SULT1A1

Functionⁱ

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.2 Publications

Catalytic activityⁱ

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	108	Proton acceptorBy similarity	1
Binding siteⁱ	130	PAPS	1
Binding siteⁱ	138	PAPS	1
Binding siteⁱ	193	PAPS	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	48 – 53	PAPS	6
Nucleotide bindingⁱ	227 – 232	PAPS	6
Nucleotide bindingⁱ	255 – 259	PAPS	5

GO - Molecular functionⁱ

aryl sulfotransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12471039
flavonol 3-sulfotransferase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20056724
steroid sulfotransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16221673
sulfotransferase activity
Source: MGI
Inferred from direct assayⁱ
- 19548878

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

3'-phosphoadenosine 5'-phosphosulfate metabolic process
Source: CAFA
Inferred from direct assayⁱ
- 23207770
amine metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8661000
catecholamine metabolic process Source: UniProtKB-KW
estrogen metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16221673
ethanol catabolic process
Source: CAFA
Inferred from direct assayⁱ
- 23207770
flavonoid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 20056724
sulfation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20056724
xenobiotic metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12471039

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS09898-MONOMER
BRENDAⁱ	2.8.2.1 2681
Reactomeⁱ	R-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKⁱ	P50225

Chemistry databases

SwissLipidsⁱ	SLP:000001651

SwissLipidsⁱ

SLP:000001651

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sulfotransferase 1A1 (EC:2.8.2.1) Short name: ST1A1 Alternative name(s): Aryl sulfotransferase 1 HAST1/HAST2 Phenol sulfotransferase 1 Phenol-sulfating phenol sulfotransferase 1 Short name: P-PST 1 ST1A3 Thermostable phenol sulfotransferase Short name: Ts-PST
Gene namesⁱ	Name:SULT1A1 Synonyms:STP, STP1 ORF Names:OK/SW-cl.88
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196502.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11453 SULT1A1
MIMⁱ	171150 gene
neXtProtⁱ	NX_P50225

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	70	C → S: Increased sensitivity of enzyme activity to heat inactivation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6817
Open Targets More...OpenTargetsⁱ	ENSG00000196502
PharmGKBⁱ	PA343

Chemistry databases

ChEMBLⁱ	CHEMBL1743291
Drug and drug target database More...DrugBankⁱ	DB00316 Acetaminophen DB01812 Adenosine-3'-5'-Diphosphate DB04417 P-Nitrophenol DB00675 Tamoxifen

Polymorphism and mutation databases

BioMutaⁱ	SULT1A1
DMDMⁱ	313104286

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085127	1 – 295	Sulfotransferase 1A1Add BLAST		295

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	138	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P50225
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50225
PaxDbⁱ	P50225
PeptideAtlas More...PeptideAtlasⁱ	P50225
PRIDEⁱ	P50225
ProteomicsDBⁱ	56209 56210 [P50225-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P50225

OGPⁱ

P50225

PTM databases

iPTMnetⁱ	P50225
PhosphoSitePlusⁱ	P50225

Expressionⁱ

Tissue specificityⁱ

Liver, lung, adrenal, brain, platelets and skin.

Gene expression databases

Bgeeⁱ	ENSG00000196502 Expressed in 138 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_SULT1A1
ExpressionAtlasⁱ	P50225 baseline and differential
Genevisibleⁱ	P50225 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049500 HPA051051

HPAⁱ

HPA049500
HPA051051

Interactionⁱ

Subunit structureⁱ

Homodimer.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SULT2B1	O00204	6	EBI-2814403,EBI-749441

With

Entry

#Exp.

IntAct

Notes

SULT2B1

O00204

6

EBI-2814403,EBI-749441

Protein-protein interaction databases

BioGridⁱ	112686, 43 interactors
IntActⁱ	P50225, 5 interactors
STRINGⁱ	9606.ENSP00000321988

Chemistry databases

BindingDBⁱ

P50225

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	13 – 15	Combined sources	3
Beta strandⁱ	18 – 20	Combined sources	3
Helixⁱ	22 – 31	Combined sources	10
Beta strandⁱ	41 – 46	Combined sources	6
Helixⁱ	51 – 62	Combined sources	12
Turnⁱ	63 – 65	Combined sources	3
Helixⁱ	67 – 70	Combined sources	4
Helixⁱ	75 – 78	Combined sources	4
Beta strandⁱ	87 – 89	Combined sources	3
Helixⁱ	92 – 97	Combined sources	6
Beta strandⁱ	104 – 107	Combined sources	4
Turnⁱ	111 – 113	Combined sources	3
Helixⁱ	116 – 120	Combined sources	5
Beta strandⁱ	124 – 129	Combined sources	6
Helixⁱ	132 – 145	Combined sources	14
Helixⁱ	155 – 164	Combined sources	10
Helixⁱ	172 – 182	Combined sources	11
Turnⁱ	183 – 185	Combined sources	3
Beta strandⁱ	188 – 192	Combined sources	5
Helixⁱ	193 – 198	Combined sources	6
Helixⁱ	200 – 211	Combined sources	12
Helixⁱ	217 – 226	Combined sources	10
Helixⁱ	229 – 234	Combined sources	6
Turnⁱ	236 – 238	Combined sources	3
Turnⁱ	245 – 247	Combined sources	3
Turnⁱ	250 – 252	Combined sources	3
Helixⁱ	263 – 266	Combined sources	4
Helixⁱ	270 – 283	Combined sources	14
Turnⁱ	284 – 286	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P50225
SMRⁱ	P50225
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P50225

EvolutionaryTraceⁱ

P50225

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	106 – 108	Substrate binding		3

Sequence similaritiesⁱ

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1584 Eukaryota ENOG4111H56 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118932
HOGENOMⁱ	HOG000037209
HOVERGENⁱ	HBG001195
InParanoidⁱ	P50225
KEGG Orthology (KO) More...KOⁱ	K01014
OMAⁱ	FAIMSRK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D5F
PhylomeDBⁱ	P50225
TreeFamⁱ	TF321745

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR000863 Sulfotransferase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00685 Sulfotransfer_1, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P50225-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG 
        60         70         80         90        100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP 
       110        120        130        140        150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP 
       160        170        180        190        200
EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP 
       210        220        230        240        250
KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH 
       260        270        280        290 
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL

Length:295

Mass (Da):34,165

Last modified:November 30, 2010 - v3

Checksum:ⁱ7D4362A603A29176

GO

Isoform 2 (identifier: P50225-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-124: MELIQDTSRP...PQTLLDQKVK → MLAKLLCDQV...LKQKFWNTYM

« Hide

        10         20         30         40         50
MLAKLLCDQV VGAPIAVSAF YAGMSILQGK DDIFLDLKQK FWNTYMVVYV 
        60         70         80         90        100
ARNAKDVAVS YYHFYHMAKV HPEPGTWDSF LEKFMVGEVS YGSWYQHVQE 
       110        120        130        140        150
WWELSRTHPV LYLFYEDMKE NPKREIQKIL EFVGRSLPEE TVDFVVQHTS 
       160        170        180        190        200
FKEMKKNPMT NYTTVPQEFM DHSISPFMRK GMAGDWKTTF TVAQNERFDA 
       210 
DYAEKMAGCS LSFRSEL

Note: No experimental confirmation available.

Show »

Length:217

Mass (Da):25,388

Checksum:ⁱ8A6A935E4DD11A6D

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BRY5	H3BRY5_HUMAN	Sulfotransferase Sulfotransferase, EC 2.8.2.-	SULT1A1	281	Annotation score:
H3BQX5	H3BQX5_HUMAN	Sulfotransferase Sulfotransferase, EC 2.8.2.-	SULT1A1	169	Annotation score:
H3BT96	H3BT96_HUMAN	Sulfotransferase 1A1 Sulfotransferase 1A1	SULT1A1	85	Annotation score:
H3BMH9	H3BMH9_HUMAN	Sulfotransferase 1A1 Sulfotransferase 1A1	SULT1A1	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	90	P → L in AAA67895 (PubMed:8423770).Curated	1
Sequence conflictⁱ	146	A → T in CAA59147 (PubMed:7864863).Curated	1
Sequence conflictⁱ	181	E → G in CAA59147 (PubMed:7864863).Curated	1
Sequence conflictⁱ	243	V → A in AAA67895 (PubMed:8423770).Curated	1
Sequence conflictⁱ	290	S → T in AAA99892 (PubMed:8423770).Curated	1
Sequence conflictⁱ	290	S → T in AAC50480 (PubMed:8924211).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009302	37	R → Q1 PublicationCorresponds to variant dbSNP:rs72547527Ensembl.	1
Natural variantⁱVAR_028721	151	E → D. Corresponds to variant dbSNP:rs1042014Ensembl.	1
Natural variantⁱVAR_057339	151	E → Q. Corresponds to variant dbSNP:rs1042011Ensembl.	1
Natural variantⁱVAR_007425	213	R → H in allele SULT1A1*2; common polymorphism; has a lower activity. 4 PublicationsCorresponds to variant dbSNP:rs1042028Ensembl.	1
Natural variantⁱVAR_009303	223	V → MCombined sources14 PublicationsCorresponds to variant dbSNP:rs1801030Ensembl.	1
Natural variantⁱVAR_014889	235	N → T. Corresponds to variant dbSNP:rs35728980Ensembl.	1
Natural variantⁱVAR_061886	282	E → K2 PublicationsCorresponds to variant dbSNP:rs36043491Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040101	1 – 124	MELIQ…DQKVK → MLAKLLCDQVVGAPIAVSAF YAGMSILQGKDDIFLDLKQK FWNTYM in isoform 2. 1 PublicationAdd BLAST		124

