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Protein

Homeobox protein MOX-2

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi187 – 246HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • blood circulation Source: ProtInc
  • limb development Source: Ensembl
  • multicellular organism development Source: ProtInc
  • negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • neuron death Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • roof of mouth development Source: Ensembl
  • skeletal muscle tissue development Source: Ensembl
  • somite development Source: GO_Central
  • somite specification Source: Ensembl

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP50222

Protein family/group databases

MoonDBiP50222 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
Gene namesi
Name:MEOX2
Synonyms:GAX, MOX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106511.5
HGNCiHGNC:7014 MEOX2
MIMi600535 gene
neXtProtiNX_P50222

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi236Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication1

Organism-specific databases

DisGeNETi4223
OpenTargetsiENSG00000106511
PharmGKBiPA30748

Polymorphism and mutation databases

BioMutaiMEOX2
DMDMi93141286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491971 – 304Homeobox protein MOX-2Add BLAST304

Proteomic databases

PaxDbiP50222
PeptideAtlasiP50222
PRIDEiP50222
ProteomicsDBi56206

PTM databases

iPTMnetiP50222
PhosphoSitePlusiP50222

Expressioni

Tissue specificityi

Embryo and placenta.

Gene expression databases

BgeeiENSG00000106511 Expressed in 174 organ(s), highest expression level in lung
CleanExiHS_MEOX2
GenevisibleiP50222 HS

