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UniProtKB - P50162 (TRN1_DATST)
Protein
Tropinone reductase 1
Gene
TR1
Organism
Datura stramonium (Jimsonweed) (Common thornapple)
Status
Functioni
Catalyzes the stereospecific reduction of tropinone to tropine.
1 PublicationCatalytic activityi
- EC:1.1.1.2061 Publication
: tropane alkaloid biosynthesis Pathwayi
This protein is involved in the pathway tropane alkaloid biosynthesis, which is part of Alkaloid biosynthesis.View all proteins of this organism that are known to be involved in the pathway tropane alkaloid biosynthesis and in Alkaloid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 158 | Substrate1 Publication | 1 | |
Active sitei | 171 | Proton acceptor1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 25 – 49 | NADP1 PublicationAdd BLAST | 25 |
GO - Molecular functioni
- tropine dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- tropane alkaloid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.206, 1839 |
SABIO-RKi | P50162 |
UniPathwayi | UPA00330 |
Names & Taxonomyi
Protein namesi | Recommended name: Tropinone reductase 11 Publication (EC:1.1.1.2061 Publication)Alternative name(s): Tropine dehydrogenase Tropinone reductase I Short name: TR-I |
Gene namesi | Name:TR11 Publication |
Organismi | Datura stramonium (Jimsonweed) (Common thornapple) |
Taxonomic identifieri | 4076 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Datureae › Datura |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054785 | 1 – 273 | Tropinone reductase 1Add BLAST | 273 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P50162 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P50162 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam IPR045000, TR |
PANTHERi | PTHR42898, PTHR42898, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
P50162-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEESKVSMMN CNNEGRWSLK GTTALVTGGS KGIGYAIVEE LAGLGARVYT
60 70 80 90 100
CSRNEKELDE CLEIWREKGL NVEGSVCDLL SRTERDKLMQ TVAHVFDGKL
110 120 130 140 150
NILVNNAGVV IHKEAKDFTE KDYNIIMGTN FEAAYHLSQI AYPLLKASQN
160 170 180 190 200
GNVIFLSSIA GFSALPSVSL YSASKGAINQ MTKSLACEWA KDNIRVNSVA
210 220 230 240 250
PGVILTPLVE TAIKKNPHQK EEIDNFIVKT PMGRAGKPQE VSALIAFLCF
260 270
PAASYITGQI IWADGGFTAN GGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20473 mRNA Translation: AAA33281.1 |
PIRi | A48674 |
Genome annotation databases
KEGGi | ag:AAA33281 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20473 mRNA Translation: AAA33281.1 |
PIRi | A48674 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AE1 | X-ray | 2.40 | A/B | 1-273 | [»] | |
SMRi | P50162 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
KEGGi | ag:AAA33281 |
Enzyme and pathway databases
UniPathwayi | UPA00330 |
BRENDAi | 1.1.1.206, 1839 |
SABIO-RKi | P50162 |
Miscellaneous databases
EvolutionaryTracei | P50162 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam IPR045000, TR |
PANTHERi | PTHR42898, PTHR42898, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRN1_DATST | |
Accessioni | P50162Primary (citable) accession number: P50162 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families