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Entry version 193 (18 Sep 2019)
Sequence version 2 (28 Jul 2009)
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Protein

Sulfate transporter

Gene

SLC26A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfate transporter. May play a role in endochondral bone formation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-174362 Transport and synthesis of PAPS
R-HSA-3560792 Defective SLC26A2 causes chondrodysplasias
R-HSA-427601 Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.1 the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein
Solute carrier family 26 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A2
Synonyms:DTD, DTDST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10994 SLC26A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606718 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50443

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diastrophic dysplasia (DTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities.
Related information in OMIM
Achondrogenesis 1B (ACG1B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. ACG1B is an autosomal recessive disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007436340Missing in ACG1B. 1 Publication1
Natural variantiVAR_007437425N → D in ACG1B. 1 PublicationCorresponds to variant dbSNP:rs104893920EnsemblClinVar.1
Natural variantiVAR_007438678G → V in ACG1B. 1 PublicationCorresponds to variant dbSNP:rs104893916EnsemblClinVar.1
Atelosteogenesis 2 (AO2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA perinatal dysplasia characterized by shortening of the limbs, a dysmorphic syndrome and radiographic skeletal features. Patients are stillborn or die soon after birth.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007434255G → E in AO2. 1 PublicationCorresponds to variant dbSNP:rs104893917EnsemblClinVar.1
Natural variantiVAR_007435279R → W in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893915EnsemblClinVar.1
Natural variantiVAR_007439715A → V in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893918EnsemblClinVar.1
Multiple epiphyseal dysplasia 4 (EDM4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Multiple epiphyseal dysplasia type 4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature is not frequent.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066835256F → S in EDM4. 1 PublicationCorresponds to variant dbSNP:rs1419613966EnsemblClinVar.1
Natural variantiVAR_007435279R → W in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893915EnsemblClinVar.1
Natural variantiVAR_018655653C → S in EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893924EnsemblClinVar.1
Natural variantiVAR_007439715A → V in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893918EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
1836

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC26A2

MalaCards human disease database

More...
MalaCardsi
SLC26A2
MIMi222600 phenotype
226900 phenotype
256050 phenotype
600972 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000155850

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93298 Achondrogenesis type 1B
56304 Atelosteogenesis type II
628 Diastrophic dwarfism
93307 Multiple epiphyseal dysplasia type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA149

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50443

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801581 – 739Sulfate transporterAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P50443

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P50443

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P50443

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50443

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50443

PeptideAtlas

More...
PeptideAtlasi
P50443

PRoteomics IDEntifications database

More...
PRIDEi
P50443

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56225

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50443

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P50443

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P50443

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155850 Expressed in 225 organ(s), highest expression level in colonic mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P50443 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50443 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041957
HPA058090

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108169, 20 interactors

Protein interaction database and analysis system

More...
IntActi
P50443, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286298

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini568 – 719STASPROSITE-ProRule annotationAdd BLAST152

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006546

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P50443

KEGG Orthology (KO)

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KOi
K14701

Identification of Orthologs from Complete Genome Data

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OMAi
DANQEMY

Database of Orthologous Groups

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OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P50443

