DNM2

Functionⁱ

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).By similarity1 Publication

Miscellaneous

Overexpression of CNM- and CMT-related DNM2 mutants in COS7 cells, whatever the mutated domain, led to a reduction in clathrin-mediated receptor endocytosis associated with MAPK ERK-1 and ERK-2 impairment. The membrane trafficking impairment process may represent a common pathophysiological pathway in the autosomal forms of CNM DNM2-CMT neuropathy.

Catalytic activityⁱ

GTP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
GDP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
EC:
3.6.5.5
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
GTP
+
H₂O
=
GDP
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H⁺
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phosphate
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Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	38 – 46	GTPBy similarity	9
Nucleotide bindingⁱ	205 – 211	GTPBy similarity	7
Nucleotide bindingⁱ	236 – 239	GTPBy similarity	4

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Motor protein
Biological process	Endocytosis, Phagocytosis
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.5.5 2681
Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-177504 Retrograde neurotrophin signalling R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-203641 NOSTRIN mediated eNOS trafficking R-HSA-2132295 MHC class II antigen presentation R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-437239 Recycling pathway of L1 R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P50570
SIGNORⁱ	P50570

Protein family/group databases

MoonDBⁱ	P50570 Curated
TCDBⁱ	1.R.1.1.1 the membrane contact site (mcs) family 8.A.34.1.4 the endophilin (endophilin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dynamin-2 (EC:3.6.5.5)
Gene namesⁱ	Name:DNM2 Synonyms:DYN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2974 DNM2
MIMⁱ	602378 gene
neXtProtⁱ	NX_P50570

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Myopathy, centronuclear, 1 (CNM1)9 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031962	368	E → K in CNM1. 2 PublicationsCorresponds to variant dbSNP:rs121909092EnsemblClinVar.	1
Natural variantⁱVAR_068365	368	E → Q in CNM1. 1 Publication	1
Natural variantⁱVAR_031963	369	R → Q in CNM1. 1 PublicationCorresponds to variant dbSNP:rs121909089EnsemblClinVar.	1
Natural variantⁱVAR_031964	369	R → W in CNM1; reduced association with the centrosome. 1 PublicationCorresponds to variant dbSNP:rs121909090EnsemblClinVar.	1
Natural variantⁱVAR_031965	465	R → W in CNM1; reduced association with the centrosome; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 3 PublicationsCorresponds to variant dbSNP:rs121909091EnsemblClinVar.	1
Natural variantⁱVAR_068366	522	R → C in CNM1. 1 Publication	1
Natural variantⁱVAR_068367	522	R → H in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783595EnsemblClinVar.	1
Natural variantⁱVAR_068368	523	R → G in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783596EnsemblClinVar.	1
Natural variantⁱVAR_068369	560	E → K in CNM1. 1 PublicationCorresponds to variant dbSNP:rs879254086EnsemblClinVar.	1
Natural variantⁱVAR_068370	618	A → D in CNM1. 1 PublicationCorresponds to variant dbSNP:rs1555715869EnsemblClinVar.	1
Natural variantⁱVAR_039041	618	A → T in CNM1; severe. 2 Publications	1
Natural variantⁱVAR_039042	619	S → L in CNM1; severe. 2 PublicationsCorresponds to variant dbSNP:rs121909095EnsemblClinVar.	1
Natural variantⁱVAR_039043	619	S → W in CNM1; severe. 1 PublicationCorresponds to variant dbSNP:rs121909095EnsemblClinVar.	1
Natural variantⁱVAR_068371	621	L → P in CNM1; centronuclear myopathy with cataracts. 1 PublicationCorresponds to variant dbSNP:rs587783597EnsemblClinVar.	1
Natural variantⁱVAR_039044	625	Missing in CNM1; severe; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 Publications	1
Natural variantⁱVAR_068372	627	P → H in CNM1. 1 Publication	1
Natural variantⁱVAR_068373	627	P → R in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783598EnsemblClinVar.	1
Natural variantⁱVAR_062576	650	E → K in CNM1; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 1 Publication	1

Lethal congenital contracture syndrome 5 (LCCS5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070163	379	F → V in LCCS5; hypomorphic mutation impacting on endocytosis. 1 PublicationCorresponds to variant dbSNP:rs397514735EnsemblClinVar.		1

