MEOX1

Functionⁱ

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	171 – 230	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
HMG box domain binding Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hematopoietic stem cell differentiation Source: UniProtKB
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 7987315
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sclerotome development Source: UniProtKB
somite development Source: UniProtKB
somite specification Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P50221

SIGNORⁱ

P50221

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein MOX-1 Alternative name(s): Mesenchyme homeobox 1
Gene namesⁱ	Name:MEOX1 Synonyms:MOX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000005102.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7013 MEOX1
MIMⁱ	600147 gene
neXtProtⁱ	NX_P50221

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Klippel-Feil syndrome 2, autosomal recessive (KFS2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4222
MalaCards human disease database More...MalaCardsⁱ	MEOX1
MIMⁱ	214300 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000005102
Orphanetⁱ	2345 Isolated Klippel-Feil syndrome
PharmGKBⁱ	PA30747

Polymorphism and mutation databases

BioMutaⁱ	MEOX1
DMDMⁱ	1709078

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049195	1 – 254	Homeobox protein MOX-1Add BLAST		254

Proteomic databases

PaxDbⁱ	P50221
PeptideAtlas More...PeptideAtlasⁱ	P50221
PRIDEⁱ	P50221
ProteomicsDBⁱ	56204 56205 [P50221-2]

PTM databases

iPTMnetⁱ	P50221
PhosphoSitePlusⁱ	P50221

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000005102 Expressed in 154 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_MEOX1
ExpressionAtlasⁱ	P50221 baseline and differential
Genevisibleⁱ	P50221 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045214

HPAⁱ

HPA045214

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACBD4	K7EM05	3	EBI-2864512,EBI-16431307
ALOX5	P09917	3	EBI-2864512,EBI-79934
APPL1	Q9UKG1	3	EBI-2864512,EBI-741243
BANP	A0A0S2Z5G4	3	EBI-2864512,EBI-16429704
BANP	B4DE54	3	EBI-2864512,EBI-16429313
BANP	Q8N9N5-2	3	EBI-2864512,EBI-11524452
BANP	Q8N9N5-7	3	EBI-2864512,EBI-16429296
CIAO1	O76071	3	EBI-2864512,EBI-725145
CIB3	Q96Q77	3	EBI-2864512,EBI-10292696
CKS1B	P61024	5	EBI-2864512,EBI-456371
CWF19L2	Q2TBE0	5	EBI-2864512,EBI-5453285
DCX	O43602	3	EBI-2864512,EBI-8646694
MAPK9	P45984	5	EBI-2864512,EBI-713568
MEF2A	Q02078-2	3	EBI-2864512,EBI-16431401
MID1	O15344	6	EBI-2864512,EBI-2340316
MORF4L1	Q9UBU8	3	EBI-2864512,EBI-399246
NAGK	Q9UJ70	3	EBI-2864512,EBI-372578
NEIL2	Q969S2	5	EBI-2864512,EBI-10281234
PAGE3	Q5JUK9	3	EBI-2864512,EBI-10244544
QRICH1	Q2TAL8	3	EBI-2864512,EBI-2798044
RBM5	P52756	4	EBI-2864512,EBI-714003
SYT17	Q9BSW7	3	EBI-2864512,EBI-745392
TCEANC	Q8N8B7	3	EBI-2864512,EBI-954696
TXLNA	P40222	3	EBI-2864512,EBI-359793
UBE2R2	Q712K3	5	EBI-2864512,EBI-2340879
UBXN2B	Q14CS0	3	EBI-2864512,EBI-1993619

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110385, 33 interactors
IntActⁱ	P50221, 96 interactors
Molecular INTeraction database More...MINTⁱ	P50221
STRINGⁱ	9606.ENSP00000321684

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50221
SMRⁱ	P50221
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144024
HOGENOMⁱ	HOG000230987
HOVERGENⁱ	HBG053889
InParanoidⁱ	P50221
KEGG Orthology (KO) More...KOⁱ	K09322
OMAⁱ	WHFPVSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PFO
PhylomeDBⁱ	P50221
TreeFamⁱ	TF351603