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.750.24, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030280 SLC26A2
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF16 PTHR11814:SF16, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P50443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESKEQHN VSPRDSAEGN DSYPSGIHLE LQRESSTDFK QFETNDQCRP
60 70 80 90 100
YHRILIERQE KSDTNFKEFV IKKLQKNCQC SPAKAKNMIL GFLPVLQWLP
110 120 130 140 150
KYDLKKNILG DVMSGLIVGI LLVPQSIAYS LLAGQEPVYG LYTSFFASII
160 170 180 190 200
YFLLGTSRHI SVGIFGVLCL MIGETVDREL QKAGYDNAHS APSLGMVSNG
210 220 230 240 250
STLLNHTSDR ICDKSCYAIM VGSTVTFIAG VYQVAMGFFQ VGFVSVYLSD
260 270 280 290 300
ALLSGFVTGA SFTILTSQAK YLLGLNLPRT NGVGSLITTW IHVFRNIHKT
310 320 330 340 350
NLCDLITSLL CLLVLLPTKE LNEHFKSKLK APIPIELVVV VAATLASHFG
360 370 380 390 400
KLHENYNSSI AGHIPTGFMP PKVPEWNLIP SVAVDAIAIS IIGFAITVSL
410 420 430 440 450
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCFTTSAAL AKTLVKESTG
460 470 480 490 500
CHTQLSGVVT ALVLLLVLLV IAPLFYSLQK SVLGVITIVN LRGALRKFRD
510 520 530 540 550
LPKMWSISRM DTVIWFVTML SSALLSTEIG LLVGVCFSIF CVILRTQKPK
560 570 580 590 600
SSLLGLVEES EVFESVSAYK NLQIKPGIKI FRFVAPLYYI NKECFKSALY
610 620 630 640 650
KQTVNPILIK VAWKKAAKRK IKEKVVTLGG IQDEMSVQLS HDPLELHTIV
660 670 680 690 700
IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPTV RDSLTNGEYC
710 720 730
KKEEENLLFY SVYEAMAFAE VSKNQKGVCV PNGLSLSSD
Length:739
Mass (Da):81,662
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i577984D0E973087F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA38H0YA38_HUMAN
Sulfate transporter
SLC26A2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAN6C9JAN6_HUMAN
Sulfate transporter
SLC26A2
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti619R → G in CAE45819 (PubMed:17974005).Curated1
Sequence conflicti622K → R in BAG35488 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007434255G → E in AO2. 1 PublicationCorresponds to variant dbSNP:rs104893917EnsemblClinVar.1
Natural variantiVAR_066835256F → S in EDM4. 1 PublicationCorresponds to variant dbSNP:rs1419613966EnsemblClinVar.1
Natural variantiVAR_007435279R → W in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893915EnsemblClinVar.1
Natural variantiVAR_007436340Missing in ACG1B. 1 Publication1
Natural variantiVAR_007437425N → D in ACG1B. 1 PublicationCorresponds to variant dbSNP:rs104893920EnsemblClinVar.1
Natural variantiVAR_018654454Q → P in diatrophic dysplasia; broad bone-platyspondylic variant. 1 PublicationCorresponds to variant dbSNP:rs104893921EnsemblClinVar.1
Natural variantiVAR_058415574I → T3 PublicationsCorresponds to variant dbSNP:rs30832EnsemblClinVar.1
Natural variantiVAR_018655653C → S in EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893924EnsemblClinVar.1
Natural variantiVAR_007438678G → V in ACG1B. 1 PublicationCorresponds to variant dbSNP:rs104893916EnsemblClinVar.1
Natural variantiVAR_020402689T → S. Corresponds to variant dbSNP:rs3776070EnsemblClinVar.1
Natural variantiVAR_007439715A → V in AO2 and EDM4. 2 PublicationsCorresponds to variant dbSNP:rs104893918EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U14528 mRNA Translation: AAA70081.1
AK290358 mRNA Translation: BAF83047.1
AK312596 mRNA Translation: BAG35488.1
AC008427 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61755.1
BC059390 mRNA Translation: AAH59390.1
BX640696 mRNA Translation: CAE45819.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4300.1

Protein sequence database of the Protein Information Resource

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PIRi
A54808

NCBI Reference Sequences

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RefSeqi
NP_000103.2, NM_000112.3
XP_016864680.1, XM_017009191.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000286298; ENSP00000286298; ENSG00000155850

Database of genes from NCBI RefSeq genomes

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GeneIDi
1836

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1836

UCSC genome browser

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UCSCi
uc003lrh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14528 mRNA Translation: AAA70081.1
AK290358 mRNA Translation: BAF83047.1
AK312596 mRNA Translation: BAG35488.1
AC008427 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61755.1
BC059390 mRNA Translation: AAH59390.1
BX640696 mRNA Translation: CAE45819.1
CCDSiCCDS4300.1
PIRiA54808
RefSeqiNP_000103.2, NM_000112.3
XP_016864680.1, XM_017009191.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi108169, 20 interactors
IntActiP50443, 12 interactors
STRINGi9606.ENSP00000286298

Protein family/group databases

TCDBi2.A.53.2.1 the sulfate permease (sulp) family

PTM databases

iPTMnetiP50443
PhosphoSitePlusiP50443
SwissPalmiP50443

Polymorphism and mutation databases

BioMutaiSLC26A2
DMDMi254763328

Proteomic databases

EPDiP50443
jPOSTiP50443
MassIVEiP50443
MaxQBiP50443
PaxDbiP50443
PeptideAtlasiP50443
PRIDEiP50443
ProteomicsDBi56225

Genome annotation databases

EnsembliENST00000286298; ENSP00000286298; ENSG00000155850
GeneIDi1836
KEGGihsa:1836
UCSCiuc003lrh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1836
DisGeNETi1836

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC26A2
GeneReviewsiSLC26A2
HGNCiHGNC:10994 SLC26A2
HPAiHPA041957
HPA058090
MalaCardsiSLC26A2
MIMi222600 phenotype
226900 phenotype
256050 phenotype
600972 phenotype
606718 gene
neXtProtiNX_P50443
OpenTargetsiENSG00000155850
Orphaneti93298 Achondrogenesis type 1B
56304 Atelosteogenesis type II
628 Diastrophic dwarfism
93307 Multiple epiphyseal dysplasia type 4
PharmGKBiPA149

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00950000183057
HOGENOMiHOG000006546
InParanoidiP50443
KOiK14701
OMAiDANQEMY
OrthoDBi690428at2759
PhylomeDBiP50443
TreeFamiTF313784

Enzyme and pathway databases

ReactomeiR-HSA-174362 Transport and synthesis of PAPS
R-HSA-3560792 Defective SLC26A2 causes chondrodysplasias
R-HSA-427601 Multifunctional anion exchangers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC26A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC26A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1836
PharosiP50443

Protein Ontology

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PROi
PR:P50443

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155850 Expressed in 225 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiP50443 baseline and differential
GenevisibleiP50443 HS

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030280 SLC26A2
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF16 PTHR11814:SF16, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50443
Secondary accession number(s): A8K2U3, B2R6J1, Q6N051
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 28, 2009
Last modified: September 18, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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