hxk2

Functionⁱ

Catalytic activityⁱ

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayⁱ: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	93	ATPBy similarity		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
fructokinase activity
Source: PomBase
Inferred from direct assayⁱ
- 8549830
glucokinase activity
Source: PomBase
Inferred from direct assayⁱ
- 8549830
- 9790975
glucose binding Source: InterPro
mannokinase activity
Source: PomBase
Inferred from direct assayⁱ
- 8549830

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

canonical glycolysis Source: PomBase
cellular glucose homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fructose 6-phosphate metabolic process
Source: PomBase
Inferred from direct assayⁱ
- 8549830
glucose 6-phosphate metabolic process
Source: PomBase
Inferred from direct assayⁱ
- 8549830
glycolytic fermentation
Source: PomBase
Inferred from mutant phenotypeⁱ
- 9790975
glycolytic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mannose metabolic process
Source: PomBase
Inferred from direct assayⁱ
- 8549830

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Glycolysis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.1.1 5613
Reactomeⁱ	R-SPO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-SPO-6798695 Neutrophil degranulation R-SPO-70171 Glycolysis
SABIO-RKⁱ	P50521
UniPathwayⁱ	UPA00242

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hexokinase-2 (EC:2.7.1.1)
Gene namesⁱ	Name:hxk2 ORF Names:SPAC4F8.07c
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome I

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC4F8.07c
PomBaseⁱ	SPAC4F8.07c hxk2

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197610	1 – 455	Hexokinase-2Add BLAST		455

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50521
PaxDbⁱ	P50521
PRIDEⁱ	P50521

PTM databases

iPTMnetⁱ	P50521

iPTMnetⁱ

P50521

Interactionⁱ

Subunit structureⁱ

Monomer.

Protein-protein interaction databases

BioGridⁱ	280022, 6 interactors
STRINGⁱ	4896.SPAC4F8.07c.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50521
SMRⁱ	P50521
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 445	HexokinasePROSITE-ProRule annotationAdd BLAST		443

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	57 – 195	Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST	139
Regionⁱ	138 – 164	Glucose-bindingSequence analysisAdd BLAST	27
Regionⁱ	196 – 434	Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST	239

Sequence similaritiesⁱ

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

HOGENOMⁱ	HOG000162670
InParanoidⁱ	P50521
KEGG Orthology (KO) More...KOⁱ	K00844
OMAⁱ	MIPTFVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2JW4
PhylomeDBⁱ	P50521

Family and domain databases

InterProⁱ	View protein in InterPro IPR001312 Hexokinase IPR019807 Hexokinase_BS IPR022673 Hexokinase_C IPR022672 Hexokinase_N
PANTHERⁱ	PTHR19443 PTHR19443, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00349 Hexokinase_1, 1 hit PF03727 Hexokinase_2, 1 hit
PROSITEⁱ	View protein in PROSITE PS00378 HEXOKINASE_1, 1 hit PS51748 HEXOKINASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P50521-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEANFQQAVK KLVNDFEYPT ESLREAVKEF DELRQKGLQK NGEVLAMAPA 
        60         70         80         90        100
FISTLPTGAE TGDFLALDFG GTNLRVCWIQ LLGDGKYEMK HSKSVLPREC 
       110        120        130        140        150
VRNESVKPII DFMSDHVELF IKEHFPSKFG CPEEEYLPMG FTFSYPANQV 
       160        170        180        190        200
SITESYLLRW TKGLNIPEAI NKDFAQFLTE GFKARNLPIR IEAVINDTVG 
       210        220        230        240        250
TLVTRAYTSK ESDTFMGIIF GTGTNGAYVE QMNQIPKLAG KCTGDHMLIN 
       260        270        280        290        300
MEWGATDFSC LHSTRYDLLL DHDTPNAGRQ IFEKRVGGMY LGELFRRALF 
       310        320        330        340        350
HLIKVYNFNE GIFPPSITDA WSLETSVLSR MMVERSAENV RNVLSTFKFR 
       360        370        380        390        400
FRSDEEALYL WDAAHAIGRR AARMSAVPIA SLYLSTGRAG KKSDVGVDGS 
       410        420        430        440        450
LVEHYPHFVD MLREALRELI GDNEKLISIG IAKDGSGIGA ALCALQAVKE 

KKGLA

Length:455

Mass (Da):50,920

Last modified:October 1, 1996 - v1

Checksum:ⁱ9751F9969F63AC96

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	295	F → S in BAA13859 (PubMed:9501991).Curated		1
Sequence conflictⁱ	298	A → V in BAA13859 (PubMed:9501991).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92895 mRNA Translation: CAA63488.1 CU329670 Genomic DNA Translation: CAB11054.1 D89198 mRNA Translation: BAA13859.1
PIRⁱ	S68693 T42997
NCBI Reference Sequences More...RefSeqⁱ	NP_593865.1, NM_001019294.2

Genome annotation databases

EnsemblFungiⁱ	SPAC4F8.07c.1; SPAC4F8.07c.1:pep; SPAC4F8.07c
GeneIDⁱ	2543607
KEGGⁱ	spo:SPAC4F8.07c

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50521	Phosphotransferase		SCHOY		451	UniRef50_P50521
Phosphotransferase		SCHJY		454
Phosphotransferase		SCHCR		462

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92895 mRNA Translation: CAA63488.1 CU329670 Genomic DNA Translation: CAB11054.1 D89198 mRNA Translation: BAA13859.1
PIRⁱ	S68693 T42997
RefSeqⁱ	NP_593865.1, NM_001019294.2

3D structure databases

ProteinModelPortalⁱ	P50521
SMRⁱ	P50521
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	280022, 6 interactors
STRINGⁱ	4896.SPAC4F8.07c.1

PTM databases

iPTMnetⁱ	P50521

iPTMnetⁱ

P50521

Proteomic databases

MaxQBⁱ	P50521
PaxDbⁱ	P50521
PRIDEⁱ	P50521

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPAC4F8.07c.1; SPAC4F8.07c.1:pep; SPAC4F8.07c
GeneIDⁱ	2543607
KEGGⁱ	spo:SPAC4F8.07c

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC4F8.07c
PomBaseⁱ	SPAC4F8.07c hxk2

Phylogenomic databases

HOGENOMⁱ	HOG000162670
InParanoidⁱ	P50521
KOⁱ	K00844
OMAⁱ	MIPTFVT
OrthoDBⁱ	EOG092C2JW4
PhylomeDBⁱ	P50521

Enzyme and pathway databases

UniPathwayⁱ	UPA00242
BRENDAⁱ	2.7.1.1 5613
Reactomeⁱ	R-SPO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-SPO-6798695 Neutrophil degranulation R-SPO-70171 Glycolysis
SABIO-RKⁱ	P50521

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P50521

PROⁱ

PR:P50521

Family and domain databases

InterProⁱ	View protein in InterPro IPR001312 Hexokinase IPR019807 Hexokinase_BS IPR022673 Hexokinase_C IPR022672 Hexokinase_N
PANTHERⁱ	PTHR19443 PTHR19443, 1 hit
Pfamⁱ	View protein in Pfam PF00349 Hexokinase_1, 1 hit PF03727 Hexokinase_2, 1 hit
PROSITEⁱ	View protein in PROSITE PS00378 HEXOKINASE_1, 1 hit PS51748 HEXOKINASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXK2_SCHPO
Accessionⁱ	P50521Primary (citable) accession number: P50521 Secondary accession number(s): P78848
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	February 28, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50521 (HXK2_SCHPO)

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Hexokinase-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hexose metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: hexose metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