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P50221-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD 
        60         70         80         90        100
FLATATAAYP DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSD 
       110        120        130        140        150
ARRRPNSGPA GGSKEMGTSS LGLVDTTGGP GDDYGVLGST ANETEKKSSR 
       160        170        180        190        200
RRKESSDNQE NRGKPEGSSK ARKERTAFTK EQLRELEAEF AHHNYLTRLR 
       210        220        230        240        250
RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPISPNGQ DPEDGDSTAS 

PSSE

Length:254

Mass (Da):27,997

Last modified:October 1, 1996 - v1

Checksum:ⁱA53724BF77C02166

GO

Isoform 2 (identifier: P50221-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
157-254: DNQENRGKPE...GDSTASPSSE → GQSVVPEPKDEVEACEGRSAHLPQWAGP

« Hide

        10         20         30         40         50
MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD 
        60         70         80         90        100
FLATATAAYP DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSD 
       110        120        130        140        150
ARRRPNSGPA GGSKEMGTSS LGLVDTTGGP GDDYGVLGST ANETEKKSSR 
       160        170        180 
RRKESSGQSV VPEPKDEVEA CEGRSAHLPQ WAGP

Show »

Length:184

Mass (Da):19,557

Checksum:ⁱ59096E1E7C9801ED

GO

Isoform 3 (identifier: P50221-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.

« Hide

        10         20         30         40         50
MGTSSLGLVD TTGGPGDDYG VLGSTANETE KKSSRRRKES SDNQENRGKP 
        60         70         80         90        100
EGSSKARKER TAFTKEQLRE LEAEFAHHNY LTRLRRYEIA VNLDLSERQV 
       110        120        130 
KVWFQNRRMK WKRVKGGQPI SPNGQDPEDG DSTASPSSE

Note: Gene prediction based on EST data.

Show »

Length:139

Mass (Da):15,628

Checksum:ⁱ004537165848FC9C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8VXS6	F8VXS6_HUMAN		Homeobox protein MOX-1 Homeobox protein MOX-1	MEOX1	167	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	69	A → G in BAF83828 (PubMed:14702039).		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049584	27	S → L. Corresponds to variant dbSNP:rs9898682EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046700	1 – 115	Missing in isoform 3. CuratedAdd BLAST		115
Alternative sequenceⁱVSP_043340	157 – 254	DNQEN…SPSSE → GQSVVPEPKDEVEACEGRSA HLPQWAGP in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U10492 mRNA Translation: AAA19983.1 U10493 mRNA Translation: AAA19984.1 AK291139 mRNA Translation: BAF83828.1 AC004149 Genomic DNA No translation available. AC068675 Genomic DNA No translation available. CH471178 Genomic DNA Translation: EAW51672.1 BC069474 mRNA Translation: AAH69474.1 BC069506 mRNA Translation: AAH69506.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11466.1 [P50221-1] CCDS11467.1 [P50221-2] CCDS42343.1 [P50221-3]
PIRⁱ	I38034
NCBI Reference Sequences More...RefSeqⁱ	NP_001035091.1, NM_001040002.1 [P50221-3] NP_004518.1, NM_004527.3 [P50221-1] NP_054705.1, NM_013999.3 [P50221-2]
UniGeneⁱ	Hs.438

Genome annotation databases

Ensemblⁱ	ENST00000318579; ENSP00000321684; ENSG00000005102 [P50221-1] ENST00000329168; ENSP00000328678; ENSG00000005102 [P50221-2] ENST00000393661; ENSP00000377271; ENSG00000005102 [P50221-3]
GeneIDⁱ	4222
KEGGⁱ	hsa:4222
UCSC genome browser More...UCSCⁱ	uc002idz.4 human [P50221-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50221	Isoform 3 of Homeobox protein MOX-1		HUMAN		139	UniRef100_P50221
MEOX1 (Fragment)		western gorilla		97

Protein	Similar proteins		Species	Score	Length	Source
P50221	Homeobox protein MOX-1		PANPA		254	UniRef90_P50221
Homeobox protein MOX-1		PANTR		254
Homeobox protein MOX-1		PONPY		254
Isoform 3 of Homeobox protein MOX-1		HUMAN		139
MEOX1 (Fragment)		western gorilla		97
+12
P50221-2	Uncharacterized protein		COLAP		204	UniRef90_P50221-2
Uncharacterized protein		CERAT		185
Uncharacterized protein		PAPAN		185
Homeobox protein MOX-1		PANTR		184
MEOX1 isoform 2		PONAB		184
+6

