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UniProtKB - P50453 (SPB9_HUMAN)
Protein
Serpin B9
Gene
SERPINB9
Organism
Homo sapiens (Human)
Status
Functioni
Granzyme B inhibitor.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 340 – 341 | Reactive bondBy similarity | 2 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- protease binding Source: UniProtKB
- serine-type endopeptidase inhibitor activity Source: UniProtKB
GO - Biological processi
- cellular response to estrogen stimulus Source: UniProtKB
- immune response Source: UniProtKB
- mast cell mediated immunity Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of endopeptidase activity Source: UniProtKB
- protection from natural killer cell mediated cytotoxicity Source: UniProtKB
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
PathwayCommonsi | P50453 |
SignaLinki | P50453 |
Protein family/group databases
MEROPSi | I04.014 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin B9Alternative name(s): Cytoplasmic antiproteinase 3 Short name: CAP-3 Short name: CAP3 Peptidase inhibitor 9 Short name: PI-9 |
Gene namesi | Name:SERPINB9 Synonyms:PI9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8955, SERPINB9 |
MIMi | 601799, gene |
neXtProti | NX_P50453 |
VEuPathDBi | HostDB:ENSG00000170542 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 5272 |
OpenTargetsi | ENSG00000170542 |
PharmGKBi | PA35519 |
Miscellaneous databases
Pharosi | P50453, Tbio |
Chemistry databases
DrugBanki | DB00481, Raloxifene |
Genetic variation databases
BioMutai | SERPINB9 |
DMDMi | 1709896 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094113 | 1 – 376 | Serpin B9Add BLAST | 376 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P50453 |
jPOSTi | P50453 |
MassIVEi | P50453 |
MaxQBi | P50453 |
PaxDbi | P50453 |
PeptideAtlasi | P50453 |
PRIDEi | P50453 |
ProteomicsDBi | 56228 |
2D gel databases
OGPi | P50453 |
REPRODUCTION-2DPAGEi | IPI00032139 |
PTM databases
GlyGeni | P50453, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P50453 |
PhosphoSitePlusi | P50453 |
SwissPalmi | P50453 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170542, Expressed in female gonad and 222 other tissues |
ExpressionAtlasi | P50453, baseline and differential |
Genevisiblei | P50453, HS |
Organism-specific databases
HPAi | ENSG00000170542, Tissue enhanced (lymphoid tissue, placenta) |
Interactioni
Binary interactionsi
P50453
With | #Exp. | IntAct |
---|---|---|
TRAF5 [O00463] | 6 | EBI-711626,EBI-523498 |
GO - Molecular functioni
- protease binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111290, 46 interactors |
IntActi | P50453, 31 interactors |
STRINGi | 9606.ENSP00000370074 |
Miscellaneous databases
RNActi | P50453, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000154931 |
HOGENOMi | CLU_023330_0_2_1 |
InParanoidi | P50453 |
OMAi | FGEKTCE |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P50453 |
TreeFami | TF352619 |
Family and domain databases
Gene3Di | 2.30.39.10, 2 hits 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR000240, Serpin_B9/Maspin IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
PRINTSi | PR00676, MASPIN |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P50453-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT
60 70 80 90 100
ATQMAQALSL NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF
110 120 130 140 150
LSTFKESCLQ FYHAELKELS FIRAAEESRK HINTWVSKKT EGKIEELLPG
160 170 180 190 200
SSIDAETRLV LVNAIYFKGK WNEPFDETYT REMPFKINQE EQRPVQMMYQ
210 220 230 240 250
EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS TVEKSLTFEK
260 270 280 290 300
LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL
310 320 330 340 350
SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC
360 370
