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UniProtKB - P50406 (5HT6R_HUMAN)

Entry version 175 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

5-hydroxytryptamine receptor 6

Gene

HTR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).

Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).

Is an activator of TOR signaling (PubMed:23027611).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P50406

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390666, Serotonin receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P50406

SIGNOR Signaling Network Open Resource

More...SIGNORi		P50406

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
Serotonin receptor 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5301, HTR6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601109, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P50406

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158748

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 57Helical; Name=1By similarityAdd BLAST23
Topological domaini58 – 64CytoplasmicBy similarity7
Transmembranei65 – 85Helical; Name=2By similarityAdd BLAST21
Topological domaini86 – 100ExtracellularBy similarityAdd BLAST15
Transmembranei101 – 122Helical; Name=3By similarityAdd BLAST22
Topological domaini123 – 144CytoplasmicBy similarityAdd BLAST22
Transmembranei145 – 166Helical; Name=4By similarityAdd BLAST22
Topological domaini167 – 184ExtracellularBy similarityAdd BLAST18
Transmembranei185 – 208Helical; Name=5By similarityAdd BLAST24
Topological domaini209 – 265CytoplasmicBy similarityAdd BLAST57
Transmembranei266 – 290Helical; Name=6By similarityAdd BLAST25
Topological domaini291 – 295ExtracellularBy similarity5
Transmembranei296 – 320Helical; Name=7By similarityAdd BLAST25
Topological domaini321 – 440CytoplasmicBy similarityAdd BLAST120

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3362

Open Targets

More...OpenTargetsi		ENSG00000158748

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29560

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P50406, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3371

Drug and drug target database

More...DrugBanki		DB00321, Amitriptyline
DB00543, Amoxapine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00363, Clozapine
DB00924, Cyclobenzaprine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB01488, Dimethyltryptamine
DB01142, Doxepin
DB01049, Ergoloid mesylate
DB12141, Gilteritinib
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB00408, Loxapine
DB04829, Lysergic acid diethylamide
DB06148, Mianserin
DB00334, Olanzapine
DB00715, Paroxetine
DB05993, PRX-07034
DB01224, Quetiapine
DB06144, Sertindole
DB09304, Setiptiline
DB05042, SGS518
DB06140, SUVN-502
DB13025, Tiapride
DB00246, Ziprasidone
DB09225, Zotepine

DrugCentral

More...DrugCentrali		P50406

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		11

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTR6

Domain mapping of disease mutations (DMDM)

More...DMDMi		1703010

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689741 – 4405-hydroxytryptamine receptor 6Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P50406

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50406

PeptideAtlas

More...PeptideAtlasi		P50406

PRoteomics IDEntifications database

More...PRIDEi		P50406

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56219

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50406

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50406

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several human brain regions, most prominently in the caudate nucleus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158748, Expressed in putamen and 29 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50406, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158748, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTOR, RPTOR and NF1 (PubMed:23027611).

Interacts with CDK5 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109594, 52 interactors

Protein interaction database and analysis system

More...IntActi		P50406, 31 interactors

Molecular INTeraction database

More...MINTi		P50406

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000289753

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P50406

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P50406, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50406

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni346 – 392DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi348 – 363Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50406

Identification of Orthologs from Complete Genome Data

More...OMAi		FQCRLQV

Database of Orthologous Groups

More...OrthoDBi		1173208at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50406

TreeFam database of animal gene trees

More...TreeFami		TF351753

Family and domain databases

Conserved Domains Database

More...CDDi		cd15054, 7tmA_5-HT6, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002232, 5HT6_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL 
        60         70         80         90        100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 
       110        120        130        140        150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA 
       160        170        180        190        200
WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP 
       210        220        230        240        250
SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA 
       260        270        280        290        300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG 
       310        320        330        340        350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS 
       360        370        380        390        400
PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL 
       410        420        430        440
PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
Length:440
Mass (Da):46,954
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC888F47650C1D2EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247V → M in CAA88929 (PubMed:7656980).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L41147 mRNA Translation: AAA92622.1
AY429105 mRNA Translation: AAR07900.1
AL031727 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94896.1
BC074995 mRNA Translation: AAH74995.1
BC074996 mRNA Translation: AAH74996.1
Z49119 mRNA Translation: CAA88929.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS197.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5520

