HTR6

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).By similarity1 Publication

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histamine receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8522988
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cerebral cortex cell migration Source: UniProtKB
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of TOR signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 23027611

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 6 Short name: 5-HT-6 Short name: 5-HT6 Alternative name(s): Serotonin receptor 6
Gene namesⁱ	Name:HTR6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158748.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5301 HTR6
MIMⁱ	601109 gene
neXtProtⁱ	NX_P50406

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularBy similarityAdd BLAST	34
Transmembraneⁱ	35 – 57	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	58 – 64	CytoplasmicBy similarity	7
Transmembraneⁱ	65 – 85	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	86 – 100	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	101 – 122	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	123 – 144	CytoplasmicBy similarityAdd BLAST	22
Transmembraneⁱ	145 – 166	Helical; Name=4By similarityAdd BLAST	22
Topological domainⁱ	167 – 184	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	185 – 208	Helical; Name=5By similarityAdd BLAST	24
Topological domainⁱ	209 – 265	CytoplasmicBy similarityAdd BLAST	57
Transmembraneⁱ	266 – 290	Helical; Name=6By similarityAdd BLAST	25
Topological domainⁱ	291 – 295	ExtracellularBy similarity	5
Transmembraneⁱ	296 – 320	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	321 – 440	CytoplasmicBy similarityAdd BLAST	120

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3362
Open Targets More...OpenTargetsⁱ	ENSG00000158748
PharmGKBⁱ	PA29560

Chemistry databases

ChEMBLⁱ	CHEMBL3371
Drug and drug target database More...DrugBankⁱ	DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB06216 Asenapine DB00477 Chlorpromazine DB00363 Clozapine DB01488 Dimethyltryptamine DB01142 Doxepin DB01049 Ergoloid mesylate DB04946 Iloperidone DB00458 Imipramine DB00408 Loxapine DB06148 Mianserin DB00540 Nortriptyline DB00334 Olanzapine DB01224 Quetiapine DB06144 Sertindole DB05042 SGS518 DB13025 Tiapride DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	11

Polymorphism and mutation databases

DMDMⁱ	1703010

DMDMⁱ

1703010

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068974	1 – 440	5-hydroxytryptamine receptor 6Add BLAST		440

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	99 ↔ 180	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P50406
PRIDEⁱ	P50406
ProteomicsDBⁱ	56219

PTM databases

iPTMnetⁱ	P50406
PhosphoSitePlusⁱ	P50406

Expressionⁱ

Tissue specificityⁱ

Expressed in several human brain regions, most prominently in the caudate nucleus.

Gene expression databases

Bgeeⁱ	ENSG00000158748 Expressed in 19 organ(s), highest expression level in putamen
CleanExⁱ	HS_HTR6
Genevisibleⁱ	P50406 HS

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FYN	P06241	7	EBI-1182222,EBI-515315

With

Entry

#Exp.

IntAct

Notes

FYN

P06241

7

EBI-1182222,EBI-515315

Protein-protein interaction databases

BioGridⁱ	109594, 26 interactors
IntActⁱ	P50406, 2 interactors
STRINGⁱ	9606.ENSP00000289753

Chemistry databases

BindingDBⁱ

P50406

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000241520
HOVERGENⁱ	HBG106962
InParanoidⁱ	P50406
KEGG Orthology (KO) More...KOⁱ	K04162
OMAⁱ	GWHELGH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P50406
TreeFamⁱ	TF351753

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15054 7tmA_5-HT6, 1 hit
InterProⁱ	View protein in InterPro IPR002232 5HT6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P50406-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL 
        60         70         80         90        100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 
       110        120        130        140        150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA 
       160        170        180        190        200
WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP 
       210        220        230        240        250
SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA 
       260        270        280        290        300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG 
       310        320        330        340        350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS 
       360        370        380        390        400
PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL 
       410        420        430        440
PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN

Length:440

Mass (Da):46,954

Last modified:October 1, 1996 - v1

Checksum:ⁱC888F47650C1D2EF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	247	V → M in CAA88929 (PubMed:7656980).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41147 mRNA Translation: AAA92622.1 AY429105 mRNA Translation: AAR07900.1 AL031727 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94896.1 BC074995 mRNA Translation: AAH74995.1 BC074996 mRNA Translation: AAH74996.1 Z49119 mRNA Translation: CAA88929.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS197.1
PIRⁱ	JC5520
NCBI Reference Sequences More...RefSeqⁱ	NP_000862.1, NM_000871.2
UniGeneⁱ	Hs.22180

