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UniProtKB - P50150 (GBG4_HUMAN)

Entry version 187 (25 May 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene

GNG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P50150

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P50150

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNG4
Synonyms:GNGT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4407, GNG4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604388, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P50150

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168243

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2786

Open Targets

More...OpenTargetsi		ENSG00000168243

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28786

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P50150, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GNG4

Domain mapping of disease mutations (DMDM)

More...DMDMi		1730219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000126211 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4Add BLAST72
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001262273 – 75Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72Cysteine methyl ester1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi72S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P50150

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50150

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P50150

MaxQB - The MaxQuant DataBase

More...MaxQBi		P50150

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50150

PeptideAtlas

More...PeptideAtlasi		P50150

PRoteomics IDEntifications database

More...PRIDEi		P50150

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50150

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168243, Expressed in subventricular zone (outer) (primate) and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P50150, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50150, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168243, Tissue enhanced (brain, ovary, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Interacts with beta-1 and beta-2, but not with beta-3 (PubMed:7665596).

Interacts with KCNK1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109048, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P50150

Protein interaction database and analysis system

More...IntActi		P50150, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P50150, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P50150

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50150

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4119, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_168377_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50150

Identification of Orthologs from Complete Genome Data

More...OMAi		HMGEDPL

Database of Orthologous Groups

More...OrthoDBi		1581168at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50150

TreeFam database of animal gene trees

More...TreeFami		TF319909

Family and domain databases

Conserved Domains Database

More...CDDi		cd00068, GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma

The PANTHER Classification System

More...PANTHERi		PTHR13809, PTHR13809, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00631, G-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00321, GPROTEING

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00224, GGL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48670, SSF48670, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P50150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR 
        60         70 
EDPLIIPVPA SENPFREKKF FCTIL
Length:75
Mass (Da):8,389
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42FAEF4728F83FF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U31382 mRNA Translation: AAC50204.1
AF493872 mRNA Translation: AAM12586.1
BC022485 mRNA Translation: AAH22485.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1607.1

Protein sequence database of the Protein Information Resource

More...PIRi		I39157

NCBI Reference Sequences

More...RefSeqi		NP_001092191.1, NM_001098721.1
NP_001092192.1, NM_001098722.1
NP_004476.1, NM_004485.3
XP_006711824.1, XM_006711761.2
XP_011542469.1, XM_011544167.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366597.5; ENSP00000355556.1; ENSG00000168243.11
ENST00000366598.8; ENSP00000355557.4; ENSG00000168243.11
ENST00000391854.7; ENSP00000375727.2; ENSG00000168243.11
ENST00000450593.5; ENSP00000398629.1; ENSG00000168243.11
ENST00000484517.2; ENSP00000482192.1; ENSG00000168243.11
ENST00000634574.2; ENSP00000489027.2; ENSG00000282972.3
ENST00000635006.3; ENSP00000489228.2; ENSG00000282972.3
ENST00000635235.2; ENSP00000489454.2; ENSG00000282972.3
ENST00000635387.2; ENSP00000489307.2; ENSG00000282972.3
ENST00000635595.2; ENSP00000489194.2; ENSG00000282972.3

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2786

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000391854.7; ENSP00000375727.2; NM_001098722.2; NP_001092192.1

UCSC genome browser

More...UCSCi		uc001hxe.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31382 mRNA Translation: AAC50204.1
AF493872 mRNA Translation: AAM12586.1
BC022485 mRNA Translation: AAH22485.1
CCDSiCCDS1607.1
PIRiI39157
RefSeqiNP_001092191.1, NM_001098721.1
NP_001092192.1, NM_001098722.1
NP_004476.1, NM_004485.3
XP_006711824.1, XM_006711761.2
XP_011542469.1, XM_011544167.2

3D structure databases

AlphaFoldDBiP50150
SMRiP50150
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109048, 26 interactors
CORUMiP50150
IntActiP50150, 15 interactors
STRINGi9606.ENSP00000375727

PTM databases

iPTMnetiP50150
PhosphoSitePlusiP50150

Genetic variation databases

BioMutaiGNG4
DMDMi1730219

Proteomic databases

EPDiP50150
jPOSTiP50150
MassIVEiP50150
MaxQBiP50150
PaxDbiP50150
PeptideAtlasiP50150
PRIDEiP50150
ProteomicsDBi56199

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34696, 94 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		2786

Genome annotation databases

EnsembliENST00000366597.5; ENSP00000355556.1; ENSG00000168243.11
ENST00000366598.8; ENSP00000355557.4; ENSG00000168243.11
ENST00000391854.7; ENSP00000375727.2; ENSG00000168243.11
ENST00000450593.5; ENSP00000398629.1; ENSG00000168243.11
ENST00000484517.2; ENSP00000482192.1; ENSG00000168243.11
ENST00000634574.2; ENSP00000489027.2; ENSG00000282972.3
ENST00000635006.3; ENSP00000489228.2; ENSG00000282972.3
ENST00000635235.2; ENSP00000489454.2; ENSG00000282972.3
ENST00000635387.2; ENSP00000489307.2; ENSG00000282972.3
ENST00000635595.2; ENSP00000489194.2; ENSG00000282972.3
GeneIDi2786
KEGGihsa:2786
MANE-SelectiENST00000391854.7; ENSP00000375727.2; NM_001098722.2; NP_001092192.1
UCSCiuc001hxe.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2786
DisGeNETi2786

GeneCards: human genes, protein and diseases

More...GeneCardsi		GNG4
HGNCiHGNC:4407, GNG4
HPAiENSG00000168243, Tissue enhanced (brain, ovary, pituitary gland)
MIMi604388, gene
neXtProtiNX_P50150
OpenTargetsiENSG00000168243
PharmGKBiPA28786
VEuPathDBiHostDB:ENSG00000168243

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4119, Eukaryota
GeneTreeiENSGT00990000203647
HOGENOMiCLU_168377_0_1_1
InParanoidiP50150
OMAiHMGEDPL
OrthoDBi1581168at2759
PhylomeDBiP50150
TreeFamiTF319909

Enzyme and pathway databases

PathwayCommonsiP50150
ReactomeiR-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP50150

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2786, 13 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GNG4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2786
PharosiP50150, Tbio

Protein Ontology

More...PROi		PR:P50150
RNActiP50150, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168243, Expressed in subventricular zone (outer) (primate) and 148 other tissues
ExpressionAtlasiP50150, baseline and differential
GenevisibleiP50150, HS

Family and domain databases

CDDicd00068, GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma
PANTHERiPTHR13809, PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631, G-gamma, 1 hit
PRINTSiPR00321, GPROTEING
SMARTiView protein in SMART
SM00224, GGL, 1 hit
SUPFAMiSSF48670, SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBG4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50150
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 25, 2022
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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