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09031 mRNA Translation: AAA18613.1 L19955 mRNA Translation: AAA02935.1 L10819 mRNA Translation: AAA35562.1 L19999 mRNA Translation: AAA99892.1 U26309 mRNA Translation: AAA67895.1 X84654 mRNA Translation: CAA59147.1 X78283 mRNA Translation: CAA55089.1 U71086 Genomic DNA Translation: AAB09597.1 U54701 Genomic DNA Translation: AAC50480.1 AJ007418 mRNA Translation: CAA07495.1 U52852 Genomic DNA Translation: AAC51816.1 AB062428 mRNA Translation: BAB93491.1 BT007324 mRNA Translation: AAP35988.1 CR608214 mRNA No translation available. AC020765 Genomic DNA No translation available. BC000923 mRNA Translation: AAH00923.1 BC110887 mRNA Translation: AAI10888.1 L15346 Genomic DNA Translation: AAA60595.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10637.1 [P50225-2] CCDS32420.1 [P50225-1]
PIRⁱ	I57945 JC2523 JC5248 S52399 S52794
NCBI Reference Sequences More...RefSeqⁱ	NP_001046.2, NM_001055.3 [P50225-1] NP_803565.1, NM_177529.2 [P50225-1] NP_803566.1, NM_177530.2 [P50225-1] NP_803878.1, NM_177534.2 [P50225-1] NP_803880.1, NM_177536.3 [P50225-2] XP_016879095.1, XM_017023606.1 XP_016879100.1, XM_017023611.1 [P50225-1] XP_016879101.1, XM_017023612.1 [P50225-1] XP_016879102.1, XM_017023613.1 [P50225-1]
UniGeneⁱ	Hs.567342 Hs.736805

Genome annotation databases

Ensemblⁱ	ENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1] ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2] ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1] ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1] ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDⁱ	6817
KEGGⁱ	hsa:6817
UCSC genome browser More...UCSCⁱ	uc002dqi.4 human [P50225-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50225	Sulfotransferase (Fragment)		HUMAN		281	UniRef100_P50225
Sulfotransferase (Fragment)		HUMAN		42
UPI000D0C8037		HUMAN		387

Protein	Similar proteins		Species	Score	Length	Source
P50225	Sulfotransferase (Fragment)		HUMAN		281	UniRef90_P50225
Sulfotransferase		PANTR		295
Sulfotransferase (Fragment)		HUMAN		42
Sulfotransferase		HUMAN		295
Sulfotransferase (Fragment)		PANTR		281
+7
P50225-2	Sulfotransferase		PANTR		217	UniRef90_P50225-2
Sulfotransferase (Fragment)		PANTR		217

Protein	Similar proteins		Species	Score	Length	Source
P50225	Sulfotransferase (Fragment)		HUMAN		281	UniRef50_P50225
Sulfotransferase		PANTR		295
Sulfotransferase		ALLMI		364
Sulfotransferase		ALLSI		295
Sulfotransferase		RHIBE		386
+42
P50225-2	Sulfotransferase		PANTR		217	UniRef50_P50225-2
Sulfotransferase (Fragment)		NEOLE		241
Sulfotransferase (Fragment)		CARIC		209
Sulfotransferase		PETMA		214
Sulfotransferase		ERIEU		210
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09031 mRNA Translation: AAA18613.1 L19955 mRNA Translation: AAA02935.1 L10819 mRNA Translation: AAA35562.1 L19999 mRNA Translation: AAA99892.1 U26309 mRNA Translation: AAA67895.1 X84654 mRNA Translation: CAA59147.1 X78283 mRNA Translation: CAA55089.1 U71086 Genomic DNA Translation: AAB09597.1 U54701 Genomic DNA Translation: AAC50480.1 AJ007418 mRNA Translation: CAA07495.1 U52852 Genomic DNA Translation: AAC51816.1 AB062428 mRNA Translation: BAB93491.1 BT007324 mRNA Translation: AAP35988.1 CR608214 mRNA No translation available. AC020765 Genomic DNA No translation available. BC000923 mRNA Translation: AAH00923.1 BC110887 mRNA Translation: AAI10888.1 L15346 Genomic DNA Translation: AAA60595.1
CCDSⁱ	CCDS10637.1 [P50225-2] CCDS32420.1 [P50225-1]
PIRⁱ	I57945 JC2523 JC5248 S52399 S52794
RefSeqⁱ	NP_001046.2, NM_001055.3 [P50225-1] NP_803565.1, NM_177529.2 [P50225-1] NP_803566.1, NM_177530.2 [P50225-1] NP_803878.1, NM_177534.2 [P50225-1] NP_803880.1, NM_177536.3 [P50225-2] XP_016879095.1, XM_017023606.1 XP_016879100.1, XM_017023611.1 [P50225-1] XP_016879101.1, XM_017023612.1 [P50225-1] XP_016879102.1, XM_017023613.1 [P50225-1]
UniGeneⁱ	Hs.567342 Hs.736805

