UniProtKB - P50281 (MMP14_HUMAN)
Protein
Matrix metalloproteinase-14
Gene
MMP14
Organism
Homo sapiens (Human)
Status
Functioni
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).By similarity4 Publications
Catalytic activityi
- Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. EC:3.4.24.80
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 93 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 239 | Zinc; catalytic | 1 | |
Active sitei | 240 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 243 | Zinc; catalytic | 1 | |
Metal bindingi | 249 | Zinc; catalytic | 1 |
GO - Molecular functioni
- endopeptidase activity Source: UniProtKB
- integrin binding Source: Ensembl
- metalloaminopeptidase activity Source: ParkinsonsUK-UCL
- metalloendopeptidase activity Source: UniProtKB
- zinc ion binding Source: ProtInc
GO - Biological processi
- angiogenesis Source: Ensembl
- astrocyte cell migration Source: Ensembl
- branching morphogenesis of an epithelial tube Source: Ensembl
- cell motility Source: ParkinsonsUK-UCL
- chondrocyte proliferation Source: Ensembl
- collagen catabolic process Source: GO_Central
- craniofacial suture morphogenesis Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: Ensembl
- endochondral ossification Source: Ensembl
- endodermal cell differentiation Source: UniProtKB
- endothelial cell proliferation Source: Ensembl
- extracellular matrix disassembly Source: Reactome
- extracellular matrix organization Source: GO_Central
- head development Source: Ensembl
- lung development Source: Ensembl
- male gonad development Source: Ensembl
- negative regulation of focal adhesion assembly Source: Ensembl
- negative regulation of Notch signaling pathway Source: UniProtKB
- ovarian follicle development Source: Ensembl
- positive regulation of B cell differentiation Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of macrophage migration Source: Ensembl
- positive regulation of myotube differentiation Source: UniProtKB
- positive regulation of protein processing Source: Ensembl
- protein processing Source: ParkinsonsUK-UCL
- proteolysis Source: ParkinsonsUK-UCL
- regulation of protein localization to plasma membrane Source: UniProtKB
- response to estrogen Source: Ensembl
- response to hypoxia Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to odorant Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to oxidative stress Source: Ensembl
- skeletal system development Source: GO_Central
- tissue remodeling Source: Ensembl
- zymogen activation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000157227-MONOMER |
BRENDAi | 3.4.24.80, 2681 3.4.24.B5, 2681 |
PathwayCommonsi | P50281 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases |
SIGNORi | P50281 |
Protein family/group databases
MEROPSi | M10.014 |
TCDBi | 8.B.14.2.3, the sea anemone peptide toxin, class 1 (bgk) family |
Names & Taxonomyi
Protein namesi | Recommended name: Matrix metalloproteinase-14 (EC:3.4.24.80)Short name: MMP-14 Alternative name(s): MMP-X1 Membrane-type matrix metalloproteinase 1 Short name: MT-MMP 1 Short name: MTMMP1 Membrane-type-1 matrix metalloproteinase Short name: MT1-MMP Short name: MT1MMP |
Gene namesi | Name:MMP14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157227.12 |
HGNCi | HGNC:7160, MMP14 |
MIMi | 600754, gene |
neXtProti | NX_P50281 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- Melanosome
- Cytoplasm
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Cytoskeleton
- intermediate filament cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Endosome
- macropinosome Source: UniProtKB
Extracellular region or secreted
- extracellular matrix Source: InterPro
- extracellular space Source: CAFA
Golgi apparatus
- Golgi lumen Source: Reactome
Nucleus
- nucleus Source: CAFA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Other locations
- cytoplasmic vesicle Source: UniProtKB
- focal adhesion Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 112 – 541 | ExtracellularSequence analysisAdd BLAST | 430 | |
Transmembranei | 542 – 562 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 563 – 582 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Winchester syndrome (WNCHRS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070567 | 17 | T → R in WNCHRS; results in increased MMP14 proteosomal degradation and reduced protein localization to cell membrane. 1 PublicationCorresponds to variant dbSNP:rs587777039EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 4323 |
MalaCardsi | MMP14 |
MIMi | 277950, phenotype |
OpenTargetsi | ENSG00000157227 |
Orphaneti | 371428, Multicentric osteolysis-nodulosis-arthropathy spectrum |
PharmGKBi | PA30872 |
Miscellaneous databases
Pharosi | P50281, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3869 |
DrugBanki | DB00786, Marimastat |
DrugCentrali | P50281 |
GuidetoPHARMACOLOGYi | 1638 |
Polymorphism and mutation databases
BioMutai | MMP14 |
DMDMi | 317373419 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000028798 | 21 – 111 | Activation peptide1 PublicationAdd BLAST | 91 | |
ChainiPRO_0000028799 | 112 – 582 | Matrix metalloproteinase-14Add BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 319 ↔ 508 | By similarity | ||
Modified residuei | 399 | Phosphotyrosine; by PKDCC1 Publication | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase.By similarity
Tyrosine phosphorylated by PKDCC/VLK.1 Publication
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, ZymogenProteomic databases
EPDi | P50281 |
jPOSTi | P50281 |
MassIVEi | P50281 |
MaxQBi | P50281 |
PaxDbi | P50281 |
PeptideAtlasi | P50281 |
PRIDEi | P50281 |
ProteomicsDBi | 56213 |
PTM databases
GlyGeni | P50281, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P50281 |
PhosphoSitePlusi | P50281 |
SwissPalmi | P50281 |
Expressioni
Tissue specificityi
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.1 Publication
Inductioni
Up-regulated by NANOS1.1 Publication
Gene expression databases
Bgeei | ENSG00000157227, Expressed in stromal cell of endometrium and 209 other tissues |
ExpressionAtlasi | P50281, baseline and differential |
Genevisiblei | P50281, HS |
Organism-specific databases
HPAi | ENSG00000157227, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via C-terminal cytoplasmic tail) with BST2.
