HTR2A

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca²⁺ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	229	Hydrophobic barrier that decreases the speed of ligand binding and dissociationBy similarity		1

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity Source: InterPro
neurotransmitter receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavior Source: UniProtKB-KW
phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Behavior

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 2A Short name: 5-HT-2 Short name: 5-HT-2A Short name: 5-HT2A Alternative name(s): Serotonin receptor 2A
Gene namesⁱ	Name:HTR2A
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Unplaced

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 75	ExtracellularBy similarityAdd BLAST	75
Transmembraneⁱ	76 – 99	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	100 – 110	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	111 – 132	Helical; Name=2By similarityAdd BLAST	22
Topological domainⁱ	133 – 148	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	149 – 171	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	172 – 191	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	192 – 215	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	216 – 233	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	234 – 254	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	255 – 323	CytoplasmicBy similarityAdd BLAST	69
Transmembraneⁱ	324 – 345	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	346 – 361	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	362 – 383	Helical; Name=7By similarityAdd BLAST	22
Topological domainⁱ	384 – 470	CytoplasmicBy similarityAdd BLAST	87

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2490

ChEMBLⁱ

CHEMBL2490

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068949	1 – 470	5-hydroxytryptamine receptor 2AAdd BLAST		470

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	44	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	148 ↔ 227	PROSITE-ProRule annotation
Modified residueⁱ	280	PhosphoserineBy similarity	1
Disulfide bondⁱ	348 ↔ 352	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P50129
PRIDEⁱ	P50129

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.By similarity

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000010037

STRINGⁱ

9823.ENSSSCP00000010037

Chemistry databases

BindingDBⁱ

P50129

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50129
SMRⁱ	P50129
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	155 – 160	Agonist bindingBy similarity		6
Regionⁱ	335 – 339	Agonist bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	172 – 174	DRY motif; important for ligand-induced conformation changesBy similarity	3
Motifⁱ	375 – 379	NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity	5
Motifⁱ	468 – 470	PDZ-bindingBy similarity	3

Domainⁱ

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.By similarity

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000240378
HOVERGENⁱ	HBG107487
InParanoidⁱ	P50129
KEGG Orthology (KO) More...KOⁱ	K04157

Family and domain databases

InterProⁱ	View protein in InterPro IPR000455 5HT2A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF30 PTHR24247:SF30, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00516 5HT2ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P50129-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVLCEENTS LSSPTNSFMQ LNDDTRLYHN DFNSGEANTS DAFNWTVDSE 
        60         70         80         90        100
NRTNLSCEGC LSPPCFSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS 
       110        120        130        140        150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV 
       160        170        180        190        200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHRRFNSRT KAFLKIIAVW 
       210        220        230        240        250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM 
       260        270        280        290        300
VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 
       310        320        330        340        350
REPGSYGRRT MQSISNEQKA CKVLGIVFFL FVVMWCPFFI TNIMAVICKE 
       360        370        380        390        400
SCNEDVIGAL LNVFVWIGYL SSAVNPLVYT LFNKTYRSAF SRYIQCQYKE 
       410        420        430        440        450
NKKPLQLILV NTIPALAYKS SQLQTGQKEN SKQDDKATEN DCTMVALGKQ 
       460        470
HSEDAPADNS NTVNEKVSCV

Length:470

Mass (Da):52,676

Last modified:October 1, 1996 - v1

Checksum:ⁱ8231AD580BEE2A8F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	184	R → S in CAA88169 (PubMed:7656980).Curated		1
Sequence conflictⁱ	208	M → K in CAA88169 (PubMed:7656980).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78208 mRNA Translation: AAB34690.1 Z48152 mRNA Translation: CAA88169.1
PIRⁱ	S66489
NCBI Reference Sequences More...RefSeqⁱ	NP_999382.1, NM_214217.1
UniGeneⁱ	Ssc.16141

Genome annotation databases

GeneIDⁱ	397432
KEGGⁱ	ssc:397432

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P50129	UPI000788F665		ROUAE		472
5-hydroxytryptamine receptor 2A isoform X1		TARSY		471
5-hydroxytryptamine receptor 2A		SAIBB		471
5-hydroxytryptamine receptor 2A		AOTNA		471
5-hydroxytryptamine receptor 2A		PROCO		471
+20

Protein	Similar proteins		Species	Score	Length
P50129	UPI000788F665		ROUAE		472
5-hydroxytryptamine receptor 2A		SAIBB		471
5-hydroxytryptamine receptor 2A		AOTNA		471
5-hydroxytryptamine receptor 2A		PROCO		471
5-hydroxytryptamine receptor 2A isoform X1		TARSY		471
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78208 mRNA Translation: AAB34690.1 Z48152 mRNA Translation: CAA88169.1
PIRⁱ	S66489
NCBI Reference Sequences More...RefSeqⁱ	NP_999382.1, NM_214217.1
UniGeneⁱ	Ssc.16141

3D structure databases

ProteinModelPortalⁱ	P50129
SMRⁱ	P50129
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000010037

STRINGⁱ

9823.ENSSSCP00000010037

Chemistry databases

BindingDBⁱ	P50129
ChEMBLⁱ	CHEMBL2490

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PaxDbⁱ	P50129
PRIDEⁱ	P50129

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	397432
KEGGⁱ	ssc:397432

Organism-specific databases

CTDⁱ	3356

CTDⁱ

3356

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000240378
HOVERGENⁱ	HBG107487
InParanoidⁱ	P50129
KEGG Orthology (KO) More...KOⁱ	K04157

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P50129

PROⁱ

PR:P50129

Family and domain databases

InterProⁱ	View protein in InterPro IPR000455 5HT2A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF30 PTHR24247:SF30, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00516 5HT2ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT2A_PIG
Accessionⁱ	P50129Primary (citable) accession number: P50129 Secondary accession number(s): Q29004
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	June 20, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P50129 (5HT2A_PIG)

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5-hydroxytryptamine receptor 2A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