Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carnitine O-palmitoyltransferase 1, liver isoform

Gene

CPT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.2 Publications

Activity regulationi

Inhibited by malonyl-CoA.1 Publication

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei473Proton acceptorBy similarity1
Binding sitei589CarnitineBy similarity1
Binding sitei602CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS03286-MONOMER
BRENDAi2.3.1.21 2681
ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-5362517 Signaling by Retinoic Acid
SABIO-RKiP50416
SIGNORiP50416
UniPathwayi
UPA00659

Protein family/group databases

TCDBi4.C.2.1.3 the carnitine o-acyl transferase (crat) family

Chemistry databases

SwissLipidsiSLP:000001056

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 1, liver isoform (EC:2.3.1.21)
Short name:
CPT1-L
Alternative name(s):
Carnitine O-palmitoyltransferase I, liver isoform
Short name:
CPT I
Short name:
CPTI-L
Carnitine palmitoyltransferase 1A
Gene namesi
Name:CPT1A
Synonyms:CPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110090.12
HGNCiHGNC:2328 CPT1A
MIMi600528 gene
neXtProtiNX_P50416

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 47CytoplasmicSequence analysisAdd BLAST46
Transmembranei48 – 73HelicalSequence analysisAdd BLAST26
Topological domaini74 – 102Mitochondrial intermembraneSequence analysisAdd BLAST29
Transmembranei103 – 122HelicalSequence analysisAdd BLAST20
Topological domaini123 – 773CytoplasmicSequence analysisAdd BLAST651

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Involvement in diseasei

Carnitine palmitoyltransferase 1A deficiency (CPT1AD)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive metabolic disorder of long-chain fatty acid oxidation characterized by severe episodes of hypoketotic hypoglycemia usually occurring after fasting or illness. Onset is in infancy or early childhood.
See also OMIM:255120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020546123R → C in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356775EnsemblClinVar.1
Natural variantiVAR_020548304C → W in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356789EnsemblClinVar.1
Natural variantiVAR_020549314T → I in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356776EnsemblClinVar.1
Natural variantiVAR_046767316R → G in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356796EnsemblClinVar.1
Natural variantiVAR_046768343F → V in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356783EnsemblClinVar.1
Natural variantiVAR_020550357R → W in CPT1AD; decreased stability. 1 PublicationCorresponds to variant dbSNP:rs80356777EnsemblClinVar.1
Natural variantiVAR_020551360E → G in CPT1AD; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs80356787EnsemblClinVar.1
Natural variantiVAR_020552395Missing in CPT1AD; loss of activity. 1 Publication1
Natural variantiVAR_020553414A → V in CPT1AD; decreased activity. 2 PublicationsCorresponds to variant dbSNP:rs80356790EnsemblClinVar.1
Natural variantiVAR_020554454D → G in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356778EnsemblClinVar.1
Natural variantiVAR_046769465G → W in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356784EnsemblClinVar.1
Natural variantiVAR_020555479P → L in CPT1AD; decreased activity. 1 PublicationCorresponds to variant dbSNP:rs80356779EnsemblClinVar.1
Natural variantiVAR_020556484L → P in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356793EnsemblClinVar.1
Natural variantiVAR_020557498Y → C in CPT1AD; decreased activity. 2 PublicationsCorresponds to variant dbSNP:rs80356791EnsemblClinVar.1
Natural variantiVAR_020558709G → E in CPT1AD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs28936374EnsemblClinVar.1
Natural variantiVAR_020559710G → E in CPT1AD; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs80356780EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1374
GeneReviewsiCPT1A
MalaCardsiCPT1A
MIMi255120 phenotype
OpenTargetsiENSG00000110090
Orphaneti156 Carnitine palmitoyl transferase 1A deficiency
PharmGKBiPA26847

Chemistry databases

ChEMBLiCHEMBL1293194
DrugBankiDB01016 Glyburide
DB00583 L-Carnitine
DB01074 Perhexiline

