UniProtKB - P50406 (5HT6R_HUMAN)
5-hydroxytryptamine receptor 6
HTR6
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).
Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).
Is an activator of TOR signaling (PubMed:23027611).
By similarity1 PublicationGO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: GO_Central
- histamine receptor activity Source: ProtInc
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- cerebral cortex cell migration Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- positive regulation of TOR signaling Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P50406 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P50406 |
SIGNORi | P50406 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 6Short name: 5-HT-6 Short name: 5-HT6 Alternative name(s): Serotonin receptor 6 |
Gene namesi | Name:HTR6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5301, HTR6 |
MIMi | 601109, gene |
neXtProti | NX_P50406 |
VEuPathDBi | HostDB:ENSG00000158748 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 35 – 57 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 58 – 64 | CytoplasmicBy similarity | 7 | |
Transmembranei | 65 – 85 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 86 – 100 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 101 – 122 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 123 – 144 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 145 – 166 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 167 – 184 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 185 – 208 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 209 – 265 | CytoplasmicBy similarityAdd BLAST | 57 | |
Transmembranei | 266 – 290 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 291 – 295 | ExtracellularBy similarity | 5 | |
Transmembranei | 296 – 320 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 321 – 440 | CytoplasmicBy similarityAdd BLAST | 120 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3362 |
OpenTargetsi | ENSG00000158748 |
PharmGKBi | PA29560 |
Miscellaneous databases
Pharosi | P50406, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3371 |
DrugBanki | DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB00924, Cyclobenzaprine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB01488, Dimethyltryptamine DB01142, Doxepin DB01049, Ergoloid mesylate DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB00408, Loxapine DB04829, Lysergic acid diethylamide DB06148, Mianserin DB00334, Olanzapine DB00715, Paroxetine DB05993, PRX-07034 DB01224, Quetiapine DB06144, Sertindole DB09304, Setiptiline DB05042, SGS518 DB06140, SUVN-502 DB13025, Tiapride DB00246, Ziprasidone DB09225, Zotepine |
DrugCentrali | P50406 |
GuidetoPHARMACOLOGYi | 11 |
Genetic variation databases
BioMutai | HTR6 |
DMDMi | 1703010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068974 | 1 – 440 | 5-hydroxytryptamine receptor 6Add BLAST | 440 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 99 ↔ 180 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P50406 |
PaxDbi | P50406 |
PeptideAtlasi | P50406 |
PRIDEi | P50406 |
ProteomicsDBi | 56219 |
PTM databases
iPTMneti | P50406 |
PhosphoSitePlusi | P50406 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000158748, Expressed in putamen and 29 other tissues |
Genevisiblei | P50406, HS |
Organism-specific databases
HPAi | ENSG00000158748, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with MTOR, RPTOR and NF1 (PubMed:23027611).
Interacts with CDK5 (By similarity).
By similarity1 PublicationBinary interactionsi
P50406
With | #Exp. | IntAct |
---|---|---|
FYN [P06241] | 7 | EBI-1182222,EBI-515315 |
MAP1B [P46821] | 4 | EBI-1182222,EBI-764611 |
NOVA1 [P51513] | 9 | EBI-1182222,EBI-726123 |
Protein-protein interaction databases
BioGRIDi | 109594, 52 interactors |
IntActi | P50406, 31 interactors |
MINTi | P50406 |
STRINGi | 9606.ENSP00000289753 |
Chemistry databases
BindingDBi | P50406 |
Miscellaneous databases
RNActi | P50406, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 346 – 392 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 348 – 363 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P50406 |
OMAi | FQCRLQV |
OrthoDBi | 1173208at2759 |
PhylomeDBi | P50406 |
