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Entry version 132 (13 Feb 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Anaphase spindle elongation protein

Gene

ASE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for anaphase spindle elongation.1 Publication

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: SGD

GO - Biological processi

  • microtubule bundle formation Source: SGD
  • mitotic spindle elongation Source: SGD
  • mitotic spindle organization Source: SGD
  • mitotic spindle pole body separation Source: SGD
  • septum digestion after cytokinesis Source: SGD
  • spindle midzone assembly Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33598-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase spindle elongation protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASE1
Ordered Locus Names:YOR058C
ORF Names:YOR29-09
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YOR058C

Saccharomyces Genome Database

More...
SGDi
S000005584 ASE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646941 – 885Anaphase spindle elongation proteinAdd BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P50275

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50275

PRoteomics IDEntifications database

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PRIDEi
P50275

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P50275

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50275

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDC48; the interaction is likely to result in CDC5 degradation.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
34456, 275 interactors

Database of interacting proteins

More...
DIPi
DIP-7343N

Protein interaction database and analysis system

More...
IntActi
P50275, 2 interactors

Molecular INTeraction database

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MINTi
P50275

STRING: functional protein association networks

More...
STRINGi
4932.YOR058C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P50275

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50275

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAP65/ASE1 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000034091

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P50275

KEGG Orthology (KO)

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KOi
K16732

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECEWLRQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007145 MAP65_Ase1_PRC1

The PANTHER Classification System

More...
PANTHERi
PTHR19321 PTHR19321, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50275-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METATSSPLP IKSRRNSENS GSTTVIPHMN PSLATPLTVS TMVNQSNSKE
60 70 80 90 100
FMKLTPVRIR DFGSPLKNVS TNYHFLDSEN GKGNTMDNMY RENFILISKD
110 120 130 140 150
LEKLLENLNV IYQNIGYSNT EIITKEKIIF TTISNSIKQF FEQADEELKR
160 170 180 190 200
LSAENGIEQD ILNNILERIN DPSGIKTIPD LYIRNAILLQ ESKTVPQSPK
210 220 230 240 250
KPLSLLSKKA ALDTAKKFVL GSFLPRLRDY LKSLITLKHL IQSVKENLPG
260 270 280 290 300
LTEADNEAIA EFPELSTLTA YLLQIENGKG DIGLSMKFII DNRKDILKGS
310 320 330 340 350
AFKTINEESV KHMNEVIKIY EEEYERRFKS VLTKKVSISS ICEQLGTPLA
360 370 380 390 400
TLIGEDFEQD LRSYGEEENS TSEIPNFHPV DRERMSKIDI TLEKLQAIHK
410 420 430 440 450
ERADKKRLLM EQCQKLWTRL KISQEYIKTF MRNNSSLSTE SLGRISKEVM
460 470 480 490 500
RLEAMKKKLI KKLISDSWDK IQELWRTLQY SEESRSKFII VFEELRNSAT
510 520 530 540 550
TLQEDELLLE TCENELKRLE EKLTLYKPIL KLISDFESLQ EDQEFLERSS
560 570 580 590 600
KDSSRLLSRN SHKILLTEEK MRKRITRHFP RVINDLRIKL EEADGLFDQP
610 620 630 640 650
FLFKGKPLSE AIDIQQQEIE AKYPRCRVRM QRSKKGKCGA NKENKVIKNT
660 670 680 690 700
FKATESSIRV PIGLNLNDAN ITYKTPSKKT IQGLTKNDLS QENSLARHMQ
710 720 730 740 750
GTTKLSSPNR RATRLLAPTV ISRNSKGNIE RPTLNRNRSS DLSSSPRINH
760 770 780 790 800
THGEHAVKPR QLFPIPLNKV DTKGSHIPQL TKEKALELLK RSTGTTGKEN
810 820 830 840 850
VRSPERKSSL EDYAQKLSSP YKEPEHSIYK LSMSPEGKFQ LNIQQKDIES
860 870 880
GFDDTSMMED ENDKDFITWK NEQVSKLNGF SFTDI
Length:885
Mass (Da):101,624
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EDE11E887E89207
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U20235 Genomic DNA Translation: AAA75026.1
Z74966 Genomic DNA Translation: CAA99251.1
Z70678 Genomic DNA Translation: CAA94543.1
BK006948 Genomic DNA Translation: DAA10837.1

Protein sequence database of the Protein Information Resource

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PIRi
S59660

NCBI Reference Sequences

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RefSeqi
NP_116582.1, NM_001183477.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR058C_mRNA; YOR058C_mRNA; YOR058C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR058C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20235 Genomic DNA Translation: AAA75026.1
Z74966 Genomic DNA Translation: CAA99251.1
Z70678 Genomic DNA Translation: CAA94543.1
BK006948 Genomic DNA Translation: DAA10837.1
PIRiS59660
RefSeqiNP_116582.1, NM_001183477.1

3D structure databases

ProteinModelPortaliP50275
SMRiP50275
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34456, 275 interactors
DIPiDIP-7343N
IntActiP50275, 2 interactors
MINTiP50275
STRINGi4932.YOR058C

PTM databases

iPTMnetiP50275

Proteomic databases

MaxQBiP50275
PaxDbiP50275
PRIDEiP50275
TopDownProteomicsiP50275

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR058C_mRNA; YOR058C_mRNA; YOR058C
GeneIDi854223
KEGGisce:YOR058C

Organism-specific databases

EuPathDBiFungiDB:YOR058C
SGDiS000005584 ASE1

Phylogenomic databases

GeneTreeiENSGT00390000009453
HOGENOMiHOG000034091
InParanoidiP50275
KOiK16732
OMAiECEWLRQ

Enzyme and pathway databases

BioCyciYEAST:G3O-33598-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P50275

Family and domain databases

InterProiView protein in InterPro
IPR007145 MAP65_Ase1_PRC1
PANTHERiPTHR19321 PTHR19321, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASE1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50275
Secondary accession number(s): D6W2C1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 13, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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