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Protein

Max-interacting protein 1

Gene

MXI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP50539

Names & Taxonomyi

Protein namesi
Recommended name:
Max-interacting protein 1
Short name:
Max interactor 1
Alternative name(s):
Class C basic helix-loop-helix protein 11
Short name:
bHLHc11
Gene namesi
Name:MXI1
Synonyms:BHLHC11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119950.20
HGNCiHGNC:7534 MXI1
MIMi600020 gene
neXtProtiNX_P50539

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4601
MalaCardsiMXI1
MIMi176807 phenotype
OpenTargetsiENSG00000119950
PharmGKBiPA31335

Polymorphism and mutation databases

BioMutaiMXI1
DMDMi116242666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272851 – 228Max-interacting protein 1Add BLAST228

Proteomic databases

EPDiP50539
MaxQBiP50539
PaxDbiP50539
PeptideAtlasiP50539
PRIDEiP50539
ProteomicsDBi56235
56236 [P50539-2]
56237 [P50539-3]
56238 [P50539-4]

PTM databases

iPTMnetiP50539
PhosphoSitePlusiP50539

Expressioni

Tissue specificityi

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Gene expression databases

BgeeiENSG00000119950 Expressed in 243 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_MXI1
ExpressionAtlasiP50539 baseline and differential
GenevisibleiP50539 HS

Organism-specific databases

HPAiHPA035319
HPA056762

Interactioni

Subunit structurei

Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110686, 21 interactors
CORUMiP50539
DIPiDIP-205N
ELMiP50539
IntActiP50539, 19 interactors
MINTiP50539
STRINGi9606.ENSP00000331152

Structurei

3D structure databases

ProteinModelPortaliP50539
SMRiP50539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 119bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IPD8 Eukaryota
ENOG410XSF5 LUCA
GeneTreeiENSGT00510000046360
HOGENOMiHOG000247060
HOVERGENiHBG006314
InParanoidiP50539
KOiK09114
OMAiGLQDPKP
OrthoDBiEOG091G0QBK
PhylomeDBiP50539
TreeFamiTF315654

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERVKMINVQ RLLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR
60 70 80 90 100
LSRAQKHSSG SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC
110 120 130 140 150
TRHTTLGLLN KAKAHIKKLE EAERKSQHQL ENLEREQRFL KWRLEQLQGP
160 170 180 190 200
QEMERIRMDS IGSTISSDRS DSEREEIEVD VESTEFSHGE VDNISTTSIS
210 220
DIDDHSSLPS IGSDEGYSSA SVKLSFTS
Length:228
Mass (Da):26,062
Last modified:October 17, 2006 - v2
Checksum:i82F83F499B907DD3
GO
Isoform 2 (identifier: P50539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:192
Mass (Da):21,767
Checksum:i3D8B586EEA033591
GO
Isoform 3 (identifier: P50539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MERVKMINVQRLLEAAEFLERRERE → MGKRGRPRKE...LEQIEKENKK

Show »
Length:295
Mass (Da):32,820
Checksum:iCD3E9228C9DB7660
GO
Isoform 4 (identifier: P50539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     68-77: Missing.

Show »
Length:182
Mass (Da):20,558
Checksum:iC6A82E8A3F12A152
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ANN8B1ANN8_HUMAN
Max-interacting protein 1
MXI1
218Annotation score:
F6U3F6F6U3F6_HUMAN
Max-interacting protein 1
MXI1
226Annotation score:
F6WCI9F6WCI9_HUMAN
Max-interacting protein 1
MXI1
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61S → T in AAA75508 (PubMed:8425219).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004499152E → A in prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs137852603Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128251 – 36Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST36
Alternative sequenceiVSP_0379431 – 25MERVK…RRERE → MGKRGRPRKEARCEGAGLAP AAPPAVPPAVAAPQPPALPE DPAGAKPRCPFSDIFNTSEN SMEKHINTFLQNVQILLEAA SYLEQIEKENKK in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_04317068 – 77Missing in isoform 4. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07648 mRNA Translation: AAA75508.1
U32515
, U32512, U32513, U32514 Genomic DNA Translation: AAC50446.1
D63940 mRNA Translation: BAA09972.1
BT007069 mRNA Translation: AAP35732.1
CR536576 mRNA Translation: CAG38813.1
AL360182 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49565.1
CH471066 Genomic DNA Translation: EAW49567.1
CH471066 Genomic DNA Translation: EAW49568.1
CH471066 Genomic DNA Translation: EAW49569.1
CH471066 Genomic DNA Translation: EAW49570.1
BC012907 mRNA Translation: AAH12907.1
BC035128 mRNA Translation: AAH35128.2
S78470 Genomic DNA Translation: AAD14282.1
CCDSiCCDS31284.1 [P50539-4]
CCDS7563.1 [P50539-3]
CCDS7564.2 [P50539-1]
PIRiA45182
RefSeqiNP_001008541.1, NM_001008541.1 [P50539-4]
NP_005953.4, NM_005962.4 [P50539-1]
NP_569157.2, NM_130439.3 [P50539-3]
UniGeneiHs.602078
Hs.728542

