Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein MOX-2

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi187 – 246HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • blood circulation Source: ProtInc
  • limb development Source: Ensembl
  • multicellular organism development Source: ProtInc
  • negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • roof of mouth development Source: Ensembl
  • skeletal muscle tissue development Source: Ensembl
  • somite development Source: GO_Central
  • somite specification Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P50222

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P50222 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEOX2
Synonyms:GAX, MOX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106511.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7014 MEOX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600535 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50222

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi236Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4223

Open Targets

More...
OpenTargetsi
ENSG00000106511

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30748

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEOX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93141286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491971 – 304Homeobox protein MOX-2Add BLAST304

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P50222

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50222

PeptideAtlas

More...
PeptideAtlasi
P50222

PRoteomics IDEntifications database

More...
PRIDEi
P50222

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56206

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50222

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P50222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Embryo and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106511 Expressed in 174 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_MEOX2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50222 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053793

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF10.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q6ZVW33EBI-748397,EBI-10255586
Q7Z7833EBI-748397,EBI-9088990
Q9NWJ23EBI-748397,EBI-10315029
ACTN4O437073EBI-748397,EBI-351526
ADAMTS12P583973EBI-748397,EBI-9028051
AGPAT1Q999433EBI-748397,EBI-3893468
AHCYL1O438653EBI-748397,EBI-2371423
AHSA2PQ719I03EBI-748397,EBI-9361704
ANP32BQ926883EBI-748397,EBI-762428
ARD1AQ6P4J03EBI-748397,EBI-10252815
ARHGEF7Q141553EBI-748397,EBI-717515
ATG5A9UGY93EBI-748397,EBI-10175276
BCL2L15Q5TBC73EBI-748397,EBI-10247136
BTKQ061873EBI-748397,EBI-624835
C1orf109Q9NX043EBI-748397,EBI-8643161
CARD9Q9H2573EBI-748397,EBI-751319
CASP14P319443EBI-748397,EBI-2510738
CCDC103Q8IW403EBI-748397,EBI-10261970
CCNCP248633EBI-748397,EBI-395261
CEP57L1Q8IYX8-23EBI-748397,EBI-10181988
