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Protein

Retinol-binding protein 2

Gene

RBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Retinoic acid1
Binding sitei109Retinoic acidBy similarity1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: ProtInc
  • retinol binding Source: UniProtKB-KW

GO - Biological processi

  • epidermis development Source: ProtInc
  • retinoid metabolic process Source: Reactome
  • vitamin A metabolic process Source: ProtInc

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000114113-MONOMER
ReactomeiR-HSA-975634 Retinoid metabolism and transport

Protein family/group databases

TCDBi8.A.33.1.3 the fatty acid binding protein (fabp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:RBP2
Synonyms:CRBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114113.6
HGNCiHGNC:9920 RBP2
MIMi180280 gene
neXtProtiNX_P50120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5948
OpenTargetsiENSG00000114113
PharmGKBiPA34287

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRBP2
DMDMi62297500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673951 – 134Retinol-binding protein 2Add BLAST134

Proteomic databases

MaxQBiP50120
PaxDbiP50120
PeptideAtlasiP50120
PRIDEiP50120
ProteomicsDBi56194

PTM databases

iPTMnetiP50120
PhosphoSitePlusiP50120

Expressioni

Tissue specificityi

Higher expression in adult small intestine and to a much lesser extent in fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000114113
CleanExiHS_RBP2
ExpressionAtlasiP50120 baseline and differential
GenevisibleiP50120 HS

Organism-specific databases

HPAiHPA035866

Interactioni

Protein-protein interaction databases

BioGridi111882, 3 interactors
IntActiP50120, 3 interactors
STRINGi9606.ENSP00000232217

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Helixi17 – 23Combined sources7
Helixi28 – 34Combined sources7
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi61 – 66Combined sources6
Beta strandi71 – 74Combined sources4
Turni76 – 79Combined sources4
Beta strandi82 – 90Combined sources9
Beta strandi93 – 104Combined sources12
Beta strandi106 – 112Combined sources7
Beta strandi115 – 122Combined sources8
Beta strandi125 – 133Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCQX-ray1.20A2-134[»]
2RCTX-ray1.20A2-134[»]
4EDEX-ray1.40A/B2-134[»]
4EEJX-ray1.50A/B2-134[»]
4EFGX-ray1.58A/B2-134[»]
4EXZX-ray1.61A/B2-134[»]
4GKCX-ray1.30A/B2-134[»]
4QYNX-ray1.19A/B2-134[»]
4QYPX-ray1.62A/B/C/D2-134[»]
4QZTX-ray1.90A/B/C/D2-134[»]
4QZUX-ray1.50A/B/C/D2-134[»]
4RUUX-ray1.40A/B2-134[»]
4ZCBX-ray1.70A/B2-134[»]
4ZGUX-ray1.49A/B/C/D2-134[»]
4ZH6X-ray1.55A2-134[»]
4ZH9X-ray2.66A2-134[»]
4ZJ0X-ray1.50A/B2-134[»]
4ZR2X-ray1.80A/B2-134[»]
5DG4X-ray1.50A/B/C/D2-134[»]
5DPQX-ray1.77A/B2-134[»]
5F58X-ray1.54A/B2-134[»]
5F6BX-ray1.31A/B2-134[»]
5F7GX-ray1.48A/B2-134[»]
5FAZX-ray1.40A/B2-134[»]
5FENX-ray1.55A/B2-134[»]
5FFHX-ray1.68A/B2-134[»]
5U6GX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L2-134[»]
6C7ZX-ray1.42A/B2-134[»]
ProteinModelPortaliP50120
SMRiP50120
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50120

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP50120
KOiK14622
OMAiENRGWKQ
OrthoDBiEOG091G0QSV
PhylomeDBiP50120
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

P50120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KVIDQDGDNF
60 70 80 90 100
KTKTTSTFRN YDVDFTVGVE FDEYTKSLDN RHVKALVTWE GDVLVCVQKG
110 120 130
EKENRGWKQW IEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,707
Last modified:January 23, 2007 - v3
Checksum:iA4A7FB157B099A7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31R → P in AAC50162 (PubMed:7657783).Curated1
Sequence conflicti114D → G in AAH69396 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13831 mRNA Translation: AAC50162.1
AK291978 mRNA Translation: BAF84667.1
CH471052 Genomic DNA Translation: EAW79036.1
BC069296 mRNA Translation: AAH69296.1
BC069361 mRNA Translation: AAH69361.1
BC069396 mRNA Translation: AAH69396.1
BC069424 mRNA Translation: AAH69424.1
BC069447 mRNA Translation: AAH69447.1
BC069513 mRNA Translation: AAH69513.1
BC069522 mRNA Translation: AAH69522.1
CCDSiCCDS3109.1
RefSeqiNP_004155.2, NM_004164.2
UniGeneiHs.655516

Genome annotation databases

EnsembliENST00000232217; ENSP00000232217; ENSG00000114113
GeneIDi5948
KEGGihsa:5948
UCSCiuc003eth.4 human

Similar proteinsi

Entry informationi

Entry nameiRET2_HUMAN
AccessioniPrimary (citable) accession number: P50120
Secondary accession number(s): A8K7G3, Q6ISQ9, Q6ISS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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