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Entry version 116 (16 Jan 2019)
Sequence version 2 (01 Mar 2005)
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Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mt:CoII
Synonyms:CoII
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila simulans (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000304 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0012878 Dsim\mt:CoII

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 48HelicalSequence analysisAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 228Mitochondrial intermembraneSequence analysisAdd BLAST146

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001835851 – 228Cytochrome c oxidase subunit 2Add BLAST228

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P50253

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P50253

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K02261

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13912 CcO_II_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.90, 1 hit
2.60.40.420, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02866 CoxB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY
60 70 80 90 100
VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNIEFDS YMIPTNELTT DGFRLLDVDN RVILPMNSQI
160 170 180 190 200
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC
210 220
GANHSFMPIV IESVPVNHFI KWISSNNS
Length:228
Mass (Da):26,148
Last modified:March 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7C1A3EE91730B85
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD13956 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti25D → A in strain: 14021-0251.0. 1 Publication1
Natural varianti115N → S in strain: HW00, HW09, NC37, NC48, TT00 and TT01. 1 Publication1
Natural varianti118F → Y in strain: MD106, MD225 and RU35. 2 Publications1
Natural varianti129T → S in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications1
Natural varianti130T → I in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications1
Natural varianti165V → I in strain: AU023, C167, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 3 Publications1
Natural varianti218H → N in strain: 14021-0251.0. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S64977 Genomic DNA Translation: AAD13956.2 Different initiation.
AF474082 Genomic DNA Translation: AAL83266.1
AY370272 Genomic DNA Translation: AAR21759.1
AY370273 Genomic DNA Translation: AAR21760.1
AY370274 Genomic DNA Translation: AAR21761.1
AY370275 Genomic DNA Translation: AAR21762.1
AY370276 Genomic DNA Translation: AAR21763.1
AY370277 Genomic DNA Translation: AAR21764.1
AY370278 Genomic DNA Translation: AAR21765.1
AY370279 Genomic DNA Translation: AAR21766.1
AY370280 Genomic DNA Translation: AAR21767.1
AY370281 Genomic DNA Translation: AAR21768.1
AY370282 Genomic DNA Translation: AAR21769.1
AY370283 Genomic DNA Translation: AAR21770.1
AY370284 Genomic DNA Translation: AAR21771.1
AY370285 Genomic DNA Translation: AAR21772.1
AY370286 Genomic DNA Translation: AAR21773.1
AY370287 Genomic DNA Translation: AAR21774.1
AY370288 Genomic DNA Translation: AAR21775.1
AY370289 Genomic DNA Translation: AAR21776.1
AY370290 Genomic DNA Translation: AAR21777.1
AY370291 Genomic DNA Translation: AAR21778.1
AY370292 Genomic DNA Translation: AAR21779.1
AY370293 Genomic DNA Translation: AAR21780.1
AY370294 Genomic DNA Translation: AAR21781.1
AY370295 Genomic DNA Translation: AAR21782.1
AY370296 Genomic DNA Translation: AAR21783.1
AY370297 Genomic DNA Translation: AAR21784.1
AY370298 Genomic DNA Translation: AAR21785.1