CHIC2Q9UKJ53EBI-748397,EBI-741528
CHRDQ9H2X03EBI-748397,EBI-947551
CHRNGP07510-23EBI-748397,EBI-11979451
CIAPIN1Q6FI813EBI-748397,EBI-750511
CIB3Q96Q773EBI-748397,EBI-10292696
CNTNAP2Q9UHC63EBI-748397,EBI-310892
CPNE6O957413EBI-748397,EBI-719005
CPSF4O956393EBI-748397,EBI-725860
CRCT1Q9UGL93EBI-748397,EBI-713677
CSDC2Q9Y5343EBI-748397,EBI-1763657
CSF2P041416EBI-748397,EBI-1809826
CTNNBL1Q8WYA63EBI-748397,EBI-748128
CXXC1Q9P0U43EBI-748397,EBI-949911
DGCR8Q8WYQ53EBI-748397,EBI-528411
DOCK8Q8NF503EBI-748397,EBI-2548605
DYNLL2Q96FJ23EBI-748397,EBI-742371
EDF1O608693EBI-748397,EBI-781301
EFEMP1Q128053EBI-748397,EBI-536772
EFEMP2O959673EBI-748397,EBI-743414
EFNA3P527973EBI-748397,EBI-722730
EIF1ADQ8N9N83EBI-748397,EBI-750700
EIF5AP632413EBI-748397,EBI-373150
EMDP504023EBI-748397,EBI-489887
EPM2AIP1Q7L7753EBI-748397,EBI-6255981
ESRRGP625083EBI-748397,EBI-2834260
FAM13CQ8NE313EBI-748397,EBI-751248
FAM3AQ9BU273EBI-748397,EBI-10298603
FAM74A6Q5TZK33EBI-748397,EBI-10247271
FBF1Q8TES7-63EBI-748397,EBI-10244131
FBLN5Q9UBX53EBI-748397,EBI-947897
FKBP6O753443EBI-748397,EBI-744771
FOXR1Q6PIV23EBI-748397,EBI-10253815
FUCA2Q9BTY23EBI-748397,EBI-9050116
FUT11Q495W53EBI-748397,EBI-2907712
GAGE1Q130653EBI-748397,EBI-10227730
GMCL2Q8NEA93EBI-748397,EBI-745707
GMPR2Q6PKC03EBI-748397,EBI-10254128
GNG11Q53Y013EBI-748397,EBI-10243023
GOLGA8DPQ0D2H93EBI-748397,EBI-10181276
GOLGA8GQ08AF83EBI-748397,EBI-10181260
GPATCH2LQ9NWQ43EBI-748397,EBI-5666657
GPSM3Q9Y4H43EBI-748397,EBI-347538
HAT1O149293EBI-748397,EBI-2339359
HAT1O14929-23EBI-748397,EBI-10181798
HDHD2Q9H0R43EBI-748397,EBI-10304657
HEXIM2Q96MH23EBI-748397,EBI-5460660
HGFP142103EBI-748397,EBI-1039104
HP1BP3Q5SSJ53EBI-748397,EBI-2880687
HTR1EP285663EBI-748397,EBI-1043151
IGFN1Q86VF23EBI-748397,EBI-10259767
IL1AP015833EBI-748397,EBI-1749782
IP6K2Q9UHH93EBI-748397,EBI-747509
ITM2AO437363EBI-748397,EBI-2431769
KAT5Q929933EBI-748397,EBI-399080
KIZQ2M2Z53EBI-748397,EBI-2554344
KLC4Q9NSK03EBI-748397,EBI-949319
KLHL38Q2WGJ63EBI-748397,EBI-6426443
KRT80Q6KB663EBI-748397,EBI-3046635
KRT86O437903EBI-748397,EBI-9996498
KRTAP10-11P604123EBI-748397,EBI-10217483
KRTAP10-5P603703EBI-748397,EBI-10172150
KRTAP10-8P604103EBI-748397,EBI-10171774
KRTAP10-9P604114EBI-748397,EBI-10172052
KRTAP12-1P599903EBI-748397,EBI-10210845
KRTAP12-4P603293EBI-748397,EBI-10176396
KRTAP4-11Q9BYQ63EBI-748397,EBI-10302392
KRTAP4-2Q9BYR53EBI-748397,EBI-10172511
KRTAP4-7Q9BYR03EBI-748397,EBI-10302547
KRTAP5-6Q6L8G93EBI-748397,EBI-10250562
KRTAP5-9P263713EBI-748397,EBI-3958099
KRTAP9-2Q9BYQ43EBI-748397,EBI-1044640
KTN1Q86UP23EBI-748397,EBI-359761
LAMTOR5A0A0C4DGV43EBI-748397,EBI-10173304
LCE1BQ5T7P33EBI-748397,EBI-10245913
LCE2AQ5TA793EBI-748397,EBI-10246607
LCE4AQ5TA783EBI-748397,EBI-10246358
LSM2Q9Y3333EBI-748397,EBI-347416
MAGED1Q9Y5V33EBI-748397,EBI-716006
MAPKBP1O603363EBI-748397,EBI-947402
MKRN3Q6NSB63EBI-748397,EBI-10195599
MLLT6Q6P2C63EBI-748397,EBI-5773143
MMP3P082543EBI-748397,EBI-6957351
MORN3Q6PF183EBI-748397,EBI-9675802