Genome annotation databases

Ensemblⁱ	ENST00000289753; ENSP00000289753; ENSG00000158748
GeneIDⁱ	3362
KEGGⁱ	hsa:3362
UCSC genome browser More...UCSCⁱ	uc001bcl.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50406	5-hydroxytryptamine receptor 6		PANTR		440	UniRef90_P50406
5-hydroxytryptamine receptor 6		PHYCD		456
5-hydroxytryptamine receptor 6		DELLE		447
5-hydroxytryptamine receptor 6		SAIBB		440
5-alpha-hydroxytryptamine receptor 6 (Fragment)		Bolivian squirrel monkey		393
+35

Protein	Similar proteins		Species	Score	Length	Source
P50406	5-hydroxytryptamine receptor 6		RAT		436	UniRef50_P31388
5-hydroxytryptamine receptor 6		MOUSE		440
5-hydroxytryptamine receptor 6		PANTR		440
5-hydroxytryptamine receptor 6		PTEAL		438
5-hydroxytryptamine receptor 6		DIPOR		438
+191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41147 mRNA Translation: AAA92622.1 AY429105 mRNA Translation: AAR07900.1 AL031727 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94896.1 BC074995 mRNA Translation: AAH74995.1 BC074996 mRNA Translation: AAH74996.1 Z49119 mRNA Translation: CAA88929.1
CCDSⁱ	CCDS197.1
PIRⁱ	JC5520
RefSeqⁱ	NP_000862.1, NM_000871.2
UniGeneⁱ	Hs.22180

3D structure databases

ProteinModelPortalⁱ	P50406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109594, 26 interactors
IntActⁱ	P50406, 2 interactors
STRINGⁱ	9606.ENSP00000289753

Chemistry databases

BindingDBⁱ	P50406
ChEMBLⁱ	CHEMBL3371
DrugBankⁱ	DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB06216 Asenapine DB00477 Chlorpromazine DB00363 Clozapine DB01488 Dimethyltryptamine DB01142 Doxepin DB01049 Ergoloid mesylate DB04946 Iloperidone DB00458 Imipramine DB00408 Loxapine DB06148 Mianserin DB00540 Nortriptyline DB00334 Olanzapine DB01224 Quetiapine DB06144 Sertindole DB05042 SGS518 DB13025 Tiapride DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	11

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P50406
PhosphoSitePlusⁱ	P50406

Polymorphism and mutation databases

DMDMⁱ	1703010

DMDMⁱ

1703010

Proteomic databases

PaxDbⁱ	P50406
PRIDEⁱ	P50406
ProteomicsDBⁱ	56219

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000289753; ENSP00000289753; ENSG00000158748
GeneIDⁱ	3362
KEGGⁱ	hsa:3362
UCSCⁱ	uc001bcl.5 human

Organism-specific databases

CTDⁱ	3362
DisGeNETⁱ	3362
EuPathDBⁱ	HostDB:ENSG00000158748.3
GeneCardsⁱ	HTR6
HGNCⁱ	HGNC:5301 HTR6
MIMⁱ	601109 gene
neXtProtⁱ	NX_P50406
OpenTargetsⁱ	ENSG00000158748
PharmGKBⁱ	PA29560
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000241520
HOVERGENⁱ	HBG106962
InParanoidⁱ	P50406
KOⁱ	K04162
OMAⁱ	GWHELGH
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P50406
TreeFamⁱ	TF351753

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	5-HT6_receptor
GenomeRNAiⁱ	3362
Protein Ontology More...PROⁱ	PR:P50406
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158748 Expressed in 19 organ(s), highest expression level in putamen
CleanExⁱ	HS_HTR6
Genevisibleⁱ	P50406 HS

Family and domain databases

CDDⁱ	cd15054 7tmA_5-HT6, 1 hit
InterProⁱ	View protein in InterPro IPR002232 5HT6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT6R_HUMAN
Accessionⁱ	P50406Primary (citable) accession number: P50406 Secondary accession number(s): Q13640, Q5TGZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P50406 (5HT6R_HUMAN)

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5-hydroxytryptamine receptor 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