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Protein

Tumor necrosis factor receptor superfamily member 3

Gene

Ltbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
Lymphotoxin-beta receptor
Gene namesi
Name:Ltbr
Synonyms:Tnfcr, Tnfrsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104875 Ltbr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 223ExtracellularSequence analysisAdd BLAST193
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 415CytoplasmicSequence analysisAdd BLAST171

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003455331 – 415Tumor necrosis factor receptor superfamily member 3Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi126 ↔ 132PROSITE-ProRule annotation
Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
Disulfide bondi142 ↔ 169PROSITE-ProRule annotation
Disulfide bondi172 ↔ 187PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei315PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP50284
PaxDbiP50284
PRIDEiP50284

PTM databases

PhosphoSitePlusiP50284

Expressioni

Gene expression databases

BgeeiENSMUSG00000030339
CleanExiMM_LTBR
ExpressionAtlasiP50284 baseline and differential
GenevisibleiP50284 MM

Interactioni

Subunit structurei

Self-associates (By similarity). Associates with TRAF5. Associates with TRAF3 and TRAF4 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201222, 5 interactors
DIPiDIP-49695N
IntActiP50284, 8 interactors
MINTiP50284
STRINGi10090.ENSMUSP00000032489

Structurei

3D structure databases

ProteinModelPortaliP50284
SMRiP50284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 81TNFR-Cys 1Add BLAST40
Repeati82 – 124TNFR-Cys 2Add BLAST43
Repeati125 – 170TNFR-Cys 3Add BLAST46
Repeati171 – 213TNFR-Cys 4Add BLAST43

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNN Eukaryota
ENOG410YQJW LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000294180
HOVERGENiHBG023187
InParanoidiP50284
KOiK03159
OMAiEDGKAWH
OrthoDBiEOG091G03XW
PhylomeDBiP50284
TreeFamiTF331157

Family and domain databases

CDDicd10578 TNFRSF3, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR017349 TNFR_3_LTBR
IPR033997 TNFRSF3_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
PIRSFiPIRSF037999 TNFR_3_LTBR, 1 hit
PRINTSiPR01920 TNFACTORR3
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY
60 70 80 90 100
YEPMHDVCCS RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL
110 120 130 140 150
CRPCDIVLGF EEVAPCTSDR KAECRCQPGM SCVYLDNECV HCEEERLVLC
160 170 180 190 200
QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT SSPRARCQPH TRCEIQGLVE
210 220 230 240 250
AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL ACAWMRHPSL
260 270 280 290 300
CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP
310 320 330 340 350
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT
360 370 380 390 400
GNIYIYNGPV LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK
410
AWHLAETETL GCQDL
Length:415
Mass (Da):44,956
Last modified:October 1, 1996 - v1
Checksum:i29B326A566AEF661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29173 mRNA Translation: AAA68964.1
L38423 mRNA Translation: AAB00846.1
U30798 Genomic DNA Translation: AAA81334.1
CCDSiCCDS20549.1
RefSeqiNP_034866.1, NM_010736.3
UniGeneiMm.3122

Genome annotation databases

EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339
GeneIDi17000
KEGGimmu:17000
UCSCiuc009duj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTNR3_MOUSE
AccessioniPrimary (citable) accession number: P50284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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