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Protein

Rab GDP dissociation inhibitor beta

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rab GDP-dissociation inhibitor activity Source: ProtInc
  • RNA binding Source: UniProtKB
  • small GTPase binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-6798695 Neutrophil degranulation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:GDI2
Synonyms:RABGDIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16
HGNCiHGNC:4227 GDI2
MIMi600767 gene
neXtProtiNX_P50395

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2665
OpenTargetsiENSG00000057608
PharmGKBiPA28642

Polymorphism and mutation databases

BioMutaiGDI2
DMDMi13638228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566791 – 445Rab GDP dissociation inhibitor betaAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei61PhosphoserineCombined sources1
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei130PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP50395
PaxDbiP50395
PeptideAtlasiP50395
PRIDEiP50395
ProteomicsDBi56216
56217 [P50395-2]

2D gel databases

OGPiP50395
REPRODUCTION-2DPAGEiIPI00031461
P50395

PTM databases

iPTMnetiP50395
PhosphoSitePlusiP50395
SwissPalmiP50395

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000057608 Expressed in 234 organ(s), highest expression level in female gonad
CleanExiHS_GDI2
ExpressionAtlasiP50395 baseline and differential
GenevisibleiP50395 HS

Organism-specific databases

HPAiHPA049290
HPA057668

Interactioni

Subunit structurei

Interacts with RHOH.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108933, 59 interactors
DIPiDIP-50593N
IntActiP50395, 28 interactors
MINTiP50395
STRINGi9606.ENSP00000369538

Structurei

3D structure databases

ProteinModelPortaliP50395
SMRiP50395
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiP50395
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV
PhylomeDBiP50395
TreeFamiTF300449

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50395-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI
410 420 430 440
SRTYDATTHF ETTCDDIKNI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,663
Last modified:April 27, 2001 - v2
Checksum:iCE186A2E3A47FCC9
GO
Isoform 2 (identifier: P50395-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-130: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):45,619
Checksum:i9B80298F66BA048B
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SX90Q5SX90_HUMAN
Rab GDP dissociation inhibitor
GDI2
148Annotation score:
Q5SX87Q5SX87_HUMAN
Rab GDP dissociation inhibitor
GDI2
263Annotation score:
Q5SX91Q5SX91_HUMAN
Rab GDP dissociation inhibitor
GDI2
203Annotation score:
Q5SX86Q5SX86_HUMAN
Rab GDP dissociation inhibitor
GDI2
155Annotation score:
V9GYF8V9GYF8_HUMAN
Rab GDP dissociation inhibitor
GDI2
130Annotation score:
V9GYJ7V9GYJ7_HUMAN
Rab GDP dissociation inhibitor
GDI2
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2N → D in BAA03095 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04346986 – 130Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13988 mRNA Translation: BAA03095.1
Y13286 mRNA Translation: CAA73734.1
Y13287
, Y13288, Y13289, Y13290, Y13291, Y13292, Y13293, Y13294, Y13295, Y13296, Y13297 Genomic DNA Translation: CAA73735.1
BT006868 mRNA Translation: AAP35514.1
AK297554 mRNA Translation: BAG59947.1
AL596094 Genomic DNA No translation available.
BC005145 mRNA Translation: AAH05145.1
AF144713 mRNA Translation: AAD34588.1
CCDSiCCDS44352.1 [P50395-2]
CCDS7071.1 [P50395-1]
RefSeqiNP_001108628.1, NM_001115156.1 [P50395-2]
NP_001485.2, NM_001494.3 [P50395-1]
UniGeneiHs.299055

Genome annotation databases

EnsembliENST00000380181; ENSP00000369528; ENSG00000057608 [P50395-2]
ENST00000380191; ENSP00000369538; ENSG00000057608 [P50395-1]
GeneIDi2665
KEGGihsa:2665
UCSCiuc001iim.5 human [P50395-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13988 mRNA Translation: BAA03095.1
Y13286 mRNA Translation: CAA73734.1
Y13287
, Y13288, Y13289, Y13290, Y13291, Y13292, Y13293, Y13294, Y13295, Y13296, Y13297 Genomic DNA Translation: CAA73735.1
BT006868 mRNA Translation: AAP35514.1
AK297554 mRNA Translation: BAG59947.1
AL596094 Genomic DNA No translation available.
BC005145 mRNA Translation: AAH05145.1
AF144713 mRNA Translation: AAD34588.1
CCDSiCCDS44352.1 [P50395-2]
CCDS7071.1 [P50395-1]
RefSeqiNP_001108628.1, NM_001115156.1 [P50395-2]
NP_001485.2, NM_001494.3 [P50395-1]
UniGeneiHs.299055

3D structure databases

ProteinModelPortaliP50395
SMRiP50395
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108933, 59 interactors
DIPiDIP-50593N
IntActiP50395, 28 interactors
MINTiP50395
STRINGi9606.ENSP00000369538

PTM databases

iPTMnetiP50395
PhosphoSitePlusiP50395
SwissPalmiP50395

Polymorphism and mutation databases

BioMutaiGDI2
DMDMi13638228

2D gel databases

OGPiP50395
REPRODUCTION-2DPAGEiIPI00031461
P50395

Proteomic databases

EPDiP50395
PaxDbiP50395
PeptideAtlasiP50395
PRIDEiP50395
ProteomicsDBi56216
56217 [P50395-2]

Protocols and materials databases

DNASUi2665
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380181; ENSP00000369528; ENSG00000057608 [P50395-2]
ENST00000380191; ENSP00000369538; ENSG00000057608 [P50395-1]
GeneIDi2665
KEGGihsa:2665
UCSCiuc001iim.5 human [P50395-1]

Organism-specific databases

CTDi2665
DisGeNETi2665
EuPathDBiHostDB:ENSG00000057608.16
GeneCardsiGDI2
HGNCiHGNC:4227 GDI2
HPAiHPA049290
HPA057668
MIMi600767 gene
neXtProtiNX_P50395
OpenTargetsiENSG00000057608
PharmGKBiPA28642
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiP50395
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV
PhylomeDBiP50395
TreeFamiTF300449

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-6798695 Neutrophil degranulation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiGDI2 human
GeneWikiiGDI2
GenomeRNAii2665
PROiPR:P50395
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057608 Expressed in 234 organ(s), highest expression level in female gonad
CleanExiHS_GDI2
ExpressionAtlasiP50395 baseline and differential
GenevisibleiP50395 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGDIB_HUMAN
AccessioniPrimary (citable) accession number: P50395
Secondary accession number(s): O43928, Q5SX88, Q9UQM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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