Charcot-Marie-Tooth disease, dominant, intermediate type, B (CMTDIB)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type B is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031966	555 – 557	Missing in CMTDIB; may affect binding to vesicles and membranes in favor of binding to microtubules; may affect receptor-mediated endocytosis. 1 Publication	3
Natural variantⁱVAR_031967	562	K → E in CMTDIB; with neutropenia; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 PublicationsCorresponds to variant dbSNP:rs121909088EnsemblClinVar.	1
Natural variantⁱVAR_070164	562	Missing in CMTDIB. 1 Publication	1

Charcot-Marie-Tooth disease 2M (CMT2M)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068425	358	G → R in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs267606772EnsemblClinVar.	1
Natural variantⁱVAR_062574	537	G → C in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909093EnsemblClinVar.	1
Natural variantⁱVAR_062575	570	L → H in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909094EnsemblClinVar.	1

Keywords - Diseaseⁱ

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1785
GeneReviewsⁱ	DNM2
MalaCards human disease database More...MalaCardsⁱ	DNM2
MIMⁱ	160150 phenotype 606482 phenotype 615368 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000079805
Orphanetⁱ	169189 Autosomal dominant centronuclear myopathy 228179 Autosomal dominant Charcot-Marie-Tooth disease type 2M 100044 Autosomal dominant intermediate Charcot-Marie-Tooth disease type B 363409 Fetal akinesia-cerebral and retinal hemorrhage syndrome
PharmGKBⁱ	PA27442

Chemistry databases

ChEMBLⁱ	CHEMBL5812

ChEMBLⁱ

CHEMBL5812

Polymorphism and mutation databases

BioMutaⁱ	DNM2
DMDMⁱ	47117856

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206570	1 – 870	Dynamin-2Add BLAST		870

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	231	PhosphotyrosineBy similarity	1
Modified residueⁱ	299	N6-acetyllysineBy similarity	1
Modified residueⁱ	597	PhosphotyrosineBy similarity	1
Modified residueⁱ	598	N6-acetyllysineCombined sources	1
Modified residueⁱ	755	PhosphothreonineCombined sources	1
Modified residueⁱ	764	Phosphoserine; by CDK1By similarity	1

Post-translational modificationⁱ

Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P50570
jPOSTⁱ	P50570
MassIVEⁱ	P50570
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50570
PaxDbⁱ	P50570
PeptideAtlas More...PeptideAtlasⁱ	P50570
PRIDEⁱ	P50570
ProteomicsDBⁱ	1845 19939 56250 [P50570-1] 56251 [P50570-2]

PTM databases

iPTMnetⁱ	P50570
PhosphoSitePlusⁱ	P50570
SwissPalmⁱ	P50570

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000079805 Expressed in 184 organ(s), highest expression level in cortex of kidney
ExpressionAtlasⁱ	P50570 baseline and differential
Genevisibleⁱ	P50570 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054246

HPAⁱ

HPA054246

Interactionⁱ

Subunit structureⁱ

Interacts with MYOF (By similarity).

Interacts with CTTN and ACTN1 (By similarity).

Interacts with SHANK1, SHANK2, SH3BP4 and NOSTRIN.

Interacts with SNX9.

Interacts with SNX33 (via SH3 domain).

Interacts with MYO1E (via SH3 domain).

Interacts with PSTPIP1.

Interacts with CTNND2 (PubMed:22022388). May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity).

Interacts with BIN1 (PubMed:17676042).

By similarity9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AHI1	Q8N157	2	EBI-346547,EBI-1049056
CTTN	Q14247	5	EBI-346547,EBI-351886
GRB2	P62993	6	EBI-346547,EBI-401755
ITSN1	Q15811	2	EBI-346547,EBI-602041
MYO1E	Q12965	2	EBI-346547,EBI-4279548
nef	Q9QPN3	4	EBI-346547,EBI-7355146	From Human immunodeficiency virus type 1 group M subtype B (isolate Lai).
NME2	P22392	2	EBI-346547,EBI-713693
PACSIN2	Q9UNF0	4	EBI-346547,EBI-742503
SH3BP4	Q9P0V3	3	EBI-346547,EBI-1049513
SH3GL2	Q99962	2	EBI-346547,EBI-77938
SH3KBP1	Q96B97	5	EBI-346547,EBI-346595
SNX9	Q9Y5X1	4	EBI-346547,EBI-77848

