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Protein

Sulfotransferase 1A2

Gene

SULT1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi255 – 259PAPS5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCatecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS11091-MONOMER
BRENDAi2.8.2.1 2681
2.8.2.9 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKiP50226

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A2 (EC:2.8.2.1)
Short name:
ST1A2
Alternative name(s):
Aryl sulfotransferase 2
Phenol sulfotransferase 2
Phenol-sulfating phenol sulfotransferase 2
Short name:
P-PST 2
Gene namesi
Name:SULT1A2
Synonyms:STP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000197165.10
HGNCiHGNC:11454 SULT1A2
MIMi601292 gene
neXtProtiNX_P50226

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6799
OpenTargetsiENSG00000197165
PharmGKBiPA341

Chemistry databases

ChEMBLiCHEMBL1743292

Polymorphism and mutation databases

BioMutaiSULT1A2
DMDMi288558827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851281 – 295Sulfotransferase 1A2Add BLAST295

Proteomic databases

EPDiP50226
MaxQBiP50226
PaxDbiP50226
PeptideAtlasiP50226
PRIDEiP50226
ProteomicsDBi56211

PTM databases

iPTMnetiP50226
PhosphoSitePlusiP50226

Expressioni

Gene expression databases

BgeeiENSG00000197165 Expressed in 225 organ(s), highest expression level in duodenum
CleanExiHS_SULT1A2
ExpressionAtlasiP50226 baseline and differential
GenevisibleiP50226 HS

Organism-specific databases

HPAiHPA049500
HPA051051

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NIF3L1Q9GZT83EBI-6137631,EBI-740897

Protein-protein interaction databases

BioGridi112673, 9 interactors
IntActiP50226, 1 interactor
STRINGi9606.ENSP00000338742

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP50226
SMRiP50226
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50226

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP50226
KOiK01014
OMAiPLMAIPN
OrthoDBiEOG091G0D5F
PhylomeDBiP50226
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P50226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELIQDISRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKVPGIP SGMETLKNTP
110 120 130 140 150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVYP
160 170 180 190 200
HPGTWESFLE KFMAGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILEF VGRSLPEETV DLMVEHTSFK EMKKNPMTNY TTVRREFMDH
260 270 280 290
SISPFMRKGM AGDWKTTFTV AQNERFDADY AKKMAGCSLS FRSEL
Length:295
Mass (Da):34,310
Last modified:February 9, 2010 - v2
Checksum:iEB505BBDAA3A2E09
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKW4E9PKW4_HUMAN
Sulfotransferase
SULT1A2
262Annotation score:
E9PKR8E9PKR8_HUMAN
Sulfotransferase
SULT1A2
192Annotation score:
E9PM76E9PM76_HUMAN
Sulfotransferase
SULT1A2
221Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290S → T in AAC51149 (PubMed:9119390).Curated1
Sequence conflicti290S → T in ABX65442 (PubMed:9119390).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0074267I → T3 PublicationsCorresponds to variant dbSNP:rs1136703Ensembl.1
Natural variantiVAR_05734019P → L1 PublicationCorresponds to variant dbSNP:rs10797300Ensembl.1
Natural variantiVAR_05734162Y → F. Corresponds to variant dbSNP:rs4987024Ensembl.1
Natural variantiVAR_007427235N → T4 PublicationsCorresponds to variant dbSNP:rs1059491Ensembl.1
Natural variantiVAR_057342239N → S. Corresponds to variant dbSNP:rs45472392Ensembl.1
Natural variantiVAR_061887282K → E6 PublicationsCorresponds to variant dbSNP:rs27742Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28170 mRNA Translation: AAB09659.1
U28169 mRNA Translation: AAB09658.1
X78282 mRNA Translation: CAA55088.1
U34804 Genomic DNA Translation: AAB09758.1
U72202
, U72196, U72197, U72198, U72199, U72200, U72201 Genomic DNA Translation: AAB08970.1
U76619 Genomic DNA Translation: AAB18753.1
U33886 Genomic DNA Translation: AAC51149.1
U33886 Genomic DNA Translation: ABX65442.1
AC020765 Genomic DNA No translation available.
BC113727 mRNA Translation: AAI13728.1
BC113729 mRNA Translation: AAI13730.1
CCDSiCCDS10636.1
PIRiG01843
JC5249
S52791
RefSeqiNP_001045.1, NM_001054.3
NP_803564.1, NM_177528.2
UniGeneiHs.546304

Genome annotation databases

EnsembliENST00000335715; ENSP00000338742; ENSG00000197165
ENST00000395630; ENSP00000378992; ENSG00000197165
GeneIDi6799
KEGGihsa:6799
UCSCiuc002dqg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28170 mRNA Translation: AAB09659.1
U28169 mRNA Translation: AAB09658.1
X78282 mRNA Translation: CAA55088.1
U34804 Genomic DNA Translation: AAB09758.1
U72202
, U72196, U72197, U72198, U72199, U72200, U72201 Genomic DNA Translation: AAB08970.1
U76619 Genomic DNA Translation: AAB18753.1
U33886 Genomic DNA Translation: AAC51149.1
U33886 Genomic DNA Translation: ABX65442.1
AC020765 Genomic DNA No translation available.
BC113727 mRNA Translation: AAI13728.1
BC113729 mRNA Translation: AAI13730.1
CCDSiCCDS10636.1
PIRiG01843
JC5249
S52791
RefSeqiNP_001045.1, NM_001054.3
NP_803564.1, NM_177528.2
UniGeneiHs.546304

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z29X-ray2.40A1-295[»]
ProteinModelPortaliP50226
SMRiP50226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112673, 9 interactors
IntActiP50226, 1 interactor
STRINGi9606.ENSP00000338742

Chemistry databases

ChEMBLiCHEMBL1743292

PTM databases

iPTMnetiP50226
PhosphoSitePlusiP50226

Polymorphism and mutation databases

BioMutaiSULT1A2
DMDMi288558827

Proteomic databases

EPDiP50226
MaxQBiP50226
PaxDbiP50226
PeptideAtlasiP50226
PRIDEiP50226
ProteomicsDBi56211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335715; ENSP00000338742; ENSG00000197165
ENST00000395630; ENSP00000378992; ENSG00000197165
GeneIDi6799
KEGGihsa:6799
UCSCiuc002dqg.3 human

Organism-specific databases

CTDi6799
DisGeNETi6799
EuPathDBiHostDB:ENSG00000197165.10
GeneCardsiSULT1A2
HGNCiHGNC:11454 SULT1A2
HPAiHPA049500
HPA051051
MIMi601292 gene
neXtProtiNX_P50226
OpenTargetsiENSG00000197165
PharmGKBiPA341
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP50226
KOiK01014
OMAiPLMAIPN
OrthoDBiEOG091G0D5F
PhylomeDBiP50226
TreeFamiTF321745

Enzyme and pathway databases

BioCyciMetaCyc:HS11091-MONOMER
BRENDAi2.8.2.1 2681
2.8.2.9 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKiP50226

Miscellaneous databases

EvolutionaryTraceiP50226
GeneWikiiSULT1A2
GenomeRNAii6799
PROiPR:P50226
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197165 Expressed in 225 organ(s), highest expression level in duodenum
CleanExiHS_SULT1A2
ExpressionAtlasiP50226 baseline and differential
GenevisibleiP50226 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST1A2_HUMAN
AccessioniPrimary (citable) accession number: P50226
Secondary accession number(s): A9QY25, P78393, Q14CJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 9, 2010
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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