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Entry version 181 (22 Apr 2020)
Sequence version 2 (24 Jan 2001)
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Protein

ETS translocation variant 1

Gene

ETV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi335 – 415ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P50549

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS translocation variant 1
Alternative name(s):
Ets-related protein 81
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETV1
Synonyms:ER81
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3490 ETV1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600541 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50549

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ewing sarcoma (ES)1 Publication
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.1 Publication
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi191S → A: Loss of phosphorylation by RPS6KA5. 1 Publication1
Mutagenesisi216S → A: Loss of phosphorylation by RPS6KA5. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
2115

MalaCards human disease database

More...
MalaCardsi
ETV1
MIMi612219 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000006468

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319 Ewing sarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27904

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50549 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2010626

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ETV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643411

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041101 – 477ETS translocation variant 1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineBy similarity1
Modified residuei191Phosphoserine; by RPS6KA1 and RPS6KA52 Publications1
Modified residuei216Phosphoserine; by RPS6KA1 and RPS6KA52 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P50549

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50549

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50549

PeptideAtlas

More...
PeptideAtlasi
P50549

PRoteomics IDEntifications database

More...
PRIDEi
P50549

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20494
24498
56244 [P50549-1]
56245 [P50549-2]
56246 [P50549-3]
56247 [P50549-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50549

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P50549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000006468 Expressed in cerebellum and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P50549 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50549 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000006468 Tissue enhanced (brain, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108416, 22 interactors

Database of interacting proteins

More...
DIPi
DIP-60463N

Protein interaction database and analysis system

More...
IntActi
P50549, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405327

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P50549

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50549 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50549

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030025_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50549

KEGG Orthology (KO)

More...
KOi
K09431

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50549

TreeFam database of animal gene trees

More...
TreeFami
TF316214

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR032928 ETS_V1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11849:SF196 PTHR11849:SF196, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50549-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL
60 70 80 90 100
SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS
110 120 130 140 150
SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH
160 170 180 190 200
ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY PMDHRFRRQL SEPCNSFPPL
210 220 230 240 250
PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT MVGSAASQSF
260 270 280 290 300
PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ
310 320 330 340 350
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN
360 370 380 390 400
SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG
410 420 430 440 450
IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL
460 470
SHFDESMAYM PEGGCCNPHP YNEGYVY
Length:477
Mass (Da):55,131
Last modified:January 24, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE95FA3F07196F06
GO
Isoform 2 (identifier: P50549-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-79: AQVPDNDEQFVPDYQAESL → V

Show »
Length:459
Mass (Da):53,083
Checksum:i558A574E5B53979B
GO
Isoform 3 (identifier: P50549-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: Missing.

Show »
Length:454
Mass (Da):52,474
Checksum:iF0BB1A4835FCF45D
GO
Isoform 4 (identifier: P50549-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     122-184: Missing.

Show »
Length:374
Mass (Da):43,455
Checksum:iE493CC2364AD60C2
GO
Isoform 5 (identifier: P50549-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     61-79: AQVPDNDEQFVPDYQAESL → V

Show »
Length:419
Mass (Da):48,168
Checksum:i24285CFD0B256971
GO
Isoform 6 (identifier: P50549-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL

Show »
Length:437
Mass (Da):50,217
Checksum:i37A55122A463957C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCT2B5MCT2_HUMAN
ETS translocation variant 1
ETV1
491Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX69C9JX69_HUMAN
ETS translocation variant 1
ETV1
288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEH6F8WEH6_HUMAN
ETS translocation variant 1
ETV1
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4P4C9J4P4_HUMAN
ETS translocation variant 1
ETV1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9L1C9J9L1_HUMAN
ETS translocation variant 1
ETV1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQH6C9JQH6_HUMAN
ETS translocation variant 1
ETV1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0B7C9J0B7_HUMAN
ETS translocation variant 1
ETV1
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92439 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39L → V in CAA60642 (PubMed:7651741).Curated1
Sequence conflicti117C → S in AAA79844 (PubMed:7700648).Curated1
Sequence conflicti127K → N in AAA79844 (PubMed:7700648).Curated1
Sequence conflicti253Missing in CAA60642 (PubMed:7651741).Curated1
Sequence conflicti349S → A in CAA60642 (PubMed:7651741).Curated1
Sequence conflicti445E → G in CAH10484 (PubMed:17974005).Curated1
Sequence conflicti471Y → C in BAH13104 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048948100S → G2 PublicationsCorresponds to variant dbSNP:rs9639168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438081 – 60MDGFY…TWLAE → MLQDLSASVFFPPCSQHRTL in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_00147261 – 79AQVPD…QAESL → V in isoform 2 and isoform 5. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_043809122 – 184Missing in isoform 4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_043750268 – 290Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17163 mRNA Translation: AAA79844.1
X87175 mRNA Translation: CAA60642.1
AF109632 AF109631 Genomic DNA Translation: AAD29877.1
AF109632 AF109631 Genomic DNA Translation: AAD29878.1
AK294755 mRNA Translation: BAH11870.1
AK299693 mRNA Translation: BAH13104.1
AK312863 mRNA Translation: BAG35715.1
AK316007 mRNA Translation: BAH14378.1
AB209202 mRNA Translation: BAD92439.1 Different initiation.
CR627389 mRNA Translation: CAH10484.1
AC004857 Genomic DNA Translation: AAC62435.1
AC004909 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24294.1
BC098403 mRNA Translation: AAH98403.1
BC106762 mRNA Translation: AAI06763.1
BC106763 mRNA Translation: AAI06764.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55083.1 [P50549-5]
CCDS55084.1 [P50549-4]
CCDS55085.1 [P50549-6]
CCDS55086.1 [P50549-2]
CCDS55087.1 [P50549-3]
CCDS55088.1 [P50549-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38893

NCBI Reference Sequences

More...
RefSeqi
NP_001156619.1, NM_001163147.1 [P50549-3]
NP_001156620.1, NM_001163148.1 [P50549-2]
NP_001156621.1, NM_001163149.1 [P50549-2]
NP_001156622.1, NM_001163150.1 [P50549-6]
NP_001156623.1, NM_001163151.1 [P50549-5]
NP_001156624.1, NM_001163152.1 [P50549-4]
NP_004947.2, NM_004956.4 [P50549-1]
XP_005249692.1, XM_005249635.4 [P50549-1]
XP_005249693.1, XM_005249636.4
XP_011513470.1, XM_011515168.2 [P50549-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242066; ENSP00000242066; ENSG00000006468 [P50549-2]
ENST00000399357; ENSP00000382293; ENSG00000006468 [P50549-4]
ENST00000403527; ENSP00000384138; ENSG00000006468 [P50549-6]
ENST00000403685; ENSP00000385686; ENSG00000006468 [P50549-2]
ENST00000405192; ENSP00000385381; ENSG00000006468 [P50549-3]
ENST00000405218; ENSP00000385551; ENSG00000006468 [P50549-1]
ENST00000420159; ENSP00000411626; ENSG00000006468 [P50549-5]
ENST00000430479; ENSP00000405327; ENSG00000006468 [P50549-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2115