AY370299 Genomic DNA Translation: AAR21786.1
AY370300 Genomic DNA Translation: AAR21787.1
AY370301 Genomic DNA Translation: AAR21788.1
AY370302 Genomic DNA Translation: AAR21789.1
AY370303 Genomic DNA Translation: AAR21790.1
AY370304 Genomic DNA Translation: AAR21791.1
AY370305 Genomic DNA Translation: AAR21792.1
AY370306 Genomic DNA Translation: AAR21793.1
AY370307 Genomic DNA Translation: AAR21794.1
AY370308 Genomic DNA Translation: AAR21795.1
AY370309 Genomic DNA Translation: AAR21796.1
AY370310 Genomic DNA Translation: AAR21797.1
AY370311 Genomic DNA Translation: AAR21798.1
AY370312 Genomic DNA Translation: AAR21799.1
AY370313 Genomic DNA Translation: AAR21800.1
AY370314 Genomic DNA Translation: AAR21801.1
AY370315 Genomic DNA Translation: AAR21802.1
AY370316 Genomic DNA Translation: AAR21803.1
AY370317 Genomic DNA Translation: AAR21804.1
AY370318 Genomic DNA Translation: AAR21805.1
AY370319 Genomic DNA Translation: AAR21806.1
AY370320 Genomic DNA Translation: AAR21807.1
AY370321 Genomic DNA Translation: AAR21808.1
AY370322 Genomic DNA Translation: AAR21809.1
AY370323 Genomic DNA Translation: AAR21810.1
AY370324 Genomic DNA Translation: AAR21811.1
AY370325 Genomic DNA Translation: AAR21812.1
AY370326 Genomic DNA Translation: AAR21813.1
AY370327 Genomic DNA Translation: AAR21814.1
AY370328 Genomic DNA Translation: AAR21815.1
AY370329 Genomic DNA Translation: AAR21816.1
AY370330 Genomic DNA Translation: AAR21817.1
AY370331 Genomic DNA Translation: AAR21818.1
AY370332 Genomic DNA Translation: AAR21819.1
AY370333 Genomic DNA Translation: AAR21820.1
AY370334 Genomic DNA Translation: AAR21821.1
AY370335 Genomic DNA Translation: AAR21822.1
AY370336 Genomic DNA Translation: AAR21823.1
AY370337 Genomic DNA Translation: AAR21824.1
AY370338 Genomic DNA Translation: AAR21825.1
AY370339 Genomic DNA Translation: AAR21826.1
AY370340 Genomic DNA Translation: AAR21827.1
AY370341 Genomic DNA Translation: AAR21828.1
AY370342 Genomic DNA Translation: AAR21829.1
AY370343 Genomic DNA Translation: AAR21830.1
AY370344 Genomic DNA Translation: AAR21831.1
AY370345 Genomic DNA Translation: AAR21832.1
AY370346 Genomic DNA Translation: AAR21833.1
AY370347 Genomic DNA Translation: AAR21834.1
AY370348 Genomic DNA Translation: AAR21835.1
AY370349 Genomic DNA Translation: AAR21836.1
AY370350 Genomic DNA Translation: AAR21837.1
AY518670 Genomic DNA Translation: AAR91395.1
AY518671 Genomic DNA Translation: AAR91403.1
AY518672 Genomic DNA Translation: AAR91416.1
AY518673 Genomic DNA Translation: AAR91429.1
AY518674 Genomic DNA Translation: AAR91442.1
GQ222022 Genomic DNA Translation: ACT09365.1
AF200833 Genomic DNA Translation: AAF77297.1
AF200834 Genomic DNA Translation: AAF77311.1
AF200835 Genomic DNA Translation: AAF77318.1
AF200836 Genomic DNA Translation: AAF77331.1
AF200837 Genomic DNA Translation: AAF77344.1
AF200838 Genomic DNA Translation: AAF77357.1
AF200839 Genomic DNA Translation: AAF77371.1
AF200840 Genomic DNA Translation: AAF77383.1
AF200841 Genomic DNA Translation: AAF77396.1
AF200842 Genomic DNA Translation: AAF77414.1
AF200843 Genomic DNA Translation: AAF77422.1
AF200844 Genomic DNA Translation: AAF77435.1
AF200845 Genomic DNA Translation: AAF77448.1
AF200846 Genomic DNA Translation: AAF77461.1
AF200847 Genomic DNA Translation: AAF77474.1
AF200848 Genomic DNA Translation: AAF77487.1
AF200849 Genomic DNA Translation: AAF77501.1
AF200850 Genomic DNA Translation: AAF77513.1
AF200851 Genomic DNA Translation: AAF77527.1
AF200852 Genomic DNA Translation: AAF77539.1
AF200853 Genomic DNA Translation: AAF77552.1
AF200854 Genomic DNA Translation: AAF77565.1

NCBI Reference Sequences

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RefSeqi
NP_982324.1, NC_005781.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
2760956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dsi:COX2

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64977 Genomic DNA Translation: AAD13956.2 Different initiation.
AF474082 Genomic DNA Translation: AAL83266.1
AY370272 Genomic DNA Translation: AAR21759.1
AY370273 Genomic DNA Translation: AAR21760.1
AY370274 Genomic DNA Translation: AAR21761.1
AY370275 Genomic DNA Translation: AAR21762.1
AY370276 Genomic DNA Translation: AAR21763.1
AY370277 Genomic DNA Translation: AAR21764.1
AY370278 Genomic DNA Translation: AAR21765.1
AY370279 Genomic DNA Translation: AAR21766.1
AY370280 Genomic DNA Translation: AAR21767.1
AY370281 Genomic DNA Translation: AAR21768.1
AY370282 Genomic DNA Translation: AAR21769.1
AY370283 Genomic DNA Translation: AAR21770.1
AY370284 Genomic DNA Translation: AAR21771.1
AY370285 Genomic DNA Translation: AAR21772.1
AY370286 Genomic DNA Translation: AAR21773.1
AY370287 Genomic DNA Translation: AAR21774.1
AY370288 Genomic DNA Translation: AAR21775.1
AY370289 Genomic DNA Translation: AAR21776.1
AY370290 Genomic DNA Translation: AAR21777.1
AY370291 Genomic DNA Translation: AAR21778.1
AY370292 Genomic DNA Translation: AAR21779.1
AY370293 Genomic DNA Translation: AAR21780.1
AY370294 Genomic DNA Translation: AAR21781.1
AY370295 Genomic DNA Translation: AAR21782.1
AY370296 Genomic DNA Translation: AAR21783.1
AY370297 Genomic DNA Translation: AAR21784.1
AY370298 Genomic DNA Translation: AAR21785.1
AY370299 Genomic DNA Translation: AAR21786.1
AY370300 Genomic DNA Translation: AAR21787.1
AY370301 Genomic DNA Translation: AAR21788.1
AY370302 Genomic DNA Translation: AAR21789.1
AY370303 Genomic DNA Translation: AAR21790.1
AY370304 Genomic DNA Translation: AAR21791.1
AY370305 Genomic DNA Translation: AAR21792.1
AY370306 Genomic DNA Translation: AAR21793.1
AY370307 Genomic DNA Translation: AAR21794.1
AY370308 Genomic DNA Translation: AAR21795.1
AY370309 Genomic DNA Translation: AAR21796.1
AY370310 Genomic DNA Translation: AAR21797.1
AY370311 Genomic DNA Translation: AAR21798.1
AY370312 Genomic DNA Translation: AAR21799.1
AY370313 Genomic DNA Translation: AAR21800.1
AY370314 Genomic DNA Translation: AAR21801.1
AY370315 Genomic DNA Translation: AAR21802.1
AY370316 Genomic DNA Translation: AAR21803.1
AY370317 Genomic DNA Translation: AAR21804.1
AY370318 Genomic DNA Translation: AAR21805.1
AY370319 Genomic DNA Translation: AAR21806.1
AY370320 Genomic DNA Translation: AAR21807.1
AY370321 Genomic DNA Translation: AAR21808.1
AY370322 Genomic DNA Translation: AAR21809.1
AY370323 Genomic DNA Translation: AAR21810.1
AY370324 Genomic DNA Translation: AAR21811.1
AY370325 Genomic DNA Translation: AAR21812.1
AY370326 Genomic DNA Translation: AAR21813.1
AY370327 Genomic DNA Translation: AAR21814.1
AY370328 Genomic DNA Translation: AAR21815.1
AY370329 Genomic DNA Translation: AAR21816.1
AY370330 Genomic DNA Translation: AAR21817.1
AY370331 Genomic DNA Translation: AAR21818.1
AY370332 Genomic DNA Translation: AAR21819.1
AY370333 Genomic DNA Translation: AAR21820.1
AY370334 Genomic DNA Translation: AAR21821.1
AY370335 Genomic DNA Translation: AAR21822.1
AY370336 Genomic DNA Translation: AAR21823.1
AY370337 Genomic DNA Translation: AAR21824.1
AY370338 Genomic DNA Translation: AAR21825.1
AY370339 Genomic DNA Translation: AAR21826.1
AY370340 Genomic DNA Translation: AAR21827.1
AY370341 Genomic DNA Translation: AAR21828.1
AY370342 Genomic DNA Translation: AAR21829.1
AY370343 Genomic DNA Translation: AAR21830.1
AY370344 Genomic DNA Translation: AAR21831.1
AY370345 Genomic DNA Translation: AAR21832.1
AY370346 Genomic DNA Translation: AAR21833.1
AY370347 Genomic DNA Translation: AAR21834.1
AY370348 Genomic DNA Translation: AAR21835.1
AY370349 Genomic DNA Translation: AAR21836.1
AY370350 Genomic DNA Translation: AAR21837.1
AY518670 Genomic DNA Translation: AAR91395.1
AY518671 Genomic DNA Translation: AAR91403.1
AY518672 Genomic DNA Translation: AAR91416.1
AY518673 Genomic DNA Translation: AAR91429.1
AY518674 Genomic DNA Translation: AAR91442.1
GQ222022 Genomic DNA Translation: ACT09365.1
AF200833 Genomic DNA Translation: AAF77297.1
AF200834 Genomic DNA Translation: AAF77311.1
AF200835 Genomic DNA Translation: AAF77318.1
AF200836 Genomic DNA Translation: AAF77331.1
AF200837 Genomic DNA Translation: AAF77344.1
AF200838 Genomic DNA Translation: AAF77357.1
AF200839 Genomic DNA Translation: AAF77371.1
AF200840 Genomic DNA Translation: AAF77383.1
AF200841 Genomic DNA Translation: AAF77396.1
AF200842 Genomic DNA Translation: AAF77414.1
AF200843 Genomic DNA Translation: AAF77422.1
AF200844 Genomic DNA Translation: AAF77435.1
AF200845 Genomic DNA Translation: AAF77448.1
AF200846 Genomic DNA Translation: AAF77461.1
AF200847 Genomic DNA Translation: AAF77474.1
AF200848 Genomic DNA Translation: AAF77487.1
AF200849 Genomic DNA Translation: AAF77501.1
AF200850 Genomic DNA Translation: AAF77513.1
AF200851 Genomic DNA Translation: AAF77527.1
AF200852 Genomic DNA Translation: AAF77539.1
AF200853 Genomic DNA Translation: AAF77552.1
AF200854 Genomic DNA Translation: AAF77565.1
RefSeqiNP_982324.1, NC_005781.1

3D structure databases

ProteinModelPortaliP50253
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP50253

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2760956
KEGGidsi:COX2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4513
FlyBaseiFBgn0012878 Dsim\mt:CoII

Phylogenomic databases

KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX2_DROSI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50253
Secondary accession number(s): C6KI55
, Q6UHJ8, Q6UHP0, Q8SGU5, Q9MD62, Q9MD70, Q9MDM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 1, 2005
Last modified: January 16, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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