164562Missing in CMTDIB. 1 Publication1
Charcot-Marie-Tooth disease 2M (CMT2M)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
See also OMIM:606482
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068425358G → R in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs267606772EnsemblClinVar.1
Natural variantiVAR_062574537G → C in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909093EnsemblClinVar.1
Natural variantiVAR_062575570L → H in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909094EnsemblClinVar.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		1785

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DNM2

MalaCards human disease database

More...MalaCardsi		DNM2
MIMi160150 phenotype
606482 phenotype
615368 phenotype

Open Targets

More...OpenTargetsi		ENSG00000079805

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169189 Autosomal dominant centronuclear myopathy
228179 Autosomal dominant Charcot-Marie-Tooth disease type 2M
100044 Autosomal dominant intermediate Charcot-Marie-Tooth disease type B
363409 Fetal akinesia-cerebral and retinal hemorrhage syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27442

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5812

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		47117856

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065701 – 870Dynamin-2Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphotyrosineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei597PhosphotyrosineBy similarity1
Modified residuei598N6-acetyllysineCombined sources1
Modified residuei755PhosphothreonineCombined sources1
Modified residuei764Phosphoserine; by CDK1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P50570

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50570

MaxQB - The MaxQuant DataBase

More...MaxQBi		P50570

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50570

PeptideAtlas

More...PeptideAtlasi		P50570

PRoteomics IDEntifications database

More...PRIDEi		P50570

ProteomicsDB human proteome resource

More...ProteomicsDBi		56250
56251 [P50570-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50570

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50570

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P50570

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000079805 Expressed in 184 organ(s), highest expression level in cortex of kidney

CleanEx database of gene expression profiles

More...CleanExi		HS_DNM2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P50570 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50570 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA054246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOF (By similarity). Interacts with CTTN and ACTN1 (By similarity). Interacts with SHANK1, SHANK2, SH3BP4 and NOSTRIN. Interacts with SNX9. Interacts with SNX33 (via SH3 domain). Interacts with MYO1E (via SH3 domain). Interacts with PSTPIP1. Interacts with CTNND2 (PubMed:22022388). May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with BIN1 (PubMed:17676042).By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108122, 134 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P50570

Database of interacting proteins

More...DIPi		DIP-31244N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P50570

Protein interaction database and analysis system

More...IntActi		P50570, 108 interactors

Molecular INTeraction database

More...MINTi		P50570

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347890

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P50570

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1870
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YS1NMR-A520-625[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P50570

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50570

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P50570

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini519 – 625PHPROSITE-ProRule annotationAdd BLAST107
Domaini653 – 744GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi747 – 866Pro-richAdd BLAST120

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0446 Eukaryota
COG0699 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155764

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000161069

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107833

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50570

KEGG Orthology (KO)

More...KOi		K01528

Identification of Orthologs from Complete Genome Data

More...OMAi		ANRYIPE

Database of Orthologous Groups

More...OrthoDBi		264244at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50570

TreeFam database of animal gene trees

More...TreeFami		TF300362

Family and domain databases

Conserved Domains Database

More...CDDi		cd08771 DLP_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027188 DNM2
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR11566 PTHR11566, 1 hit
PTHR11566:SF23 PTHR11566:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00195 DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL 
       560        570        580        590        600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 
       610        620        630        640        650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE 
       660        670        680        690        700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY 
       710        720        730        740        750
SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP 
       760        770        780        790        800
PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA 
       810        820        830        840        850
AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR 
       860        870
PPAAPSRPTI IRPAEPSLLD
Length:870
Mass (Da):98,064
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F4567B75980935D
GO
Isoform 2 (identifier: P50570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-519: Missing.

Show »
Length:866
Mass (Da):97,652
Checksum:iC76BA1762A012127
GO
Isoform 3 (identifier: P50570-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEAIVKKQ...LINTVRQCTS → MAFEAIVKKQ...LATVIKKCAE
     516-519: Missing.

Show »
Length:866
Mass (Da):97,554
Checksum:i566396D3E6159245
GO
Isoform 4 (identifier: P50570-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEAIVKKQ...LINTVRQCTS → MAFEAIVKKQ...LATVIKKCAE

Note: Gene prediction based on EST data.
Show »
Length:870
Mass (Da):97,966
Checksum:i9018503EA888A4F8
GO
Isoform 5 (identifier: P50570-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     848-848: Missing.

Note: No experimental confirmation available.
Show »
Length:869
Mass (Da):97,977
Checksum:iC33CD394EC8F1A6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENE7K7ENE7_HUMAN
Dynamin-2
DNM2
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMQ3K7EMQ3_HUMAN
Dynamin-2
DNM2
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPK9K7EPK9_HUMAN
Dynamin-2
DNM2
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMR9K7EMR9_HUMAN
Dynamin-2
DNM2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155 – 156QI → RV in AAA88025 (PubMed:7590285).Curated2
Sequence conflicti207L → P in AK312260 (PubMed:14702039).Curated1
Sequence conflicti316N → I in AAA88025 (PubMed:7590285).Curated1
Sequence conflicti324R → P in AAA88025 (PubMed:7590285).Curated1
Sequence conflicti475I → T in AK312260 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031961263P → L. Corresponds to variant dbSNP:rs3745674EnsemblClinVar.1
Natural variantiVAR_068425358G → R in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs267606772EnsemblClinVar.1
Natural variantiVAR_031962368E → K in CNM1. 2 PublicationsCorresponds to variant dbSNP:rs121909092EnsemblClinVar.1
Natural variantiVAR_068365368E → Q in CNM1. 1 Publication1
Natural variantiVAR_031963369R → Q in CNM1. 1 PublicationCorresponds to variant dbSNP:rs121909089EnsemblClinVar.1
Natural variantiVAR_031964369R → W in CNM1; reduced association with the centrosome. 1 PublicationCorresponds to variant dbSNP:rs121909090EnsemblClinVar.1
Natural variantiVAR_070163379F → V in LCCS5; hypomorphic mutation impacting on endocytosis. 1 PublicationCorresponds to variant dbSNP:rs397514735EnsemblClinVar.1
Natural variantiVAR_031965465R → W in CNM1; reduced association with the centrosome; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 3 PublicationsCorresponds to variant dbSNP:rs121909091EnsemblClinVar.1
Natural variantiVAR_068366522R → C in CNM1. 1 Publication1
Natural variantiVAR_068367522R → H in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783595EnsemblClinVar.1
Natural variantiVAR_068368523R → G in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783596EnsemblClinVar.1
Natural variantiVAR_062574537G → C in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909093EnsemblClinVar.1
Natural variantiVAR_031966555 – 557Missing in CMTDIB; may affect binding to vesicles and membranes in favor of binding to microtubules; may affect receptor-mediated endocytosis. 1 Publication3
Natural variantiVAR_068369560E → K in CNM1. 1 PublicationCorresponds to variant dbSNP:rs879254086EnsemblClinVar.1
Natural variantiVAR_031967562K → E in CMTDIB; with neutropenia; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 PublicationsCorresponds to variant dbSNP:rs121909088EnsemblClinVar.1
Natural variantiVAR_070164562Missing in CMTDIB. 1 Publication1
Natural variantiVAR_062575570L → H in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909094EnsemblClinVar.1
Natural variantiVAR_068370618A → D in CNM1. 1 Publication1
Natural variantiVAR_039041618A → T in CNM1; severe. 2 Publications1
Natural variantiVAR_039042619S → L in CNM1; severe. 2 PublicationsCorresponds to variant dbSNP:rs121909095EnsemblClinVar.1
Natural variantiVAR_039043619S → W in CNM1; severe. 1 PublicationCorresponds to variant dbSNP:rs121909095EnsemblClinVar.1
Natural variantiVAR_068371621L → P in CNM1; centronuclear myopathy with cataracts. 1 PublicationCorresponds to variant dbSNP:rs587783597EnsemblClinVar.1
Natural variantiVAR_039044625Missing in CNM1; severe; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 Publications1
Natural variantiVAR_068372627P → H in CNM1. 1 Publication1
Natural variantiVAR_068373627P → R in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783598EnsemblClinVar.1
Natural variantiVAR_062576650E → K in CNM1; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044280407 – 444LAFEA…RQCTS → MAFEAIVKKQIVKLKEPSLK CVDLVVSELATVIKKCAE in isoform 3 and isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_001325516 – 519Missing in isoform 2 and isoform 3. 3 Publications4
Alternative sequenceiVSP_047534848Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L36983 mRNA Translation: AAA88025.1
AK289831 mRNA Translation: BAF82520.1
AK312260 mRNA No translation available.
AC007229 Genomic DNA Translation: AAD23604.1
AC011475 Genomic DNA No translation available.
AC011552 Genomic DNA No translation available.
AC011554 Genomic DNA No translation available.
AC112707 Genomic DNA No translation available.
BC039596 mRNA Translation: AAH39596.1
BC054501 mRNA Translation: AAH54501.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32907.1 [P50570-2]
CCDS32908.1 [P50570-3]
CCDS45968.1 [P50570-1]
CCDS45969.1 [P50570-4]
CCDS59351.1 [P50570-5]

Protein sequence database of the Protein Information Resource

More...PIRi		JC4305

NCBI Reference Sequences

More...RefSeqi		NP_001005360.1, NM_001005360.2 [P50570-1]
NP_001005361.1, NM_001005361.2 [P50570-4]
NP_001005362.1, NM_001005362.2 [P50570-3]
NP_001177645.1, NM_001190716.1 [P50570-5]
NP_004936.2, NM_004945.3 [P50570-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.211463