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LS6	X-ray	1.90	A	1-295	[»]
	1Z28	X-ray	2.30	A	1-295	[»]
	2D06	X-ray	2.30	A/B	1-295	[»]
	3QVU	X-ray	2.50	A/B	1-295	[»]
	3QVV	X-ray	2.35	A/B	1-295	[»]
	3U3J	X-ray	2.70	A/B	1-294	[»]
	3U3K	X-ray	2.36	A/B	1-295	[»]
	3U3M	X-ray	2.30	A	1-295	[»]
	3U3O	X-ray	2.00	A	1-295	[»]
	3U3R	X-ray	2.36	A	1-295	[»]
	4GRA	X-ray	2.56	A/B	1-295	[»]
ProteinModelPortalⁱ	P50225
SMRⁱ	P50225
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112686, 43 interactors
IntActⁱ	P50225, 5 interactors
STRINGⁱ	9606.ENSP00000321988

Chemistry databases

BindingDBⁱ	P50225
ChEMBLⁱ	CHEMBL1743291
DrugBankⁱ	DB00316 Acetaminophen DB01812 Adenosine-3'-5'-Diphosphate DB04417 P-Nitrophenol DB00675 Tamoxifen
SwissLipidsⁱ	SLP:000001651

PTM databases

iPTMnetⁱ	P50225
PhosphoSitePlusⁱ	P50225

Polymorphism and mutation databases

BioMutaⁱ	SULT1A1
DMDMⁱ	313104286

2D gel databases

OGPⁱ	P50225

OGPⁱ

P50225

Proteomic databases

EPDⁱ	P50225
MaxQBⁱ	P50225
PaxDbⁱ	P50225
PeptideAtlasⁱ	P50225
PRIDEⁱ	P50225
ProteomicsDBⁱ	56209 56210 [P50225-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6817
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1] ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2] ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1] ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1] ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDⁱ	6817
KEGGⁱ	hsa:6817
UCSCⁱ	uc002dqi.4 human [P50225-1]

Organism-specific databases

CTDⁱ	6817
DisGeNETⁱ	6817
EuPathDBⁱ	HostDB:ENSG00000196502.11
GeneCardsⁱ	SULT1A1
H-InvDBⁱ	HIX0017846
HGNCⁱ	HGNC:11453 SULT1A1
HPAⁱ	HPA049500 HPA051051
MIMⁱ	171150 gene
neXtProtⁱ	NX_P50225
OpenTargetsⁱ	ENSG00000196502
PharmGKBⁱ	PA343
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1584 Eukaryota ENOG4111H56 LUCA
GeneTreeⁱ	ENSGT00760000118932
HOGENOMⁱ	HOG000037209
HOVERGENⁱ	HBG001195
InParanoidⁱ	P50225
KOⁱ	K01014
OMAⁱ	FAIMSRK
OrthoDBⁱ	EOG091G0D5F
PhylomeDBⁱ	P50225
TreeFamⁱ	TF321745

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS09898-MONOMER
BRENDAⁱ	2.8.2.1 2681
Reactomeⁱ	R-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKⁱ	P50225

Miscellaneous databases

ChiTaRSⁱ	SULT1A1 human
EvolutionaryTraceⁱ	P50225
GeneWikiⁱ	SULT1A1
GenomeRNAiⁱ	6817
Protein Ontology More...PROⁱ	PR:P50225
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196502 Expressed in 138 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_SULT1A1
ExpressionAtlasⁱ	P50225 baseline and differential
Genevisibleⁱ	P50225 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR000863 Sulfotransferase_dom
Pfamⁱ	View protein in Pfam PF00685 Sulfotransfer_1, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ST1A1_HUMAN
Accessionⁱ	P50225Primary (citable) accession number: P50225 Secondary accession number(s): Q2NL71 , Q86U58, Q92818, Q9BVU6, Q9UGG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Proteomes

Annotation systems

Supporting data

UniProtKB - P50225 (ST1A1_HUMAN)

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Sulfotransferase 1A1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