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Protein

Histone H4

Gene

H4-I

more
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:H4-I
AND
Name:H4-II
AND
Name:H4-III
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001582992 – 103Histone H4Add BLAST102

Proteomic databases

PRIDEiP50566

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP50566
SMRiP50566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
KOiK11254
OMAiHINGITK

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRTVLK TFLENVIRDS VTYTEHARRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,457
Last modified:January 23, 2007 - v2
Checksum:i62973B661293637F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41841 Genomic DNA Translation: AAA99966.1
U16724 Genomic DNA Translation: AAA98445.1
U16725 Genomic DNA Translation: AAA98449.1
U16825 Genomic DNA Translation: AAA98456.1
PIRiS59586
RefSeqiXP_001690685.1, XM_001690633.1
XP_001690721.1, XM_001690669.1
XP_001690810.1, XM_001690758.1
XP_001690828.1, XM_001690776.1
XP_001690996.1, XM_001690944.1
XP_001691002.1, XM_001690950.1
XP_001691010.1, XM_001690958.1
XP_001691527.1, XM_001691475.1
XP_001691544.1, XM_001691492.1
XP_001691698.1, XM_001691646.1
XP_001696174.1, XM_001696122.1
XP_001696191.1, XM_001696139.1
XP_001696262.1, XM_001696210.1
XP_001696277.1, XM_001696225.1
XP_001696279.1, XM_001696227.1
XP_001696285.1, XM_001696233.1
XP_001696452.1, XM_001696400.1
XP_001696459.1, XM_001696407.1
XP_001696488.1, XM_001696436.1
XP_001696520.1, XM_001696468.1
XP_001696524.1, XM_001696472.1
XP_001696553.1, XM_001696501.1
XP_001698167.1, XM_001698115.1
XP_001698253.1, XM_001698201.1
XP_001700398.1, XM_001700346.1
XP_001700408.1, XM_001700356.1
XP_001700424.1, XM_001700372.1
XP_001700455.1, XM_001700403.1
XP_001702964.1, XM_001702912.1
XP_001703063.1, XM_001703011.1
UniGeneiCre.5997

Genome annotation databases

EnsemblPlantsiEDO95785; EDO95785; CHLREDRAFT_110341
EDO95843; EDO95843; CHLREDRAFT_124889
EDO95850; EDO95850; CHLREDRAFT_181346
EDO96244; EDO96244; CHLREDRAFT_796
EDO96260; EDO96260; CHLREDRAFT_123650
EDO98087; EDO98087; CHLREDRAFT_121845
EDO98097; EDO98097; CHLREDRAFT_653
EDO98113; EDO98113; CHLREDRAFT_121805
EDO98144; EDO98144; CHLREDRAFT_121757
EDO99452; EDO99452; CHLREDRAFT_106054
EDO99538; EDO99538; CHLREDRAFT_579
EDP04635; EDP04635; CHLREDRAFT_115475
EDP04652; EDP04652; CHLREDRAFT_100662
EDP04806; EDP04806; CHLREDRAFT_100611
EDP05256; EDP05256; CHLREDRAFT_114706
EDP05274; EDP05274; CHLREDRAFT_144564
EDP05442; EDP05442; CHLREDRAFT_99975
EDP05448; EDP05448; CHLREDRAFT_99976
EDP05456; EDP05456; CHLREDRAFT_100020
EDP08151; EDP08151; CHLREDRAFT_97616
EDP08168; EDP08168; CHLREDRAFT_97613
EDP08239; EDP08239; CHLREDRAFT_167195
EDP08254; EDP08254; CHLREDRAFT_112470
EDP08256; EDP08256; CHLREDRAFT_98022
EDP08262; EDP08262; CHLREDRAFT_97647
EDP08429; EDP08429; CHLREDRAFT_112822
EDP08436; EDP08436; CHLREDRAFT_97581
EDP08465; EDP08465; CHLREDRAFT_97742
EDP08497; EDP08497; CHLREDRAFT_112559
EDP08501; EDP08501; CHLREDRAFT_167163
EDP08530; EDP08530; CHLREDRAFT_98181
GeneIDi5716266
5716318
5716449
5716454
5716466
5716482
5716484
5717133
5717168
5717177
5721749
5721766
5721776
5721781
5721835
5721892
5721901
5721930
5721954
5721959
5721962
5721972
5723807
5723810
5725955
5726000
5726011
5726025
5728507
5728603
GrameneiEDO95785; EDO95785; CHLREDRAFT_110341
EDO95843; EDO95843; CHLREDRAFT_124889
EDO95850; EDO95850; CHLREDRAFT_181346
EDO96244; EDO96244; CHLREDRAFT_796
EDO96260; EDO96260; CHLREDRAFT_123650
EDO98087; EDO98087; CHLREDRAFT_121845
EDO98097; EDO98097; CHLREDRAFT_653
EDO98113; EDO98113; CHLREDRAFT_121805
EDO98144; EDO98144; CHLREDRAFT_121757
EDO99452; EDO99452; CHLREDRAFT_106054
EDO99538; EDO99538; CHLREDRAFT_579
EDP04635; EDP04635; CHLREDRAFT_115475
EDP04652; EDP04652; CHLREDRAFT_100662
EDP04806; EDP04806; CHLREDRAFT_100611
EDP05256; EDP05256; CHLREDRAFT_114706
EDP05274; EDP05274; CHLREDRAFT_144564
EDP05442; EDP05442; CHLREDRAFT_99975
EDP05448; EDP05448; CHLREDRAFT_99976
EDP05456; EDP05456; CHLREDRAFT_100020
EDP08151; EDP08151; CHLREDRAFT_97616
EDP08168; EDP08168; CHLREDRAFT_97613
EDP08239; EDP08239; CHLREDRAFT_167195
EDP08254; EDP08254; CHLREDRAFT_112470
EDP08256; EDP08256; CHLREDRAFT_98022
EDP08262; EDP08262; CHLREDRAFT_97647
EDP08429; EDP08429; CHLREDRAFT_112822
EDP08436; EDP08436; CHLREDRAFT_97581
EDP08465; EDP08465; CHLREDRAFT_97742
EDP08497; EDP08497; CHLREDRAFT_112559
EDP08501; EDP08501; CHLREDRAFT_167163
EDP08530; EDP08530; CHLREDRAFT_98181
KEGGicre:CHLREDRAFT_100020
cre:CHLREDRAFT_100611
cre:CHLREDRAFT_100662
cre:CHLREDRAFT_106054
cre:CHLREDRAFT_110341
cre:CHLREDRAFT_112470
cre:CHLREDRAFT_112559
cre:CHLREDRAFT_112822
cre:CHLREDRAFT_114706
cre:CHLREDRAFT_115475
cre:CHLREDRAFT_121757
cre:CHLREDRAFT_121805
cre:CHLREDRAFT_121845
cre:CHLREDRAFT_123650
cre:CHLREDRAFT_124889
cre:CHLREDRAFT_144564
cre:CHLREDRAFT_167163
cre:CHLREDRAFT_167195
cre:CHLREDRAFT_181346
cre:CHLREDRAFT_579
cre:CHLREDRAFT_653
cre:CHLREDRAFT_97581
cre:CHLREDRAFT_97613
cre:CHLREDRAFT_97616
cre:CHLREDRAFT_97647
cre:CHLREDRAFT_97742
cre:CHLREDRAFT_98022
cre:CHLREDRAFT_98181
cre:CHLREDRAFT_99975
cre:CHLREDRAFT_99976

Similar proteinsi

Entry informationi

Entry nameiH4_CHLRE
AccessioniPrimary (citable) accession number: P50566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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