Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 172 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Protein ZDS1

Gene

ZDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in establishing cell polarity. Together with cAMP-dependent protein kinase regulatory subunit BCY1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.
When associated with DBP5, GFD1 and nucleoporins at the cytosolic fibrils of the nuclear pore complex, is required for mRNA export form the nucleus.

Miscellaneous

'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens.
Present with 279 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell wall biogenesis/degradation, mRNA transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32944-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ZDS1
Alternative name(s):
Protein NRC1
RT2GS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDS1
Synonyms:CES1, CKM1, HST1, NRC1, OSS1, STM2
Ordered Locus Names:YMR273C
ORF Names:YM8156.15C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004886, ZDS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YMR273C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000665691 – 915Protein ZDS1Add BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei229PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50111

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50111

PRoteomics IDEntifications database

More...
PRIDEi
P50111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50111

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCY1, DBP5, GFD1 and SKG6.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35452, 187 interactors

Database of interacting proteins

More...
DIPi
DIP-5774N

Protein interaction database and analysis system

More...
IntActi
P50111, 19 interactors

Molecular INTeraction database

More...
MINTi
P50111

STRING: functional protein association networks

More...
STRINGi
4932.YMR273C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50111, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50111

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi716 – 719Poly-Glu4
Compositional biasi907 – 914Poly-Gln8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To yeast ZDS2/MCS1.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S5WJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011999_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50111

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPERSSL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040206, Zds1/2
IPR013941, ZDS1_C

The PANTHER Classification System

More...
PANTHERi
PTHR28089, PTHR28089, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08632, Zds_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01327, Zds_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNRDNESML RTTSSDKAIA SQRDKRKSEV LIAAQSLDNE IRSVKNLKRL
60 70 80 90 100
SIGSMDLLID PELDIKFGGE SSGRRSWSGT TSSSASMPSD TTTVNNTRYS
110 120 130 140 150
DPTPLENLHG RGNSGIESSN KTKQGNYLGI KKGVHSPSRK LNANVLKKNL
160 170 180 190 200
LWVPANQHPN VKPDNFLELV QDTLQNIQLS DNGEDNDGNS NENNDIEDNG
210 220 230 240 250
EDKESQSYEN KENNTINLNR GLSRHGNASL IRRPSTLRRS YTEFDDNEDD
260 270 280 290 300
DNKGDSASET VNKVEERISK IKERPVSLRD ITEELTKISN SAGLTDNDAI
310 320 330 340 350
TLARTLSMAG SYSDKKDQPQ PEGHYDEGDI GFSTSQANTL DDGEFASNMP
360 370 380 390 400
INNTMTWPER SSLRRSRFNT YRIRSQEQEK EVEQSVDEMK NDDEERLKLT
410 420 430 440 450
KNTIKVEIDP HKSPFRQQDE DSENMSSPGS IGDFQDIYNH YRQSSGEWEQ
460 470 480 490 500
EMGIEKEAEE VPVKVRNDTV EQDLELREGT TDMVKPSATD DNKETKRHRR
510 520 530 540 550
RNGWTWLNNK MSREDDNEEN QGDDENEENV DSQRMELDNS KKHYISLFNG
560 570 580 590 600
GEKTEVSNKE EMNNSSTSTA TSQTRQKIEK TFANLFRRKP HHKHDASSSP
610 620 630 640 650
SSSPSSSPSI PNNDAVHVRV RKSKKLGNKS GREPVEPIVL RNRPRPHRHH
660 670 680 690 700
HSRHGSQKIS VKTLKDSQPQ QQIPLQPQLE GAIEIEKKEE SDSESLPQLQ
710 720 730 740 750
PAVSVSSTKS NSRDREEEEA KKKNKKRSNT TEISNQQHSK HVQKENTDEQ
760 770 780 790 800
KAQLQAPAQE QVQTSVPVQA SAPVQNSAPV QTSAPVEASA QTQAPAAPPL
810 820 830 840 850
KHTSILPPRK LTFADVKKPD KPNSPVQFTD SAFGFPLPLL TVSTVIMFDH
860 870 880 890 900
RLPINVERAI YRLSHLKLSN SKRGLREQVL LSNFMYAYLN LVNHTLYMEQ
910
VAHDKEQQQQ QQQQP
Length:915
Mass (Da):103,358
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5F4C2117DBE1210
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84S → P (Ref. 5) Curated1
Sequence conflicti393D → E in AAA74626 (PubMed:8836740).Curated1
Sequence conflicti413S → C in AAA74626 (PubMed:8836740).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L42821 Genomic DNA Translation: AAB38423.1
U32580 Genomic DNA Translation: AAA74626.1
U63849 Genomic DNA Translation: AAB49281.1
U65682 Genomic DNA Translation: AAB06617.1
D50276 Genomic DNA Translation: BAA08819.1
Z49260 Genomic DNA Translation: CAA89256.1
BK006946 Genomic DNA Translation: DAA10174.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54485

NCBI Reference Sequences

More...
RefSeqi
NP_014000.1, NM_001182780.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR273C_mRNA; YMR273C; YMR273C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR273C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42821 Genomic DNA Translation: AAB38423.1
U32580 Genomic DNA Translation: AAA74626.1
U63849 Genomic DNA Translation: AAB49281.1
U65682 Genomic DNA Translation: AAB06617.1
D50276 Genomic DNA Translation: BAA08819.1
Z49260 Genomic DNA Translation: CAA89256.1
BK006946 Genomic DNA Translation: DAA10174.1
PIRiS54485
RefSeqiNP_014000.1, NM_001182780.1

3D structure databases

SMRiP50111
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35452, 187 interactors
DIPiDIP-5774N
IntActiP50111, 19 interactors
MINTiP50111
STRINGi4932.YMR273C

PTM databases

iPTMnetiP50111

Proteomic databases

MaxQBiP50111
PaxDbiP50111
PRIDEiP50111

Genome annotation databases

EnsemblFungiiYMR273C_mRNA; YMR273C; YMR273C
GeneIDi855316
KEGGisce:YMR273C

Organism-specific databases

SGDiS000004886, ZDS1
VEuPathDBiFungiDB:YMR273C

Phylogenomic databases

eggNOGiENOG502S5WJ, Eukaryota
GeneTreeiENSGT00940000176802
HOGENOMiCLU_011999_0_0_1
InParanoidiP50111
OMAiWPERSSL

Enzyme and pathway databases

BioCyciYEAST:G3O-32944-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P50111
RNActiP50111, protein

Family and domain databases

InterProiView protein in InterPro
IPR040206, Zds1/2
IPR013941, ZDS1_C
PANTHERiPTHR28089, PTHR28089, 1 hit
PfamiView protein in Pfam
PF08632, Zds_C, 1 hit
SMARTiView protein in SMART
SM01327, Zds_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50111
Secondary accession number(s): D6W0A0, P41373
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again