UniProtKB - P50228 (CXCL5_MOUSE)
Protein
C-X-C motif chemokine 5
Gene
Cxcl5
Organism
Mus musculus (Mouse)
Status
Functioni
May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation.1 Publication
GO - Molecular functioni
- chemokine activity Source: MGI
- CXCR chemokine receptor binding Source: GO_Central
GO - Biological processi
- animal organ regeneration Source: MGI
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- chemokine-mediated signaling pathway Source: GO_Central
- inflammatory response Source: MGI
- leukocyte homeostasis Source: MGI
- neutrophil activation Source: MGI
- neutrophil chemotaxis Source: MGI
- positive regulation of neuron projection development Source: MGI
- positive regulation of receptor signaling pathway via JAK-STAT Source: MGI
- regulation of chemokine production Source: MGI
- regulation of neutrophil mediated killing of gram-negative bacterium Source: MGI
- response to lipopolysaccharide Source: MGI
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 5Alternative name(s): Cytokine LIX Small-inducible cytokine B5 Cleaved into the following 2 chains: |
Gene namesi | Name:Cxcl5 Synonyms:Scyb5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096868, Cxcl5 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | 1 PublicationAdd BLAST | 40 | |
ChainiPRO_0000005078 | 41 – 132 | C-X-C motif chemokine 5Add BLAST | 92 | |
ChainiPRO_0000005079 | 41 – 118 | GCP-2(1-78)Add BLAST | 78 | |
ChainiPRO_0000005080 | 49 – 118 | GCP-2(9-78)Add BLAST | 70 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 79 | By similarity | ||
Disulfide bondi | 55 ↔ 95 | By similarity |
Post-translational modificationi
GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states.2 Publications
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P50228 |
PRIDEi | P50228 |
ProteomicsDBi | 279221 |
PTM databases
iPTMneti | P50228 |
PhosphoSitePlusi | P50228 |
Expressioni
Inductioni
By lipopolysaccharide (LPS).
Gene expression databases
Bgeei | ENSMUSG00000029371, Expressed in fibroblast and 102 other tissues |
Genevisiblei | P50228, MM |
Interactioni
Subunit structurei
Monomer. Homodimer.
By similarityGO - Molecular functioni
- chemokine activity Source: MGI
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031318 |
Miscellaneous databases
RNActi | P50228, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000162749 |
HOGENOMi | CLU_143902_1_0_1 |
InParanoidi | P50228 |
OMAi | FPAGPQC |
OrthoDBi | 1556509at2759 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P50228-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLQLRSSAR IPSGSISPFM RMAPLAFLLL FTLPQHLAEA APSSVIAATE
60 70 80 90 100
LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA
110 120 130
PVIKKIIQKI LGSDKKKAKR NALAVERTAS VQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | R → H in AAC52238 (PubMed:7622488).Curated | 1 | |
Sequence conflicti | 10 | R → H in AAH24392 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 16 | I → S in AAC52238 (PubMed:7622488).Curated | 1 | |
Sequence conflicti | 16 | I → S in AAH24392 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 81 – 82 | TV → N AA sequence (PubMed:8759763).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27267 mRNA Translation: AAC52238.1 AY100019 Genomic DNA Translation: AAM48589.1 AC105995 Genomic DNA No translation available. BC024392 mRNA Translation: AAH24392.1 |
CCDSi | CCDS19414.1 |
PIRi | A57325 |
RefSeqi | NP_033167.2, NM_009141.3 |
Genome annotation databases
Ensembli | ENSMUST00000031318; ENSMUSP00000031318; ENSMUSG00000029371 |
GeneIDi | 20311 |
KEGGi | mmu:20311 |
UCSCi | uc008ybg.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27267 mRNA Translation: AAC52238.1 AY100019 Genomic DNA Translation: AAM48589.1 AC105995 Genomic DNA No translation available. BC024392 mRNA Translation: AAH24392.1 |
CCDSi | CCDS19414.1 |
PIRi | A57325 |
RefSeqi | NP_033167.2, NM_009141.3 |
3D structure databases
SMRi | P50228 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031318 |
PTM databases
iPTMneti | P50228 |
PhosphoSitePlusi | P50228 |
Proteomic databases
PaxDbi | P50228 |
PRIDEi | P50228 |
ProteomicsDBi | 279221 |
Protocols and materials databases
ABCDi | P50228, 2 sequenced antibodies |
Antibodypediai | 13323, 275 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031318; ENSMUSP00000031318; ENSMUSG00000029371 |
GeneIDi | 20311 |
KEGGi | mmu:20311 |
UCSCi | uc008ybg.2, mouse |
Organism-specific databases
CTDi | 6374 |
MGIi | MGI:1096868, Cxcl5 |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000162749 |
HOGENOMi | CLU_143902_1_0_1 |
InParanoidi | P50228 |
OMAi | FPAGPQC |
OrthoDBi | 1556509at2759 |
TreeFami | TF333433 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 20311, 1 hit in 53 CRISPR screens |
PROi | PR:P50228 |
RNActi | P50228, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029371, Expressed in fibroblast and 102 other tissues |
Genevisiblei | P50228, MM |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCL5_MOUSE | |
Accessioni | P50228Primary (citable) accession number: P50228 Secondary accession number(s): Q8K3I3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 3, 2012 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families