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Protein

Histone H2A

Gene

H2A-II

more
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:H2A-II
AND
Name:H2A-III
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000552181 – 129Histone H2AAdd BLAST129

Proteomic databases

PRIDEiP50567
ProMEXiP50567

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP50567
SMRiP50567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
KOiK11251
OMAiMPNIHQT

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

P50567-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRGKGKTS GKKAVSRSAK AGLQFPVGRI ARYLKKGKYA ERIGAGAPVY
60 70 80 90 100
LAAVLEYLTA EVLELAGNAA RDNKKNRIVP RHIQLAIRND EELGKLLGEV
110 120
TIASGGVLPN IHAVLLPKKT KGGKGEETA
Length:129
Mass (Da):13,628
Last modified:October 1, 1996 - v1
Checksum:iEB5FFBBEF2EF6AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41841 Genomic DNA Translation: AAA99968.1
U16724 Genomic DNA Translation: AAA98447.1
U16725 Genomic DNA Translation: AAA98451.1
PIRiS59126
RefSeqiXP_001690672.1, XM_001690620.1
XP_001690682.1, XM_001690630.1
XP_001690722.1, XM_001690670.1
XP_001691528.1, XM_001691476.1
XP_001691688.1, XM_001691636.1
XP_001693466.1, XM_001693414.1
XP_001700399.1, XM_001700347.1
XP_001700409.1, XM_001700357.1
XP_001700425.1, XM_001700373.1
XP_001700454.1, XM_001700402.1

Genome annotation databases

EnsemblPlantsiEDO95786; EDO95786; CHLREDRAFT_872
EDO96247; EDO96247; CHLREDRAFT_800
EDO96257; EDO96257; CHLREDRAFT_793
EDO98088; EDO98088; CHLREDRAFT_645
EDO98098; EDO98098; CHLREDRAFT_655
EDO98114; EDO98114; CHLREDRAFT_107113
EDO98143; EDO98143; CHLREDRAFT_647
EDP04636; EDP04636; CHLREDRAFT_246
EDP04796; EDP04796; CHLREDRAFT_248
EDP08720; EDP08720; CHLREDRAFT_187
GeneIDi5716279
5716280
5716319
5717135
5717160
5719121
5725954
5726001
5726012
5726026
GrameneiEDO95786; EDO95786; CHLREDRAFT_872
EDO96247; EDO96247; CHLREDRAFT_800
EDO96257; EDO96257; CHLREDRAFT_793
EDO98088; EDO98088; CHLREDRAFT_645
EDO98098; EDO98098; CHLREDRAFT_655
EDO98114; EDO98114; CHLREDRAFT_107113
EDO98143; EDO98143; CHLREDRAFT_647
EDP04636; EDP04636; CHLREDRAFT_246
EDP04796; EDP04796; CHLREDRAFT_248
EDP08720; EDP08720; CHLREDRAFT_187
KEGGicre:CHLREDRAFT_107113
cre:CHLREDRAFT_187
cre:CHLREDRAFT_246
cre:CHLREDRAFT_248
cre:CHLREDRAFT_645
cre:CHLREDRAFT_647
cre:CHLREDRAFT_655
cre:CHLREDRAFT_793
cre:CHLREDRAFT_800
cre:CHLREDRAFT_872

Similar proteinsi

Entry informationi

Entry nameiH2A_CHLRE
AccessioniPrimary (citable) accession number: P50567
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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