Interacts with DLL1; inhibits DLL1-induced Notch signaling (PubMed:21572390).
3 PublicationsBinary interactionsi
Hide detailsP50281
GO - Molecular functioni
- integrin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110466, 40 interactors |
CORUMi | P50281 |
DIPi | DIP-35111N |
IntActi | P50281, 46 interactors |
MINTi | P50281 |
STRINGi | 9606.ENSP00000308208 |
Chemistry databases
BindingDBi | P50281 |
Miscellaneous databases
RNActi | P50281, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P50281 |
SMRi | P50281 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P50281 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 316 – 364 | Hemopexin 1Add BLAST | 49 | |
Repeati | 365 – 410 | Hemopexin 2Add BLAST | 46 | |
Repeati | 412 – 460 | Hemopexin 3Add BLAST | 49 | |
Repeati | 461 – 508 | Hemopexin 4Add BLAST | 48 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 91 – 98 | Cysteine switchBy similarity | 8 |
Domaini
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence similaritiesi
Belongs to the peptidase M10A family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000157808 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | P50281 |
OMAi | LPTKMPP |
OrthoDBi | 881347at2759 |
PhylomeDBi | P50281 |
TreeFami | TF352396 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P50281-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL
60 70 80 90 100
RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG
110 120 130 140 150
AEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT YEAIRKAFRV
160 170 180 190 200
WESATPLRFR EVPYAYIREG HEKQADIMIF FAEGFHGDST PFDGEGGFLA
210 220 230 240 250
HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE LGHALGLEHS
260 270 280 290 300
SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT
310 320 330 340 350
SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM
360 370 380 390 400
DGYPMPIGQF WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP
410 420 430 440 450
KHIKELGRGL PTDKIDAALF WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP
460 470 480 490 500
KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG NKYWKFNNQK LKVEPGYPKS
510 520 530 540 550
ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA AVVLPVLLLL
560 570 580
LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W1B7 | F8W1B7_HUMAN | Matrix metalloproteinase-14 | MMP14 | 194 | Annotation score: | ||
F8VP90 | F8VP90_HUMAN | Matrix metalloproteinase-14 | MMP14 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 338 | E → K in BAA05519 (PubMed:8015608).Curated | 1 | |
Sequence conflicti | 500 | S → P in CAA62432 (PubMed:8706726).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021029 | 4 | A → T1 PublicationCorresponds to variant dbSNP:rs17882219EnsemblClinVar. | 1 | |
Natural variantiVAR_021030 | 6 | R → K1 PublicationCorresponds to variant dbSNP:rs17884647Ensembl. | 1 | |
Natural variantiVAR_021031 | 8 | P → S7 PublicationsCorresponds to variant dbSNP:rs1042703Ensembl. | 1 | |
Natural variantiVAR_070567 | 17 | T → R in WNCHRS; results in increased MMP14 proteosomal degradation and reduced protein localization to cell membrane. 1 PublicationCorresponds to variant dbSNP:rs587777039EnsemblClinVar. | 1 | |
Natural variantiVAR_021032 | 233 | I → V1 PublicationCorresponds to variant dbSNP:rs17884841EnsemblClinVar. | 1 | |
Natural variantiVAR_021033 | 273 | D → N1 PublicationCorresponds to variant dbSNP:rs1042704Ensembl. | 1 | |
Natural variantiVAR_021034 | 302 | R → W1 PublicationCorresponds to variant dbSNP:rs17884719Ensembl. | 1 | |
Natural variantiVAR_021035 | 355 | M → I1 PublicationCorresponds to variant dbSNP:rs17880989Ensembl. | 1 | |
Natural variantiVAR_031267 | 431 | R → H. Corresponds to variant dbSNP:rs3751489EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26512 mRNA Translation: BAA05519.1 X83535 mRNA Translation: CAA58519.1 Z48481 mRNA Translation: CAA88372.1 U41078 mRNA Translation: AAA83770.1 X90925 mRNA Translation: CAA62432.1 AK291325 mRNA Translation: BAF84014.1 AY795074 Genomic DNA Translation: AAV40837.1 AL135998 Genomic DNA No translation available. BC064803 mRNA Translation: AAH64803.1 |
