The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P50110 (SAM37_YEAST)
Protein
Sorting assembly machinery 37 kDa subunit
Gene
SAM37
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
1 PublicationMiscellaneous
Present with 1580 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- mitochondrial outer membrane translocase complex assembly Source: SGD
- mitochondrion organization Source: GO_Central
- phospholipid transport Source: SGD
- protein import into mitochondrial matrix Source: ComplexPortal
- protein insertion into mitochondrial outer membrane Source: SGD
Keywordsi
Biological process | Protein transport, Transport |
Protein family/group databases
TCDBi | 1.B.33.3.1, the outer membrane protein insertion porin (bam complex) (ompip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting assembly machinery 37 kDa subunitAlternative name(s): MAS37 protein Mitochondrial 37 kDa outer membrane protein |
Gene namesi | Name:SAM37 Synonyms:MAS37, PET3027, TOM37 Ordered Locus Names:YMR060C ORF Names:YM9796.13C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004664, SAM37 |
VEuPathDBi | FungiDB:YMR060C |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial outer membrane Source: SGD
- mitochondrion Source: ComplexPortal
- SAM complex Source: SGD
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 33 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 247 – 265 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072630 | 1 – 327 | Sorting assembly machinery 37 kDa subunitAdd BLAST | 327 |
Proteomic databases
MaxQBi | P50110 |
PaxDbi | P50110 |
PRIDEi | P50110 |
Interactioni
Subunit structurei
Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50. SAM37 interacts with TOM70.
3 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 35235, 325 interactors |
ComplexPortali | CPX-1744, Mitochondrial sorting and assembly machinery complex |
IntActi | P50110, 9 interactors |
MINTi | P50110 |
STRINGi | 4932.YMR060C |
Miscellaneous databases
RNActi | P50110, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P50110 |
SMRi | P50110 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3028, Eukaryota |
HOGENOMi | CLU_069449_0_0_1 |
InParanoidi | P50110 |
OMAi | PMWYNTP |
Family and domain databases
InterProi | View protein in InterPro IPR019564, Sam37/metaxin_N IPR031317, Tom37_C |
Pfami | View protein in Pfam PF10568, Tom37, 1 hit PF11801, Tom37_C, 1 hit |
i Sequence
Sequence statusi: Complete.
P50110-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKGSVHLWG KDGKASLISV DSIALVWFIK LCTSEEAKSM VAGLQIVFSN
60 70 80 90 100
NTDLSSDGKL PVLILDNGTK VSGYVNIVQF LHKNICTSKY EKGTDYEEDL
110 120 130 140 150
AIVRKKDRLL EYSLLNYVDV EISRLTDYQL FLNTKNYNEY TKKLFSKLLY
160 170 180 190 200
FPMWYNTPLQ LRSQARENCE EIIGSLTLED DEEFVESKAM ESASQLAQSK
210 220 230 240 250
TFKIAHKNKI KGKQELQQVK YNLQFDNRLQ SCVSNWLAAR KKLDDSVILS
260 270 280 290 300
SDLLFLANLY VQLGLPDGNR IRSKLEQTFG SELLNSMSNK IDDFVHRPSN
310 320
NLEQRDPQFR EQGNVVMSLY NLACKYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62565 Genomic DNA Translation: CAA44438.1 Z49703 Genomic DNA Translation: CAA89770.1 AY557989 Genomic DNA Translation: AAS56315.1 BK006946 Genomic DNA Translation: DAA09958.1 |
PIRi | S54560 |
RefSeqi | NP_013776.1, NM_001182558.1 |
Genome annotation databases
EnsemblFungii | YMR060C_mRNA; YMR060C; YMR060C |
GeneIDi | 855082 |
KEGGi | sce:YMR060C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62565 Genomic DNA Translation: CAA44438.1 Z49703 Genomic DNA Translation: CAA89770.1 AY557989 Genomic DNA Translation: AAS56315.1 BK006946 Genomic DNA Translation: DAA09958.1 |
PIRi | S54560 |
RefSeqi | NP_013776.1, NM_001182558.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7BTX | electron microscopy | 2.80 | C | 1-327 | [»] | |
7BTY | electron microscopy | 3.20 | C | 1-327 | [»] | |
7E4H | electron microscopy | 3.01 | C | 1-327 | [»] | |
7E4I | electron microscopy | 3.05 | C | 1-327 | [»] | |
AlphaFoldDBi | P50110 | |||||
SMRi | P50110 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35235, 325 interactors |
ComplexPortali | CPX-1744, Mitochondrial sorting and assembly machinery complex |
IntActi | P50110, 9 interactors |
MINTi | P50110 |
STRINGi | 4932.YMR060C |
Protein family/group databases
TCDBi | 1.B.33.3.1, the outer membrane protein insertion porin (bam complex) (ompip) family |
Proteomic databases
MaxQBi | P50110 |
PaxDbi | P50110 |
PRIDEi | P50110 |
Genome annotation databases
EnsemblFungii | YMR060C_mRNA; YMR060C; YMR060C |
GeneIDi | 855082 |
KEGGi | sce:YMR060C |
Organism-specific databases
SGDi | S000004664, SAM37 |
VEuPathDBi | FungiDB:YMR060C |
Phylogenomic databases
eggNOGi | KOG3028, Eukaryota |
HOGENOMi | CLU_069449_0_0_1 |
InParanoidi | P50110 |
OMAi | PMWYNTP |
Miscellaneous databases
PROi | PR:P50110 |
RNActi | P50110, protein |
Family and domain databases
InterProi | View protein in InterPro IPR019564, Sam37/metaxin_N IPR031317, Tom37_C |
Pfami | View protein in Pfam PF10568, Tom37, 1 hit PF11801, Tom37_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAM37_YEAST | |
Accessioni | P50110Primary (citable) accession number: P50110 Secondary accession number(s): D6VZN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references