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Entry version 183 (13 Nov 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Max-interacting protein 1

Gene

MXI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P50539

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Max-interacting protein 1
Short name:
Max interactor 1
Alternative name(s):
Class C basic helix-loop-helix protein 11
Short name:
bHLHc11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MXI1
Synonyms:BHLHC11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:7534 MXI1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600020 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50539

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Prostate cancer (PC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Related information in OMIM

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4601

MalaCards human disease database

More...
MalaCardsi
MXI1
MIMi176807 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000119950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31335

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50539

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MXI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001272851 – 228Max-interacting protein 1Add BLAST228

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P50539

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P50539

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P50539

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50539

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50539

PeptideAtlas

More...
PeptideAtlasi
P50539

PRoteomics IDEntifications database

More...
PRIDEi
P50539

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56235 [P50539-1]
56236 [P50539-2]
56237 [P50539-3]
56238 [P50539-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50539

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P50539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119950 Expressed in 243 organ(s), highest expression level in subthalamic nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P50539 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P50539 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035319
HPA056762

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Interacts with RNF17 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110686, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P50539

Database of interacting proteins

More...
DIPi
DIP-205N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P50539

Protein interaction database and analysis system

More...
IntActi
P50539, 21 interactors

Molecular INTeraction database

More...
MINTi
P50539

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331152

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50539

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 119bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPD8 Eukaryota
ENOG410XSF5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155809

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000247060

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P50539

KEGG Orthology (KO)

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KOi
K09114

Identification of Orthologs from Complete Genome Data

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OMAi
AVQLINI

Database of Orthologous Groups

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OrthoDBi
1311585at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P50539

TreeFam database of animal gene trees

More...
TreeFami
TF315654

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERVKMINVQ RLLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR
60 70 80 90 100
LSRAQKHSSG SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC
110 120 130 140 150
TRHTTLGLLN KAKAHIKKLE EAERKSQHQL ENLEREQRFL KWRLEQLQGP
160 170 180 190 200
QEMERIRMDS IGSTISSDRS DSEREEIEVD VESTEFSHGE VDNISTTSIS
210 220
DIDDHSSLPS IGSDEGYSSA SVKLSFTS
Length:228
Mass (Da):26,062
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82F83F499B907DD3
GO
Isoform 2 (identifier: P50539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:192
Mass (Da):21,767
Checksum:i3D8B586EEA033591
GO
Isoform 3 (identifier: P50539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MERVKMINVQRLLEAAEFLERRERE → MGKRGRPRKE...LEQIEKENKK

Show »
Length:295
Mass (Da):32,820
Checksum:iCD3E9228C9DB7660
GO
Isoform 4 (identifier: P50539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     68-77: Missing.

Show »
Length:182
Mass (Da):20,558
Checksum:iC6A82E8A3F12A152
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ANN8B1ANN8_HUMAN
Max-interacting protein 1
MXI1
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U3F6F6U3F6_HUMAN
Max-interacting protein 1
MXI1
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WCI9F6WCI9_HUMAN
Max-interacting protein 1
MXI1
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1C1A0A494C1C1_HUMAN
Max-interacting protein 1
MXI1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S2Z429A0A0S2Z429_HUMAN
MAX interactor 1 isoform 2
MXI1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZS3A0A494BZS3_HUMAN
Max-interacting protein 1
MXI1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0I8A0A494C0I8_HUMAN
Max-interacting protein 1
MXI1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0W2A0A494C0W2_HUMAN
Max-interacting protein 1
MXI1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1P8A0A494C1P8_HUMAN
Max-interacting protein 1
MXI1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61S → T in AAA75508 (PubMed:8425219).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004499152E → A in prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs137852603Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128251 – 36Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST36
Alternative sequenceiVSP_0379431 – 25MERVK…RRERE → MGKRGRPRKEARCEGAGLAP AAPPAVPPAVAAPQPPALPE DPAGAKPRCPFSDIFNTSEN SMEKHINTFLQNVQILLEAA SYLEQIEKENKK in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_04317068 – 77Missing in isoform 4. 2 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L07648 mRNA Translation: AAA75508.1
U32515
, U32512, U32513, U32514 Genomic DNA Translation: AAC50446.1
D63940 mRNA Translation: BAA09972.1
BT007069 mRNA Translation: AAP35732.1
CR536576 mRNA Translation: CAG38813.1
AL360182 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49565.1
CH471066 Genomic DNA Translation: EAW49567.1
CH471066 Genomic DNA Translation: EAW49568.1
CH471066 Genomic DNA Translation: EAW49569.1
CH471066 Genomic DNA Translation: EAW49570.1
BC012907 mRNA Translation: AAH12907.1
BC035128 mRNA Translation: AAH35128.2
S78470 Genomic DNA Translation: AAD14282.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31284.1 [P50539-4]
CCDS7563.1 [P50539-3]
CCDS7564.2 [P50539-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A45182