Polymorphism and mutation databases

BioMutaiCPT1A
DMDMi56405343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002101592 – 773Carnitine O-palmitoyltransferase 1, liver isoformAdd BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei282Nitrated tyrosineBy similarity1
Modified residuei588PhosphothreonineBy similarity1
Modified residuei589Nitrated tyrosineBy similarity1
Modified residuei604PhosphothreonineBy similarity1
Modified residuei741PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

EPDiP50416
MaxQBiP50416
PaxDbiP50416
PeptideAtlasiP50416
PRIDEiP50416
ProteomicsDBi56220
56221 [P50416-2]

PTM databases

iPTMnetiP50416
PhosphoSitePlusiP50416
SwissPalmiP50416

Expressioni

Tissue specificityi

Strong expression in kidney and heart, and lower in liver and skeletal muscle.

Inductioni

Up-regulated by fatty acids.1 Publication

Gene expression databases

BgeeiENSG00000110090 Expressed in 227 organ(s), highest expression level in colonic mucosa
CleanExiHS_CPT1A
ExpressionAtlasiP50416 baseline and differential
GenevisibleiP50416 HS

Organism-specific databases

HPAiHPA008835

Interactioni

Subunit structurei

Homohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107765, 56 interactors
IntActiP50416, 32 interactors
MINTiP50416
STRINGi9606.ENSP00000265641

Chemistry databases

BindingDBiP50416

Structurei

Secondary structure

1773
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP50416
SMRiP50416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni555 – 567Coenzyme A bindingBy similarityAdd BLAST13

Domaini

A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3717 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00760000119220
HOGENOMiHOG000233542
HOVERGENiHBG003458
InParanoidiP50416
KOiK08765
OMAiASHMWEN
OrthoDBiEOG091G026C
PhylomeDBiP50416
TreeFamiTF313836

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
IPR032476 CPT_N
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PF16484 CPT_N, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50416-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAHQAVAF QFTVTPDGID LRLSHEALRQ IYLSGLHSWK KKFIRFKNGI
60 70 80 90 100
ITGVYPASPS SWLIVVVGVM TTMYAKIDPS LGIIAKINRT LETANCMSSQ
110 120 130 140 150
TKNVVSGVLF GTGLWVALIV TMRYSLKVLL SYHGWMFTEH GKMSRATKIW
160 170 180 190 200
MGMVKIFSGR KPMLYSFQTS LPRLPVPAVK DTVNRYLQSV RPLMKEEDFK
210 220 230 240 250
RMTALAQDFA VGLGPRLQWY LKLKSWWATN YVSDWWEEYI YLRGRGPLMV
260 270 280 290 300
NSNYYAMDLL YILPTHIQAA RAGNAIHAIL LYRRKLDREE IKPIRLLGST
310 320 330 340 350
IPLCSAQWER MFNTSRIPGE ETDTIQHMRD SKHIVVYHRG RYFKVWLYHD
360 370 380 390 400
GRLLKPREME QQMQRILDNT SEPQPGEARL AALTAGDRVP WARCRQAYFG
410 420 430 440 450
RGKNKQSLDA VEKAAFFVTL DETEEGYRSE DPDTSMDSYA KSLLHGRCYD
460 470 480 490 500
RWFDKSFTFV VFKNGKMGLN AEHSWADAPI VAHLWEYVMS IDSLQLGYAE
510 520 530 540 550
DGHCKGDINP NIPYPTRLQW DIPGECQEVI ETSLNTANLL ANDVDFHSFP
560 570 580 590 600
FVAFGKGIIK KCRTSPDAFV QLALQLAHYK DMGKFCLTYE ASMTRLFREG
610 620 630 640 650
RTETVRSCTT ESCDFVRAMV DPAQTVEQRL KLFKLASEKH QHMYRLAMTG
660 670 680 690 700
SGIDRHLFCL YVVSKYLAVE SPFLKEVLSE PWRLSTSQTP QQQVELFDLE
710 720 730 740 750
NNPEYVSSGG GFGPVADDGY GVSYILVGEN LINFHISSKF SCPETDSHRF
760 770
GRHLKEAMTD IITLFGLSSN SKK
Length:773
Mass (Da):88,368
Last modified:December 7, 2004 - v2
Checksum:iE5DC9141B6301947
GO
Isoform 2 (identifier: P50416-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     746-773: DSHRFGRHLKEAMTDIITLFGLSSNSKK → GIISQGPSSDT

