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Protein

5-hydroxytryptamine receptor 6

Gene

HTR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).By similarity1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • G protein-coupled serotonin receptor activity Source: GO_Central
  • histamine receptor activity Source: ProtInc
  • neurotransmitter receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
Serotonin receptor 6
Gene namesi
Name:HTR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158748.3
HGNCiHGNC:5301 HTR6
MIMi601109 gene
neXtProtiNX_P50406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 57Helical; Name=1By similarityAdd BLAST23
Topological domaini58 – 64CytoplasmicBy similarity7
Transmembranei65 – 85Helical; Name=2By similarityAdd BLAST21
Topological domaini86 – 100ExtracellularBy similarityAdd BLAST15
Transmembranei101 – 122Helical; Name=3By similarityAdd BLAST22
Topological domaini123 – 144CytoplasmicBy similarityAdd BLAST22
Transmembranei145 – 166Helical; Name=4By similarityAdd BLAST22
Topological domaini167 – 184ExtracellularBy similarityAdd BLAST18
Transmembranei185 – 208Helical; Name=5By similarityAdd BLAST24
Topological domaini209 – 265CytoplasmicBy similarityAdd BLAST57
Transmembranei266 – 290Helical; Name=6By similarityAdd BLAST25
Topological domaini291 – 295ExtracellularBy similarity5
Transmembranei296 – 320Helical; Name=7By similarityAdd BLAST25
Topological domaini321 – 440CytoplasmicBy similarityAdd BLAST120

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3362
OpenTargetsiENSG00000158748
PharmGKBiPA29560

Chemistry databases

ChEMBLiCHEMBL3371
DrugBankiDB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB06216 Asenapine
DB00477 Chlorpromazine
DB00363 Clozapine
DB01488 Dimethyltryptamine
DB01142 Doxepin
DB01049 Ergoloid mesylate
DB04946 Iloperidone
DB00458 Imipramine
DB00408 Loxapine
DB06148 Mianserin
DB00540 Nortriptyline
DB00334 Olanzapine
DB01224 Quetiapine
DB06144 Sertindole
DB05042 SGS518
DB13025 Tiapride
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi11

Polymorphism and mutation databases

DMDMi1703010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689741 – 4405-hydroxytryptamine receptor 6Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP50406
PRIDEiP50406
ProteomicsDBi56219

PTM databases

iPTMnetiP50406
PhosphoSitePlusiP50406

Expressioni

Tissue specificityi

Expressed in several human brain regions, most prominently in the caudate nucleus.

Gene expression databases

BgeeiENSG00000158748 Expressed in 19 organ(s), highest expression level in putamen
CleanExiHS_HTR6
GenevisibleiP50406 HS

Interactioni

Subunit structurei

Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FYNP062417EBI-1182222,EBI-515315

Protein-protein interaction databases

BioGridi109594, 26 interactors
IntActiP50406, 2 interactors
STRINGi9606.ENSP00000289753

Chemistry databases

BindingDBiP50406

Structurei

3D structure databases

ProteinModelPortaliP50406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000241520
HOVERGENiHBG106962
InParanoidiP50406
KOiK04162
OMAiGWHELGH
OrthoDBiEOG091G06VI
PhylomeDBiP50406
TreeFamiTF351753

Family and domain databases

CDDicd15054 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232 5HT6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA
260 270 280 290 300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG
310 320 330 340 350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS
360 370 380 390 400
PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL
410 420 430 440
PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
Length:440
Mass (Da):46,954
Last modified:October 1, 1996 - v1
Checksum:iC888F47650C1D2EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247V → M in CAA88929 (PubMed:7656980).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41147 mRNA Translation: AAA92622.1
AY429105 mRNA Translation: AAR07900.1
AL031727 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94896.1
BC074995 mRNA Translation: AAH74995.1
BC074996 mRNA Translation: AAH74996.1
Z49119 mRNA Translation: CAA88929.1
CCDSiCCDS197.1
PIRiJC5520
RefSeqiNP_000862.1, NM_000871.2
UniGeneiHs.22180

Genome annotation databases

EnsembliENST00000289753; ENSP00000289753; ENSG00000158748
GeneIDi3362
KEGGihsa:3362
UCSCiuc001bcl.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41147 mRNA Translation: AAA92622.1
AY429105 mRNA Translation: AAR07900.1
AL031727 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94896.1
BC074995 mRNA Translation: AAH74995.1
BC074996 mRNA Translation: AAH74996.1
Z49119 mRNA Translation: CAA88929.1
CCDSiCCDS197.1
PIRiJC5520
RefSeqiNP_000862.1, NM_000871.2
UniGeneiHs.22180

3D structure databases

ProteinModelPortaliP50406
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109594, 26 interactors
IntActiP50406, 2 interactors
STRINGi9606.ENSP00000289753

Chemistry databases

BindingDBiP50406
ChEMBLiCHEMBL3371
DrugBankiDB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB06216 Asenapine
DB00477 Chlorpromazine
DB00363 Clozapine
DB01488 Dimethyltryptamine
DB01142 Doxepin
DB01049 Ergoloid mesylate
DB04946 Iloperidone
DB00458 Imipramine
DB00408 Loxapine
DB06148 Mianserin
DB00540 Nortriptyline
DB00334 Olanzapine
DB01224 Quetiapine
DB06144 Sertindole
DB05042 SGS518
DB13025 Tiapride
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi11

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP50406
PhosphoSitePlusiP50406

Polymorphism and mutation databases

DMDMi1703010

Proteomic databases

PaxDbiP50406
PRIDEiP50406
ProteomicsDBi56219

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289753; ENSP00000289753; ENSG00000158748
GeneIDi3362
KEGGihsa:3362
UCSCiuc001bcl.5 human

Organism-specific databases

CTDi3362
DisGeNETi3362
EuPathDBiHostDB:ENSG00000158748.3
GeneCardsiHTR6
HGNCiHGNC:5301 HTR6
MIMi601109 gene
neXtProtiNX_P50406
OpenTargetsiENSG00000158748
PharmGKBiPA29560
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000241520
HOVERGENiHBG106962
InParanoidiP50406
KOiK04162
OMAiGWHELGH
OrthoDBiEOG091G06VI
PhylomeDBiP50406
TreeFamiTF351753

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikii5-HT6_receptor
GenomeRNAii3362
PROiPR:P50406
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158748 Expressed in 19 organ(s), highest expression level in putamen
CleanExiHS_HTR6
GenevisibleiP50406 HS

Family and domain databases

CDDicd15054 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232 5HT6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT6R_HUMAN
AccessioniPrimary (citable) accession number: P50406
Secondary accession number(s): Q13640, Q5TGZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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