Anaphase spindle elongation protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• microtubule binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins."
    Schuyler S.C., Liu J.Y., Pellman D.
    J Cell Biol 160:517-528(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• initial mitotic spindle pole body separation Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins."
    Crasta K., Huang P., Morgan G., Winey M., Surana U.
    EMBO J 25:2551-2563(2006) [PubMed] [Europe PMC] [Abstract]
• microtubule bundle formation Source: SGDInferred from direct assayⁱ
  • "The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins."
    Schuyler S.C., Liu J.Y., Pellman D.
    J Cell Biol 160:517-528(2003) [PubMed] [Europe PMC] [Abstract]
• microtubule cytoskeleton organization Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mitotic cytokinesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mitotic spindle elongation Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins."
    Schuyler S.C., Liu J.Y., Pellman D.
    J Cell Biol 160:517-528(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae."
    Pellman D., Bagget M., Tu Y.H., Fink G.R.
    J. Cell Biol. 130:1373-1385(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
• mitotic spindle midzone assembly Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mitotic spindle organization Source: SGDInferred from mutant phenotypeⁱ
  • "APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle."
    Juang Y.L., Huang J., Peters J.M., McLaughlin M.E., Tai C.Y., Pellman D.
    Science 275:1311-1314(1997) [PubMed] [Europe PMC] [Abstract]
• septum digestion after cytokinesis Source: SGDInferred from mutant phenotypeⁱ
  • "The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage."
    Norden C., Mendoza M., Dobbelaere J., Kotwaliwale C.V., Biggins S., Barral Y.
    Cell 125:85-98(2006) [PubMed] [Europe PMC] [Abstract]
• spindle midzone assembly Source: SGDInferred from mutant phenotypeⁱ
  • "Cdc14-regulated midzone assembly controls anaphase B."
    Khmelinskii A., Lawrence C., Roostalu J., Schiebel E.
    J. Cell Biol. 177:981-993(2007) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• microtubule binding Source: SGDInferred from direct assayⁱ
  • "The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins."
    Schuyler S.C., Liu J.Y., Pellman D.
    J Cell Biol 160:517-528(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
METATSSPLP IKSRRNSENS GSTTVIPHMN PSLATPLTVS TMVNQSNSKE 
        60         70         80         90        100
FMKLTPVRIR DFGSPLKNVS TNYHFLDSEN GKGNTMDNMY RENFILISKD 
       110        120        130        140        150
LEKLLENLNV IYQNIGYSNT EIITKEKIIF TTISNSIKQF FEQADEELKR 
       160        170        180        190        200
LSAENGIEQD ILNNILERIN DPSGIKTIPD LYIRNAILLQ ESKTVPQSPK 
       210        220        230        240        250
KPLSLLSKKA ALDTAKKFVL GSFLPRLRDY LKSLITLKHL IQSVKENLPG 
       260        270        280        290        300
LTEADNEAIA EFPELSTLTA YLLQIENGKG DIGLSMKFII DNRKDILKGS 
       310        320        330        340        350
AFKTINEESV KHMNEVIKIY EEEYERRFKS VLTKKVSISS ICEQLGTPLA 
       360        370        380        390        400
TLIGEDFEQD LRSYGEEENS TSEIPNFHPV DRERMSKIDI TLEKLQAIHK 
       410        420        430        440        450
ERADKKRLLM EQCQKLWTRL KISQEYIKTF MRNNSSLSTE SLGRISKEVM 
       460        470        480        490        500
RLEAMKKKLI KKLISDSWDK IQELWRTLQY SEESRSKFII VFEELRNSAT 
       510        520        530        540        550
TLQEDELLLE TCENELKRLE EKLTLYKPIL KLISDFESLQ EDQEFLERSS 
       560        570        580        590        600
KDSSRLLSRN SHKILLTEEK MRKRITRHFP RVINDLRIKL EEADGLFDQP 
       610        620        630        640        650
FLFKGKPLSE AIDIQQQEIE AKYPRCRVRM QRSKKGKCGA NKENKVIKNT 
       660        670        680        690        700
FKATESSIRV PIGLNLNDAN ITYKTPSKKT IQGLTKNDLS QENSLARHMQ 
       710        720        730        740        750
GTTKLSSPNR RATRLLAPTV ISRNSKGNIE RPTLNRNRSS DLSSSPRINH 
       760        770        780        790        800
THGEHAVKPR QLFPIPLNKV DTKGSHIPQL TKEKALELLK RSTGTTGKEN 
       810        820        830        840        850
VRSPERKSSL EDYAQKLSSP YKEPEHSIYK LSMSPEGKFQ LNIQQKDIES 
       860        870        880 
GFDDTSMMED ENDKDFITWK NEQVSKLNGF SFTDI                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast chromosome XV
   Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
2. SIMILARITY comments
   Index of protein domains and families
3. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD