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Entry version 182 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.47 µM for histamine (at pH 8.0 and 25 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei28Substrate1
    Binding sitei60S-adenosyl-L-methionine; via carbonyl oxygen1
    Binding sitei89S-adenosyl-L-methionine1
    Binding sitei94S-adenosyl-L-methionine1
    Binding sitei120S-adenosyl-L-methionine; via amide nitrogen1
    Binding sitei142S-adenosyl-L-methionine; via carbonyl oxygen1
    Binding sitei283Substrate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07674-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.1.8, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P50135

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se
    R-HSA-70921, Histidine catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P50135

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.81 Publication)
    Short name:
    HMT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HNMT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000150540.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:5028, HNMT

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605238, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P50135

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Mental retardation, autosomal recessive 51 (MRT51)1 Publication
    The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
    Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07631260G → D in MRT51; no effect on protein abundance; no effect on protein localization to the cytoplasm; decreased thermal stability; decreased ligand affinity for S-adenosyl-L-methionine; loss of histamine N-methyltransferase activity. 1 PublicationCorresponds to variant dbSNP:rs758252808EnsemblClinVar.1
    Natural variantiVAR_076313208L → P in MRT51; loss of protein solubility; increased aggregation in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs745756308EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    3176

    MalaCards human disease database

    More...
    MalaCardsi
    HNMT
    MIMi616739, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000150540

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    88616, Autosomal recessive non-syndromic intellectual disability

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA190

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P50135, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2190

    Drug and drug target database

    More...
    DrugBanki
    DB00613, Amodiaquine
    DB13875, Harmaline
    DB05381, Histamine
    DB04655, Metoprine
    DB01103, Quinacrine
    DB01752, S-adenosyl-L-homocysteine
    DB07106, SKF-91488

    DrugCentral

    More...
    DrugCentrali
    P50135

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HNMT

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    1708272

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840211 – 292Histamine N-methyltransferaseAdd BLAST292

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P50135

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P50135

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P50135

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P50135

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P50135

    PeptideAtlas

    More...
    PeptideAtlasi
    P50135

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P50135

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    56195 [P50135-1]
    56196 [P50135-2]
    56197 [P50135-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P50135

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P50135

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000150540, Expressed in adipose tissue and 238 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P50135, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000150540, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    109418, 7 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P50135, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000280097

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P50135

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P50135, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1292
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P50135

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P50135

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QQJ1, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000002862

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_058117_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P50135

    KEGG Orthology (KO)

    More...
    KOi
    K00546

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ETCNFNT

    Database of Orthologous Groups

    More...
    OrthoDBi
    870728at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P50135

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF331080

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016673, HHMT-like
    IPR029063, SAM-dependent_MTases

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF016616, HHMT, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335, SSF53335, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51597, SAM_HNMT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: P50135-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT
    60 70 80 90 100
    KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE
    110 120 130 140 150
    LVAKTSNLEN VKFAWHKETS SEYQSRMLEK KELQKWDFIH MIQMLYYVKD
    160 170 180 190 200
    IPATLKFFHS LLGTNAKMLI IVVSGSSGWD KLWKKYGSRF PQDDLCQYIT
    210 220 230 240 250
    SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF
    260 270 280 290
    NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA
    Length:292
    Mass (Da):33,295
    Last modified:October 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CCADD1EE0CCB653
    GO
    Isoform 2 (identifier: P50135-2) [UniParc]FASTAAdd to basket
    Also known as: HNMT-S

    The sequence of this isoform differs from the canonical sequence as follows:
         64-292: GEIDLQILSK...NTLSFIVIEA → DCLIRGSSRV...PSFLVSFILF

    Note: Has no histamine-methylating activity.Curated
    Show »
    Length:126
    Mass (Da):14,207
    Checksum:iD3215E15F10E7EB3
    GO
    Isoform 3 (identifier: P50135-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-51: IGDTK → YQNCC
         52-292: Missing.