ADHPFLFFIR HNRANSILFC GRFSSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40378 mRNA Translation: AAC41940.1 U71364 mRNA Translation: AAC50793.1 AB060690 mRNA Translation: BAB91078.1 AK314842 mRNA Translation: BAG37360.1 BT006673 mRNA Translation: AAP35319.1 CR407627 mRNA Translation: CAG28555.1 AL133351 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55093.1 BC002538 mRNA Translation: AAH02538.1 |
CCDSi | CCDS4478.1 |
PIRi | B59273 |
RefSeqi | NP_004146.1, NM_004155.5 XP_005249241.1, XM_005249184.4 |
Genome annotation databases
Ensembli | ENST00000380698; ENSP00000370074; ENSG00000170542 |
GeneIDi | 5272 |
KEGGi | hsa:5272 |
MANE-Selecti | ENST00000380698.5; ENSP00000370074.4; NM_004155.6; NP_004146.1 |
UCSCi | uc003mug.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40378 mRNA Translation: AAC41940.1 U71364 mRNA Translation: AAC50793.1 AB060690 mRNA Translation: BAB91078.1 AK314842 mRNA Translation: BAG37360.1 BT006673 mRNA Translation: AAP35319.1 CR407627 mRNA Translation: CAG28555.1 AL133351 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55093.1 BC002538 mRNA Translation: AAH02538.1 |
CCDSi | CCDS4478.1 |
PIRi | B59273 |
RefSeqi | NP_004146.1, NM_004155.5 XP_005249241.1, XM_005249184.4 |
3D structure databases
SMRi | P50453 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111290, 46 interactors |
IntActi | P50453, 31 interactors |
STRINGi | 9606.ENSP00000370074 |
Chemistry databases
DrugBanki | DB00481, Raloxifene |
Protein family/group databases
MEROPSi | I04.014 |
PTM databases
GlyGeni | P50453, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P50453 |
PhosphoSitePlusi | P50453 |
SwissPalmi | P50453 |
Genetic variation databases
BioMutai | SERPINB9 |
DMDMi | 1709896 |
2D gel databases
OGPi | P50453 |
REPRODUCTION-2DPAGEi | IPI00032139 |
Proteomic databases
EPDi | P50453 |
jPOSTi | P50453 |
MassIVEi | P50453 |
MaxQBi | P50453 |
PaxDbi | P50453 |
PeptideAtlasi | P50453 |
PRIDEi | P50453 |
ProteomicsDBi | 56228 |
Protocols and materials databases
Antibodypediai | 9285, 413 antibodies from 38 providers |
DNASUi | 5272 |
Genome annotation databases
Ensembli | ENST00000380698; ENSP00000370074; ENSG00000170542 |
GeneIDi | 5272 |
KEGGi | hsa:5272 |
MANE-Selecti | ENST00000380698.5; ENSP00000370074.4; NM_004155.6; NP_004146.1 |
UCSCi | uc003mug.5, human |
Organism-specific databases
CTDi | 5272 |
DisGeNETi | 5272 |
GeneCardsi | SERPINB9 |
HGNCi | HGNC:8955, SERPINB9 |
HPAi | ENSG00000170542, Tissue enhanced (lymphoid tissue, placenta) |
MIMi | 601799, gene |
neXtProti | NX_P50453 |
OpenTargetsi | ENSG00000170542 |
PharmGKBi | PA35519 |
VEuPathDBi | HostDB:ENSG00000170542 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000154931 |
HOGENOMi | CLU_023330_0_2_1 |
InParanoidi | P50453 |
OMAi | FGEKTCE |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P50453 |
TreeFami | TF352619 |
Enzyme and pathway databases
PathwayCommonsi | P50453 |
SignaLinki | P50453 |
Miscellaneous databases
BioGRID-ORCSi | 5272, 2 hits in 1045 CRISPR screens |
ChiTaRSi | SERPINB9, human |
GeneWikii | SERPINB9 |
GenomeRNAii | 5272 |
Pharosi | P50453, Tbio |
PROi | PR:P50453 |
RNActi | P50453, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170542, Expressed in female gonad and 222 other tissues |
ExpressionAtlasi | P50453, baseline and differential |
Genevisiblei | P50453, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 2 hits 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR000240, Serpin_B9/Maspin IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
PRINTSi | PR00676, MASPIN |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPB9_HUMAN | |
Accessioni | P50453Primary (citable) accession number: P50453 Secondary accession number(s): B2RBW3, Q5TD03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families