Protein	Similar proteins		Species	Score	Length	Source
P50221	Homeobox protein MOX-1		PANTR		254	UniRef50_P50221
Homeobox protein MOX-1		PONPY		254
Homeobox protein MOX-1		PANPA		254
Homeobox protein MOX-1		MOUSE		253
Homeobox protein MOX-1		DANRE		253
+154
P50221-2	Uncharacterized protein		COLAP		204	UniRef50_P50221-2
Uncharacterized protein		CERAT		185
Uncharacterized protein		PAPAN		185
Mesenchyme homeobox 1		GORGO		184
Homeobox protein MOX-1		PANTR		184
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U10492 mRNA Translation: AAA19983.1 U10493 mRNA Translation: AAA19984.1 AK291139 mRNA Translation: BAF83828.1 AC004149 Genomic DNA No translation available. AC068675 Genomic DNA No translation available. CH471178 Genomic DNA Translation: EAW51672.1 BC069474 mRNA Translation: AAH69474.1 BC069506 mRNA Translation: AAH69506.1
CCDSⁱ	CCDS11466.1 [P50221-1] CCDS11467.1 [P50221-2] CCDS42343.1 [P50221-3]
PIRⁱ	I38034
RefSeqⁱ	NP_001035091.1, NM_001040002.1 [P50221-3] NP_004518.1, NM_004527.3 [P50221-1] NP_054705.1, NM_013999.3 [P50221-2]
UniGeneⁱ	Hs.438

3D structure databases

ProteinModelPortalⁱ	P50221
SMRⁱ	P50221
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110385, 33 interactors
IntActⁱ	P50221, 96 interactors
MINTⁱ	P50221
STRINGⁱ	9606.ENSP00000321684

PTM databases

iPTMnetⁱ	P50221
PhosphoSitePlusⁱ	P50221

Polymorphism and mutation databases

BioMutaⁱ	MEOX1
DMDMⁱ	1709078

Proteomic databases

PaxDbⁱ	P50221
PeptideAtlasⁱ	P50221
PRIDEⁱ	P50221
ProteomicsDBⁱ	56204 56205 [P50221-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4222
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000318579; ENSP00000321684; ENSG00000005102 [P50221-1] ENST00000329168; ENSP00000328678; ENSG00000005102 [P50221-2] ENST00000393661; ENSP00000377271; ENSG00000005102 [P50221-3]
GeneIDⁱ	4222
KEGGⁱ	hsa:4222
UCSCⁱ	uc002idz.4 human [P50221-1]

Organism-specific databases

CTDⁱ	4222
DisGeNETⁱ	4222
EuPathDBⁱ	HostDB:ENSG00000005102.12
GeneCardsⁱ	MEOX1
HGNCⁱ	HGNC:7013 MEOX1
HPAⁱ	HPA045214
MalaCardsⁱ	MEOX1
MIMⁱ	214300 phenotype 600147 gene
neXtProtⁱ	NX_P50221
OpenTargetsⁱ	ENSG00000005102
Orphanetⁱ	2345 Isolated Klippel-Feil syndrome
PharmGKBⁱ	PA30747
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000144024
HOGENOMⁱ	HOG000230987
HOVERGENⁱ	HBG053889
InParanoidⁱ	P50221
KOⁱ	K09322
OMAⁱ	WHFPVSE
OrthoDBⁱ	EOG091G0PFO
PhylomeDBⁱ	P50221
TreeFamⁱ	TF351603

Enzyme and pathway databases

SIGNORⁱ	P50221

SIGNORⁱ

P50221

Miscellaneous databases

ChiTaRSⁱ	MEOX1 human
GeneWikiⁱ	MEOX1
GenomeRNAiⁱ	4222
Protein Ontology More...PROⁱ	PR:P50221
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000005102 Expressed in 154 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_MEOX1
ExpressionAtlasⁱ	P50221 baseline and differential
Genevisibleⁱ	P50221 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MEOX1_HUMAN
Accessionⁱ	P50221Primary (citable) accession number: P50221 Secondary accession number(s): A8K524, A8MWF9, Q15069
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50221 (MEOX1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Homeobox protein MOX-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