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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi255 – 259PAPS5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCatecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER
BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKiP50225

Chemistry databases

SwissLipidsiSLP:000001651

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase 1
HAST1/HAST2
Phenol sulfotransferase 1
Phenol-sulfating phenol sulfotransferase 1
Short name:
P-PST 1
ST1A3
Thermostable phenol sulfotransferase
Short name:
Ts-PST
Gene namesi
Name:SULT1A1
Synonyms:STP, STP1
ORF Names:OK/SW-cl.88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000196502.11
HGNCiHGNC:11453 SULT1A1
MIMi171150 gene
neXtProtiNX_P50225

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi70C → S: Increased sensitivity of enzyme activity to heat inactivation. 1 Publication1

Organism-specific databases

DisGeNETi6817
OpenTargetsiENSG00000196502
PharmGKBiPA343

Chemistry databases

ChEMBLiCHEMBL1743291
DrugBankiDB00316 Acetaminophen
DB01812 Adenosine-3'-5'-Diphosphate
DB04417 P-Nitrophenol
DB00675 Tamoxifen

Polymorphism and mutation databases

BioMutaiSULT1A1
DMDMi313104286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851271 – 295Sulfotransferase 1A1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50225
MaxQBiP50225
PaxDbiP50225
PeptideAtlasiP50225
PRIDEiP50225
ProteomicsDBi56209
56210 [P50225-2]

2D gel databases

OGPiP50225

PTM databases

iPTMnetiP50225
PhosphoSitePlusiP50225

Expressioni

Tissue specificityi

Liver, lung, adrenal, brain, platelets and skin.

Gene expression databases

BgeeiENSG00000196502 Expressed in 138 organ(s), highest expression level in right adrenal gland
CleanExiHS_SULT1A1
ExpressionAtlasiP50225 baseline and differential
GenevisibleiP50225 HS

Organism-specific databases

HPAiHPA049500
HPA051051

Interactioni

Subunit structurei

Homodimer.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SULT2B1O002046EBI-2814403,EBI-749441

Protein-protein interaction databases

BioGridi112686, 43 interactors
IntActiP50225, 5 interactors
STRINGi9606.ENSP00000321988

Chemistry databases

BindingDBiP50225

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP50225
SMRiP50225
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50225

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate binding3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP50225
KOiK01014
OMAiFAIMSRK
OrthoDBiEOG091G0D5F
PhylomeDBiP50225
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP
110 120 130 140 150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP
160 170 180 190 200
EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH
260 270 280 290
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,165
Last modified:November 30, 2010 - v3
Checksum:i7D4362A603A29176
GO
Isoform 2 (identifier: P50225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: MELIQDTSRP...PQTLLDQKVK → MLAKLLCDQV...LKQKFWNTYM

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,388
Checksum:i8A6A935E4DD11A6D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRY5H3BRY5_HUMAN
Sulfotransferase
SULT1A1
281Annotation score:
H3BQX5H3BQX5_HUMAN
Sulfotransferase
SULT1A1
169Annotation score:
H3BT96H3BT96_HUMAN
Sulfotransferase 1A1
SULT1A1
85Annotation score:
H3BMH9H3BMH9_HUMAN
Sulfotransferase 1A1
SULT1A1
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90P → L in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti146A → T in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti181E → G in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti243V → A in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAA99892 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAC50480 (PubMed:8924211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00930237R → Q1 PublicationCorresponds to variant dbSNP:rs72547527Ensembl.1
Natural variantiVAR_028721151E → D. Corresponds to variant dbSNP:rs1042014Ensembl.1
Natural variantiVAR_057339151E → Q. Corresponds to variant dbSNP:rs1042011Ensembl.1
Natural variantiVAR_007425213R → H in allele SULT1A1*2; common polymorphism; has a lower activity. 4 PublicationsCorresponds to variant dbSNP:rs1042028Ensembl.1
Natural variantiVAR_009303223V → MCombined sources14 PublicationsCorresponds to variant dbSNP:rs1801030Ensembl.1
Natural variantiVAR_014889235N → T. Corresponds to variant dbSNP:rs35728980Ensembl.1
Natural variantiVAR_061886282E → K2 PublicationsCorresponds to variant dbSNP:rs36043491Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401011 – 124MELIQ…DQKVK → MLAKLLCDQVVGAPIAVSAF YAGMSILQGKDDIFLDLKQK FWNTYM in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA Translation: AAA18613.1
L19955 mRNA Translation: AAA02935.1
L10819 mRNA Translation: AAA35562.1
L19999 mRNA Translation: AAA99892.1
U26309 mRNA Translation: AAA67895.1
X84654 mRNA Translation: CAA59147.1
X78283 mRNA Translation: CAA55089.1
U71086 Genomic DNA Translation: AAB09597.1
U54701 Genomic DNA Translation: AAC50480.1
AJ007418 mRNA Translation: CAA07495.1
U52852 Genomic DNA Translation: AAC51816.1
AB062428 mRNA Translation: BAB93491.1
BT007324 mRNA Translation: AAP35988.1
CR608214 mRNA No translation available.
AC020765 Genomic DNA No translation available.
BC000923 mRNA Translation: AAH00923.1
BC110887 mRNA Translation: AAI10888.1
L15346 Genomic DNA Translation: AAA60595.1
CCDSiCCDS10637.1 [P50225-2]
CCDS32420.1 [P50225-1]
PIRiI57945
JC2523
JC5248
S52399
S52794
RefSeqiNP_001046.2, NM_001055.3 [P50225-1]
NP_803565.1, NM_177529.2 [P50225-1]
NP_803566.1, NM_177530.2 [P50225-1]
NP_803878.1, NM_177534.2 [P50225-1]
NP_803880.1, NM_177536.3 [P50225-2]
XP_016879095.1, XM_017023606.1
XP_016879100.1, XM_017023611.1 [P50225-1]
XP_016879101.1, XM_017023612.1 [P50225-1]
XP_016879102.1, XM_017023613.1 [P50225-1]
UniGeneiHs.567342
Hs.736805