Genome annotation databases

EnsembliENST00000239007; ENSP00000239007; ENSG00000119950 [P50539-1]
ENST00000332674; ENSP00000331152; ENSG00000119950 [P50539-3]
ENST00000361248; ENSP00000354606; ENSG00000119950 [P50539-4]
ENST00000369612; ENSP00000358625; ENSG00000119950 [P50539-2]
GeneIDi4601
KEGGihsa:4601
UCSCiuc001kyy.3 human [P50539-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07648 mRNA Translation: AAA75508.1
U32515
, U32512, U32513, U32514 Genomic DNA Translation: AAC50446.1
D63940 mRNA Translation: BAA09972.1
BT007069 mRNA Translation: AAP35732.1
CR536576 mRNA Translation: CAG38813.1
AL360182 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49565.1
CH471066 Genomic DNA Translation: EAW49567.1
CH471066 Genomic DNA Translation: EAW49568.1
CH471066 Genomic DNA Translation: EAW49569.1
CH471066 Genomic DNA Translation: EAW49570.1
BC012907 mRNA Translation: AAH12907.1
BC035128 mRNA Translation: AAH35128.2
S78470 Genomic DNA Translation: AAD14282.1
CCDSiCCDS31284.1 [P50539-4]
CCDS7563.1 [P50539-3]
CCDS7564.2 [P50539-1]
PIRiA45182
RefSeqiNP_001008541.1, NM_001008541.1 [P50539-4]
NP_005953.4, NM_005962.4 [P50539-1]
NP_569157.2, NM_130439.3 [P50539-3]
UniGeneiHs.602078
Hs.728542

3D structure databases

ProteinModelPortaliP50539
SMRiP50539
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110686, 21 interactors
CORUMiP50539
DIPiDIP-205N
ELMiP50539
IntActiP50539, 19 interactors
MINTiP50539
STRINGi9606.ENSP00000331152

PTM databases

iPTMnetiP50539
PhosphoSitePlusiP50539

Polymorphism and mutation databases

BioMutaiMXI1
DMDMi116242666

Proteomic databases

EPDiP50539
MaxQBiP50539
PaxDbiP50539
PeptideAtlasiP50539
PRIDEiP50539
ProteomicsDBi56235
56236 [P50539-2]
56237 [P50539-3]
56238 [P50539-4]

Protocols and materials databases

DNASUi4601
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239007; ENSP00000239007; ENSG00000119950 [P50539-1]
ENST00000332674; ENSP00000331152; ENSG00000119950 [P50539-3]
ENST00000361248; ENSP00000354606; ENSG00000119950 [P50539-4]
ENST00000369612; ENSP00000358625; ENSG00000119950 [P50539-2]
GeneIDi4601
KEGGihsa:4601
UCSCiuc001kyy.3 human [P50539-1]

Organism-specific databases

CTDi4601
DisGeNETi4601
EuPathDBiHostDB:ENSG00000119950.20
GeneCardsiMXI1
HGNCiHGNC:7534 MXI1
HPAiHPA035319
HPA056762
MalaCardsiMXI1
MIMi176807 phenotype
600020 gene
neXtProtiNX_P50539
OpenTargetsiENSG00000119950
PharmGKBiPA31335
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPD8 Eukaryota
ENOG410XSF5 LUCA
GeneTreeiENSGT00510000046360
HOGENOMiHOG000247060
HOVERGENiHBG006314
InParanoidiP50539
KOiK09114
OMAiGLQDPKP
OrthoDBiEOG091G0QBK
PhylomeDBiP50539
TreeFamiTF315654

Enzyme and pathway databases

SIGNORiP50539

Miscellaneous databases

ChiTaRSiMXI1 human
GeneWikiiMXI1
GenomeRNAii4601
PROiPR:P50539
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119950 Expressed in 243 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_MXI1
ExpressionAtlasiP50539 baseline and differential
GenevisibleiP50539 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMXI1_HUMAN
AccessioniPrimary (citable) accession number: P50539
Secondary accession number(s): B1ANN7
, D3DR25, D3DRA9, Q15887, Q6FHW2, Q96E53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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