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108122, 147 interactors
CORUMⁱ	P50570
Database of interacting proteins More...DIPⁱ	DIP-31244N
ELMⁱ	P50570
IntActⁱ	P50570, 119 interactors
Molecular INTeraction database More...MINTⁱ	P50570
STRINGⁱ	9606.ENSP00000373905

Chemistry databases

BindingDBⁱ

P50570

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	522 – 530	Combined sources	9
Beta strandⁱ	533 – 535	Combined sources	3
Beta strandⁱ	540 – 545	Combined sources	6
Beta strandⁱ	550 – 555	Combined sources	6
Beta strandⁱ	560 – 565	Combined sources	6
Beta strandⁱ	567 – 573	Combined sources	7
Beta strandⁱ	585 – 590	Combined sources	6
Beta strandⁱ	596 – 599	Combined sources	4
Beta strandⁱ	601 – 606	Combined sources	6
Helixⁱ	610 – 623	Combined sources	14

Show more details

3D structure databases

SMRⁱ	P50570
ModBaseⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P50570

EvolutionaryTraceⁱ

P50570

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 294	Dynamin-type GPROSITE-ProRule annotationAdd BLAST	267
Domainⁱ	519 – 625	PHPROSITE-ProRule annotationAdd BLAST	107
Domainⁱ	653 – 744	GEDPROSITE-ProRule annotationAdd BLAST	92

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	38 – 45	G1 motifPROSITE-ProRule annotation	8
Regionⁱ	64 – 66	G2 motifPROSITE-ProRule annotation	3
Regionⁱ	136 – 139	G3 motifPROSITE-ProRule annotation	4
Regionⁱ	205 – 208	G4 motifPROSITE-ProRule annotation	4
Regionⁱ	235 – 238	G5 motifPROSITE-ProRule annotation	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	747 – 866	Pro-richAdd BLAST		120

Sequence similaritiesⁱ

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0446 Eukaryota COG0699 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155764
HOGENOMⁱ	HOG000161069
InParanoidⁱ	P50570
KEGG Orthology (KO) More...KOⁱ	K23484
OMAⁱ	ANRYIPE
Database of Orthologous Groups More...OrthoDBⁱ	264244at2759
PhylomeDBⁱ	P50570
TreeFamⁱ	TF300362

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08771 DLP_1, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR027188 DNM2 IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit PTHR11566:SF23 PTHR11566:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit PF00169 PH, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P50570-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL 
       560        570        580        590        600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 
       610        620        630        640        650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE 
       660        670        680        690        700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY 
       710        720        730        740        750
SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP 
       760        770        780        790        800
PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA 
       810        820        830        840        850
AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR 
       860        870
PPAAPSRPTI IRPAEPSLLD

Length:870

Mass (Da):98,064

Last modified:May 10, 2004 - v2

Checksum:ⁱ2F4567B75980935D

GO

Isoform 2 (identifier: P50570-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
516-519: Missing.

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQVIRRG WLTINNISLM KGGSKEYWFV LTAESLSWYK 
       560        570        580        590        600
DEEEKEKKYM LPLDNLKIRD VEKGFMSNKH VFAIFNTEQR NVYKDLRQIE 
       610        620        630        640        650
LACDSQEDVD SWKASFLRAG VYPEKDQAEN EDGAQENTFS MDPQLERQVE 
       660        670        680        690        700
TIRNLVDSYV AIINKSIRDL MPKTIMHLMI NNTKAFIHHE LLAYLYSSAD 
       710        720        730        740        750
QSSLMEESAD QAQRRDDMLR MYHALKEALN IIGDISTSTV STPVPPPVDD 
       760        770        780        790        800
TWLQSASSHS PTPQRRPVSS IHPPGRPPAV RGPTPGPPLI PVPVGAAASF 
       810        820        830        840        850
SAPPIPSRPG PQSVFANSDL FPAPPQIPSR PVRIPPGIPP GVPSRRPPAA 
       860 
PSRPTIIRPA EPSLLD

Show »

Length:866

Mass (Da):97,652

Checksum:ⁱC76BA1762A012127

GO

Isoform 3 (identifier: P50570-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
407-444: LAFEAIVKKQ...LINTVRQCTS → MAFEAIVKKQ...LATVIKKCAE
516-519: Missing.