CCDSi | CCDS9577.1 |
PIRi | I38028 |
RefSeqi | NP_004986.1, NM_004995.3 |
Genome annotation databases
Ensembli | ENST00000311852; ENSP00000308208; ENSG00000157227 |
GeneIDi | 4323 |
KEGGi | hsa:4323 |
UCSCi | uc001whc.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26512 mRNA Translation: BAA05519.1 X83535 mRNA Translation: CAA58519.1 Z48481 mRNA Translation: CAA88372.1 U41078 mRNA Translation: AAA83770.1 X90925 mRNA Translation: CAA62432.1 AK291325 mRNA Translation: BAF84014.1 AY795074 Genomic DNA Translation: AAV40837.1 AL135998 Genomic DNA No translation available. BC064803 mRNA Translation: AAH64803.1 |
CCDSi | CCDS9577.1 |
PIRi | I38028 |
RefSeqi | NP_004986.1, NM_004995.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BQQ | X-ray | 2.75 | M | 114-287 | [»] | |
1BUV | X-ray | 2.75 | M | 114-287 | [»] | |
2MQS | NMR | - | A | 316-511 | [»] | |
3C7X | X-ray | 1.70 | A | 316-511 | [»] | |
3MA2 | X-ray | 2.05 | A/D | 112-292 | [»] | |
3X23 | X-ray | 2.40 | B | 563-582 | [»] | |
4P3C | X-ray | 1.94 | M | 215-227 | [»] | |
4P3D | X-ray | 1.95 | C/M | 215-227 | [»] | |
4QXU | X-ray | 2.30 | K | 218-228 | [»] | |
5H0U | X-ray | 2.24 | A | 116-285 | [»] | |
6CLZ | NMR | - | A | 316-511 | [»] | |
6CM1 | NMR | - | A | 316-511 | [»] | |
BMRBi | P50281 | |||||
SMRi | P50281 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110466, 40 interactors |
CORUMi | P50281 |
DIPi | DIP-35111N |
IntActi | P50281, 46 interactors |
MINTi | P50281 |
STRINGi | 9606.ENSP00000308208 |
Chemistry databases
BindingDBi | P50281 |
ChEMBLi | CHEMBL3869 |
DrugBanki | DB00786, Marimastat |
DrugCentrali | P50281 |
GuidetoPHARMACOLOGYi | 1638 |
Protein family/group databases
MEROPSi | M10.014 |
TCDBi | 8.B.14.2.3, the sea anemone peptide toxin, class 1 (bgk) family |
PTM databases
GlyGeni | P50281, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P50281 |
PhosphoSitePlusi | P50281 |
SwissPalmi | P50281 |
Polymorphism and mutation databases
BioMutai | MMP14 |
DMDMi | 317373419 |
Proteomic databases
EPDi | P50281 |
jPOSTi | P50281 |
MassIVEi | P50281 |
MaxQBi | P50281 |
PaxDbi | P50281 |
PeptideAtlasi | P50281 |
PRIDEi | P50281 |
ProteomicsDBi | 56213 |
Protocols and materials databases
ABCDi | P50281, 1 sequenced antibody |
Antibodypediai | 4088, 1006 antibodies |
Genome annotation databases
Ensembli | ENST00000311852; ENSP00000308208; ENSG00000157227 |
GeneIDi | 4323 |
KEGGi | hsa:4323 |
UCSCi | uc001whc.5, human |
Organism-specific databases
CTDi | 4323 |
DisGeNETi | 4323 |
EuPathDBi | HostDB:ENSG00000157227.12 |
GeneCardsi | MMP14 |
HGNCi | HGNC:7160, MMP14 |
HPAi | ENSG00000157227, Low tissue specificity |
MalaCardsi | MMP14 |
MIMi | 277950, phenotype 600754, gene |
neXtProti | NX_P50281 |
OpenTargetsi | ENSG00000157227 |
Orphaneti | 371428, Multicentric osteolysis-nodulosis-arthropathy spectrum |
PharmGKBi | PA30872 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000157808 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | P50281 |
OMAi | LPTKMPP |
OrthoDBi | 881347at2759 |
PhylomeDBi | P50281 |
TreeFami | TF352396 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000157227-MONOMER |
BRENDAi | 3.4.24.80, 2681 3.4.24.B5, 2681 |
PathwayCommonsi | P50281 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases |
SIGNORi | P50281 |
Miscellaneous databases
BioGRID-ORCSi | 4323, 7 hits in 847 CRISPR screens |
ChiTaRSi | MMP14, human |
EvolutionaryTracei | P50281 |
GeneWikii | MMP14 |
GenomeRNAii | 4323 |
Pharosi | P50281, Tchem |
PROi | PR:P50281 |
RNActi | P50281, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157227, Expressed in stromal cell of endometrium and 209 other tissues |
ExpressionAtlasi | P50281, baseline and differential |
Genevisiblei | P50281, HS |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MMP14_HUMAN | |
Accessioni | P50281Primary (citable) accession number: P50281 Secondary accession number(s): A8K5L0, Q6GSF3, Q92678 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 214 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries