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Protein

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Gene

LYS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.1 Publication

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

Kineticsi

  1. KM=1 µM for CoA1 Publication
  2. KM=1 µM for alpha-aminoadipate reductase PCP fragment1 Publication

    GO - Molecular functioni

    • holo-[acyl-carrier-protein] synthase activity Source: SGD
    • magnesium ion binding Source: InterPro

    GO - Biological processi

    • lysine biosynthetic process via aminoadipic acid Source: SGD
    • protein-cofactor linkage Source: SGD

    Keywordsi

    Molecular functionTransferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30645-MONOMER
    SABIO-RKiP50113

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.7)
    Short name:
    AASD-PPT
    Gene namesi
    Name:LYS5
    Ordered Locus Names:YGL154C
    ORF Names:G1867
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome VII

    Organism-specific databases

    EuPathDBiFungiDB:YGL154C
    SGDiS000003122 LYS5

    Subcellular locationi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001757421 – 272L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAdd BLAST272

    Proteomic databases

    PaxDbiP50113
    PRIDEiP50113

    Interactioni

    Protein-protein interaction databases

    BioGridi33100, 10 interactors
    DIPiDIP-1426N
    IntActiP50113, 9 interactors
    MINTiP50113
    STRINGi4932.YGL154C

    Structurei

    3D structure databases

    ProteinModelPortaliP50113
    SMRiP50113
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000113423
    InParanoidiP50113
    KOiK06133
    OMAiKECYTKY
    OrthoDBiEOG092C5M6A

    Family and domain databases

    Gene3Di3.90.470.20, 2 hits
    InterProiView protein in InterPro
    IPR008278 4-PPantetheinyl_Trfase_dom
    IPR037143 4-PPantetheinyl_Trfase_dom_sf
    PfamiView protein in Pfam
    PF01648 ACPS, 1 hit
    SUPFAMiSSF56214 SSF56214, 2 hits

    Sequencei

    Sequence statusi: Complete.

    P50113-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MVKTTEVVSE VSKVAGVRPW AGIFVVEIQE DILADEFTFE ALMRTLPLAS
    60 70 80 90 100
    QARILNKKSF HDRCSNLCSQ LLQLFGCSIV TGLNFQELKF DKGSFGKPFL
    110 120 130 140 150
    DNNRFLPFSM TIGEQYVAMF LVKCVSTDEY QDVGIDIASP CNYGGREELE
    160 170 180 190 200
    LFKEVFSERE FNGLLKASDP CTIFTYLWSL KESYTKFTGT GLNTDLSLID
    210 220 230 240 250
    FGAISFFPAE GASMCITLDE VPLIFHSQWF NNEIVTICMP KSISDKINTN
    260 270
    RPKLYNISLS TLIDYFIEND GL
    Length:272
    Mass (Da):30,683
    Last modified:October 1, 1996 - v1
    Checksum:i3722252E7EC97787
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U32586 Genomic DNA Translation: AAC49449.1
    Z48618 Genomic DNA No translation available.
    Z72676 Genomic DNA Translation: CAA96866.1
    AY692861 Genomic DNA Translation: AAT92880.1
    BK006941 Genomic DNA Translation: DAA07958.1
    PIRiS59762
    RefSeqiNP_011361.1, NM_001181019.1

    Genome annotation databases

    EnsemblFungiiYGL154C; YGL154C; YGL154C
    GeneIDi852723
    KEGGisce:YGL154C

    Similar proteinsi

    Entry informationi

    Entry nameiLYS5_YEAST
    AccessioniPrimary (citable) accession number: P50113
    Secondary accession number(s): D6VTZ7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: March 28, 2018
    This is version 130 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health