Organism-specific databases

HPAiHPA053793

Interactioni

Subunit structurei

Interacts with RNF10.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q6ZVW33EBI-748397,EBI-10255586
Q7Z7833EBI-748397,EBI-9088990
Q9NWJ23EBI-748397,EBI-10315029
ACTN4O437073EBI-748397,EBI-351526
ADAMTS12P583973EBI-748397,EBI-9028051
AGPAT1Q999433EBI-748397,EBI-3893468
AHCYL1O438653EBI-748397,EBI-2371423
AHSA2PQ719I03EBI-748397,EBI-9361704
ANP32BQ926883EBI-748397,EBI-762428
ARD1AQ6P4J03EBI-748397,EBI-10252815
ARHGEF7Q141553EBI-748397,EBI-717515
ATG5A9UGY93EBI-748397,EBI-10175276
BCL2L15Q5TBC73EBI-748397,EBI-10247136
BTKQ061873EBI-748397,EBI-624835
C1orf109Q9NX043EBI-748397,EBI-8643161
CARD9Q9H2573EBI-748397,EBI-751319
CASP14P319443EBI-748397,EBI-2510738
CCDC103Q8IW403EBI-748397,EBI-10261970
CCNCP248633EBI-748397,EBI-395261
CEP57L1Q8IYX8-23EBI-748397,EBI-10181988
CHIC2Q9UKJ53EBI-748397,EBI-741528
CHRDQ9H2X03EBI-748397,EBI-947551
CHRNGP07510-23EBI-748397,EBI-11979451
CIAPIN1Q6FI813EBI-748397,EBI-750511
CIB3Q96Q773EBI-748397,EBI-10292696
CNTNAP2Q9UHC63EBI-748397,EBI-310892
CPNE6O957413EBI-748397,EBI-719005
CPSF4O956393EBI-748397,EBI-725860
CRCT1Q9UGL93EBI-748397,EBI-713677
CSDC2Q9Y5343EBI-748397,EBI-1763657
CSF2P041416EBI-748397,EBI-1809826
CTNNBL1Q8WYA63EBI-748397,EBI-748128
CXXC1Q9P0U43EBI-748397,EBI-949911
DGCR8Q8WYQ53EBI-748397,EBI-528411
DOCK8Q8NF503EBI-748397,EBI-2548605
DYNLL2Q96FJ23EBI-748397,EBI-742371
EDF1O608693EBI-748397,EBI-781301
EFEMP1Q128053EBI-748397,EBI-536772
EFEMP2O959673EBI-748397,EBI-743414
EFNA3P527973EBI-748397,EBI-722730
EIF1ADQ8N9N83EBI-748397,EBI-750700
EIF5AP632413EBI-748397,EBI-373150
EMDP504023EBI-748397,EBI-489887
EPM2AIP1Q7L7753EBI-748397,EBI-6255981
ESRRGP625083EBI-748397,EBI-2834260
FAM13CQ8NE313EBI-748397,EBI-751248
FAM3AQ9BU273EBI-748397,EBI-10298603
FAM74A6Q5TZK33EBI-748397,EBI-10247271
FBF1Q8TES7-63EBI-748397,EBI-10244131
FBLN5Q9UBX53EBI-748397,EBI-947897
FKBP6O753443EBI-748397,EBI-744771
FOXR1Q6PIV23EBI-748397,EBI-10253815
FUCA2Q9BTY23EBI-748397,EBI-9050116
FUT11Q495W53EBI-748397,EBI-2907712
GAGE1Q130653EBI-748397,EBI-10227730
GMCL2Q8NEA93EBI-748397,EBI-745707
GMPR2Q6PKC03EBI-748397,EBI-10254128
GNG11Q53Y013EBI-748397,EBI-10243023
GOLGA8DPQ0D2H93EBI-748397,EBI-10181276
GOLGA8GQ08AF83EBI-748397,EBI-10181260
GPATCH2LQ9NWQ43EBI-748397,EBI-5666657
GPSM3Q9Y4H43EBI-748397,EBI-347538
HAT1O149293EBI-748397,EBI-2339359
HAT1O14929-23EBI-748397,EBI-10181798
HDHD2Q9H0R43EBI-748397,EBI-10304657
HEXIM2Q96MH23EBI-748397,EBI-5460660
HGFP142103EBI-748397,EBI-1039104
HP1BP3Q5SSJ53EBI-748397,EBI-2880687
HTR1EP285663EBI-748397,EBI-1043151
IGFN1Q86VF23EBI-748397,EBI-10259767
IL1AP015833EBI-748397,EBI-1749782
IP6K2Q9UHH93EBI-748397,EBI-747509
ITM2AO437363EBI-748397,EBI-2431769
KAT5Q929933EBI-748397,EBI-399080
KIZQ2M2Z53EBI-748397,EBI-2554344
KLC4Q9NSK03EBI-748397,EBI-949319
KLHL38Q2WGJ63EBI-748397,EBI-6426443
KRT80Q6KB663EBI-748397,EBI-3046635
KRT86O437903EBI-748397,EBI-9996498
KRTAP10-11P604123EBI-748397,EBI-10217483
KRTAP10-5P603703EBI-748397,EBI-10172150
KRTAP10-8P604103EBI-748397,EBI-10171774
KRTAP10-9P604114EBI-748397,EBI-10172052
KRTAP12-1P599903EBI-748397,EBI-10210845
KRTAP12-4P603293EBI-748397,EBI-10176396
KRTAP4-11Q9BYQ63EBI-748397,EBI-10302392
KRTAP4-2Q9BYR53EBI-748397,EBI-10172511
KRTAP4-7Q9BYR03EBI-748397,EBI-10302547
KRTAP5-6Q6L8G93EBI-748397,EBI-10250562
KRTAP5-9P263713EBI-748397,EBI-3958099
KRTAP9-2Q9BYQ43EBI-748397,EBI-1044640
KTN1Q86UP23EBI-748397,EBI-359761
LAMTOR5A0A0C4DGV43EBI-748397,EBI-10173304
LCE1BQ5T7P33EBI-748397,EBI-10245913
LCE2AQ5TA793EBI-748397,EBI-10246607
LCE4AQ5TA783EBI-748397,EBI-10246358
LSM2Q9Y3333EBI-748397,EBI-347416
MAGED1Q9Y5V33EBI-748397,EBI-716006
MAPKBP1O603363EBI-748397,EBI-947402
MKRN3Q6NSB63EBI-748397,EBI-10195599
MLLT6Q6P2C63EBI-748397,EBI-5773143
MMP3P082543EBI-748397,EBI-6957351
MORN3Q6PF183EBI-748397,EBI-9675802
MRFAP1L1Q96HT83EBI-748397,EBI-748896
MSI2Q96DH63EBI-748397,EBI-2462339
MT1DPA1L3X43EBI-748397,EBI-10172129
MUM1Q9H6H23EBI-748397,EBI-10307610
NAA10P412273EBI-748397,EBI-747693
NALCNQ8IZF03EBI-748397,EBI-7085333
NCALDP616013EBI-748397,EBI-749635
NCK2O436393EBI-748397,EBI-713635
NTF3P207833EBI-748397,EBI-1025994
OIT3Q8WWZ83EBI-748397,EBI-10277776
OSGIN1Q9UJX03EBI-748397,EBI-9057006
P4HA3Q7Z4N83EBI-748397,EBI-10181968
PACSIN2Q9UNF03EBI-748397,EBI-742503
PAGE2Q7Z2X73EBI-748397,EBI-10256818
PARVGQ9HBI03EBI-748397,EBI-3921217
PCSK5Q928243EBI-748397,EBI-751290
PGBD1Q96JS36EBI-748397,EBI-10290053
PIN1Q135263EBI-748397,EBI-714158
PKIGQ549H93EBI-748397,EBI-10243311
POM121CA1L4L93EBI-748397,EBI-10172978
PRKAB2O437413EBI-748397,EBI-1053424
PRR19A6NJB73EBI-748397,EBI-10174045
PSMB10P403063EBI-748397,EBI-603329
PSMC1P621913EBI-748397,EBI-357598
PSMC1Q53XL83EBI-748397,EBI-10242995
PSMD14O004873EBI-748397,EBI-722193
PTGER3P43115-123EBI-748397,EBI-10234038
RARBP10826-23EBI-748397,EBI-8583223
RCHY1Q96PM53EBI-748397,EBI-947779
RECKQ6P9E23EBI-748397,EBI-10253121
RHOJQ9H4E53EBI-748397,EBI-6285694
RMND5AQ9H8713EBI-748397,EBI-2797992
RPL15P613133EBI-748397,EBI-443462
RUNX1T1Q06455-43EBI-748397,EBI-10224192
RYDENQ9NUL53EBI-748397,EBI-10313866
SCNM1Q9BWG63EBI-748397,EBI-748391
SETQ011053EBI-748397,EBI-1053182
SIRPB1O00241-23EBI-748397,EBI-10179231
SLC48A1Q6P1K13EBI-748397,EBI-1222191
SMAD3P840226EBI-748397,EBI-347161
SMARCE1Q969G33EBI-748397,EBI-455078
SPP1P104513EBI-748397,EBI-723648
SPRY1O436093EBI-748397,EBI-3866665
SPRY2O435973EBI-748397,EBI-742487
SSX3Q999093EBI-748397,EBI-10295431
STK16O757163EBI-748397,EBI-749295
STX11O755583EBI-748397,EBI-714135
STX16O146623EBI-748397,EBI-2853548
STXBP1P617643EBI-748397,EBI-960169
SYT17Q9BSW73EBI-748397,EBI-745392
TBCELQ5QJ743EBI-748397,EBI-10244795
TCEA2Q155603EBI-748397,EBI-710310
TCL6A0A024R6G03EBI-748397,EBI-10173366
TCTEX1D1Q8N7M03EBI-748397,EBI-10267606
TGFB1P011373EBI-748397,EBI-779636
TICAM2Q86XR73EBI-748397,EBI-525927
TMEM100Q9NV293EBI-748397,EBI-8644968
TP53BP1Q128883EBI-748397,EBI-396540
TRAF6Q9Y4K33EBI-748397,EBI-359276
TRIM41Q8WV443EBI-748397,EBI-725997
TRIM42Q8IWZ53EBI-748397,EBI-5235829
TTC25Q96NG33EBI-748397,EBI-1046387
TTC39BQ5VTQ0-43EBI-748397,EBI-10247626
TTC9CQ8N5M43EBI-748397,EBI-2851213
TXLNAP402223EBI-748397,EBI-359793
UBL4AP114413EBI-748397,EBI-356983
UBL4BQ8N7F73EBI-748397,EBI-10267507
UNC45AQ9H3U13EBI-748397,EBI-1048763
USE1Q9NZ433EBI-748397,EBI-742842
VDRP114733EBI-748397,EBI-286357
WFDC9Q8NEX53EBI-748397,EBI-10270812
XRCC2O435433EBI-748397,EBI-3918457
ZBED4O751323EBI-748397,EBI-2860059
ZMAT2Q96NC03EBI-748397,EBI-2682299
ZNF124Q159733EBI-748397,EBI-2555767
ZNF329Q86UD43EBI-748397,EBI-7233259
ZNF404Q494X33EBI-748397,EBI-10241626
ZNF417Q8TAU33EBI-748397,EBI-740727
ZNF483Q6P0883EBI-748397,EBI-10196963
ZNF564Q8TBZ83EBI-748397,EBI-10273713
ZNF572Q7Z3I73EBI-748397,EBI-10172590
ZNF587Q96SQ53EBI-748397,EBI-6427977
ZNF695Q8IW363EBI-748397,EBI-10261951

