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Protein

Cell cycle negative regulator roughex

Gene

rux

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye.1 Publication

Miscellaneous

The rux phenotype is suppressed by mutations of genes involved in cell cycle progression such as CycA and string, and enhanced by mutations of intercellular signaling genes, Ras1 and Star.

GO - Biological processi

  • eye-antennal disc morphogenesis Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of exit from mitosis Source: FlyBase
  • regulation of meiotic nuclear division Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle negative regulator roughex
Gene namesi
Name:rux
ORF Names:CG4336
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003302 rux

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Rough eye phenotype, and/or male sterility and in, some cases, pupal death.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975361 – 335Cell cycle negative regulator roughexAdd BLAST335

Proteomic databases

PaxDbiP50445
PRIDEiP50445

Expressioni

Gene expression databases

BgeeiFBgn0003302 Expressed in 31 organ(s), highest expression level in testis
ExpressionAtlasiP50445 baseline and differential
GenevisibleiP50445 DM

Interactioni

Protein-protein interaction databases

BioGridi58031, 57 interactors
DIPiDIP-23711N
ELMiP50445
IntActiP50445, 38 interactors
STRINGi7227.FBpp0298289

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KB35 Eukaryota
ENOG4110NPX LUCA
InParanoidiP50445
OMAiICLAVYD
OrthoDBiEOG091G0BVX
PhylomeDBiP50445

Family and domain databases

InterProiView protein in InterPro
IPR009259 Roughex
PfamiView protein in Pfam
PF06020 Roughex, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P50445-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPEEHKET PLEVIHEFIN GVDDGTIRRD LGEDCILSFY SRNVRGAKAI
60 70 80 90 100
TGFLRNQLTM RYKHEGFEEA AQIEWGDELL LKARFGRSFD SERRRIYEEK
110 120 130 140 150
ERTGTTLHVR PESDDEEVNE KFSSTLITPP RPSSYNLNSL KYVEACGLLN
160 170 180 190 200
KRNEHIYGGL DMGESCAVHL TLGYRSTFLP GGQVSGFEIC LAVYDRGLTS
210 220 230 240 250
LKRSTLIPPL CSISFARRAS ARCNPTTDDE EDTEEDSTPP TARRCVRRTL
260 270 280 290 300
FTEENTQKEE DADFIPVVEQ EQPAPQEQPA PQQAEETGEV VIPVDISTAL
310 320 330
KTTNFSSCTP RKRQQATNGN EVVRKRATGP RRMRF
Length:335
Mass (Da):37,898
Last modified:June 1, 2001 - v2
Checksum:i0A48CECB08C8774F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NDP7M9NDP7_DROME
Roughex, isoform B
rux CG4336, Dmel\CG4336, Rux, CG4336, Dmel_CG4336
335Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328T → M in AAA61580 (PubMed:8020091).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19583 mRNA Translation: AAA61580.1
AE014298 Genomic DNA Translation: AAF46113.1
AY119537 mRNA Translation: AAM50191.1
PIRiA54458
RefSeqiNP_001245540.1, NM_001258611.1
NP_511053.2, NM_078498.4
UniGeneiDm.2950

Genome annotation databases

EnsemblMetazoaiFBtr0070889; FBpp0070854; FBgn0003302
FBtr0307288; FBpp0298289; FBgn0003302
GeneIDi31535
KEGGidme:Dmel_CG4336
UCSCiCG4336-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRUX_DROME
AccessioniPrimary (citable) accession number: P50445
Secondary accession number(s): Q540W5, Q9W446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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