    Show »
    Length:51
    Mass (Da):6,046
    Checksum:i722B5977BDD19382
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199I → V in BAA03752 (PubMed:7943261).Curated1
    Sequence conflicti234N → D in AAH20677 (PubMed:15489334).Curated1

    <p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma.2 Publications

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07631260G → D in MRT51; no effect on protein abundance; no effect on protein localization to the cytoplasm; decreased thermal stability; decreased ligand affinity for S-adenosyl-L-methionine; loss of histamine N-methyltransferase activity. 1 PublicationCorresponds to variant dbSNP:rs758252808EnsemblClinVar.1
    Natural variantiVAR_010252105T → I2 PublicationsCorresponds to variant dbSNP:rs11558538EnsemblClinVar.1
    Natural variantiVAR_076313208L → P in MRT51; loss of protein solubility; increased aggregation in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs745756308EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04348247 – 51IGDTK → YQNCC in isoform 3. 1 Publication5
    Alternative sequenceiVSP_04348352 – 292Missing in isoform 3. 1 PublicationAdd BLAST241
    Alternative sequenceiVSP_04202764 – 292GEIDL…IVIEA → DCLIRGSSRVLKRNSCFILC STRQKDKPGMRIHDERSSEL PFGAARLESKSAFPSFLVSF ILF in isoform 2. 1 PublicationAdd BLAST229

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D16224 mRNA Translation: BAA03752.1
    U08092 mRNA Translation: AAA17423.1
    U44111 U44110 Genomic DNA Translation: AAB18137.1
    AF523358 mRNA Translation: AAN33016.1
    AF523359 mRNA Translation: AAN33017.1
    AF523360 mRNA Translation: AAN33018.1
    AF523356 mRNA Translation: AAN33014.1
    AF523357 mRNA Translation: AAN33015.1
    AK313804 mRNA Translation: BAG36540.1
    AC093674 Genomic DNA Translation: AAY24212.1
    CH471058 Genomic DNA Translation: EAX11612.1
    CH471058 Genomic DNA Translation: EAX11613.1
    CH471058 Genomic DNA Translation: EAX11614.1
    BC005907 mRNA Translation: AAH05907.1
    BC020677 mRNA Translation: AAH20677.1
    AH012839 Genomic DNA Translation: AAP42155.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2181.1 [P50135-1]
    CCDS33296.1 [P50135-2]
    CCDS33297.1 [P50135-3]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    G01409

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001019245.1, NM_001024074.2 [P50135-3]
    NP_001019246.1, NM_001024075.1 [P50135-2]
    NP_008826.1, NM_006895.2 [P50135-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000280096; ENSP00000280096; ENSG00000150540 [P50135-3]
    ENST00000280097; ENSP00000280097; ENSG00000150540 [P50135-1]
    ENST00000329366; ENSP00000333259; ENSG00000150540 [P50135-2]
    ENST00000410115; ENSP00000386940; ENSG00000150540 [P50135-1]
    ENST00000475675; ENSP00000419415; ENSG00000150540 [P50135-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3176

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:3176

    UCSC genome browser

    More...
    UCSCi
    uc002tvd.4, human [P50135-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D16224 mRNA Translation: BAA03752.1
    U08092 mRNA Translation: AAA17423.1
    U44111 U44110 Genomic DNA Translation: AAB18137.1
    AF523358 mRNA Translation: AAN33016.1
    AF523359 mRNA Translation: AAN33017.1
    AF523360 mRNA Translation: AAN33018.1
    AF523356 mRNA Translation: AAN33014.1
    AF523357 mRNA Translation: AAN33015.1
    AK313804 mRNA Translation: BAG36540.1
    AC093674 Genomic DNA Translation: AAY24212.1
    CH471058 Genomic DNA Translation: EAX11612.1
    CH471058 Genomic DNA Translation: EAX11613.1
    CH471058 Genomic DNA Translation: EAX11614.1
    BC005907 mRNA Translation: AAH05907.1
    BC020677 mRNA Translation: AAH20677.1
    AH012839 Genomic DNA Translation: AAP42155.1
    CCDSiCCDS2181.1 [P50135-1]
    CCDS33296.1 [P50135-2]
    CCDS33297.1 [P50135-3]
    PIRiG01409
    RefSeqiNP_001019245.1, NM_001024074.2 [P50135-3]
    NP_001019246.1, NM_001024075.1 [P50135-2]
    NP_008826.1, NM_006895.2 [P50135-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1ICZmodel-A1-249[»]
    1JQDX-ray2.28A/B1-292[»]
    1JQEX-ray1.91A/B1-292[»]
    2AOTX-ray1.90A/B1-292[»]
    2AOUX-ray2.30A/B1-292[»]
    2AOVX-ray2.48A/B1-292[»]
    2AOWX-ray2.97A/B1-292[»]
    2AOXX-ray3.12A/B1-292[»]
    SMRiP50135
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi109418, 7 interactors
    IntActiP50135, 5 interactors
    STRINGi9606.ENSP00000280097

