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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei184NADUniRule annotation1
Binding sitei236NADUniRule annotation1
Binding sitei271NADUniRule annotation1
Binding sitei339NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 152NADUniRule annotation3
Nucleotide bindingi213 – 218NADUniRule annotation6
Nucleotide bindingi292 – 294NADUniRule annotation3

GO - Molecular functioni

  • adenosylhomocysteinase activity Source: GO_Central
  • NAD binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi3.3.1.1 6163
UniPathwayi
UPA00314;UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:SSO0755
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170151 – 417AdenosylhomocysteinaseAdd BLAST417

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0755

Structurei

3D structure databases

ProteinModelPortaliP50252
SMRiP50252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137 Archaea
COG0499 LUCA
HOGENOMiHOG000227987
InParanoidiP50252
KOiK01251
OMAiTGNRDII
OrthoDBiPOG093Z03XF

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 2 hits
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50252-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYKIKDLSL ASEGKKQIEW AERHMPTLME IRKRFKAEKP LKGINISAVL
60 70 80 90 100
HVTKETAALV KTLKIGGANV ALAGSNPLST QDDVAAALVE EGISVFAWKG
110 120 130 140 150
ENETEYYSNI ESIVKIHEPN IVMDDGADLH AYIHEKVSSK LDIYGGTEET
160 170 180 190 200
TTGVIRLKAM EKDGVLKYPL VAVNNAYTKY LFDNRYGTGQ SAIDGILRAT
210 220 230 240 250
NILIAGKIAV VAGYGWVGRG IANRLRGMGA RVIVTEVDPI RALEAVMDGF
260 270 280 290 300
DVMPIAEASK VGDIFVTATG NTKAIRVEHM LNMKDGAILS NAGHFNVEVD
310 320 330 340 350
VKGLKETAVK VRNIRPYVDE YTLPNGKRVY LLADGRLVNL AAAEGHPSEV
360 370 380 390 400
MDMSFANQAL AVEYLVKNRG KLEKKVYNMP MELDYEVARI KLKSMGIQID
410
ELTEEQKEYL EQWKSGT
Length:417
Mass (Da):45,965
Last modified:October 1, 1996 - v1
Checksum:i7CD55A391ED7B4C9
GO

Sequence cautioni

The sequence AAK41050 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB57547 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50174 Genomic DNA Translation: CAA90536.1
Y18930 Genomic DNA Translation: CAB57547.1 Different initiation.
AE006641 Genomic DNA Translation: AAK41050.1 Different initiation.
PIRiC90224
JC5156 S58193
RefSeqiWP_009991332.1, NZ_CP011056.1

Genome annotation databases

EnsemblBacteriaiAAK41050; AAK41050; SSO0755
GeneIDi25404287
KEGGisso:SSO0755
PATRICifig|273057.12.peg.752

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50174 Genomic DNA Translation: CAA90536.1
Y18930 Genomic DNA Translation: CAB57547.1 Different initiation.
AE006641 Genomic DNA Translation: AAK41050.1 Different initiation.
PIRiC90224
JC5156 S58193
RefSeqiWP_009991332.1, NZ_CP011056.1

3D structure databases

ProteinModelPortaliP50252
SMRiP50252
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0755

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41050; AAK41050; SSO0755
GeneIDi25404287
KEGGisso:SSO0755
PATRICifig|273057.12.peg.752

Phylogenomic databases

eggNOGiarCOG04137 Archaea
COG0499 LUCA
HOGENOMiHOG000227987
InParanoidiP50252
KOiK01251
OMAiTGNRDII
OrthoDBiPOG093Z03XF

Enzyme and pathway databases

UniPathwayi
UPA00314;UER00076

BRENDAi3.3.1.1 6163

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 2 hits
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAHH_SULSO
AccessioniPrimary (citable) accession number: P50252
Secondary accession number(s): Q9UXE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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