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Protein

Serpin B9

Gene

SERPINB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granzyme B inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei340 – 341Reactive bondBy similarity2

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.014

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B9
Alternative name(s):
Cytoplasmic antiproteinase 3
Short name:
CAP-3
Short name:
CAP3
Peptidase inhibitor 9
Short name:
PI-9
Gene namesi
Name:SERPINB9
Synonyms:PI9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000170542.5
HGNCiHGNC:8955 SERPINB9
MIMi601799 gene
neXtProtiNX_P50453

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5272
OpenTargetsiENSG00000170542
PharmGKBiPA35519

Polymorphism and mutation databases

BioMutaiSERPINB9
DMDMi1709896

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941131 – 376Serpin B9Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP50453
MaxQBiP50453
PaxDbiP50453
PeptideAtlasiP50453
PRIDEiP50453
ProteomicsDBi56228

2D gel databases

OGPiP50453
REPRODUCTION-2DPAGEiIPI00032139

PTM databases

iPTMnetiP50453
PhosphoSitePlusiP50453

Expressioni

Gene expression databases

BgeeiENSG00000170542 Expressed in 210 organ(s), highest expression level in female gonad
CleanExiHS_SERPINB9
ExpressionAtlasiP50453 baseline and differential
GenevisibleiP50453 HS

Organism-specific databases

HPAiHPA030067

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF5O004635EBI-711626,EBI-523498

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111290, 37 interactors
IntActiP50453, 26 interactors
STRINGi9606.ENSP00000370074

Structurei

3D structure databases

ProteinModelPortaliP50453
SMRiP50453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP50453
KOiK13963
OMAiKILCQDN
OrthoDBiEOG091G0ION
PhylomeDBiP50453
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

P50453-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT
60 70 80 90 100
ATQMAQALSL NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF
110 120 130 140 150
LSTFKESCLQ FYHAELKELS FIRAAEESRK HINTWVSKKT EGKIEELLPG
160 170 180 190 200
SSIDAETRLV LVNAIYFKGK WNEPFDETYT REMPFKINQE EQRPVQMMYQ
210 220 230 240 250
EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS TVEKSLTFEK
260 270 280 290 300
LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL
310 320 330 340 350
SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC
360 370
ADHPFLFFIR HNRANSILFC GRFSSP
Length:376
Mass (Da):42,404
Last modified:October 1, 1996 - v1
Checksum:iECBA80869B939753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40378 mRNA Translation: AAC41940.1
U71364 mRNA Translation: AAC50793.1
AB060690 mRNA Translation: BAB91078.1
AK314842 mRNA Translation: BAG37360.1
BT006673 mRNA Translation: AAP35319.1
CR407627 mRNA Translation: CAG28555.1
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55093.1
BC002538 mRNA Translation: AAH02538.1
CCDSiCCDS4478.1
PIRiB59273
RefSeqiNP_004146.1, NM_004155.5
XP_005249241.1, XM_005249184.4
UniGeneiHs.104879

Genome annotation databases

EnsembliENST00000380698; ENSP00000370074; ENSG00000170542
GeneIDi5272
KEGGihsa:5272
UCSCiuc003mug.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40378 mRNA Translation: AAC41940.1
U71364 mRNA Translation: AAC50793.1
AB060690 mRNA Translation: BAB91078.1
AK314842 mRNA Translation: BAG37360.1
BT006673 mRNA Translation: AAP35319.1
CR407627 mRNA Translation: CAG28555.1
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55093.1
BC002538 mRNA Translation: AAH02538.1
CCDSiCCDS4478.1
PIRiB59273
RefSeqiNP_004146.1, NM_004155.5
XP_005249241.1, XM_005249184.4
UniGeneiHs.104879

3D structure databases

ProteinModelPortaliP50453
SMRiP50453
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111290, 37 interactors
IntActiP50453, 26 interactors
STRINGi9606.ENSP00000370074

Protein family/group databases

MEROPSiI04.014

PTM databases

iPTMnetiP50453
PhosphoSitePlusiP50453

Polymorphism and mutation databases

BioMutaiSERPINB9
DMDMi1709896

2D gel databases

OGPiP50453
REPRODUCTION-2DPAGEiIPI00032139

Proteomic databases

EPDiP50453
MaxQBiP50453
PaxDbiP50453
PeptideAtlasiP50453
PRIDEiP50453
ProteomicsDBi56228

Protocols and materials databases

DNASUi5272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380698; ENSP00000370074; ENSG00000170542
GeneIDi5272
KEGGihsa:5272
UCSCiuc003mug.5 human

Organism-specific databases

CTDi5272
DisGeNETi5272
EuPathDBiHostDB:ENSG00000170542.5
GeneCardsiSERPINB9
H-InvDBiHIX0057760
HGNCiHGNC:8955 SERPINB9
HPAiHPA030067
MIMi601799 gene
neXtProtiNX_P50453
OpenTargetsiENSG00000170542
PharmGKBiPA35519
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP50453
KOiK13963
OMAiKILCQDN
OrthoDBiEOG091G0ION
PhylomeDBiP50453
TreeFamiTF352619

Miscellaneous databases

GeneWikiiSERPINB9
GenomeRNAii5272
PROiPR:P50453
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170542 Expressed in 210 organ(s), highest expression level in female gonad
CleanExiHS_SERPINB9
ExpressionAtlasiP50453 baseline and differential
GenevisibleiP50453 HS

Family and domain databases

InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB9_HUMAN
AccessioniPrimary (citable) accession number: P50453
Secondary accession number(s): B2RBW3, Q5TD03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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