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Protein

LIM/homeobox protein Lhx2

Gene

LHX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiP50458

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:LHX2
Synonyms:LH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106689.10
HGNCiHGNC:6594 LHX2
MIMi603759 gene
neXtProtiNX_P50458

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9355
OpenTargetsiENSG00000106689
PharmGKBiPA30365

Polymorphism and mutation databases

BioMutaiLHX2
DMDMi8247936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757781 – 406LIM/homeobox protein Lhx2Add BLAST406

Proteomic databases

PaxDbiP50458
PeptideAtlasiP50458
PRIDEiP50458
ProteomicsDBi56230

PTM databases

iPTMnetiP50458
PhosphoSitePlusiP50458

Expressioni

Gene expression databases

BgeeiENSG00000106689 Expressed in 98 organ(s), highest expression level in hair follicle
CleanExiHS_LHX2
ExpressionAtlasiP50458 baseline and differential
GenevisibleiP50458 HS

Organism-specific databases

HPAiHPA000838

Interactioni

Subunit structurei

Interacts (via LIM domains) with CITED2. Interacts with POU4F2.By similarity

Protein-protein interaction databases

BioGridi114758, 5 interactors
IntActiP50458, 25 interactors
STRINGi9606.ENSP00000362717

Structurei

3D structure databases

ProteinModelPortaliP50458
SMRiP50458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini115 – 168LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 323Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 196Poly-Ala10

Domaini

LIM domains are necessary for transcription activation.By similarity

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiP50458
KOiK09373
PhylomeDBiP50458
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P50458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,373
Last modified:May 30, 2000 - v2
Checksum:iDF73AAC81867D30D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0H1H7C0H1_HUMAN
LIM/homeobox protein Lhx2
LHX2
412Annotation score:
U3KQT5U3KQT5_HUMAN
LIM/homeobox protein Lhx2
LHX2
115Annotation score:
H0YM35H0YM35_HUMAN
LIM/homeobox protein Lhx2
LHX2
146Annotation score:

Sequence cautioni

The sequence BAC04371 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 28AKSEAPA → QERGSR in AAB08752 (PubMed:8649822).Curated7
Sequence conflicti54A → G in AAB08752 (PubMed:8649822).Curated1
Sequence conflicti107Y → YSPSLHGPY (PubMed:14702039).Curated1
Sequence conflicti187A → Q (PubMed:8649822).Curated1
Sequence conflicti190 – 192AAA → RAR (PubMed:8649822).Curated3
Sequence conflicti196Missing (PubMed:8649822).Curated1
Sequence conflicti241 – 242NA → TR in AAB08752 (PubMed:8649822).Curated2
Sequence conflicti391 – 406GHEPH…LTNLF → AMSLTAPHKRLLPTFSNDSQ PPHPTISLKKKLSLV in AAB08752 (PubMed:8649822).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11701 mRNA Translation: AAB08752.1
BC093662 mRNA Translation: AAH93662.1
BC112185 mRNA Translation: AAI12186.1
AK094511 mRNA Translation: BAC04371.1 Different initiation.
AF124735 mRNA Translation: AAD20013.1
CCDSiCCDS6853.1
RefSeqiNP_004780.3, NM_004789.3
UniGeneiHs.696425

Genome annotation databases

EnsembliENST00000373615; ENSP00000362717; ENSG00000106689
GeneIDi9355
KEGGihsa:9355
UCSCiuc004boe.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11701 mRNA Translation: AAB08752.1
BC093662 mRNA Translation: AAH93662.1
BC112185 mRNA Translation: AAI12186.1
AK094511 mRNA Translation: BAC04371.1 Different initiation.
AF124735 mRNA Translation: AAD20013.1
CCDSiCCDS6853.1
RefSeqiNP_004780.3, NM_004789.3
UniGeneiHs.696425

3D structure databases

ProteinModelPortaliP50458
SMRiP50458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114758, 5 interactors
IntActiP50458, 25 interactors
STRINGi9606.ENSP00000362717

PTM databases

iPTMnetiP50458
PhosphoSitePlusiP50458

Polymorphism and mutation databases

BioMutaiLHX2
DMDMi8247936

Proteomic databases

PaxDbiP50458
PeptideAtlasiP50458
PRIDEiP50458
ProteomicsDBi56230

Protocols and materials databases

DNASUi9355
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373615; ENSP00000362717; ENSG00000106689
GeneIDi9355
KEGGihsa:9355
UCSCiuc004boe.2 human

Organism-specific databases

CTDi9355
DisGeNETi9355
EuPathDBiHostDB:ENSG00000106689.10
GeneCardsiLHX2
HGNCiHGNC:6594 LHX2
HPAiHPA000838
MIMi603759 gene
neXtProtiNX_P50458
OpenTargetsiENSG00000106689
PharmGKBiPA30365
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiP50458
KOiK09373
PhylomeDBiP50458
TreeFamiTF315442

Enzyme and pathway databases

ReactomeiR-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiP50458

Miscellaneous databases

ChiTaRSiLHX2 human
GeneWikiiLHX2
GenomeRNAii9355
PROiPR:P50458
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106689 Expressed in 98 organ(s), highest expression level in hair follicle
CleanExiHS_LHX2
ExpressionAtlasiP50458 baseline and differential
GenevisibleiP50458 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLHX2_HUMAN
AccessioniPrimary (citable) accession number: P50458
Secondary accession number(s): O95860, Q52M57, Q8N1Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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