MRFAP1L1Q96HT83EBI-748397,EBI-748896
MSI2Q96DH63EBI-748397,EBI-2462339
MT1DPA1L3X43EBI-748397,EBI-10172129
MUM1Q9H6H23EBI-748397,EBI-10307610
NAA10P412273EBI-748397,EBI-747693
NALCNQ8IZF03EBI-748397,EBI-7085333
NCALDP616013EBI-748397,EBI-749635
NCK2O436393EBI-748397,EBI-713635
NTF3P207833EBI-748397,EBI-1025994
OIT3Q8WWZ83EBI-748397,EBI-10277776
OSGIN1Q9UJX03EBI-748397,EBI-9057006
P4HA3Q7Z4N83EBI-748397,EBI-10181968
PACSIN2Q9UNF03EBI-748397,EBI-742503
PAGE2Q7Z2X73EBI-748397,EBI-10256818
PARVGQ9HBI03EBI-748397,EBI-3921217
PCSK5Q928243EBI-748397,EBI-751290
PGBD1Q96JS36EBI-748397,EBI-10290053
PIN1Q135263EBI-748397,EBI-714158
PKIGQ549H93EBI-748397,EBI-10243311
POM121CA1L4L93EBI-748397,EBI-10172978
PRKAB2O437413EBI-748397,EBI-1053424
PRR19A6NJB73EBI-748397,EBI-10174045
PSMB10P403063EBI-748397,EBI-603329
PSMC1P621913EBI-748397,EBI-357598
PSMC1Q53XL83EBI-748397,EBI-10242995
PSMD14O004873EBI-748397,EBI-722193
PTGER3P43115-123EBI-748397,EBI-10234038
RARBP10826-23EBI-748397,EBI-8583223
RCHY1Q96PM53EBI-748397,EBI-947779
RECKQ6P9E23EBI-748397,EBI-10253121
RHOJQ9H4E53EBI-748397,EBI-6285694
RMND5AQ9H8713EBI-748397,EBI-2797992
RPL15P613133EBI-748397,EBI-443462
RUNX1T1Q06455-43EBI-748397,EBI-10224192
RYDENQ9NUL53EBI-748397,EBI-10313866
SCNM1Q9BWG63EBI-748397,EBI-748391
SETQ011053EBI-748397,EBI-1053182
SIRPB1O00241-23EBI-748397,EBI-10179231
SLC48A1Q6P1K13EBI-748397,EBI-1222191
SMAD3P840226EBI-748397,EBI-347161
SMARCE1Q969G33EBI-748397,EBI-455078
SPP1P104513EBI-748397,EBI-723648
SPRY1O436093EBI-748397,EBI-3866665
SPRY2O435973EBI-748397,EBI-742487
SSX3Q999093EBI-748397,EBI-10295431
STK16O757163EBI-748397,EBI-749295
STX11O755583EBI-748397,EBI-714135
STX16O146623EBI-748397,EBI-2853548
STXBP1P617643EBI-748397,EBI-960169
SYT17Q9BSW73EBI-748397,EBI-745392
TBCELQ5QJ743EBI-748397,EBI-10244795
TCEA2Q155603EBI-748397,EBI-710310
TCL6A0A024R6G03EBI-748397,EBI-10173366
TCTEX1D1Q8N7M03EBI-748397,EBI-10267606
TGFB1P011373EBI-748397,EBI-779636
TICAM2Q86XR73EBI-748397,EBI-525927
TMEM100Q9NV293EBI-748397,EBI-8644968
TP53BP1Q128883EBI-748397,EBI-396540
TRAF6Q9Y4K33EBI-748397,EBI-359276
TRIM41Q8WV443EBI-748397,EBI-725997
TRIM42Q8IWZ53EBI-748397,EBI-5235829
TTC25Q96NG33EBI-748397,EBI-1046387
TTC39BQ5VTQ0-43EBI-748397,EBI-10247626
TTC9CQ8N5M43EBI-748397,EBI-2851213
TXLNAP402223EBI-748397,EBI-359793
UBL4AP114413EBI-748397,EBI-356983
UBL4BQ8N7F73EBI-748397,EBI-10267507
UNC45AQ9H3U13EBI-748397,EBI-1048763
USE1Q9NZ433EBI-748397,EBI-742842
VDRP114733EBI-748397,EBI-286357
WFDC9Q8NEX53EBI-748397,EBI-10270812
XRCC2O435433EBI-748397,EBI-3918457
ZBED4O751323EBI-748397,EBI-2860059
ZMAT2Q96NC03EBI-748397,EBI-2682299
ZNF124Q159733EBI-748397,EBI-2555767
ZNF329Q86UD43EBI-748397,EBI-7233259
ZNF404Q494X33EBI-748397,EBI-10241626
ZNF417Q8TAU33EBI-748397,EBI-740727
ZNF483Q6P0883EBI-748397,EBI-10196963
ZNF564Q8TBZ83EBI-748397,EBI-10273713
ZNF572Q7Z3I73EBI-748397,EBI-10172590
ZNF587Q96SQ53EBI-748397,EBI-6427977
ZNF695Q8IW363EBI-748397,EBI-10261951

