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UniProtKB - P50225 (ST1A1_HUMAN)

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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi255 – 259PAPS5

GO - Molecular functioni

  • aryl sulfotransferase activity Source: UniProtKB
  • flavonol 3-sulfotransferase activity Source: BHF-UCL
  • steroid sulfotransferase activity Source: UniProtKB
  • sulfotransferase activity Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: CAFA
  • amine metabolic process Source: ProtInc
  • catecholamine metabolic process Source: UniProtKB-KW
  • estrogen metabolic process Source: UniProtKB
  • ethanol catabolic process Source: CAFA
  • flavonoid metabolic process Source: BHF-UCL
  • sulfation Source: BHF-UCL
  • xenobiotic metabolic process Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionTransferase
Biological processCatecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER
BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules
SABIO-RKiP50225

Chemistry databases

SwissLipidsiSLP:000001651

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase 1
HAST1/HAST2
Phenol sulfotransferase 1
Phenol-sulfating phenol sulfotransferase 1
Short name:
P-PST 1
ST1A3
Thermostable phenol sulfotransferase
Short name:
Ts-PST
Gene namesi
Name:SULT1A1
Synonyms:STP, STP1
ORF Names:OK/SW-cl.88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000196502.11
HGNCiHGNC:11453 SULT1A1
MIMi171150 gene
neXtProtiNX_P50225

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi70C → S: Increased sensitivity of enzyme activity to heat inactivation. 1 Publication1

Organism-specific databases

DisGeNETi6817
OpenTargetsiENSG00000196502
PharmGKBiPA343

Chemistry databases

ChEMBLiCHEMBL1743291
DrugBankiDB00316 Acetaminophen
DB01812 Adenosine-3'-5'-Diphosphate
DB04417 P-Nitrophenol
DB00675 Tamoxifen

Polymorphism and mutation databases

BioMutaiSULT1A1
DMDMi313104286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851271 – 295Sulfotransferase 1A1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50225
MaxQBiP50225
PaxDbiP50225
PeptideAtlasiP50225
PRIDEiP50225
ProteomicsDBi56209
56210 [P50225-2]

2D gel databases

OGPiP50225

PTM databases

iPTMnetiP50225
PhosphoSitePlusiP50225

Expressioni

Tissue specificityi

Liver, lung, adrenal, brain, platelets and skin.

Gene expression databases

BgeeiENSG00000196502
CleanExiHS_SULT1A1
ExpressionAtlasiP50225 baseline and differential
GenevisibleiP50225 HS

Organism-specific databases

HPAiHPA049500
HPA051051

Interactioni

Subunit structurei

Homodimer.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SULT2B1O002046EBI-2814403,EBI-749441

Protein-protein interaction databases

BioGridi112686, 43 interactors
IntActiP50225, 5 interactors
STRINGi9606.ENSP00000321988

Chemistry databases

BindingDBiP50225

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi18 – 20Combined sources3
Helixi22 – 31Combined sources10
Beta strandi41 – 46Combined sources6
Helixi51 – 62Combined sources12
Turni63 – 65Combined sources3
Helixi67 – 70Combined sources4
Helixi75 – 78Combined sources4
Beta strandi87 – 89Combined sources3
Helixi92 – 97Combined sources6
Beta strandi104 – 107Combined sources4
Turni111 – 113Combined sources3
Helixi116 – 120Combined sources5
Beta strandi124 – 129Combined sources6
Helixi132 – 145Combined sources14
Helixi155 – 164Combined sources10
Helixi172 – 182Combined sources11
Turni183 – 185Combined sources3
Beta strandi188 – 192Combined sources5
Helixi193 – 198Combined sources6
Helixi200 – 211Combined sources12
Helixi217 – 226Combined sources10
Helixi229 – 234Combined sources6
Turni236 – 238Combined sources3
Turni245 – 247Combined sources3
Turni250 – 252Combined sources3
Helixi263 – 266Combined sources4
Helixi270 – 283Combined sources14
Turni284 – 286Combined sources3

