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UniProtKB - P50225 (ST1A1_HUMAN)

Entry version 194 (10 Feb 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621).By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.12 µM for 3,3'-diiodothyronin1 Publication
  1. Vmax=465 µmol/min/mg enzyme with 3,3'-diiodothyronin as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei108Proton acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei130PAPS2 Publications1
Binding sitei138PAPS2 Publications1
Binding sitei193PAPS2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi48 – 53PAPS2 Publications6
Nucleotide bindingi227 – 232PAPS2 Publications6
Nucleotide bindingi255 – 259PAPS2 Publications5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCatecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09898-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.8.2.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P50225

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156584, Cytosolic sulfonation of small molecules

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P50225

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.16 Publications)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase 11 Publication
HAST1/HAST2
Phenol sulfotransferase 1
Phenol-sulfating phenol sulfotransferase 11 Publication
Short name:
P-PST 11 Publication
ST1A3
Thermostable phenol sulfotransferase
Short name:
Ts-PST
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SULT1A1
Synonyms:STP, STP1
ORF Names:OK/SW-cl.88
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11453, SULT1A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		171150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P50225

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196502.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi70C → S: Increased sensitivity of enzyme activity to heat inactivation. 1 Publication1
Mutagenesisi249D → G: Increased activity towards p-nitrophenol. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6817

Open Targets

More...OpenTargetsi		ENSG00000196502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA343

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P50225, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1743291

Drug and drug target database

More...DrugBanki		DB00316, Acetaminophen
DB01812, Adenosine 3',5'-diphosphate
DB00714, Apomorphine
DB04417, P-Nitrophenol
DB11077, Polyethylene glycol 400
DB09288, Propacetamol
DB00675, Tamoxifen
DB09100, Thyroid, porcine
DB09070, Tibolone

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SULT1A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000851271 – 295Sulfotransferase 1A1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P50225

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50225

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P50225

MaxQB - The MaxQuant DataBase

More...MaxQBi		P50225

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50225

PeptideAtlas

More...PeptideAtlasi		P50225

PRoteomics IDEntifications database

More...PRIDEi		P50225

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56209 [P50225-1]
56210 [P50225-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P50225

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50225

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, lung, adrenal, brain, platelets and skin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196502, Expressed in right adrenal gland and 154 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P50225, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50225, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196502, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112686, 45 interactors

Protein interaction database and analysis system

More...IntActi		P50225, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378972

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P50225

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P50225, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50225

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P50225

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 108Substrate binding2 Publications3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1584, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163450

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027239_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50225

Identification of Orthologs from Complete Genome Data

More...OMAi		TDLQFRT

Database of Orthologous Groups

More...OrthoDBi		780670at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50225

TreeFam database of animal gene trees

More...TreeFami		TF321745

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00685, Sulfotransfer_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG 
        60         70         80         90        100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP 
       110        120        130        140        150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP 
       160        170        180        190        200
EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP 
       210        220        230        240        250
KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH 
       260        270        280        290 
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,165
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D4362A603A29176
GO
Isoform 2 (identifier: P50225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: MELIQDTSRP...PQTLLDQKVK → MLAKLLCDQV...LKQKFWNTYM

Show »
Length:217
Mass (Da):25,388
Checksum:i8A6A935E4DD11A6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRY5H3BRY5_HUMAN
Sulfotransferase
SULT1A1
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQX5H3BQX5_HUMAN
Sulfotransferase
SULT1A1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT96H3BT96_HUMAN
Sulfotransferase 1A1
SULT1A1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMH9H3BMH9_HUMAN
Sulfotransferase 1A1
SULT1A1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90P → L in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti146A → T in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti181E → G in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti243V → A in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAA99892 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAC50480 (PubMed:8924211).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are several alleles. The sequence shown is that of allele SULT1A1*3.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00930237R → Q1 PublicationCorresponds to variant dbSNP:rs72547527Ensembl.1
Natural variantiVAR_028721151E → D. Corresponds to variant dbSNP:rs1042014Ensembl.1
Natural variantiVAR_057339151E → Q. Corresponds to variant dbSNP:rs1042011Ensembl.1
Natural variantiVAR_007425213R → H in allele SULT1A1*2; has a lower sulfotransferase activity. 4 PublicationsCorresponds to variant dbSNP:rs1042028Ensembl.1
Natural variantiVAR_009303223V → MCombined sources14 PublicationsCorresponds to variant dbSNP:rs1801030Ensembl.1
Natural variantiVAR_014889235N → T. Corresponds to variant dbSNP:rs35728980Ensembl.1
Natural variantiVAR_061886282E → K2 PublicationsCorresponds to variant dbSNP:rs36043491Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0401011 – 124MELIQ…DQKVK → MLAKLLCDQVVGAPIAVSAF YAGMSILQGKDDIFLDLKQK FWNTYM in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09031 mRNA Translation: AAA18613.1
L19955 mRNA Translation: AAA02935.1
L10819 mRNA Translation: AAA35562.1
L19999 mRNA Translation: AAA99892.1
U26309 mRNA Translation: AAA67895.1
X84654 mRNA Translation: CAA59147.1
X78283 mRNA Translation: CAA55089.1
U71086 Genomic DNA Translation: AAB09597.1
U54701 Genomic DNA Translation: AAC50480.1
AJ007418 mRNA Translation: CAA07495.1
U52852 Genomic DNA Translation: AAC51816.1
AB062428 mRNA Translation: BAB93491.1
BT007324 mRNA Translation: AAP35988.1
CR608214 mRNA No translation available.
AC020765 Genomic DNA No translation available.
BC000923 mRNA Translation: AAH00923.1
BC110887 mRNA Translation: AAI10888.1
L15346 Genomic DNA Translation: AAA60595.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10637.1 [P50225-2]
CCDS32420.1 [P50225-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I57945
JC2523
JC5248
S52399
S52794

