Serpin B9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells."
    Young J.L., Sukhova G.K., Foster D., Kisiel W., Libby P., Schonbeck U.
    J. Exp. Med. 191:1535-1544(2000) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation."
    Rowshani A.T., Strik M.C., Molenaar R., Yong S.L., Wolbink A.M., Bemelman F.J., Hack C.E., Ten Berge I.J.
    J. Infect. Dis. 192:1908-1911(2005) [PubMed] [Europe PMC] [Abstract]
• serine-type endopeptidase inhibitor activity Source: UniProtKBInferred from direct assayⁱ
  • "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses."
    Buzza M.S., Hirst C.E., Bird C.H., Hosking P., McKendrick J., Bird P.I.
    Cell. Immunol. 210:21-29(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes."
    Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., Jong T.A., Trapani J.A., Bird P.I.
    J. Biol. Chem. 271:27802-27809(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

GO - Biological processⁱ

• cellular response to estrogen stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells."
    Jiang X., Ellison S.J., Alarid E.T., Shapiro D.J.
    Oncogene 26:4106-4114(2007) [PubMed] [Europe PMC] [Abstract]
• immune response Source: UniProtKBInferred from direct assayⁱ
  • "Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells."
    Jiang X., Orr B.A., Kranz D.M., Shapiro D.J.
    Endocrinology 147:1419-1426(2006) [PubMed] [Europe PMC] [Abstract]
• mast cell mediated immunity Source: UniProtKBInferred from expression patternⁱ
  • "The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells."
    Bladergroen B.A., Strik M.C., Wolbink A.M., Wouters D., Broekhuizen R., Kummer J.A., Hack C.E.
    Eur. J. Immunol. 35:1175-1183(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation by symbiont of host apoptotic process Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Induction of serine protease inhibitor 9 by Mycobacterium tuberculosis inhibits apoptosis and promotes survival of infected macrophages."
    Toossi Z., Wu M., Rojas R., Kalsdorf B., Aung H., Hirsch C.S., Walrath J., Wolbink A., van Ham M., Silver R.F.
    J. Infect. Dis. 205:144-151(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells."
    Jiang X., Ellison S.J., Alarid E.T., Shapiro D.J.
    Oncogene 26:4106-4114(2007) [PubMed] [Europe PMC] [Abstract]
  • "Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis."
    Kummer J.A., Micheau O., Schneider P., Bovenschen N., Broekhuizen R., Quadir R., Strik M.C., Hack C.E., Tschopp J.
    Cell Death Differ. 14:1486-1496(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endopeptidase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells."
    El Haddad N., Moore R., Heathcote D., Mounayar M., Azzi J., Mfarrej B., Batal I., Ting C., Atkinson M., Sayegh M.H., Ashton-Rickardt P.G., Abdi R.
    J. Immunol. 187:2252-2260(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Induction of serine protease inhibitor 9 by Mycobacterium tuberculosis inhibits apoptosis and promotes survival of infected macrophages."
    Toossi Z., Wu M., Rojas R., Kalsdorf B., Aung H., Hirsch C.S., Walrath J., Wolbink A., van Ham M., Silver R.F.
    J. Infect. Dis. 205:144-151(2012) [PubMed] [Europe PMC] [Abstract]
• protection from natural killer cell mediated cytotoxicity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells."
    El Haddad N., Moore R., Heathcote D., Mounayar M., Azzi J., Mfarrej B., Batal I., Ting C., Atkinson M., Sayegh M.H., Ashton-Rickardt P.G., Abdi R.
    J. Immunol. 187:2252-2260(2011) [PubMed] [Europe PMC] [Abstract]
• response to bacterium Source: UniProtKBInferred from direct assayⁱ
  • "Induction of serine protease inhibitor 9 by Mycobacterium tuberculosis inhibits apoptosis and promotes survival of infected macrophages."
    Toossi Z., Wu M., Rojas R., Kalsdorf B., Aung H., Hirsch C.S., Walrath J., Wolbink A., van Ham M., Silver R.F.
    J. Infect. Dis. 205:144-151(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protease binding Source: UniProtKBInferred from physical interactionⁱ
  • "The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation."
    Rowshani A.T., Strik M.C., Molenaar R., Yong S.L., Wolbink A.M., Bemelman F.J., Hack C.E., Ten Berge I.J.
    J. Infect. Dis. 192:1908-1911(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT 
        60         70         80         90        100
ATQMAQALSL NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF 
       110        120        130        140        150
LSTFKESCLQ FYHAELKELS FIRAAEESRK HINTWVSKKT EGKIEELLPG 
       160        170        180        190        200
SSIDAETRLV LVNAIYFKGK WNEPFDETYT REMPFKINQE EQRPVQMMYQ 
       210        220        230        240        250
EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS TVEKSLTFEK 
       260        270        280        290        300
LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL 
       310        320        330        340        350
SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC 
       360        370 
ADHPFLFFIR HNRANSILFC GRFSSP                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot