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Protein

5-hydroxytryptamine receptor 7

Gene

HTR7

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:HTR7
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82ExtracellularBy similarityAdd BLAST82
Transmembranei83 – 109Helical; Name=1By similarityAdd BLAST27
Topological domaini110 – 119CytoplasmicBy similarity10
Transmembranei120 – 145Helical; Name=2By similarityAdd BLAST26
Topological domaini146 – 157ExtracellularBy similarityAdd BLAST12
Transmembranei158 – 179Helical; Name=3By similarityAdd BLAST22
Topological domaini180 – 199CytoplasmicBy similarityAdd BLAST20
Transmembranei200 – 223Helical; Name=4By similarityAdd BLAST24
Topological domaini224 – 238ExtracellularBy similarityAdd BLAST15
Transmembranei239 – 261Helical; Name=5By similarityAdd BLAST23
Topological domaini262 – 329CytoplasmicBy similarityAdd BLAST68
Transmembranei330 – 353Helical; Name=6By similarityAdd BLAST24
Topological domaini354 – 365ExtracellularBy similarityAdd BLAST12
Transmembranei366 – 388Helical; Name=7By similarityAdd BLAST23
Topological domaini389 – 446CytoplasmicBy similarityAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5494

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689781 – 4465-hydroxytryptamine receptor 7Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 232PROSITE-ProRule annotation
Lipidationi402S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP50407

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006750

Chemistry databases

BindingDBiP50407

Structurei

3D structure databases

ProteinModelPortaliP50407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP50407

Family and domain databases

InterProiView protein in InterPro
IPR001069 5HT_7_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00652 5HT7RECEPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGVNSSGRP DLYGHLHSIL LPGRGLPDWS PDGGADPGVS TWTPRLLSGV
60 70 80 90 100
PEVAASPSPS WDGTWDNVSG CGEQINYGRA EKVVIGSILT LITLLTIAGN
110 120 130 140 150
CLVVISVCFV KKLRQPSNYL IVSLALADLS VAVAVIPFVS VTDLIGGKWI
160 170 180 190 200
FGHFFCNVFI AMDVMCCTAS IMTLCVISID RYLGITRPLT YPVRQNGKCM
210 220 230 240 250
PKMILSVWLL SASITLPPLF GWAQNVNDDK VCLISQDFGY TIYSTAVAFY
260 270 280 290 300
IPMSVMLFMY YRIYKAARKS AAKHKFPGFP RVQPESIISL NGMVKLQKEV
310 320 330 340 350
EECANLSRLL KHERKNISIF KREQKAATTL GIIVGAFTVC WLPFFLLSTA
360 370 380 390 400
RPFICGTACS CIPLWVERTC LWLGYANSLI NPFIYAFFNR DLRTTYRSLL
410 420 430 440
QCQYRNINRK LSAAGMHEAL KLAERPERPE CVLQNSDYCR KKGHDS
Length:446
Mass (Da):49,614
Last modified:October 1, 1996 - v1
Checksum:iB63FA73712F3B088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41372 mRNA Translation: AAA83015.1
RefSeqiNP_001166435.1, NM_001172964.1

Genome annotation databases

GeneIDi100135549

Similar proteinsi

Entry informationi

Entry namei5HT7R_CAVPO
AccessioniPrimary (citable) accession number: P50407
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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