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Protein

Rab GDP dissociation inhibitor alpha

Gene

Gdi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rab GDP-dissociation inhibitor activity Source: RGD
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor alpha
Short name:
Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name:
GDI-1
Gene namesi
Name:Gdi1
Synonyms:Rabgdia
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2676 Gdi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566761 – 447Rab GDP dissociation inhibitor alphaAdd BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei427PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50398
PRIDEiP50398

2D gel databases

World-2DPAGEi0004:P50398

PTM databases

iPTMnetiP50398
PhosphoSitePlusiP50398
SwissPalmiP50398

Expressioni

Tissue specificityi

High expression in brain, lower in other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000056870 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP50398 RN

Interactioni

Subunit structurei

Interacts with RHOH, RAB1A, RAB3A, RAB5A and RAB10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247236, 1 interactor
CORUMiP50398
IntActiP50398, 1 interactor
STRINGi10116.ENSRNOP00000053135

Structurei

3D structure databases

ProteinModelPortaliP50398
SMRiP50398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiP50398
KOiK17255
OMAiEDPATHQ
OrthoDBiEOG091G06PV
PhylomeDBiP50398
TreeFamiTF300449

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P50398-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETA EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGSAFD FENMKRKQND VFGEADQ
Length:447
Mass (Da):50,537
Last modified:October 1, 1996 - v1
Checksum:i58384671991DF793
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199D → Y in CAA52413 (PubMed:8188702).Curated1
Sequence conflicti230G → S in AAB16909 (PubMed:7513052).Curated1
Sequence conflicti330S → P in AAB16909 (PubMed:7513052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74402 mRNA Translation: CAA52413.1
U07952 mRNA Translation: AAB16909.1
BC099763 mRNA Translation: AAH99763.1
AF130987 mRNA Translation: AAD25536.1
PIRiA54091
B56024
RefSeqiNP_058784.2, NM_017088.2
UniGeneiRn.4000

Genome annotation databases

EnsembliENSRNOT00000089814; ENSRNOP00000070171; ENSRNOG00000056870
GeneIDi25183
KEGGirno:25183

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74402 mRNA Translation: CAA52413.1
U07952 mRNA Translation: AAB16909.1
BC099763 mRNA Translation: AAH99763.1
AF130987 mRNA Translation: AAD25536.1
PIRiA54091
B56024
RefSeqiNP_058784.2, NM_017088.2
UniGeneiRn.4000

3D structure databases

ProteinModelPortaliP50398
SMRiP50398
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247236, 1 interactor
CORUMiP50398
IntActiP50398, 1 interactor
STRINGi10116.ENSRNOP00000053135

PTM databases

iPTMnetiP50398
PhosphoSitePlusiP50398
SwissPalmiP50398

2D gel databases

World-2DPAGEi0004:P50398

Proteomic databases

PaxDbiP50398
PRIDEiP50398

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089814; ENSRNOP00000070171; ENSRNOG00000056870
GeneIDi25183
KEGGirno:25183

Organism-specific databases

CTDi2664
RGDi2676 Gdi1

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiP50398
KOiK17255
OMAiEDPATHQ
OrthoDBiEOG091G06PV
PhylomeDBiP50398
TreeFamiTF300449

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:P50398

Gene expression databases

BgeeiENSRNOG00000056870 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP50398 RN

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGDIA_RAT
AccessioniPrimary (citable) accession number: P50398
Secondary accession number(s): Q499U0, Q9R274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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