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UniProtKB - P50113 (LYS5_YEAST)
Protein
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Gene
LYS5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.
1 PublicationMiscellaneous
Present with 623 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:2.7.8.71 Publication
Kineticsi
- KM=1 µM for CoA1 Publication
- KM=1 µM for alpha-aminoadipate reductase PCP fragment1 Publication
GO - Molecular functioni
- holo-[acyl-carrier-protein] synthase activity Source: SGD
- magnesium ion binding Source: InterPro
GO - Biological processi
- lysine biosynthetic process via aminoadipic acid Source: SGD
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
SABIO-RKi | P50113 |
Names & Taxonomyi
Protein namesi | Recommended name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase1 Publication (EC:2.7.8.71 Publication)Short name: AASD-PPT1 Publication |
Gene namesi | Name:LYS51 Publication Ordered Locus Names:YGL154C ORF Names:G1867 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003122, LYS5 |
VEuPathDBi | FungiDB:YGL154C |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000175742 | 1 – 272 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAdd BLAST | 272 |
Proteomic databases
PaxDbi | P50113 |
PRIDEi | P50113 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33100, 10 interactors |
DIPi | DIP-1426N |
IntActi | P50113, 3 interactors |
MINTi | P50113 |
STRINGi | 4932.YGL154C |
Miscellaneous databases
RNActi | P50113, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0945, Eukaryota |
HOGENOMi | CLU_075352_1_0_1 |
InParanoidi | P50113 |
OMAi | QLFGCSI |
Family and domain databases
Gene3Di | 3.90.470.20, 2 hits |
InterProi | View protein in InterPro IPR008278, 4-PPantetheinyl_Trfase_dom IPR037143, 4-PPantetheinyl_Trfase_dom_sf |
Pfami | View protein in Pfam PF01648, ACPS, 1 hit |
SUPFAMi | SSF56214, SSF56214, 2 hits |
i Sequence
Sequence statusi: Complete.
P50113-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKTTEVVSE VSKVAGVRPW AGIFVVEIQE DILADEFTFE ALMRTLPLAS
60 70 80 90 100
QARILNKKSF HDRCSNLCSQ LLQLFGCSIV TGLNFQELKF DKGSFGKPFL
110 120 130 140 150
DNNRFLPFSM TIGEQYVAMF LVKCVSTDEY QDVGIDIASP CNYGGREELE
160 170 180 190 200
LFKEVFSERE FNGLLKASDP CTIFTYLWSL KESYTKFTGT GLNTDLSLID
210 220 230 240 250
FGAISFFPAE GASMCITLDE VPLIFHSQWF NNEIVTICMP KSISDKINTN
260 270
RPKLYNISLS TLIDYFIEND GL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32586 Genomic DNA Translation: AAC49449.1 Z48618 Genomic DNA No translation available. Z72676 Genomic DNA Translation: CAA96866.1 AY692861 Genomic DNA Translation: AAT92880.1 BK006941 Genomic DNA Translation: DAA07958.1 |
PIRi | S59762 |
RefSeqi | NP_011361.1, NM_001181019.1 |
Genome annotation databases
EnsemblFungii | YGL154C_mRNA; YGL154C; YGL154C |
GeneIDi | 852723 |
KEGGi | sce:YGL154C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32586 Genomic DNA Translation: AAC49449.1 Z48618 Genomic DNA No translation available. Z72676 Genomic DNA Translation: CAA96866.1 AY692861 Genomic DNA Translation: AAT92880.1 BK006941 Genomic DNA Translation: DAA07958.1 |
PIRi | S59762 |
RefSeqi | NP_011361.1, NM_001181019.1 |
3D structure databases
SMRi | P50113 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33100, 10 interactors |
DIPi | DIP-1426N |
IntActi | P50113, 3 interactors |
MINTi | P50113 |
STRINGi | 4932.YGL154C |
Proteomic databases
PaxDbi | P50113 |
PRIDEi | P50113 |
Genome annotation databases
EnsemblFungii | YGL154C_mRNA; YGL154C; YGL154C |
GeneIDi | 852723 |
KEGGi | sce:YGL154C |
Organism-specific databases
SGDi | S000003122, LYS5 |
VEuPathDBi | FungiDB:YGL154C |
Phylogenomic databases
eggNOGi | KOG0945, Eukaryota |
HOGENOMi | CLU_075352_1_0_1 |
InParanoidi | P50113 |
OMAi | QLFGCSI |
Enzyme and pathway databases
SABIO-RKi | P50113 |
Miscellaneous databases
PROi | PR:P50113 |
RNActi | P50113, protein |
Family and domain databases
Gene3Di | 3.90.470.20, 2 hits |
InterProi | View protein in InterPro IPR008278, 4-PPantetheinyl_Trfase_dom IPR037143, 4-PPantetheinyl_Trfase_dom_sf |
Pfami | View protein in Pfam PF01648, ACPS, 1 hit |
SUPFAMi | SSF56214, SSF56214, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LYS5_YEAST | |
Accessioni | P50113Primary (citable) accession number: P50113 Secondary accession number(s): D6VTZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families