TreeFami | TF351753 |
Family and domain databases
CDDi | cd15054, 7tmA_5-HT6, 1 hit |
InterProi | View protein in InterPro IPR002232, 5HT6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA
260 270 280 290 300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG
310 320 330 340 350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS
360 370 380 390 400
PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL
410 420 430 440
PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 247 | V → M in CAA88929 (PubMed:7656980).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41147 mRNA Translation: AAA92622.1 AY429105 mRNA Translation: AAR07900.1 AL031727 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94896.1 BC074995 mRNA Translation: AAH74995.1 BC074996 mRNA Translation: AAH74996.1 Z49119 mRNA Translation: CAA88929.1 |
CCDSi | CCDS197.1 |
PIRi | JC5520 |
RefSeqi | NP_000862.1, NM_000871.2 |
Genome annotation databases
Ensembli | ENST00000289753; ENSP00000289753; ENSG00000158748 |
GeneIDi | 3362 |
KEGGi | hsa:3362 |
MANE-Selecti | ENST00000289753.2; ENSP00000289753.1; NM_000871.3; NP_000862.1 |
UCSCi | uc001bcl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41147 mRNA Translation: AAA92622.1 AY429105 mRNA Translation: AAR07900.1 AL031727 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94896.1 BC074995 mRNA Translation: AAH74995.1 BC074996 mRNA Translation: AAH74996.1 Z49119 mRNA Translation: CAA88929.1 |
CCDSi | CCDS197.1 |
PIRi | JC5520 |
RefSeqi | NP_000862.1, NM_000871.2 |
3D structure databases
SMRi | P50406 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109594, 52 interactors |
IntActi | P50406, 31 interactors |
MINTi | P50406 |
STRINGi | 9606.ENSP00000289753 |
Chemistry databases
BindingDBi | P50406 |
ChEMBLi | CHEMBL3371 |
DrugBanki | DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB00924, Cyclobenzaprine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB01488, Dimethyltryptamine DB01142, Doxepin DB01049, Ergoloid mesylate DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB00408, Loxapine DB04829, Lysergic acid diethylamide DB06148, Mianserin DB00334, Olanzapine DB00715, Paroxetine DB05993, PRX-07034 DB01224, Quetiapine DB06144, Sertindole DB09304, Setiptiline DB05042, SGS518 DB06140, SUVN-502 DB13025, Tiapride DB00246, Ziprasidone DB09225, Zotepine |
DrugCentrali | P50406 |
GuidetoPHARMACOLOGYi | 11 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P50406 |
PhosphoSitePlusi | P50406 |
Genetic variation databases
BioMutai | HTR6 |
DMDMi | 1703010 |
Proteomic databases
MassIVEi | P50406 |
PaxDbi | P50406 |
PeptideAtlasi | P50406 |
PRIDEi | P50406 |
ProteomicsDBi | 56219 |
Protocols and materials databases
Antibodypediai | 15009, 109 antibodies from 28 providers |
DNASUi | 3362 |
Genome annotation databases
Ensembli | ENST00000289753; ENSP00000289753; ENSG00000158748 |
GeneIDi | 3362 |
KEGGi | hsa:3362 |
MANE-Selecti | ENST00000289753.2; ENSP00000289753.1; NM_000871.3; NP_000862.1 |
UCSCi | uc001bcl.5, human |
Organism-specific databases
CTDi | 3362 |
DisGeNETi | 3362 |
GeneCardsi | HTR6 |
HGNCi | HGNC:5301, HTR6 |
HPAi | ENSG00000158748, Tissue enriched (brain) |
MIMi | 601109, gene |
neXtProti | NX_P50406 |
OpenTargetsi | ENSG00000158748 |
PharmGKBi | PA29560 |
VEuPathDBi | HostDB:ENSG00000158748 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P50406 |
OMAi | FQCRLQV |
OrthoDBi | 1173208at2759 |
PhylomeDBi | P50406 |
TreeFami | TF351753 |
Enzyme and pathway databases
PathwayCommonsi | P50406 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P50406 |
SIGNORi | P50406 |
Miscellaneous databases
BioGRID-ORCSi | 3362, 1 hit in 1035 CRISPR screens |
GeneWikii | 5-HT6_receptor |
GenomeRNAii | 3362 |
Pharosi | P50406, Tchem |
PROi | PR:P50406 |
RNActi | P50406, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158748, Expressed in putamen and 29 other tissues |
Genevisiblei | P50406, HS |
Family and domain databases
CDDi | cd15054, 7tmA_5-HT6, 1 hit |
InterProi | View protein in InterPro IPR002232, 5HT6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT6R_HUMAN | |
Accessioni | P50406Primary (citable) accession number: P50406 Secondary accession number(s): Q13640, Q5TGZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families