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110386, 217 interactors

Protein interaction database and analysis system

More...
IntActi
P50222, 202 interactors

Molecular INTeraction database

More...
MINTi
P50222

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262041

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P50222

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50222

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 47Poly-Ser6
Compositional biasi68 – 80Poly-HisAdd BLAST13
Compositional biasi81 – 86Poly-Gln6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.1 Publication

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0489 Eukaryota
ENOG410ZTBY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230987

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052456

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50222

KEGG Orthology (KO)

More...
KOi
K09322

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWHIPQM

Database of Orthologous Groups

More...
OrthoDBi
1522857at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50222

TreeFam database of animal gene trees

More...
TreeFami
TF351603

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP
110 120 130 140 150
PSAARHSLCL QPDSGGPPEL GSSPPVLCSN SSSLGSSTPT GAACAPGDYG
160 170 180 190 200
RQALSPAEAE KRSGGKRKSD SSDSQEGNYK SEVNSKPRKE RTAFTKEQIR
210 220 230 240 250
ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM KWKRVKGGQQ
260 270 280 290 300
GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE

HAHL
Length:304
Mass (Da):33,594
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C008479D6995389
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58G → D in AAA58497 (PubMed:7713505).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02604079 – 80Missing 1 Publication2
Natural variantiVAR_02604180Missing 4 Publications1
Natural variantiVAR_049585287I → L. Corresponds to variant dbSNP:rs2237493Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82629 mRNA Translation: CAA57949.1
L36328 mRNA Translation: AAA58497.1
AK313386 mRNA Translation: BAG36184.1
AC005550 Genomic DNA Translation: AAC33152.1
AC004452 Genomic DNA Translation: AAC06184.1
CH236948 Genomic DNA Translation: EAL24289.1
BC017021 mRNA Translation: AAH17021.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34605.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55641
A56837

NCBI Reference Sequences

More...
RefSeqi
NP_005915.2, NM_005924.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.170355

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262041; ENSP00000262041; ENSG00000106511

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4223

UCSC genome browser

More...
UCSCi
uc003stc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82629 mRNA Translation: CAA57949.1
L36328 mRNA Translation: AAA58497.1
AK313386 mRNA Translation: BAG36184.1
AC005550 Genomic DNA Translation: AAC33152.1
AC004452 Genomic DNA Translation: AAC06184.1
CH236948 Genomic DNA Translation: EAL24289.1
BC017021 mRNA Translation: AAH17021.1
CCDSiCCDS34605.1
PIRiA55641
A56837
RefSeqiNP_005915.2, NM_005924.4
UniGeneiHs.170355

3D structure databases

ProteinModelPortaliP50222
SMRiP50222
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110386, 217 interactors
IntActiP50222, 202 interactors
MINTiP50222
STRINGi9606.ENSP00000262041

Protein family/group databases

MoonDBiP50222 Predicted

PTM databases

iPTMnetiP50222
PhosphoSitePlusiP50222

Polymorphism and mutation databases

BioMutaiMEOX2
DMDMi93141286

Proteomic databases

jPOSTiP50222
PaxDbiP50222
PeptideAtlasiP50222
PRIDEiP50222
ProteomicsDBi56206

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4223
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262041; ENSP00000262041; ENSG00000106511
GeneIDi4223
KEGGihsa:4223
UCSCiuc003stc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4223
DisGeNETi4223
EuPathDBiHostDB:ENSG00000106511.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEOX2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006493
HGNCiHGNC:7014 MEOX2
HPAiHPA053793
MIMi600535 gene
neXtProtiNX_P50222
OpenTargetsiENSG00000106511
PharmGKBiPA30748

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00940000154018
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP50222
KOiK09322
OMAiSWHIPQM
OrthoDBi1522857at2759
PhylomeDBiP50222
TreeFamiTF351603

Enzyme and pathway databases

SIGNORiP50222

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MEOX2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MEOX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4223

Protein Ontology

More...
PROi
PR:P50222

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106511 Expressed in 174 organ(s), highest expression level in lung
CleanExiHS_MEOX2
GenevisibleiP50222 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEOX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50222
Secondary accession number(s): A4D127
, B2R8I7, O75263, Q9UPL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: January 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again