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDi6817
KEGGihsa:6817
UCSCiuc002dqi.4 human [P50225-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA Translation: AAA18613.1
L19955 mRNA Translation: AAA02935.1
L10819 mRNA Translation: AAA35562.1
L19999 mRNA Translation: AAA99892.1
U26309 mRNA Translation: AAA67895.1
X84654 mRNA Translation: CAA59147.1
X78283 mRNA Translation: CAA55089.1
U71086 Genomic DNA Translation: AAB09597.1
U54701 Genomic DNA Translation: AAC50480.1
AJ007418 mRNA Translation: CAA07495.1
U52852 Genomic DNA Translation: AAC51816.1
AB062428 mRNA Translation: BAB93491.1
BT007324 mRNA Translation: AAP35988.1
CR608214 mRNA No translation available.
AC020765 Genomic DNA No translation available.
BC000923 mRNA Translation: AAH00923.1
BC110887 mRNA Translation: AAI10888.1
L15346 Genomic DNA Translation: AAA60595.1
CCDSiCCDS10637.1 [P50225-2]
CCDS32420.1 [P50225-1]
PIRiI57945
JC2523
JC5248
S52399
S52794
RefSeqiNP_001046.2, NM_001055.3 [P50225-1]
NP_803565.1, NM_177529.2 [P50225-1]
NP_803566.1, NM_177530.2 [P50225-1]
NP_803878.1, NM_177534.2 [P50225-1]
NP_803880.1, NM_177536.3 [P50225-2]
XP_016879095.1, XM_017023606.1
XP_016879100.1, XM_017023611.1 [P50225-1]
XP_016879101.1, XM_017023612.1 [P50225-1]
XP_016879102.1, XM_017023613.1 [P50225-1]
UniGeneiHs.567342
Hs.736805

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS6X-ray1.90A1-295[»]
1Z28X-ray2.30A1-295[»]
2D06X-ray2.30A/B1-295[»]
3QVUX-ray2.50A/B1-295[»]
3QVVX-ray2.35A/B1-295[»]
3U3JX-ray2.70A/B1-294[»]
3U3KX-ray2.36A/B1-295[»]
3U3MX-ray2.30A1-295[»]
3U3OX-ray2.00A1-295[»]
3U3RX-ray2.36A1-295[»]
4GRAX-ray2.56A/B1-295[»]
ProteinModelPortaliP50225
SMRiP50225
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112686, 43 interactors
IntActiP50225, 5 interactors
STRINGi9606.ENSP00000321988

Chemistry databases

BindingDBiP50225
ChEMBLiCHEMBL1743291
DrugBankiDB00316 Acetaminophen
DB01812 Adenosine-3'-5'-Diphosphate
DB04417 P-Nitrophenol
DB00675 Tamoxifen
SwissLipidsiSLP:000001651

PTM databases

iPTMnetiP50225
PhosphoSitePlusiP50225

Polymorphism and mutation databases

BioMutaiSULT1A1
DMDMi313104286

2D gel databases

OGPiP50225

Proteomic databases

EPDiP50225
MaxQBiP50225
PaxDbiP50225
PeptideAtlasiP50225
PRIDEiP50225
ProteomicsDBi56209
56210 [P50225-2]

Protocols and materials databases

DNASUi6817
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDi6817
KEGGihsa:6817
UCSCiuc002dqi.4 human [P50225-1]

Organism-specific databases

CTDi6817
DisGeNETi6817
EuPathDBiHostDB:ENSG00000196502.11
GeneCardsiSULT1A1
H-InvDBiHIX0017846
HGNCiHGNC:11453 SULT1A1
HPAiHPA049500
HPA051051
MIMi171150 gene
neXtProtiNX_P50225
OpenTargetsiENSG00000196502
PharmGKBiPA343
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP50225
KOiK01014
OMAiFAIMSRK
OrthoDBiEOG091G0D5F
PhylomeDBiP50225
TreeFamiTF321745

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER
BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKiP50225

Miscellaneous databases

ChiTaRSiSULT1A1 human
EvolutionaryTraceiP50225
GeneWikiiSULT1A1
GenomeRNAii6817
PROiPR:P50225
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196502 Expressed in 138 organ(s), highest expression level in right adrenal gland
CleanExiHS_SULT1A1
ExpressionAtlasiP50225 baseline and differential
GenevisibleiP50225 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST1A1_HUMAN
AccessioniPrimary (citable) accession number: P50225
Secondary accession number(s): Q2NL71
, Q86U58, Q92818, Q9BVU6, Q9UGG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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