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355667; ENSP00000347890; ENSG00000079805 [P50570-1]
ENST00000359692; ENSP00000352721; ENSG00000079805 [P50570-2]
ENST00000389253; ENSP00000373905; ENSG00000079805 [P50570-4]
ENST00000408974; ENSP00000386192; ENSG00000079805 [P50570-3]
ENST00000585892; ENSP00000468734; ENSG00000079805 [P50570-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1785

UCSC genome browser

More...UCSCi		uc002mps.3 human [P50570-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

The UMD-DNM2-isoform 1 mutations database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36983 mRNA Translation: AAA88025.1
AK289831 mRNA Translation: BAF82520.1
AK312260 mRNA No translation available.
AC007229 Genomic DNA Translation: AAD23604.1
AC011475 Genomic DNA No translation available.
AC011552 Genomic DNA No translation available.
AC011554 Genomic DNA No translation available.
AC112707 Genomic DNA No translation available.
BC039596 mRNA Translation: AAH39596.1
BC054501 mRNA Translation: AAH54501.1
CCDSiCCDS32907.1 [P50570-2]
CCDS32908.1 [P50570-3]
CCDS45968.1 [P50570-1]
CCDS45969.1 [P50570-4]
CCDS59351.1 [P50570-5]
PIRiJC4305
RefSeqiNP_001005360.1, NM_001005360.2 [P50570-1]
NP_001005361.1, NM_001005361.2 [P50570-4]
NP_001005362.1, NM_001005362.2 [P50570-3]
NP_001177645.1, NM_001190716.1 [P50570-5]
NP_004936.2, NM_004945.3 [P50570-2]
UniGeneiHs.211463

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YS1NMR-A520-625[»]
ProteinModelPortaliP50570
SMRiP50570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108122, 134 interactors
CORUMiP50570
DIPiDIP-31244N
ELMiP50570
IntActiP50570, 108 interactors
MINTiP50570
STRINGi9606.ENSP00000347890

Chemistry databases

BindingDBiP50570
ChEMBLiCHEMBL5812

Protein family/group databases

MoonDBiP50570 Curated
TCDBi1.R.1.1.1 the membrane contact site (mcs) family
8.A.34.1.4 the endophilin (endophilin) family

PTM databases

iPTMnetiP50570
PhosphoSitePlusiP50570
SwissPalmiP50570

Polymorphism and mutation databases

BioMutaiDNM2
DMDMi47117856

Proteomic databases

EPDiP50570
jPOSTiP50570
MaxQBiP50570
PaxDbiP50570
PeptideAtlasiP50570
PRIDEiP50570
ProteomicsDBi56250
56251 [P50570-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355667; ENSP00000347890; ENSG00000079805 [P50570-1]
ENST00000359692; ENSP00000352721; ENSG00000079805 [P50570-2]
ENST00000389253; ENSP00000373905; ENSG00000079805 [P50570-4]
ENST00000408974; ENSP00000386192; ENSG00000079805 [P50570-3]
ENST00000585892; ENSP00000468734; ENSG00000079805 [P50570-5]
GeneIDi1785
KEGGihsa:1785
UCSCiuc002mps.3 human [P50570-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1785
DisGeNETi1785
EuPathDBiHostDB:ENSG00000079805.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNM2
GeneReviewsiDNM2
HGNCiHGNC:2974 DNM2
HPAiHPA054246
MalaCardsiDNM2
MIMi160150 phenotype
602378 gene
606482 phenotype
615368 phenotype
neXtProtiNX_P50570
OpenTargetsiENSG00000079805
Orphaneti169189 Autosomal dominant centronuclear myopathy
228179 Autosomal dominant Charcot-Marie-Tooth disease type 2M
100044 Autosomal dominant intermediate Charcot-Marie-Tooth disease type B
363409 Fetal akinesia-cerebral and retinal hemorrhage syndrome
PharmGKBiPA27442

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00940000155764
HOGENOMiHOG000161069
HOVERGENiHBG107833
InParanoidiP50570
KOiK01528
OMAiANRYIPE
OrthoDBi264244at2759
PhylomeDBiP50570
TreeFamiTF300362

Enzyme and pathway databases

BRENDAi3.6.5.5 2681
ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-203641 NOSTRIN mediated eNOS trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-437239 Recycling pathway of L1
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP50570
SIGNORiP50570

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNM2 human
EvolutionaryTraceiP50570

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1785

Protein Ontology

More...PROi		PR:P50570

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000079805 Expressed in 184 organ(s), highest expression level in cortex of kidney
CleanExiHS_DNM2
ExpressionAtlasiP50570 baseline and differential
GenevisibleiP50570 HS

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027188 DNM2
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF23 PTHR11566:SF23, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50570
Secondary accession number(s): A8K1B6
, E7EV30, E9PEQ4, K7ESI9, Q5I0Y0, Q7Z5S3, Q9UPH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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