    Chemistry databases

    BindingDBiP50135
    ChEMBLiCHEMBL2190
    DrugBankiDB00613, Amodiaquine
    DB13875, Harmaline
    DB05381, Histamine
    DB04655, Metoprine
    DB01103, Quinacrine
    DB01752, S-adenosyl-L-homocysteine
    DB07106, SKF-91488
    DrugCentraliP50135

    PTM databases

    iPTMnetiP50135
    PhosphoSitePlusiP50135

    Polymorphism and mutation databases

    BioMutaiHNMT
    DMDMi1708272

    Proteomic databases

    EPDiP50135
    jPOSTiP50135
    MassIVEiP50135
    MaxQBiP50135
    PaxDbiP50135
    PeptideAtlasiP50135
    PRIDEiP50135
    ProteomicsDBi56195 [P50135-1]
    56196 [P50135-2]
    56197 [P50135-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    33593, 299 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    3176

    Genome annotation databases

    EnsembliENST00000280096; ENSP00000280096; ENSG00000150540 [P50135-3]
    ENST00000280097; ENSP00000280097; ENSG00000150540 [P50135-1]
    ENST00000329366; ENSP00000333259; ENSG00000150540 [P50135-2]
    ENST00000410115; ENSP00000386940; ENSG00000150540 [P50135-1]
    ENST00000475675; ENSP00000419415; ENSG00000150540 [P50135-3]
    GeneIDi3176
    KEGGihsa:3176
    UCSCiuc002tvd.4, human [P50135-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3176
    DisGeNETi3176
    EuPathDBiHostDB:ENSG00000150540.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    HNMT
    HGNCiHGNC:5028, HNMT
    HPAiENSG00000150540, Low tissue specificity
    MalaCardsiHNMT
    MIMi605238, gene
    616739, phenotype
    neXtProtiNX_P50135
    OpenTargetsiENSG00000150540
    Orphaneti88616, Autosomal recessive non-syndromic intellectual disability
    PharmGKBiPA190

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG502QQJ1, Eukaryota
    GeneTreeiENSGT00390000002862
    HOGENOMiCLU_058117_1_0_1
    InParanoidiP50135
    KOiK00546
    OMAiETCNFNT
    OrthoDBi870728at2759
    PhylomeDBiP50135
    TreeFamiTF331080

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07674-MONOMER
    BRENDAi2.1.1.8, 2681
    PathwayCommonsiP50135
    ReactomeiR-HSA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se
    R-HSA-70921, Histidine catabolism
    SABIO-RKiP50135

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    3176, 4 hits in 879 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    HNMT, human
    EvolutionaryTraceiP50135

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    3176
    PharosiP50135, Tchem

    Protein Ontology

    More...
    PROi
    PR:P50135
    RNActiP50135, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000150540, Expressed in adipose tissue and 238 other tissues
    GenevisibleiP50135, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016673, HHMT-like
    IPR029063, SAM-dependent_MTases
    PIRSFiPIRSF016616, HHMT, 1 hit
    SUPFAMiSSF53335, SSF53335, 1 hit
    PROSITEiView protein in PROSITE
    PS51597, SAM_HNMT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNMT_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50135
    Secondary accession number(s): B2R9J3
    , Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: August 12, 2020
    This is version 182 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
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