Protein-protein interaction databases

BioGridi110386, 217 interactors
IntActiP50222, 202 interactors
MINTiP50222
STRINGi9606.ENSP00000262041

Structurei

3D structure databases

ProteinModelPortaliP50222
SMRiP50222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 47Poly-Ser6
Compositional biasi68 – 80Poly-HisAdd BLAST13
Compositional biasi81 – 86Poly-Gln6

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.1 Publication

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP50222
KOiK09322
OMAiSWHIPQM
OrthoDBiEOG091G0PFO
PhylomeDBiP50222
TreeFamiTF351603

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP
110 120 130 140 150
PSAARHSLCL QPDSGGPPEL GSSPPVLCSN SSSLGSSTPT GAACAPGDYG
160 170 180 190 200
RQALSPAEAE KRSGGKRKSD SSDSQEGNYK SEVNSKPRKE RTAFTKEQIR
210 220 230 240 250
ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM KWKRVKGGQQ
260 270 280 290 300
GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE

HAHL
Length:304
Mass (Da):33,594
Last modified:April 18, 2006 - v2
Checksum:i0C008479D6995389
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58G → D in AAA58497 (PubMed:7713505).Curated1

Polymorphismi

The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02604079 – 80Missing 1 Publication2
Natural variantiVAR_02604180Missing 4 Publications1
Natural variantiVAR_049585287I → L. Corresponds to variant dbSNP:rs2237493Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82629 mRNA Translation: CAA57949.1
L36328 mRNA Translation: AAA58497.1
AK313386 mRNA Translation: BAG36184.1
AC005550 Genomic DNA Translation: AAC33152.1
AC004452 Genomic DNA Translation: AAC06184.1
CH236948 Genomic DNA Translation: EAL24289.1
BC017021 mRNA Translation: AAH17021.1
CCDSiCCDS34605.1
PIRiA55641
A56837
RefSeqiNP_005915.2, NM_005924.4
UniGeneiHs.170355

Genome annotation databases

EnsembliENST00000262041; ENSP00000262041; ENSG00000106511
GeneIDi4223
KEGGihsa:4223
UCSCiuc003stc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMEOX2_HUMAN
AccessioniPrimary (citable) accession number: P50222
Secondary accession number(s): A4D127
, B2R8I7, O75263, Q9UPL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: September 12, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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