NCBI Reference Sequences

More...RefSeqi		NP_001046.2, NM_001055.3 [P50225-1]
NP_803565.1, NM_177529.2 [P50225-1]
NP_803566.1, NM_177530.2 [P50225-1]
NP_803878.1, NM_177534.2 [P50225-1]
NP_803880.1, NM_177536.3 [P50225-2]
XP_016879095.1, XM_017023606.1
XP_016879100.1, XM_017023611.1 [P50225-1]
XP_016879101.1, XM_017023612.1 [P50225-1]
XP_016879102.1, XM_017023613.1 [P50225-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6817

UCSC genome browser

More...UCSCi		uc002dqi.4, human [P50225-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA Translation: AAA18613.1
L19955 mRNA Translation: AAA02935.1
L10819 mRNA Translation: AAA35562.1
L19999 mRNA Translation: AAA99892.1
U26309 mRNA Translation: AAA67895.1
X84654 mRNA Translation: CAA59147.1
X78283 mRNA Translation: CAA55089.1
U71086 Genomic DNA Translation: AAB09597.1
U54701 Genomic DNA Translation: AAC50480.1
AJ007418 mRNA Translation: CAA07495.1
U52852 Genomic DNA Translation: AAC51816.1
AB062428 mRNA Translation: BAB93491.1
BT007324 mRNA Translation: AAP35988.1
CR608214 mRNA No translation available.
AC020765 Genomic DNA No translation available.
BC000923 mRNA Translation: AAH00923.1
BC110887 mRNA Translation: AAI10888.1
L15346 Genomic DNA Translation: AAA60595.1
CCDSiCCDS10637.1 [P50225-2]
CCDS32420.1 [P50225-1]
PIRiI57945
JC2523
JC5248
S52399
S52794
RefSeqiNP_001046.2, NM_001055.3 [P50225-1]
NP_803565.1, NM_177529.2 [P50225-1]
NP_803566.1, NM_177530.2 [P50225-1]
NP_803878.1, NM_177534.2 [P50225-1]
NP_803880.1, NM_177536.3 [P50225-2]
XP_016879095.1, XM_017023606.1
XP_016879100.1, XM_017023611.1 [P50225-1]
XP_016879101.1, XM_017023612.1 [P50225-1]
XP_016879102.1, XM_017023613.1 [P50225-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS6X-ray1.90A1-295[»]
1Z28X-ray2.30A1-295[»]
2D06X-ray2.30A/B1-295[»]
3QVUX-ray2.50A/B1-295[»]
3QVVX-ray2.35A/B1-295[»]
3U3JX-ray2.70A/B1-294[»]
3U3KX-ray2.36A/B1-295[»]
3U3MX-ray2.30A1-295[»]
3U3OX-ray2.00A1-295[»]
3U3RX-ray2.36A1-295[»]
4GRAX-ray2.56A/B1-295[»]
SMRiP50225
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112686, 45 interactors
IntActiP50225, 10 interactors
STRINGi9606.ENSP00000378972

Chemistry databases

BindingDBiP50225
ChEMBLiCHEMBL1743291
DrugBankiDB00316, Acetaminophen
DB01812, Adenosine 3',5'-diphosphate
DB00714, Apomorphine
DB04417, P-Nitrophenol
DB11077, Polyethylene glycol 400
DB09288, Propacetamol
DB00675, Tamoxifen
DB09100, Thyroid, porcine
DB09070, Tibolone
SwissLipidsiSLP:000001651

PTM databases

iPTMnetiP50225
PhosphoSitePlusiP50225

Genetic variation databases

BioMutaiSULT1A1
DMDMi313104286

2D gel databases

OGPiP50225

Proteomic databases

EPDiP50225
jPOSTiP50225
MassIVEiP50225
MaxQBiP50225
PaxDbiP50225
PeptideAtlasiP50225
PRIDEiP50225
ProteomicsDBi56209 [P50225-1]
56210 [P50225-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26492, 446 antibodies

The DNASU plasmid repository

More...DNASUi		6817

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDi6817
KEGGihsa:6817
UCSCiuc002dqi.4, human [P50225-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6817
DisGeNETi6817

GeneCards: human genes, protein and diseases

More...GeneCardsi		SULT1A1
HGNCiHGNC:11453, SULT1A1
HPAiENSG00000196502, Tissue enhanced (liver)
MIMi171150, gene
neXtProtiNX_P50225
OpenTargetsiENSG00000196502
PharmGKBiPA343
VEuPathDBiHostDB:ENSG00000196502.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1584, Eukaryota
GeneTreeiENSGT00940000163450
HOGENOMiCLU_027239_6_1_1
InParanoidiP50225
OMAiTDLQFRT
OrthoDBi780670at2759
PhylomeDBiP50225
TreeFamiTF321745

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER
BRENDAi2.8.2.1, 2681
PathwayCommonsiP50225
ReactomeiR-HSA-156584, Cytosolic sulfonation of small molecules
SABIO-RKiP50225

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6817, 6 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SULT1A1, human
EvolutionaryTraceiP50225

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SULT1A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6817
PharosiP50225, Tbio

Protein Ontology

More...PROi		PR:P50225
RNActiP50225, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196502, Expressed in right adrenal gland and 154 other tissues
ExpressionAtlasiP50225, baseline and differential
GenevisibleiP50225, HS

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom
PfamiView protein in Pfam
PF00685, Sulfotransfer_1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiST1A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50225
Secondary accession number(s): Q2NL71
, Q86U58, Q92818, Q9BVU6, Q9UGG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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