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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Gene

GNG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.

GO - Molecular functioni

  • GTPase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Gene namesi
Name:GNG10
Synonyms:GNGT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000242616.3
HGNCiHGNC:4402 GNG10
MIMi604389 gene
neXtProtiNX_P50151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2790
OpenTargetsiENSG00000242616
PharmGKBiPA28781

Polymorphism and mutation databases

BioMutaiGNG10
DMDMi1730222

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126552 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10Add BLAST64
PropeptideiPRO_000001265666 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP50151
MaxQBiP50151
PaxDbiP50151
PeptideAtlasiP50151
PRIDEiP50151
ProteomicsDBi56200

PTM databases

iPTMnetiP50151
PhosphoSitePlusiP50151

Expressioni

Tissue specificityi

Abundantly and ubiquitously expressed.

Gene expression databases

BgeeiENSG00000242616 Expressed in 92 organ(s), highest expression level in caudate nucleus
CleanExiHS_GNG10
ExpressionAtlasiP50151 baseline and differential
GenevisibleiP50151 HS

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

Protein-protein interaction databases

BioGridi109052, 21 interactors
IntActiP50151, 5 interactors
STRINGi9606.ENSP00000363411

Structurei

3D structure databases

ProteinModelPortaliP50151
SMRiP50151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP50151
KOiK04545
OMAiCVQNACK
OrthoDBiEOG091G17J0
PhylomeDBiP50151
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGASASAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCM QNACKDALLV
60
GVPAGSNPFR EPRSCALL
Length:68
Mass (Da):7,205
Last modified:October 1, 1996 - v1
Checksum:iE3EC3CEA0EB0BD5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31383 mRNA Translation: AAC50205.1
AF493877 mRNA Translation: AAM12591.1
AL135787 Genomic DNA No translation available.
BC010384 mRNA Translation: AAH10384.1
BC015206 mRNA No translation available.
BC016319 mRNA Translation: AAH16319.1
BC072671 mRNA Translation: AAH72671.1
BC107574 mRNA Translation: AAI07575.1
CCDSiCCDS35107.1
PIRiI39158
RefSeqiNP_001017998.1, NM_001017998.3
NP_001185593.1, NM_001198664.1
UniGeneiHs.534196
Hs.732002

Genome annotation databases

EnsembliENST00000374293; ENSP00000363411; ENSG00000242616
GeneIDi2790
KEGGihsa:2790
UCSCiuc004bfp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31383 mRNA Translation: AAC50205.1
AF493877 mRNA Translation: AAM12591.1
AL135787 Genomic DNA No translation available.
BC010384 mRNA Translation: AAH10384.1
BC015206 mRNA No translation available.
BC016319 mRNA Translation: AAH16319.1
BC072671 mRNA Translation: AAH72671.1
BC107574 mRNA Translation: AAI07575.1
CCDSiCCDS35107.1
PIRiI39158
RefSeqiNP_001017998.1, NM_001017998.3
NP_001185593.1, NM_001198664.1
UniGeneiHs.534196
Hs.732002

3D structure databases

ProteinModelPortaliP50151
SMRiP50151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109052, 21 interactors
IntActiP50151, 5 interactors
STRINGi9606.ENSP00000363411

PTM databases

iPTMnetiP50151
PhosphoSitePlusiP50151

Polymorphism and mutation databases

BioMutaiGNG10
DMDMi1730222

Proteomic databases

EPDiP50151
MaxQBiP50151
PaxDbiP50151
PeptideAtlasiP50151
PRIDEiP50151
ProteomicsDBi56200

Protocols and materials databases

DNASUi2790
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374293; ENSP00000363411; ENSG00000242616
GeneIDi2790
KEGGihsa:2790
UCSCiuc004bfp.4 human

Organism-specific databases

CTDi2790
DisGeNETi2790
EuPathDBiHostDB:ENSG00000242616.3
GeneCardsiGNG10
H-InvDBiHIX0201744
HGNCiHGNC:4402 GNG10
MIMi604389 gene
neXtProtiNX_P50151
OpenTargetsiENSG00000242616
PharmGKBiPA28781
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP50151
KOiK04545
OMAiCVQNACK
OrthoDBiEOG091G17J0
PhylomeDBiP50151
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

GenomeRNAii2790
PROiPR:P50151
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242616 Expressed in 92 organ(s), highest expression level in caudate nucleus
CleanExiHS_GNG10
ExpressionAtlasiP50151 baseline and differential
GenevisibleiP50151 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG10_HUMAN
AccessioniPrimary (citable) accession number: P50151
Secondary accession number(s): Q3B7K2, Q4VC27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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