NCBI Reference Sequences

More...
RefSeqi
NP_001008541.1, NM_001008541.1 [P50539-4]
NP_005953.4, NM_005962.4 [P50539-1]
NP_569157.2, NM_130439.3 [P50539-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000239007; ENSP00000239007; ENSG00000119950 [P50539-1]
ENST00000332674; ENSP00000331152; ENSG00000119950 [P50539-3]
ENST00000361248; ENSP00000354606; ENSG00000119950 [P50539-4]
ENST00000369612; ENSP00000358625; ENSG00000119950 [P50539-2]
ENST00000650644; ENSP00000498900; ENSG00000119950 [P50539-2]
ENST00000650696; ENSP00000499158; ENSG00000119950 [P50539-2]
ENST00000650810; ENSP00000498390; ENSG00000119950 [P50539-2]
ENST00000650843; ENSP00000498547; ENSG00000119950 [P50539-2]
ENST00000650900; ENSP00000499209; ENSG00000119950 [P50539-2]
ENST00000650952; ENSP00000499161; ENSG00000119950 [P50539-2]
ENST00000651004; ENSP00000498396; ENSG00000119950 [P50539-2]
ENST00000651167; ENSP00000498764; ENSG00000119950 [P50539-2]
ENST00000651467; ENSP00000499128; ENSG00000119950 [P50539-2]
ENST00000651495; ENSP00000498536; ENSG00000119950 [P50539-2]
ENST00000651516; ENSP00000498873; ENSG00000119950 [P50539-2]
ENST00000651613; ENSP00000498554; ENSG00000119950 [P50539-2]
ENST00000651811; ENSP00000498472; ENSG00000119950 [P50539-2]
ENST00000651848; ENSP00000498238; ENSG00000119950 [P50539-2]
ENST00000651866; ENSP00000498306; ENSG00000119950 [P50539-2]
ENST00000652028; ENSP00000498928; ENSG00000119950 [P50539-2]
ENST00000652463; ENSP00000499087; ENSG00000119950 [P50539-2]
ENST00000652506; ENSP00000498573; ENSG00000119950 [P50539-2]
ENST00000652604; ENSP00000498971; ENSG00000119950 [P50539-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4601

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4601

UCSC genome browser

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UCSCi
uc001kyy.3 human [P50539-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07648 mRNA Translation: AAA75508.1
U32515
, U32512, U32513, U32514 Genomic DNA Translation: AAC50446.1
D63940 mRNA Translation: BAA09972.1
BT007069 mRNA Translation: AAP35732.1
CR536576 mRNA Translation: CAG38813.1
AL360182 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49565.1
CH471066 Genomic DNA Translation: EAW49567.1
CH471066 Genomic DNA Translation: EAW49568.1
CH471066 Genomic DNA Translation: EAW49569.1
CH471066 Genomic DNA Translation: EAW49570.1
BC012907 mRNA Translation: AAH12907.1
BC035128 mRNA Translation: AAH35128.2
S78470 Genomic DNA Translation: AAD14282.1
CCDSiCCDS31284.1 [P50539-4]
CCDS7563.1 [P50539-3]
CCDS7564.2 [P50539-1]
PIRiA45182
RefSeqiNP_001008541.1, NM_001008541.1 [P50539-4]
NP_005953.4, NM_005962.4 [P50539-1]
NP_569157.2, NM_130439.3 [P50539-3]