Show »
Length:756
Mass (Da):86,239
Checksum:iC7B0ED8A26285110
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUV7H3BUV7_HUMAN
Carnitine O-palmitoyltransferase 1,...
CPT1A
134Annotation score:
H3BMD2H3BMD2_HUMAN
Carnitine O-palmitoyltransferase 1,...
CPT1A
78Annotation score:
H3BP22H3BP22_HUMAN
Carnitine O-palmitoyltransferase 1,...
CPT1A
117Annotation score:
H3BUJ0H3BUJ0_HUMAN
Carnitine O-palmitoyltransferase 1,...
CPT1A
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti479P → Q in AAC41748 (PubMed:7892212).Curated1
Sequence conflicti568A → T in AAC41748 (PubMed:7892212).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020546123R → C in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356775EnsemblClinVar.1
Natural variantiVAR_020547275A → T3 PublicationsCorresponds to variant dbSNP:rs2229738EnsemblClinVar.1
Natural variantiVAR_020548304C → W in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356789EnsemblClinVar.1
Natural variantiVAR_020549314T → I in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356776EnsemblClinVar.1
Natural variantiVAR_046767316R → G in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356796EnsemblClinVar.1
Natural variantiVAR_046768343F → V in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356783EnsemblClinVar.1
Natural variantiVAR_020550357R → W in CPT1AD; decreased stability. 1 PublicationCorresponds to variant dbSNP:rs80356777EnsemblClinVar.1
Natural variantiVAR_020551360E → G in CPT1AD; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs80356787EnsemblClinVar.1
Natural variantiVAR_020552395Missing in CPT1AD; loss of activity. 1 Publication1
Natural variantiVAR_020553414A → V in CPT1AD; decreased activity. 2 PublicationsCorresponds to variant dbSNP:rs80356790EnsemblClinVar.1
Natural variantiVAR_020554454D → G in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356778EnsemblClinVar.1
Natural variantiVAR_046769465G → W in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356784EnsemblClinVar.1
Natural variantiVAR_020555479P → L in CPT1AD; decreased activity. 1 PublicationCorresponds to variant dbSNP:rs80356779EnsemblClinVar.1
Natural variantiVAR_020556484L → P in CPT1AD. 1 PublicationCorresponds to variant dbSNP:rs80356793EnsemblClinVar.1
Natural variantiVAR_020557498Y → C in CPT1AD; decreased activity. 2 PublicationsCorresponds to variant dbSNP:rs80356791EnsemblClinVar.1
Natural variantiVAR_020558709G → E in CPT1AD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs28936374EnsemblClinVar.1
Natural variantiVAR_020559710G → E in CPT1AD; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs80356780EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012167746 – 773DSHRF…SNSKK → GIISQGPSSDT in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39211 mRNA Translation: AAC41748.1
AJ420747 Genomic DNA Translation: CAD12625.1
AJ420748 Genomic DNA Translation: CAD59673.1
BT009791 mRNA Translation: AAP88793.1
BC000185 mRNA Translation: AAH00185.1
CCDSiCCDS31624.1 [P50416-2]
CCDS8185.1 [P50416-1]
PIRiI59351
RefSeqiNP_001027017.1, NM_001031847.2 [P50416-2]
NP_001867.2, NM_001876.3 [P50416-1]
XP_016872709.1, XM_017017220.1 [P50416-1]
UniGeneiHs.503043

