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Entry version 160 (16 Oct 2019)
Sequence version 2 (04 Nov 2008)
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Protein

Serpin B8

Gene

SERPINB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has an important role in epithelial desmosome-mediated cell-cell adhesion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei339 – 340Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-75205 Dissolution of Fibrin Clot

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P50452

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I04.013

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serpin B8
Alternative name(s):
Cytoplasmic antiproteinase 2
Short name:
CAP-2
Short name:
CAP2
Peptidase inhibitor 8
Short name:
PI-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINB8
Synonyms:PI8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:8952 SERPINB8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601697 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50452

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peeling skin syndrome 5 (PSS5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of peeling skin syndrome, a genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. PSS5 patients manifest hyperkeratosis and superficial peeling of areas of the palmar and dorsal faces of hands and feet. Additional variable features include erythema, superficial scaling of forearms and legs and diffuse yellowish hyperkeratotic palmoplantar plaques. PSS5 inheritance is autosomal recessive.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
5271

MalaCards human disease database

More...
MalaCardsi
SERPINB8
MIMi617115 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166401

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
289586 Exfoliative ichthyosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35517

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50452

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERPINB8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000941111 – 374Serpin B8Add BLAST374

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P50452

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P50452

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P50452

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50452

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50452

PeptideAtlas

More...
PeptideAtlasi
P50452

PRoteomics IDEntifications database

More...
PRIDEi
P50452

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5132
56226 [P50452-1]
56227 [P50452-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50452

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P50452

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P50452

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166401 Expressed in 114 organ(s), highest expression level in skin of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P50452 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P50452 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034300

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111289, 32 interactors

Protein interaction database and analysis system

More...
IntActi
P50452, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381072

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50452

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238519

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50452

KEGG Orthology (KO)

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KOi
K13965

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFKESCQ

Database of Orthologous Groups

More...
OrthoDBi
1124079at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P50452

TreeFam database of animal gene trees

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TreeFami
TF352619

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2

The PANTHER Classification System

More...
PANTHERi
PTHR11461 PTHR11461, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00079 Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50452-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST
60 70 80 90 100
AAQMSQALCL YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF
110 120 130 140 150
LPDFKEYCQK FYQAELEELS FAEDTEECRK HINDWVAEKT EGKISEVLDA
160 170 180 190 200
GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE
210 220 230 240 250
AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV VEKALTYEKF
260 270 280 290 300
KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS
310 320 330 340 350
GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD
360 370
HPFLFFIRHH KTNCILFCGR FSSP
Length:374
Mass (Da):42,767
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7235A033519AC612
GO
Isoform 2 (identifier: P50452-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-374: VEKALTYEKF...ILFCGRFSSP → KE

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):27,673
Checksum:iB7CF7D13B3129681
GO
Isoform 3 (identifier: P50452-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Show »
Length:192
Mass (Da):22,134
Checksum:iEBDED15A48B73B5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVA8C9JVA8_HUMAN
Serpin B8
SERPINB8
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTJ8C9JTJ8_HUMAN
Serpin B8
SERPINB8
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXK7H7BXK7_HUMAN
Serpin B8
SERPINB8
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU38A0A1B0GU38_HUMAN
Serpin B8
SERPINB8
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTX6A0A087WTX6_HUMAN
Serpin B8
SERPINB8
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04711068R → Q. Corresponds to variant dbSNP:rs1944270Ensembl.1
Natural variantiVAR_047111158K → N. Corresponds to variant dbSNP:rs1648493Ensembl.1
Natural variantiVAR_051947304T → A1 PublicationCorresponds to variant dbSNP:rs3169983Ensembl.1
Natural variantiVAR_051948359H → R1 PublicationCorresponds to variant dbSNP:rs3826616Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0551351 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_043097241 – 374VEKAL…RFSSP → KE in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L40377 mRNA Translation: AAC41939.1
AK300391 mRNA Translation: BAG62124.1
BX571754 mRNA Translation: CAE11879.1
AC009802 Genomic DNA No translation available.
BC034528 mRNA Translation: AAH34528.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11991.1 [P50452-1]
CCDS42442.1 [P50452-2]
CCDS62460.1 [P50452-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59273

NCBI Reference Sequences

More...
RefSeqi
NP_001027018.1, NM_001031848.1 [P50452-2]
NP_001263419.1, NM_001276490.1 [P50452-3]
NP_002631.3, NM_002640.3 [P50452-1]
NP_942130.1, NM_198833.1 [P50452-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353706; ENSP00000331368; ENSG00000166401 [P50452-1]
ENST00000397985; ENSP00000381072; ENSG00000166401 [P50452-1]
ENST00000397988; ENSP00000381075; ENSG00000166401 [P50452-2]
ENST00000542677; ENSP00000438328; ENSG00000166401 [P50452-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5271

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5271

UCSC genome browser

More...
UCSCi
uc002ljt.4 human [P50452-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40377 mRNA Translation: AAC41939.1
AK300391 mRNA Translation: BAG62124.1
BX571754 mRNA Translation: CAE11879.1
AC009802 Genomic DNA No translation available.
BC034528 mRNA Translation: AAH34528.1
CCDSiCCDS11991.1 [P50452-1]
CCDS42442.1 [P50452-2]
CCDS62460.1 [P50452-3]
PIRiA59273
RefSeqiNP_001027018.1, NM_001031848.1 [P50452-2]
NP_001263419.1, NM_001276490.1 [P50452-3]
NP_002631.3, NM_002640.3 [P50452-1]
NP_942130.1, NM_198833.1 [P50452-1]

3D structure databases

SMRiP50452
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111289, 32 interactors
IntActiP50452, 14 interactors
STRINGi9606.ENSP00000381072

Protein family/group databases

MEROPSiI04.013

PTM databases

iPTMnetiP50452
PhosphoSitePlusiP50452
SwissPalmiP50452

Polymorphism and mutation databases

BioMutaiSERPINB8
DMDMi212276474

Proteomic databases

EPDiP50452
jPOSTiP50452
MassIVEiP50452
MaxQBiP50452
PaxDbiP50452
PeptideAtlasiP50452
PRIDEiP50452
ProteomicsDBi5132
56226 [P50452-1]
56227 [P50452-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5271

Genome annotation databases

EnsembliENST00000353706; ENSP00000331368; ENSG00000166401 [P50452-1]
ENST00000397985; ENSP00000381072; ENSG00000166401 [P50452-1]
ENST00000397988; ENSP00000381075; ENSG00000166401 [P50452-2]
ENST00000542677; ENSP00000438328; ENSG00000166401 [P50452-3]
GeneIDi5271
KEGGihsa:5271
UCSCiuc002ljt.4 human [P50452-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5271
DisGeNETi5271

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERPINB8
HGNCiHGNC:8952 SERPINB8
HPAiCAB034300
MalaCardsiSERPINB8
MIMi601697 gene
617115 phenotype
neXtProtiNX_P50452
OpenTargetsiENSG00000166401
Orphaneti289586 Exfoliative ichthyosis
PharmGKBiPA35517

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00940000154835
HOGENOMiHOG000238519
InParanoidiP50452
KOiK13965
OMAiAFKESCQ
OrthoDBi1124079at2759
PhylomeDBiP50452
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKiP50452

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SERPINB8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5271
PharosiP50452

Protein Ontology

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PROi
PR:P50452

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166401 Expressed in 114 organ(s), highest expression level in skin of leg
ExpressionAtlasiP50452 baseline and differential
GenevisibleiP50452 HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPB8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50452
Secondary accession number(s): B4DTW2, Q7Z2V6, Q8N178
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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