3D structure databases

SMRiP50539
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110686, 33 interactors
CORUMiP50539
DIPiDIP-205N
ELMiP50539
IntActiP50539, 21 interactors
MINTiP50539
STRINGi9606.ENSP00000331152

PTM databases

iPTMnetiP50539
PhosphoSitePlusiP50539

Polymorphism and mutation databases

BioMutaiMXI1
DMDMi116242666

Proteomic databases

EPDiP50539
jPOSTiP50539
MassIVEiP50539
MaxQBiP50539
PaxDbiP50539
PeptideAtlasiP50539
PRIDEiP50539
ProteomicsDBi56235 [P50539-1]
56236 [P50539-2]
56237 [P50539-3]
56238 [P50539-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4601

Genome annotation databases

EnsembliENST00000239007; ENSP00000239007; ENSG00000119950 [P50539-1]
ENST00000332674; ENSP00000331152; ENSG00000119950 [P50539-3]
ENST00000361248; ENSP00000354606; ENSG00000119950 [P50539-4]
ENST00000369612; ENSP00000358625; ENSG00000119950 [P50539-2]
ENST00000650644; ENSP00000498900; ENSG00000119950 [P50539-2]
ENST00000650696; ENSP00000499158; ENSG00000119950 [P50539-2]
ENST00000650810; ENSP00000498390; ENSG00000119950 [P50539-2]
ENST00000650843; ENSP00000498547; ENSG00000119950 [P50539-2]
ENST00000650900; ENSP00000499209; ENSG00000119950 [P50539-2]
ENST00000650952; ENSP00000499161; ENSG00000119950 [P50539-2]
ENST00000651004; ENSP00000498396; ENSG00000119950 [P50539-2]
ENST00000651167; ENSP00000498764; ENSG00000119950 [P50539-2]
ENST00000651467; ENSP00000499128; ENSG00000119950 [P50539-2]
ENST00000651495; ENSP00000498536; ENSG00000119950 [P50539-2]
ENST00000651516; ENSP00000498873; ENSG00000119950 [P50539-2]
ENST00000651613; ENSP00000498554; ENSG00000119950 [P50539-2]
ENST00000651811; ENSP00000498472; ENSG00000119950 [P50539-2]
ENST00000651848; ENSP00000498238; ENSG00000119950 [P50539-2]
ENST00000651866; ENSP00000498306; ENSG00000119950 [P50539-2]
ENST00000652028; ENSP00000498928; ENSG00000119950 [P50539-2]
ENST00000652463; ENSP00000499087; ENSG00000119950 [P50539-2]
ENST00000652506; ENSP00000498573; ENSG00000119950 [P50539-2]
ENST00000652604; ENSP00000498971; ENSG00000119950 [P50539-4]
GeneIDi4601
KEGGihsa:4601
UCSCiuc001kyy.3 human [P50539-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4601
DisGeNETi4601

GeneCards: human genes, protein and diseases

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GeneCardsi
MXI1
HGNCiHGNC:7534 MXI1
HPAiHPA035319
HPA056762
MalaCardsiMXI1
MIMi176807 phenotype
600020 gene
neXtProtiNX_P50539
OpenTargetsiENSG00000119950
PharmGKBiPA31335

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPD8 Eukaryota
ENOG410XSF5 LUCA
GeneTreeiENSGT00940000155809
HOGENOMiHOG000247060
InParanoidiP50539
KOiK09114
OMAiAVQLINI
OrthoDBi1311585at2759
PhylomeDBiP50539
TreeFamiTF315654

Enzyme and pathway databases

SIGNORiP50539

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MXI1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MXI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4601
PharosiP50539

Protein Ontology

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PROi
PR:P50539

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119950 Expressed in 243 organ(s), highest expression level in subthalamic nucleus
ExpressionAtlasiP50539 baseline and differential
GenevisibleiP50539 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMXI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50539
Secondary accession number(s): B1ANN7
, D3DR25, D3DRA9, Q15887, Q6FHW2, Q96E53
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: November 13, 2019
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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