UniProtKB - P50230 (CCL4_RAT)
Protein
C-C motif chemokine 4
Gene
Ccl4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Monokine with inflammatory and chemokinetic properties.
GO - Molecular functioni
- CCR1 chemokine receptor binding Source: RGD
- CCR5 chemokine receptor binding Source: RGD
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: RGD
- identical protein binding Source: RGD
GO - Biological processi
- cellular response to drug Source: RGD
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- eosinophil chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: RGD
- leukocyte chemotaxis Source: RGD
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- negative regulation by host of viral transcription Source: RGD
- neutrophil chemotaxis Source: GO_Central
- positive regulation of calcium ion transport Source: RGD
- positive regulation of calcium-mediated signaling Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of natural killer cell chemotaxis Source: RGD
- positive regulation of tumor necrosis factor production Source: RGD
- positive regulation of vascular permeability Source: RGD
- response to toxic substance Source: RGD
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 4Alternative name(s): Macrophage inflammatory protein 1-beta Short name: MIP-1-beta Small-inducible cytokine A4 |
Gene namesi | Name:Ccl4 Synonyms:Mip1b, Scya4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620441, Ccl4 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000005167 | 24 – 92 | C-C motif chemokine 4Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 58 | By similarity | ||
Disulfide bondi | 35 ↔ 74 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P50230 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- CCR1 chemokine receptor binding Source: RGD
- CCR5 chemokine receptor binding Source: RGD
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: RGD
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015199 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
InParanoidi | P50230 |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P50230 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P50230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD
60 70 80 90
YYETSSLCSQ PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V7I1 | G3V7I1_RAT | C-C motif chemokine | Ccl4 rCG_33576 | 92 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06434 mRNA Translation: AAA96497.1 EF121996 mRNA Translation: ABL63435.1 EF121997 mRNA Translation: ABL63436.1 |
RefSeqi | NP_446310.1, NM_053858.1 |
Genome annotation databases
GeneIDi | 116637 |
KEGGi | rno:116637 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06434 mRNA Translation: AAA96497.1 EF121996 mRNA Translation: ABL63435.1 EF121997 mRNA Translation: ABL63436.1 |
RefSeqi | NP_446310.1, NM_053858.1 |
3D structure databases
SMRi | P50230 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015199 |
Proteomic databases
PaxDbi | P50230 |
Genome annotation databases
GeneIDi | 116637 |
KEGGi | rno:116637 |
Organism-specific databases
CTDi | 6351 |
RGDi | 620441, Ccl4 |
Phylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
InParanoidi | P50230 |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P50230 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P50230 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL4_RAT | |
Accessioni | P50230Primary (citable) accession number: P50230 Secondary accession number(s): A1EC89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families