UniProtKB - P50503 (F10A1_RAT)
Protein
Hsc70-interacting protein
Gene
St13
Organism
Rattus norvegicus (Rat)
Status
Functioni
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.1 Publication
GO - Molecular functioni
- chaperone binding Source: RGD
- dATP binding Source: RGD
- heat shock protein binding Source: GO_Central
- Hsp70 protein binding Source: RGD
- identical protein binding Source: IntAct
- protein-containing complex binding Source: RGD
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: RGD
- unfolded protein binding Source: RGD
GO - Biological processi
- chaperone cofactor-dependent protein refolding Source: RGD
- negative regulation of protein refolding Source: RGD
- protein-containing complex assembly Source: GO_Central
- response to bacterium Source: RGD
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
Reactomei | R-RNO-3371453, Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Hsc70-interacting proteinShort name: Hip Alternative name(s): Protein FAM10A1 Protein ST13 homolog |
Gene namesi | Name:St13 Synonyms:Fam10a1, Hip |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621312, St13 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: RGD
Other locations
- protein-containing complex Source: RGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190814 | 1 – 368 | Hsc70-interacting proteinAdd BLAST | 368 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 345 | Phosphoserine; by GRK5By similarity | 1 | |
Modified residuei | 352 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 359 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P50503 |
PaxDbi | P50503 |
PRIDEi | P50503 |
PTM databases
iPTMneti | P50503 |
PhosphoSitePlusi | P50503 |
SwissPalmi | P50503 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000019070, Expressed in brain and 21 other tissues |
Genevisiblei | P50503, RN |
Interactioni
Subunit structurei
Homotetramer.
Interacts with HSC70 as well as DNAJ homologs and HSP90.
Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity).
By similarityBinary interactionsi
Hide detailsP50503
With | #Exp. | IntAct |
---|---|---|
Esr1 [P06211] | 4 | EBI-917694,EBI-7983651 |
itself | 2 | EBI-917694,EBI-917694 |
HSPA1A [P0DMV8] from Homo sapiens. | 3 | EBI-917694,EBI-11820565 |
GO - Molecular functioni
- chaperone binding Source: RGD
- heat shock protein binding Source: GO_Central
- Hsp70 protein binding Source: RGD
- identical protein binding Source: IntAct
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: RGD
- unfolded protein binding Source: RGD
Protein-protein interaction databases
DIPi | DIP-37019N |
IntActi | P50503, 5 interactors |
STRINGi | 10116.ENSRNOP00000025925 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P50503 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 113 – 146 | TPR 1Add BLAST | 34 | |
Repeati | 147 – 180 | TPR 2Add BLAST | 34 | |
Repeati | 181 – 214 | TPR 3Add BLAST | 34 | |
Domaini | 318 – 357 | STI1Add BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 278 – 311 | Gly/Met/Pro-richAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the FAM10 family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1308, Eukaryota |
GeneTreei | ENSGT00390000001347 |
HOGENOMi | CLU_026202_0_1_1 |
InParanoidi | P50503 |
OMAi | GGQGGCC |
OrthoDBi | 1282821at2759 |
PhylomeDBi | P50503 |
TreeFami | TF313244 |
Family and domain databases
CDDi | cd14438, Hip_N, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR034649, Hip_N IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF18253, HipN, 1 hit PF17830, STI1, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
P50503-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPRKVSELR AFVKMCRQDP SVLHTEEMRF LREWVESMGG KVPPATHKAK
60 70 80 90 100
SEENTKEEKR DKTTEDNIKT EEPSSEESDL EIDNEGVIEA DTDAPQEMGD
110 120 130 140 150
ENAEITEAMM DEANEKKGAA IDALNDGELQ KAIDLFTDAI KLNPRLAILY
160 170 180 190 200
AKRASVFVKL QKPNAAIRDC DRAIEINPDS AQPYKWRGKA HRLLGHWEEA
210 220 230 240 250
ARDLALACKL DYDEDASAML REVQPRAQKI AEHRRKYERK REEREIKERI
260 270 280 290 300
ERVKKAREEH EKAQREEEAR RQSGSQFGSF PGGFPGGMPG NFPGGMPGMG
310 320 330 340 350
GAMPGMAGMP GLNEILSDPE VLAAMQDPEV MVAFQDVAQN PSNMSKYQNN
360
PKVMNLISKL SAKFGGHS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82021 mRNA Translation: CAA57546.1 BC078804 mRNA Translation: AAH78804.1 |
RefSeqi | NP_112384.1, NM_031122.1 |
Genome annotation databases
Ensembli | ENSRNOT00000025925; ENSRNOP00000025925; ENSRNOG00000019070 |
GeneIDi | 81800 |
KEGGi | rno:81800 |
UCSCi | RGD:621312, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82021 mRNA Translation: CAA57546.1 BC078804 mRNA Translation: AAH78804.1 |
RefSeqi | NP_112384.1, NM_031122.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4J8C | X-ray | 1.10 | A/B | 1-44 | [»] | |
4J8D | X-ray | 2.80 | A/B/C/D | 78-247 | [»] | |
4J8E | X-ray | 2.60 | A/B | 78-247 | [»] | |
4J8F | X-ray | 2.70 | A | 77-247 | [»] | |
SMRi | P50503 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-37019N |
IntActi | P50503, 5 interactors |
STRINGi | 10116.ENSRNOP00000025925 |
PTM databases
iPTMneti | P50503 |
PhosphoSitePlusi | P50503 |
SwissPalmi | P50503 |
Proteomic databases
jPOSTi | P50503 |
PaxDbi | P50503 |
PRIDEi | P50503 |
Genome annotation databases
Ensembli | ENSRNOT00000025925; ENSRNOP00000025925; ENSRNOG00000019070 |
GeneIDi | 81800 |
KEGGi | rno:81800 |
UCSCi | RGD:621312, rat |
Organism-specific databases
CTDi | 6767 |
RGDi | 621312, St13 |
Phylogenomic databases
eggNOGi | KOG1308, Eukaryota |
GeneTreei | ENSGT00390000001347 |
HOGENOMi | CLU_026202_0_1_1 |
InParanoidi | P50503 |
OMAi | GGQGGCC |
OrthoDBi | 1282821at2759 |
PhylomeDBi | P50503 |
TreeFami | TF313244 |
Enzyme and pathway databases
Reactomei | R-RNO-3371453, Regulation of HSF1-mediated heat shock response |
Miscellaneous databases
PROi | PR:P50503 |
Gene expression databases
Bgeei | ENSRNOG00000019070, Expressed in brain and 21 other tissues |
Genevisiblei | P50503, RN |
Family and domain databases
CDDi | cd14438, Hip_N, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR034649, Hip_N IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF18253, HipN, 1 hit PF17830, STI1, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F10A1_RAT | |
Accessioni | P50503Primary (citable) accession number: P50503 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families