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDMAFE AIVKKQIVKL KEPSLKCVDL VVSELATVIK KCAEKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQVIRRG WLTINNISLM KGGSKEYWFV LTAESLSWYK 
       560        570        580        590        600
DEEEKEKKYM LPLDNLKIRD VEKGFMSNKH VFAIFNTEQR NVYKDLRQIE 
       610        620        630        640        650
LACDSQEDVD SWKASFLRAG VYPEKDQAEN EDGAQENTFS MDPQLERQVE 
       660        670        680        690        700
TIRNLVDSYV AIINKSIRDL MPKTIMHLMI NNTKAFIHHE LLAYLYSSAD 
       710        720        730        740        750
QSSLMEESAD QAQRRDDMLR MYHALKEALN IIGDISTSTV STPVPPPVDD 
       760        770        780        790        800
TWLQSASSHS PTPQRRPVSS IHPPGRPPAV RGPTPGPPLI PVPVGAAASF 
       810        820        830        840        850
SAPPIPSRPG PQSVFANSDL FPAPPQIPSR PVRIPPGIPP GVPSRRPPAA 
       860 
PSRPTIIRPA EPSLLD

Show »

Length:866

Mass (Da):97,554

Checksum:ⁱ566396D3E6159245

GO

Isoform 4 (identifier: P50570-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
407-444: LAFEAIVKKQ...LINTVRQCTS → MAFEAIVKKQ...LATVIKKCAE

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDMAFE AIVKKQIVKL KEPSLKCVDL VVSELATVIK KCAEKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL 
       560        570        580        590        600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 
       610        620        630        640        650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE 
       660        670        680        690        700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY 
       710        720        730        740        750
SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP 
       760        770        780        790        800
PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA 
       810        820        830        840        850
AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR 
       860        870
PPAAPSRPTI IRPAEPSLLD

Note: Gene prediction based on EST data.

Show »

Length:870

Mass (Da):97,966

Checksum:ⁱ9018503EA888A4F8

GO

Isoform 5 (identifier: P50570-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
848-848: Missing.

« Hide

        10         20         30         40         50
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE 
       110        120        130        140        150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA 
       260        270        280        290        300
ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 
       310        320        330        340        350
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT 
       410        420        430        440        450
GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP 
       460        470        480        490        500
RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL 
       560        570        580        590        600
SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 
       610        620        630        640        650
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE 
       660        670        680        690        700
RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY 
       710        720        730        740        750
SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP 
       760        770        780        790        800
PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA 
       810        820        830        840        850
AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPRRP 
       860 
PAAPSRPTII RPAEPSLLD

Note: No experimental confirmation available.

Show »