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2115

UCSC genome browser

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UCSCi
uc003ssw.5 human [P50549-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17163 mRNA Translation: AAA79844.1
X87175 mRNA Translation: CAA60642.1
AF109632 AF109631 Genomic DNA Translation: AAD29877.1
AF109632 AF109631 Genomic DNA Translation: AAD29878.1
AK294755 mRNA Translation: BAH11870.1
AK299693 mRNA Translation: BAH13104.1
AK312863 mRNA Translation: BAG35715.1
AK316007 mRNA Translation: BAH14378.1
AB209202 mRNA Translation: BAD92439.1 Different initiation.
CR627389 mRNA Translation: CAH10484.1
AC004857 Genomic DNA Translation: AAC62435.1
AC004909 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24294.1
BC098403 mRNA Translation: AAH98403.1
BC106762 mRNA Translation: AAI06763.1
BC106763 mRNA Translation: AAI06764.1
CCDSiCCDS55083.1 [P50549-5]
CCDS55084.1 [P50549-4]
CCDS55085.1 [P50549-6]
CCDS55086.1 [P50549-2]
CCDS55087.1 [P50549-3]
CCDS55088.1 [P50549-1]
PIRiI38893
RefSeqiNP_001156619.1, NM_001163147.1 [P50549-3]
NP_001156620.1, NM_001163148.1 [P50549-2]
NP_001156621.1, NM_001163149.1 [P50549-2]
NP_001156622.1, NM_001163150.1 [P50549-6]
NP_001156623.1, NM_001163151.1 [P50549-5]
NP_001156624.1, NM_001163152.1 [P50549-4]
NP_004947.2, NM_004956.4 [P50549-1]
XP_005249692.1, XM_005249635.4 [P50549-1]
XP_005249693.1, XM_005249636.4
XP_011513470.1, XM_011515168.2 [P50549-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AVPX-ray1.82A/B/C/D326-429[»]
4BNCX-ray2.90A326-429[»]
5ILSX-ray1.40A334-434[»]
SMRiP50549
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108416, 22 interactors
DIPiDIP-60463N
IntActiP50549, 8 interactors
STRINGi9606.ENSP00000405327

Chemistry databases

BindingDBiP50549
ChEMBLiCHEMBL2010626

PTM databases

iPTMnetiP50549
PhosphoSitePlusiP50549

Polymorphism and mutation databases

BioMutaiETV1
DMDMi12643411

Proteomic databases

MassIVEiP50549
MaxQBiP50549
PaxDbiP50549
PeptideAtlasiP50549
PRIDEiP50549
ProteomicsDBi20494
24498
56244 [P50549-1]
56245 [P50549-2]
56246 [P50549-3]
56247 [P50549-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25156 302 antibodies

The DNASU plasmid repository

More...
DNASUi
2115

Genome annotation databases

EnsembliENST00000242066; ENSP00000242066; ENSG00000006468 [P50549-2]
ENST00000399357; ENSP00000382293; ENSG00000006468 [P50549-4]
ENST00000403527; ENSP00000384138; ENSG00000006468 [P50549-6]
ENST00000403685; ENSP00000385686; ENSG00000006468 [P50549-2]
ENST00000405192; ENSP00000385381; ENSG00000006468 [P50549-3]
ENST00000405218; ENSP00000385551; ENSG00000006468 [P50549-1]
ENST00000420159; ENSP00000411626; ENSG00000006468 [P50549-5]
ENST00000430479; ENSP00000405327; ENSG00000006468 [P50549-1]
GeneIDi2115
KEGGihsa:2115
UCSCiuc003ssw.5 human [P50549-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2115
DisGeNETi2115

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ETV1
HGNCiHGNC:3490 ETV1
HPAiENSG00000006468 Tissue enhanced (brain, salivary gland)
MalaCardsiETV1
MIMi600541 gene
612219 phenotype
neXtProtiNX_P50549
OpenTargetsiENSG00000006468
Orphaneti319 Ewing sarcoma
PharmGKBiPA27904

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000157123
HOGENOMiCLU_030025_1_0_1
InParanoidiP50549
KOiK09431
PhylomeDBiP50549
TreeFamiTF316214

Enzyme and pathway databases

SIGNORiP50549

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ETV1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ETV1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2115
PharosiP50549 Tbio

Protein Ontology

More...
PROi
PR:P50549
RNActiP50549 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000006468 Expressed in cerebellum and 195 other tissues
ExpressionAtlasiP50549 baseline and differential
GenevisibleiP50549 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR032928 ETS_V1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF196 PTHR11849:SF196, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETV1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50549
Secondary accession number(s): A4D118
, B2R768, B7Z2I4, B7Z618, B7Z9P2, C9JT37, E9PHB1, F5GXR2, O75849, Q4KMQ6, Q59GA7, Q6AI30, Q9UQ71, Q9Y636
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 24, 2001
Last modified: April 22, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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