NCBI Reference Sequences

More...RefSeqi		NP_000862.1, NM_000871.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000289753; ENSP00000289753; ENSG00000158748

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3362

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000289753.2; ENSP00000289753.1; NM_000871.3; NP_000862.1

UCSC genome browser

More...UCSCi		uc001bcl.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41147 mRNA Translation: AAA92622.1
AY429105 mRNA Translation: AAR07900.1
AL031727 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94896.1
BC074995 mRNA Translation: AAH74995.1
BC074996 mRNA Translation: AAH74996.1
Z49119 mRNA Translation: CAA88929.1
CCDSiCCDS197.1
PIRiJC5520
RefSeqiNP_000862.1, NM_000871.2

3D structure databases

SMRiP50406
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109594, 52 interactors
IntActiP50406, 31 interactors
MINTiP50406
STRINGi9606.ENSP00000289753

Chemistry databases

BindingDBiP50406
ChEMBLiCHEMBL3371
DrugBankiDB00321, Amitriptyline
DB00543, Amoxapine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00363, Clozapine
DB00924, Cyclobenzaprine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB01488, Dimethyltryptamine
DB01142, Doxepin
DB01049, Ergoloid mesylate
DB12141, Gilteritinib
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB00408, Loxapine
DB04829, Lysergic acid diethylamide
DB06148, Mianserin
DB00334, Olanzapine
DB00715, Paroxetine
DB05993, PRX-07034
DB01224, Quetiapine
DB06144, Sertindole
DB09304, Setiptiline
DB05042, SGS518
DB06140, SUVN-502
DB13025, Tiapride
DB00246, Ziprasidone
DB09225, Zotepine
DrugCentraliP50406
GuidetoPHARMACOLOGYi11

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP50406
PhosphoSitePlusiP50406

Genetic variation databases

BioMutaiHTR6
DMDMi1703010

Proteomic databases

MassIVEiP50406
PaxDbiP50406
PeptideAtlasiP50406
PRIDEiP50406
ProteomicsDBi56219

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15009, 109 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		3362

Genome annotation databases

EnsembliENST00000289753; ENSP00000289753; ENSG00000158748
GeneIDi3362
KEGGihsa:3362
MANE-SelectiENST00000289753.2; ENSP00000289753.1; NM_000871.3; NP_000862.1
UCSCiuc001bcl.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3362
DisGeNETi3362

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTR6
HGNCiHGNC:5301, HTR6
HPAiENSG00000158748, Tissue enriched (brain)
MIMi601109, gene
neXtProtiNX_P50406
OpenTargetsiENSG00000158748
PharmGKBiPA29560
VEuPathDBiHostDB:ENSG00000158748

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01030000234619
HOGENOMiCLU_009579_11_0_1
InParanoidiP50406
OMAiFQCRLQV
OrthoDBi1173208at2759
PhylomeDBiP50406
TreeFamiTF351753

Enzyme and pathway databases

PathwayCommonsiP50406
ReactomeiR-HSA-390666, Serotonin receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SignaLinkiP50406
SIGNORiP50406

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3362, 1 hit in 1035 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		5-HT6_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3362
PharosiP50406, Tchem

Protein Ontology

More...PROi		PR:P50406
RNActiP50406, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000158748, Expressed in putamen and 29 other tissues
GenevisibleiP50406, HS

Family and domain databases

CDDicd15054, 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232, 5HT6_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT6R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50406
Secondary accession number(s): Q13640, Q5TGZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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