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Protein

Hexokinase-2

Gene

hxk2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

  • canonical glycolysis Source: PomBase
  • cellular glucose homeostasis Source: GO_Central
  • fructose 6-phosphate metabolic process Source: PomBase
  • glucose 6-phosphate metabolic process Source: PomBase
  • glycolytic fermentation Source: PomBase
  • glycolytic process Source: GO_Central
  • mannose metabolic process Source: PomBase

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1 5613
ReactomeiR-SPO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-SPO-6798695 Neutrophil degranulation
R-SPO-70171 Glycolysis
SABIO-RKiP50521
UniPathwayi
UPA00242

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Gene namesi
Name:hxk2
ORF Names:SPAC4F8.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F8.07c
PomBaseiSPAC4F8.07c hxk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001976101 – 455Hexokinase-2Add BLAST455

Proteomic databases

MaxQBiP50521
PaxDbiP50521
PRIDEiP50521

PTM databases

iPTMnetiP50521

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi280022, 6 interactors
STRINGi4896.SPAC4F8.07c.1

Structurei

3D structure databases

ProteinModelPortaliP50521
SMRiP50521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 445HexokinasePROSITE-ProRule annotationAdd BLAST443

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 195Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni138 – 164Glucose-bindingSequence analysisAdd BLAST27
Regioni196 – 434Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

HOGENOMiHOG000162670
InParanoidiP50521
KOiK00844
OMAiMIPTFVT
OrthoDBiEOG092C2JW4
PhylomeDBiP50521

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANFQQAVK KLVNDFEYPT ESLREAVKEF DELRQKGLQK NGEVLAMAPA
60 70 80 90 100
FISTLPTGAE TGDFLALDFG GTNLRVCWIQ LLGDGKYEMK HSKSVLPREC
110 120 130 140 150
VRNESVKPII DFMSDHVELF IKEHFPSKFG CPEEEYLPMG FTFSYPANQV
160 170 180 190 200
SITESYLLRW TKGLNIPEAI NKDFAQFLTE GFKARNLPIR IEAVINDTVG
210 220 230 240 250
TLVTRAYTSK ESDTFMGIIF GTGTNGAYVE QMNQIPKLAG KCTGDHMLIN
260 270 280 290 300
MEWGATDFSC LHSTRYDLLL DHDTPNAGRQ IFEKRVGGMY LGELFRRALF
310 320 330 340 350
HLIKVYNFNE GIFPPSITDA WSLETSVLSR MMVERSAENV RNVLSTFKFR
360 370 380 390 400
FRSDEEALYL WDAAHAIGRR AARMSAVPIA SLYLSTGRAG KKSDVGVDGS
410 420 430 440 450
LVEHYPHFVD MLREALRELI GDNEKLISIG IAKDGSGIGA ALCALQAVKE

KKGLA
Length:455
Mass (Da):50,920
Last modified:October 1, 1996 - v1
Checksum:i9751F9969F63AC96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295F → S in BAA13859 (PubMed:9501991).Curated1
Sequence conflicti298A → V in BAA13859 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92895 mRNA Translation: CAA63488.1
CU329670 Genomic DNA Translation: CAB11054.1
D89198 mRNA Translation: BAA13859.1
PIRiS68693
T42997
RefSeqiNP_593865.1, NM_001019294.2

Genome annotation databases

EnsemblFungiiSPAC4F8.07c.1; SPAC4F8.07c.1:pep; SPAC4F8.07c
GeneIDi2543607
KEGGispo:SPAC4F8.07c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92895 mRNA Translation: CAA63488.1
CU329670 Genomic DNA Translation: CAB11054.1
D89198 mRNA Translation: BAA13859.1
PIRiS68693
T42997
RefSeqiNP_593865.1, NM_001019294.2

3D structure databases

ProteinModelPortaliP50521
SMRiP50521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280022, 6 interactors
STRINGi4896.SPAC4F8.07c.1

PTM databases

iPTMnetiP50521

Proteomic databases

MaxQBiP50521
PaxDbiP50521
PRIDEiP50521

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F8.07c.1; SPAC4F8.07c.1:pep; SPAC4F8.07c
GeneIDi2543607
KEGGispo:SPAC4F8.07c

Organism-specific databases

EuPathDBiFungiDB:SPAC4F8.07c
PomBaseiSPAC4F8.07c hxk2

Phylogenomic databases

HOGENOMiHOG000162670
InParanoidiP50521
KOiK00844
OMAiMIPTFVT
OrthoDBiEOG092C2JW4
PhylomeDBiP50521

Enzyme and pathway databases

UniPathwayi
UPA00242

BRENDAi2.7.1.1 5613
ReactomeiR-SPO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-SPO-6798695 Neutrophil degranulation
R-SPO-70171 Glycolysis
SABIO-RKiP50521

Miscellaneous databases

PROiPR:P50521

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXK2_SCHPO
AccessioniPrimary (citable) accession number: P50521
Secondary accession number(s): P78848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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