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Protein

Homeobox protein GHOX-7

Gene

GHOX-7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi161 – 220HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GHOX-7
Alternative name(s):
CHOX-7
Short name:
Hox-7
Gene namesi
Name:GHOX-7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490811 – 288Homeobox protein GHOX-7Add BLAST288

Proteomic databases

PaxDbiP50223
PRIDEiP50223

Expressioni

Developmental stagei

Early limb development. First present in an asymmetric arc extending from the anterior border of the limb bud to the mesenchymal cells directly adjacent to the AER. Later abundantly expressed in the proximal anterior periphery and in the mid-proximal region of the posterior periphery. In older wing buds, detectable throughout the necrotic mesenchyme between the developing digits.

Gene expression databases

BgeeiENSGALG00000015013

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024163

Structurei

3D structure databases

ProteinModelPortaliP50223
SMRiP50223
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 145Poly-Pro4

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiP50223
KOiK09341
OMAiCMAPSIA
OrthoDBiEOG091G0P1V
PhylomeDBiP50223
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAADMTTA PTGVRSDEPP ASAFSKPGGG LPVAAAMGGE EESDKPKVSP
60 70 80 90 100
SPLPFSVEAL MADRRKPPGG RDGPEGSGPP LGSARANLGA LTTEAPTSPL
110 120 130 140 150
PLGGHFPSVG ALGKLPEDAL LKAESPEKPE RSPWMQSPRF SPPPPRRLSP
160 170 180 190 200
PACTLRKHKT NRKPRTPFTT AQLLALERKF RQKQYLSIAE RAEFSSSLSL
210 220 230 240 250
TETQVKIWFQ NRRAKAKRLQ EAELEKLKMA AKPMLPPAAF GISFPLGGPA
260 270 280
VAGASLYGAS SPFQRAGLPV APVGLYTAHV GYSMYHLT
Length:288
Mass (Da):30,517
Last modified:October 1, 1996 - v1
Checksum:i71BD89C67CCC256C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130E → G in CAA46671 (PubMed:1350765).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti247G → S in GHOX-7D. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10372 mRNA Translation: BAA01209.1
X65791 mRNA Translation: CAA46671.1
PIRiJS0659
RefSeqiNP_990819.1, NM_205488.2
UniGeneiGga.1905

Genome annotation databases

EnsembliENSGALT00000024209; ENSGALP00000024163; ENSGALG00000015013
GeneIDi396484
KEGGigga:396484

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHMGX7_CHICK
AccessioniPrimary (citable) accession number: P50223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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