3D structure databases

ProteinModelPortaliP50225
SMRiP50225
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50225

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate binding3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP50225
KOiK01014
OMAiEMCSLPN
OrthoDBiEOG091G0D5F
PhylomeDBiP50225
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG 
        60         70         80         90        100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP 
       110        120        130        140        150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP 
       160        170        180        190        200
EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP 
       210        220        230        240        250
KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH 
       260        270        280        290 
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,165
Last modified:November 30, 2010 - v3
Checksum:i7D4362A603A29176
GO
Isoform 2 (identifier: P50225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: MELIQDTSRP...PQTLLDQKVK → MLAKLLCDQV...LKQKFWNTYM

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,388
Checksum:i8A6A935E4DD11A6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90P → L in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti146A → T in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti181E → G in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti243V → A in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAA99892 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAC50480 (PubMed:8924211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00930237R → Q1 PublicationCorresponds to variant dbSNP:rs72547527Ensembl.1
Natural variantiVAR_028721151E → D. Corresponds to variant dbSNP:rs1042014Ensembl.1
Natural variantiVAR_057339151E → Q. Corresponds to variant dbSNP:rs1042011Ensembl.1
Natural variantiVAR_007425213R → H in allele SULT1A1*2; common polymorphism; has a lower activity. 4 PublicationsCorresponds to variant dbSNP:rs1042028Ensembl.1
Natural variantiVAR_009303223V → MCombined sources14 PublicationsCorresponds to variant dbSNP:rs1801030Ensembl.1
Natural variantiVAR_014889235N → T. Corresponds to variant dbSNP:rs35728980Ensembl.1
Natural variantiVAR_061886282E → K2 PublicationsCorresponds to variant dbSNP:rs36043491Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401011 – 124MELIQ…DQKVK → MLAKLLCDQVVGAPIAVSAF YAGMSILQGKDDIFLDLKQK FWNTYM in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA Translation: AAA18613.1
L19955 mRNA Translation: AAA02935.1
L10819 mRNA Translation: AAA35562.1
L19999 mRNA Translation: AAA99892.1
U26309 mRNA Translation: AAA67895.1
X84654 mRNA Translation: CAA59147.1
X78283 mRNA Translation: CAA55089.1
U71086 Genomic DNA Translation: AAB09597.1
U54701 Genomic DNA Translation: AAC50480.1
AJ007418 mRNA Translation: CAA07495.1
U52852 Genomic DNA Translation: AAC51816.1
AB062428 mRNA Translation: BAB93491.1
BT007324 mRNA Translation: AAP35988.1
CR608214 mRNA No translation available.
AC020765 Genomic DNA No translation available.
BC000923 mRNA Translation: AAH00923.1
BC110887 mRNA Translation: AAI10888.1
L15346 Genomic DNA Translation: AAA60595.1
CCDSiCCDS10637.1 [P50225-2]
CCDS32420.1 [P50225-1]
PIRiI57945
JC2523
JC5248
S52399
S52794
RefSeqiNP_001046.2, NM_001055.3 [P50225-1]
NP_803565.1, NM_177529.2 [P50225-1]
NP_803566.1, NM_177530.2 [P50225-1]
NP_803878.1, NM_177534.2 [P50225-1]
NP_803880.1, NM_177536.3 [P50225-2]
XP_016879095.1, XM_017023606.1 [P50225-1]
XP_016879100.1, XM_017023611.1 [P50225-1]
XP_016879101.1, XM_017023612.1 [P50225-1]
XP_016879102.1, XM_017023613.1 [P50225-1]
UniGeneiHs.567342
Hs.736805

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502 [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502 [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502 [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502 [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502 [P50225-1]
GeneIDi6817
KEGGihsa:6817
UCSCiuc002dqi.4 human [P50225-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST1A1_HUMAN
AccessioniPrimary (citable) accession number: P50225
Secondary accession number(s): Q2NL71
, Q86U58, Q92818, Q9BVU6, Q9UGG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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