UniProtKB - P50276 (MUP1_YEAST)
Protein
High-affinity methionine permease
Gene
MUP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
High affinity permease for methionine.
GO - Molecular functioni
- L-amino acid transmembrane transporter activity Source: GO_Central
- L-methionine secondary active transmembrane transporter activity Source: SGD
GO - Biological processi
- cysteine transport Source: UniProtKB
- methionine import across plasma membrane Source: SGD
- methionine transport Source: UniProtKB
- sulfur amino acid transport Source: SGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.3.8.4, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity methionine permease |
Gene namesi | Name:MUP1 Ordered Locus Names:YGR055W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003287, MUP1 |
VEuPathDBi | FungiDB:YGR055W |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: SGD
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 61 | CytoplasmicSequence analysisAdd BLAST | 61 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 92 | ExtracellularSequence analysis | 10 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 140 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 182 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 183 – 203 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 204 – 207 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 293 | ExtracellularSequence analysisAdd BLAST | 65 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 340 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 341 – 361 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 362 – 418 | ExtracellularSequence analysisAdd BLAST | 57 | |
Transmembranei | 419 – 439 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 440 – 455 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 477 – 490 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 491 – 511 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 512 – 574 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096648 | 1 – 574 | High-affinity methionine permeaseAdd BLAST | 574 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 28 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 552 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P50276 |
PaxDbi | P50276 |
PRIDEi | P50276 |
PTM databases
iPTMneti | P50276 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33300, 259 interactors |
DIPi | DIP-7914N |
IntActi | P50276, 57 interactors |
MINTi | P50276 |
STRINGi | 4932.YGR055W |
Miscellaneous databases
RNActi | P50276, protein |
Family & Domainsi
Sequence similaritiesi
To yeast low affinity methionine permease (MUP3).Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1287, Eukaryota |
HOGENOMi | CLU_013661_4_1_1 |
InParanoidi | P50276 |
OMAi | GRWNQRG |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P50276-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEGRTFLSQ LNVFNKENYQ FSSSTTKKEV SNSTVDADNG ASDFEAGQQF
60 70 80 90 100
ATELDQGEKQ LGILSCIGLI CNRMLGTGVF AVSSTIYTLC GSVGLALIMW
110 120 130 140 150
AVGAIIAISG LYVYMEFGTA IPKNGGEKNY LEAIFRKPKF FITCMYAAYI
160 170 180 190 200
FFLGWAAGNS INTAIMFLTA ADTEVTKWNQ RGIGVAVVFF AFLINSLNVK
210 220 230 240 250
IGLYLQNILG IFKIGIVLFI SITGWVALGG GLKDGYQSHN FRNAFEGTET
260 270 280 290 300
ATAYGIVNAL YSVIWSFVGY SNVNYALGEV KNPVRTLKIA GPTSMVFLAI
310 320 330 340 350
IYIFVNIAYF AVVPKDKLIS SKLILAADFF DIVFGGQAKR AAAALVGLSA
360 370 380 390 400
LGNVLSVIFS QGRIIQQLGR EGVLPFSNFF ASSKPFNSPM VGLFQHFIVC
410 420 430 440 450
TVTILAPPPG DAYLLVQNLI SYPMNIINFA ISAGLLWIYW QRRQGKIEWN
460 470 480 490 500
PPIKAGVFVT GFFTLSNLYL IIAPYVPPSN GESVYSSMPY WIHCVIAWGI
510 520 530 540 550
FFFGGVYYVV WAQLLPRWGH YKLVSKDVLG EDGFWRVKIA KVYDDTIGDV
560 570
DTQEDGVIET NIIEHYKSEQ EKSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40316 Genomic DNA Translation: AAB63529.1 DQ115391 Genomic DNA Translation: AAZ22468.1 Z72840 Genomic DNA Translation: CAA97055.1 BK006941 Genomic DNA Translation: DAA08151.1 |
PIRi | S61943 |
RefSeqi | NP_011569.1, NM_001181184.1 |
Genome annotation databases
EnsemblFungii | YGR055W_mRNA; YGR055W; YGR055W |
GeneIDi | 852946 |
KEGGi | sce:YGR055W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40316 Genomic DNA Translation: AAB63529.1 DQ115391 Genomic DNA Translation: AAZ22468.1 Z72840 Genomic DNA Translation: CAA97055.1 BK006941 Genomic DNA Translation: DAA08151.1 |
PIRi | S61943 |
RefSeqi | NP_011569.1, NM_001181184.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33300, 259 interactors |
DIPi | DIP-7914N |
IntActi | P50276, 57 interactors |
MINTi | P50276 |
STRINGi | 4932.YGR055W |
Protein family/group databases
TCDBi | 2.A.3.8.4, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | P50276 |
Proteomic databases
MaxQBi | P50276 |
PaxDbi | P50276 |
PRIDEi | P50276 |
Genome annotation databases
EnsemblFungii | YGR055W_mRNA; YGR055W; YGR055W |
GeneIDi | 852946 |
KEGGi | sce:YGR055W |
Organism-specific databases
SGDi | S000003287, MUP1 |
VEuPathDBi | FungiDB:YGR055W |
Phylogenomic databases
eggNOGi | KOG1287, Eukaryota |
HOGENOMi | CLU_013661_4_1_1 |
InParanoidi | P50276 |
OMAi | GRWNQRG |
Enzyme and pathway databases
Reactomei | R-SCE-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
PROi | PR:P50276 |
RNActi | P50276, protein |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUP1_YEAST | |
Accessioni | P50276Primary (citable) accession number: P50276 Secondary accession number(s): D6VUJ0, Q45U31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names