Length:869

Mass (Da):97,977

Checksum:ⁱC33CD394EC8F1A6E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ENE7	K7ENE7_HUMAN	Dynamin-2 Dynamin-2	DNM2	137	Annotation score:
K7EMQ3	K7EMQ3_HUMAN	Dynamin-2 Dynamin-2	DNM2	289	Annotation score:
K7EPK9	K7EPK9_HUMAN	Dynamin-2 Dynamin-2	DNM2	50	Annotation score:
K7EMR9	K7EMR9_HUMAN	Dynamin-2 Dynamin-2	DNM2	169	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	155 – 156	QI → RV in AAA88025 (PubMed:7590285).Curated	2
Sequence conflictⁱ	207	L → P in AK312260 (PubMed:14702039).Curated	1
Sequence conflictⁱ	316	N → I in AAA88025 (PubMed:7590285).Curated	1
Sequence conflictⁱ	324	R → P in AAA88025 (PubMed:7590285).Curated	1
Sequence conflictⁱ	475	I → T in AK312260 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031961	263	P → L. Corresponds to variant dbSNP:rs3745674EnsemblClinVar.	1
Natural variantⁱVAR_068425	358	G → R in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs267606772EnsemblClinVar.	1
Natural variantⁱVAR_031962	368	E → K in CNM1. 2 PublicationsCorresponds to variant dbSNP:rs121909092EnsemblClinVar.	1
Natural variantⁱVAR_068365	368	E → Q in CNM1. 1 Publication	1
Natural variantⁱVAR_031963	369	R → Q in CNM1. 1 PublicationCorresponds to variant dbSNP:rs121909089EnsemblClinVar.	1
Natural variantⁱVAR_031964	369	R → W in CNM1; reduced association with the centrosome. 1 PublicationCorresponds to variant dbSNP:rs121909090EnsemblClinVar.	1
Natural variantⁱVAR_070163	379	F → V in LCCS5; hypomorphic mutation impacting on endocytosis. 1 PublicationCorresponds to variant dbSNP:rs397514735EnsemblClinVar.	1
Natural variantⁱVAR_031965	465	R → W in CNM1; reduced association with the centrosome; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 3 PublicationsCorresponds to variant dbSNP:rs121909091EnsemblClinVar.	1
Natural variantⁱVAR_068366	522	R → C in CNM1. 1 Publication	1
Natural variantⁱVAR_068367	522	R → H in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783595EnsemblClinVar.	1
Natural variantⁱVAR_068368	523	R → G in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783596EnsemblClinVar.	1
Natural variantⁱVAR_062574	537	G → C in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909093EnsemblClinVar.	1
Natural variantⁱVAR_031966	555 – 557	Missing in CMTDIB; may affect binding to vesicles and membranes in favor of binding to microtubules; may affect receptor-mediated endocytosis. 1 Publication	3
Natural variantⁱVAR_068369	560	E → K in CNM1. 1 PublicationCorresponds to variant dbSNP:rs879254086EnsemblClinVar.	1
Natural variantⁱVAR_031967	562	K → E in CMTDIB; with neutropenia; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 PublicationsCorresponds to variant dbSNP:rs121909088EnsemblClinVar.	1
Natural variantⁱVAR_070164	562	Missing in CMTDIB. 1 Publication	1
Natural variantⁱVAR_062575	570	L → H in CMT2M. 1 PublicationCorresponds to variant dbSNP:rs121909094EnsemblClinVar.	1
Natural variantⁱVAR_068370	618	A → D in CNM1. 1 PublicationCorresponds to variant dbSNP:rs1555715869EnsemblClinVar.	1
Natural variantⁱVAR_039041	618	A → T in CNM1; severe. 2 Publications	1
Natural variantⁱVAR_039042	619	S → L in CNM1; severe. 2 PublicationsCorresponds to variant dbSNP:rs121909095EnsemblClinVar.	1
Natural variantⁱVAR_039043	619	S → W in CNM1; severe. 1 PublicationCorresponds to variant dbSNP:rs121909095EnsemblClinVar.	1
Natural variantⁱVAR_068371	621	L → P in CNM1; centronuclear myopathy with cataracts. 1 PublicationCorresponds to variant dbSNP:rs587783597EnsemblClinVar.	1
Natural variantⁱVAR_039044	625	Missing in CNM1; severe; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 2 Publications	1
Natural variantⁱVAR_068372	627	P → H in CNM1. 1 Publication	1
Natural variantⁱVAR_068373	627	P → R in CNM1. 1 PublicationCorresponds to variant dbSNP:rs587783598EnsemblClinVar.	1
Natural variantⁱVAR_062576	650	E → K in CNM1; COS7 cells show a reduced uptake of transferrin and low-density lipoprotein complex. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044280	407 – 444	LAFEA…RQCTS → MAFEAIVKKQIVKLKEPSLK CVDLVVSELATVIKKCAE in isoform 3 and isoform 4. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_001325	516 – 519	Missing in isoform 2 and isoform 3. 3 Publications	4
Alternative sequenceⁱVSP_047534	848	Missing in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L36983 mRNA Translation: AAA88025.1 AK289831 mRNA Translation: BAF82520.1 AK312260 mRNA No translation available. AC007229 Genomic DNA Translation: AAD23604.1 AC011475 Genomic DNA No translation available. AC011552 Genomic DNA No translation available. AC011554 Genomic DNA No translation available. AC112707 Genomic DNA No translation available. BC039596 mRNA Translation: AAH39596.1 BC054501 mRNA Translation: AAH54501.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32907.1 [P50570-2] CCDS32908.1 [P50570-3] CCDS45968.1 [P50570-1] CCDS45969.1 [P50570-4] CCDS59351.1 [P50570-5]
PIRⁱ	JC4305
NCBI Reference Sequences More...RefSeqⁱ	NP_001005360.1, NM_001005360.2 [P50570-1] NP_001005361.1, NM_001005361.2 [P50570-4] NP_001005362.1, NM_001005362.2 [P50570-3] NP_001177645.1, NM_001190716.1 [P50570-5] NP_004936.2, NM_004945.3 [P50570-2]

Genome annotation databases

Ensemblⁱ	ENST00000355667; ENSP00000347890; ENSG00000079805 [P50570-1] ENST00000359692; ENSP00000352721; ENSG00000079805 [P50570-2] ENST00000389253; ENSP00000373905; ENSG00000079805 [P50570-4] ENST00000408974; ENSP00000386192; ENSG00000079805 [P50570-3] ENST00000585892; ENSP00000468734; ENSG00000079805 [P50570-5]
GeneIDⁱ	1785
KEGGⁱ	hsa:1785
UCSC genome browser More...UCSCⁱ	uc002mps.3 human [P50570-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50570	DNM2 isoform 5		PANTR		870	UniRef100_P50570
DNM2 isoform 5		PONAB		870
Dynamin 2		GORGO		870
P50570-2	DNM2 isoform 6		PANTR		866	UniRef100_K7C0T3
DNM2 isoform 6		PONAB		866
Dynamin 2		GORGO		866
Dynamin II (Fragment)		HUMAN		393
P50570-3	Dynamin 2, isoform CRA_b		HUMAN		460	UniRef100_A0A024R7C9
DNM2 isoform 7		PANTR		866
DNM2 isoform 7		PONAB		866
P50570-4	DNM2 isoform 3		PANTR		870	UniRef100_A0A2I3RXA8
DNM2 isoform 3		PONAB		870
Dynamin 2		GORGO		870
cDNA FLJ40556 fis, clone THYMU2002583, highly similar to DYNAMIN 2		HUMAN		464
P50570-5	DNM2 isoform 8		PONAB		869	UniRef100_A0A2J8S0S5
DNM2 isoform 8		PANTR		869

Protein	Similar proteins		Species	Score	Length	Source
P50570	Dynamin-2		RAT		870	UniRef90_P50570
Dynamin-2		MOUSE		870
DNM2 isoform 5		PANTR		870
DNM2 isoform 5		PONAB		870
Dynamin 2		GORGO		870
+545
P50570-2	Isoform 4 of Dynamin-2		RAT		866	UniRef90_P39052-4
Dynamin-2		BOVIN		866
Dynamin-2 isoform 3		PIG		914
Dynamin-2-like protein		Hypsiglena sp. JMG-2014		868
Dynamin-2-like protein		BOIIR		868
+191

Protein	Similar proteins		Species	Score	Length	Source
P50570	Dynamin-2		MOUSE		870	UniRef50_P50570
Dynamin-2		RAT		870
DNM2 isoform 5		PANTR		870
DNM2 isoform 5		PONAB		870
Dynamin 2		GORGO		870
+548
P50570-2	Isoform 4 of Dynamin-2		RAT		866	UniRef50_P39052-4
Dynamin-2		BOVIN		866
Dynamin-3		MOUSE		863
Dynamin-2 isoform 3		PIG		914
Dynamin-2-like		CROAD		868
+3158

Cross-referencesⁱ

Web resourcesⁱ

The UMD-DNM2-isoform 1 mutations database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L36983 mRNA Translation: AAA88025.1 AK289831 mRNA Translation: BAF82520.1 AK312260 mRNA No translation available. AC007229 Genomic DNA Translation: AAD23604.1 AC011475 Genomic DNA No translation available. AC011552 Genomic DNA No translation available. AC011554 Genomic DNA No translation available. AC112707 Genomic DNA No translation available. BC039596 mRNA Translation: AAH39596.1 BC054501 mRNA Translation: AAH54501.1
CCDSⁱ	CCDS32907.1 [P50570-2] CCDS32908.1 [P50570-3] CCDS45968.1 [P50570-1] CCDS45969.1 [P50570-4] CCDS59351.1 [P50570-5]
PIRⁱ	JC4305
RefSeqⁱ	NP_001005360.1, NM_001005360.2 [P50570-1] NP_001005361.1, NM_001005361.2 [P50570-4] NP_001005362.1, NM_001005362.2 [P50570-3] NP_001177645.1, NM_001190716.1 [P50570-5] NP_004936.2, NM_004945.3 [P50570-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YS1	NMR	-	A	520-625	[»]
SMRⁱ	P50570
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108122, 147 interactors
CORUMⁱ	P50570
DIPⁱ	DIP-31244N
ELMⁱ	P50570
IntActⁱ	P50570, 119 interactors
MINTⁱ	P50570
STRINGⁱ	9606.ENSP00000373905

Chemistry databases

BindingDBⁱ	P50570
ChEMBLⁱ	CHEMBL5812

Protein family/group databases

MoonDBⁱ	P50570 Curated
TCDBⁱ	1.R.1.1.1 the membrane contact site (mcs) family 8.A.34.1.4 the endophilin (endophilin) family

PTM databases

iPTMnetⁱ	P50570
PhosphoSitePlusⁱ	P50570
SwissPalmⁱ	P50570

Polymorphism and mutation databases

BioMutaⁱ	DNM2
DMDMⁱ	47117856

Proteomic databases

EPDⁱ	P50570
jPOSTⁱ	P50570
MassIVEⁱ	P50570
MaxQBⁱ	P50570
PaxDbⁱ	P50570
PeptideAtlasⁱ	P50570
PRIDEⁱ	P50570
ProteomicsDBⁱ	1845 19939 56250 [P50570-1] 56251 [P50570-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000355667; ENSP00000347890; ENSG00000079805 [P50570-1] ENST00000359692; ENSP00000352721; ENSG00000079805 [P50570-2] ENST00000389253; ENSP00000373905; ENSG00000079805 [P50570-4] ENST00000408974; ENSP00000386192; ENSG00000079805 [P50570-3] ENST00000585892; ENSP00000468734; ENSG00000079805 [P50570-5]
GeneIDⁱ	1785
KEGGⁱ	hsa:1785
UCSCⁱ	uc002mps.3 human [P50570-1]

Organism-specific databases

CTDⁱ	1785
DisGeNETⁱ	1785
GeneCardsⁱ	DNM2
GeneReviewsⁱ	DNM2
HGNCⁱ	HGNC:2974 DNM2
HPAⁱ	HPA054246
MalaCardsⁱ	DNM2
MIMⁱ	160150 phenotype 602378 gene 606482 phenotype 615368 phenotype
neXtProtⁱ	NX_P50570
OpenTargetsⁱ	ENSG00000079805
Orphanetⁱ	169189 Autosomal dominant centronuclear myopathy 228179 Autosomal dominant Charcot-Marie-Tooth disease type 2M 100044 Autosomal dominant intermediate Charcot-Marie-Tooth disease type B 363409 Fetal akinesia-cerebral and retinal hemorrhage syndrome
PharmGKBⁱ	PA27442
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0446 Eukaryota COG0699 LUCA
GeneTreeⁱ	ENSGT00940000155764
HOGENOMⁱ	HOG000161069
InParanoidⁱ	P50570
KOⁱ	K23484
OMAⁱ	ANRYIPE
OrthoDBⁱ	264244at2759
PhylomeDBⁱ	P50570
TreeFamⁱ	TF300362

Enzyme and pathway databases

BRENDAⁱ	3.6.5.5 2681
Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-177504 Retrograde neurotrophin signalling R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-203641 NOSTRIN mediated eNOS trafficking R-HSA-2132295 MHC class II antigen presentation R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-437239 Recycling pathway of L1 R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P50570
SIGNORⁱ	P50570

Miscellaneous databases

ChiTaRSⁱ	DNM2 human
EvolutionaryTraceⁱ	P50570
GeneWikiⁱ	DNM2
GenomeRNAiⁱ	1785
Pharos More...Pharosⁱ	P50570
Protein Ontology More...PROⁱ	PR:P50570
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079805 Expressed in 184 organ(s), highest expression level in cortex of kidney
ExpressionAtlasⁱ	P50570 baseline and differential
Genevisibleⁱ	P50570 HS

Family and domain databases

CDDⁱ	cd08771 DLP_1, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR027188 DNM2 IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit PTHR11566:SF23 PTHR11566:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit PF00169 PH, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DYN2_HUMAN
Accessionⁱ	P50570Primary (citable) accession number: P50570 Secondary accession number(s): A8K1B6 Q9UPH4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 10, 2004
	Last modified:	September 18, 2019
	This is version 207 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

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Supporting data

UniProtKB - P50570 (DYN2_HUMAN)

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Dynamin-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