Genome annotation databases

EnsembliENST00000265641; ENSP00000265641; ENSG00000110090 [P50416-1]
ENST00000376618; ENSP00000365803; ENSG00000110090 [P50416-2]
ENST00000539743; ENSP00000446108; ENSG00000110090 [P50416-1]
ENST00000540367; ENSP00000439084; ENSG00000110090 [P50416-2]
GeneIDi1374
KEGGihsa:1374
UCSCiuc001oof.5 human [P50416-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39211 mRNA Translation: AAC41748.1
AJ420747 Genomic DNA Translation: CAD12625.1
AJ420748 Genomic DNA Translation: CAD59673.1
BT009791 mRNA Translation: AAP88793.1
BC000185 mRNA Translation: AAH00185.1
CCDSiCCDS31624.1 [P50416-2]
CCDS8185.1 [P50416-1]
PIRiI59351
RefSeqiNP_001027017.1, NM_001031847.2 [P50416-2]
NP_001867.2, NM_001876.3 [P50416-1]
XP_016872709.1, XM_017017220.1 [P50416-1]
UniGeneiHs.503043

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LE3NMR-A1-42[»]
ProteinModelPortaliP50416
SMRiP50416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107765, 56 interactors
IntActiP50416, 32 interactors
MINTiP50416
STRINGi9606.ENSP00000265641

Chemistry databases

BindingDBiP50416
ChEMBLiCHEMBL1293194
DrugBankiDB01016 Glyburide
DB00583 L-Carnitine
DB01074 Perhexiline
SwissLipidsiSLP:000001056

Protein family/group databases

TCDBi4.C.2.1.3 the carnitine o-acyl transferase (crat) family

PTM databases

iPTMnetiP50416
PhosphoSitePlusiP50416
SwissPalmiP50416

Polymorphism and mutation databases

BioMutaiCPT1A
DMDMi56405343

Proteomic databases

EPDiP50416
MaxQBiP50416
PaxDbiP50416
PeptideAtlasiP50416
PRIDEiP50416
ProteomicsDBi56220
56221 [P50416-2]

Protocols and materials databases

DNASUi1374
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265641; ENSP00000265641; ENSG00000110090 [P50416-1]
ENST00000376618; ENSP00000365803; ENSG00000110090 [P50416-2]
ENST00000539743; ENSP00000446108; ENSG00000110090 [P50416-1]
ENST00000540367; ENSP00000439084; ENSG00000110090 [P50416-2]
GeneIDi1374
KEGGihsa:1374
UCSCiuc001oof.5 human [P50416-1]

Organism-specific databases

CTDi1374
DisGeNETi1374
EuPathDBiHostDB:ENSG00000110090.12
GeneCardsiCPT1A
GeneReviewsiCPT1A
HGNCiHGNC:2328 CPT1A
HPAiHPA008835
MalaCardsiCPT1A
MIMi255120 phenotype
600528 gene
neXtProtiNX_P50416
OpenTargetsiENSG00000110090
Orphaneti156 Carnitine palmitoyl transferase 1A deficiency
PharmGKBiPA26847
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3717 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00760000119220
HOGENOMiHOG000233542
HOVERGENiHBG003458
InParanoidiP50416
KOiK08765
OMAiASHMWEN
OrthoDBiEOG091G026C
PhylomeDBiP50416
TreeFamiTF313836

Enzyme and pathway databases

UniPathwayi
UPA00659

BioCyciMetaCyc:HS03286-MONOMER
BRENDAi2.3.1.21 2681
ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-5362517 Signaling by Retinoic Acid
SABIO-RKiP50416
SIGNORiP50416

Miscellaneous databases

ChiTaRSiCPT1A human
GenomeRNAii1374
PROiPR:P50416
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110090 Expressed in 227 organ(s), highest expression level in colonic mucosa
CleanExiHS_CPT1A
ExpressionAtlasiP50416 baseline and differential
GenevisibleiP50416 HS

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
IPR032476 CPT_N
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PF16484 CPT_N, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPT1A_HUMAN
AccessioniPrimary (citable) accession number: P50416
Secondary accession number(s): Q8TCU0, Q9BWK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again