LYS5

Functionⁱ

Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.1 Publication

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

Keywordsⁱ

Molecular function	Transferase

Molecular function

Transferase

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-30645-MONOMER
SABIO-RKⁱ	P50113

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.7) Short name: AASD-PPT
Gene namesⁱ	Name:LYS5 Ordered Locus Names:YGL154C ORF Names:G1867
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome VII

Organism-specific databases

EuPathDBⁱ	FungiDB:YGL154C
Saccharomyces Genome Database More...SGDⁱ	S000003122 LYS5

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000175742	1 – 272	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAdd BLAST		272

Proteomic databases

PaxDbⁱ	P50113
PRIDEⁱ	P50113

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	33100, 10 interactors
Database of interacting proteins More...DIPⁱ	DIP-1426N
IntActⁱ	P50113, 3 interactors
Molecular INTeraction database More...MINTⁱ	P50113
STRINGⁱ	4932.YGL154C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50113
SMRⁱ	P50113
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the P-Pant transferase superfamily. AcpS family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000113423
InParanoidⁱ	P50113
KEGG Orthology (KO) More...KOⁱ	K06133
OMAⁱ	KECYTKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5M6A

Family and domain databases

Gene3Dⁱ	3.90.470.20, 2 hits
InterProⁱ	View protein in InterPro IPR008278 4-PPantetheinyl_Trfase_dom IPR037143 4-PPantetheinyl_Trfase_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01648 ACPS, 1 hit
SUPFAMⁱ	SSF56214 SSF56214, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P50113-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVKTTEVVSE VSKVAGVRPW AGIFVVEIQE DILADEFTFE ALMRTLPLAS 
        60         70         80         90        100
QARILNKKSF HDRCSNLCSQ LLQLFGCSIV TGLNFQELKF DKGSFGKPFL 
       110        120        130        140        150
DNNRFLPFSM TIGEQYVAMF LVKCVSTDEY QDVGIDIASP CNYGGREELE 
       160        170        180        190        200
LFKEVFSERE FNGLLKASDP CTIFTYLWSL KESYTKFTGT GLNTDLSLID 
       210        220        230        240        250
FGAISFFPAE GASMCITLDE VPLIFHSQWF NNEIVTICMP KSISDKINTN 
       260        270 
RPKLYNISLS TLIDYFIEND GL

Length:272

Mass (Da):30,683

Last modified:October 1, 1996 - v1

Checksum:ⁱ3722252E7EC97787

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32586 Genomic DNA Translation: AAC49449.1 Z48618 Genomic DNA No translation available. Z72676 Genomic DNA Translation: CAA96866.1 AY692861 Genomic DNA Translation: AAT92880.1 BK006941 Genomic DNA Translation: DAA07958.1
PIRⁱ	S59762
NCBI Reference Sequences More...RefSeqⁱ	NP_011361.1, NM_001181019.1

Genome annotation databases

EnsemblFungiⁱ	YGL154C; YGL154C; YGL154C
GeneIDⁱ	852723
KEGGⁱ	sce:YGL154C

Protein	Similar proteins		Species	Score	Length	Source
P50113	Lys5p		YEASC		272	UniRef90_P50113
Lys5p		YEASB		272
Alpha aminoadipate reductase phosphopantetheinyl transferase		YEAS1		272
Lys5p		YEAS8		272
Lys5p		SACCK		272
+8

Protein	Similar proteins		Species	Score	Length	Source
P50113	Lys5p		YEASC		272	UniRef50_P50113
Lys5p		YEASB		272
Alpha aminoadipate reductase phosphopantetheinyl transferase		YEAS1		272
Lys5p		YEAS8		272
Lys5p		SACCK		272
+11

Entry informationⁱ

Entry nameⁱ	LYS5_YEAST
Accessionⁱ	P50113Primary (citable) accession number: P50113 Secondary accession number(s): D6VTZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - P50113 (LYS5_YEAST)

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L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

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Functionⁱ

Miscellaneous

Catalytic activityⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Other locations

PTM / Processingⁱ

Molecule processing

Proteomic databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50113 (LYS5_YEAST)

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L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

LYS5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