UniProtKB - P50077 (CCH1_YEAST)
Protein
Calcium-channel protein CCH1
Gene
CCH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with MID1 to ensure that adequate levels of Ca2+ are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments.2 Publications
GO - Molecular functioni
- calcium channel activity Source: SGD
- calcium ion binding Source: InterPro
- voltage-gated calcium channel activity Source: SGD
GO - Biological processi
- calcium ion transport Source: SGD
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Stress response, Transport |
Ligand | Calcium |
Protein family/group databases
TCDBi | 1.A.1.11.10, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-channel protein CCH1 |
Gene namesi | Name:CCH1 Ordered Locus Names:YGR217W ORF Names:G8501 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003449, CCH1 |
VEuPathDBi | FungiDB:YGR217W |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 346 – 366 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 384 – 404 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 563 – 583 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 658 – 678 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 691 – 711 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 766 – 786 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 809 – 829 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 841 – 861 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 904 – 924 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 942 – 962 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 978 – 998 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1207 – 1227 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1247 – 1267 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1277 – 1297 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1340 – 1360 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1408 – 1428 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1452 – 1472 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1529 – 1549 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1554 – 1574 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1596 – 1616 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1618 – 1638 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1654 – 1674 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1748 – 1768 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054106 | 1 – 2039 | Calcium-channel protein CCH1Add BLAST | 2039 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 284 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P50077 |
PaxDbi | P50077 |
PRIDEi | P50077 |
PTM databases
iPTMneti | P50077 |
Interactioni
Subunit structurei
Interacts with MID1 to form a Ca2+ influx channel.
1 PublicationProtein-protein interaction databases
BioGRIDi | 33470, 166 interactors |
IntActi | P50077, 14 interactors |
MINTi | P50077 |
STRINGi | 4932.YGR217W |
Miscellaneous databases
RNActi | P50077, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1787 – 1822 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000170242 |
HOGENOMi | CLU_000443_2_0_1 |
InParanoidi | P50077 |
OMAi | CQRIVGP |
Family and domain databases
Gene3Di | 1.20.120.350, 2 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR005821, Ion_trans_dom IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P50077-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQGRKRTLTE PFEPNTNPFG DNAAVMTENV EDNSETDGNR LESKPQALVP
60 70 80 90 100
PALNIVPPES SIHSTEEKKG DEYNGNDKDS SLISNIFRTR VGRSSHENLS
110 120 130 140 150
RPKLSLKTAS FGAAESSRRN VSPSTKSAKS SSQYIDLNDE RLRRRSFSSY
160 170 180 190 200
SRSSSRRVSN SPSSTDRPPR SAKVLSLIAA DDMDDFEDLQ KGFKSAIDEE
210 220 230 240 250
GLTWLPQLKS EKSRPVSDVG EDRGEGEQES IPDVHTPNVG ASATPGSIHL
260 270 280 290 300
TPEPAQNGSV SEGLEGSINN SRKKPSPKFF HHLSPQKEDK DQTEVIEYAE
310 320 330 340 350
DILDFETLQR KLESRPFVLY GHSLGVFSPT NPLRIKIARF LLHRRYSLLY
360 370 380 390 400
NTLLTFYAIL LAIRTYNPHN VVFLYRFSNW TDYFIFILSA CFTGNDIAKI
410 420 430 440 450
IAFGFWDDSE MFKAYGREYK SILQRSGIMK LYIYLREKYG RKLIDFIIPF
460 470 480 490 500
RIISPGEETK YQRSSLSTSL TKPYGAKENQ RPFGTPRAFA RSSWNRIDLV
510 520 530 540 550
SSVSFWLGMF LSIKSYDTKT GIRIFKPLAI LRILRLVNVD TGMPSILRGL
560 570 580 590 600
KYGIPQLVNV SSMLVYFWIF FGILGVQIFQ GSFRRQCVWF NPEDPTDTYQ
610 620 630 640 650
YDMQFCGGYL DPVTKRKQNY IYEDGSEGSV SKGFLCPQYS KCVSNANPYN
660 670 680 690 700
GRISFDNIVN SMELVFVIMS ANTFTDLMYY TMDSDEMAAC LFFIVCIFVL
710 720 730 740 750
TIWLLNLLIA VLVSSFEIAN EEYKKKKFIY GSRKTGYVAR IVTGYWKYFK
760 770 780 790 800
LKANQTKFPN WSQKGLAIYS HVEFIFVILI ICDIGMRASV KVSTSANCNN
810 820 830 840 850
ILLKTDRGIS IVLFIESLAR LVLYLPNMWK FLTKPSYVYD FIISIITLVI
860 870 880 890 900
SCLAVEGVLG HMYAWLSIFH ISRFYRVIIS FNLTKKLWKQ ILSNGVMIWN
910 920 930 940 950
LSSFYFFFTF LVAIIMAVYF EGVIPPEEMA DQPFGMYSLP NSFLSLFIIG
960 970 980 990 1000
STENWTDILY ALQKHSPNIS STFFCSVFFI IWFLLSNSVI LNIFIALISE
1010 1020 1030 1040 1050
SMEVKEEEKR PQQIKHYLKF VYPQKIQEYT HASLVARIRK KFFGGHRNED
1060 1070 1080 1090 1100
TRDFKQFLMR GTAIMNIAQN MGELADEFKE PPSENLFKKG LSKLTIGVPS
1110 1120 1130 1140 1150
LKRLRMFANN PFYKNSDVVF TETNDINGRT YILELNEYED EKLDYLKKYP
1160 1170 1180 1190 1200
LFNYSYYFFS PQHRFRRFCQ RLVPPSTGKR TDGSRFFEDS TDLYNKRSYF
1210 1220 1230 1240 1250
HHIERDVFVF IFALATILLI VCSCYVTPLY RMHHKMGTWN WSSALDCAFI
1260 1270 1280 1290 1300
GAFSIEFIVK TVADGFIYSP NAYLRNPWNF IDFCVLISMW INLIAYLKNN
1310 1320 1330 1340 1350
GNLSRIFKGL TALRALRCLT ISNTARQTFN LVMFDGLNKI FEAGLISLSL
1360 1370 1380 1390 1400
LFPFTVWGLS IFKGRLGTCN DGSLGRADCY NEYSNSVFQW DIMSPRVYQQ
1410 1420 1430 1440 1450
PYLHLDSFAS AFSSLYQIIS LEGWVDLLEN MMNSSGIGTP ATVMGSAGNA
1460 1470 1480 1490 1500
LFLVLFNFLS MVFILNLFVS FIVNNQARTT GSAYFTIEEK AWLESQKLLS
1510 1520 1530 1540 1550
QAKPKAIPNL IELSRVRQFF YQLAVEKKNF YYASFLQVVL YLHIIMLLSR
1560 1570 1580 1590 1600
SYNPGNLIGY QGVYFMFSTS VFLIQEALHM CGEGPRLYFR QKWNSIRLSI
1610 1620 1630 1640 1650
IIIAFIMNAV AFHVPASHYW FHNIKGFFLL VIFLFIIPQN DTLTELLETA
1660 1670 1680 1690 1700
MASLPPILSL TYTWGVLFLV YAIALNQIFG LTRLGSNTTD NINFRTVIKS
1710 1720 1730 1740 1750
MIVLFRCSFG EGWNYIMADL TVSEPYCSSD DNSTYTDCGS ETYAYLLLMS
1760 1770 1780 1790 1800
WNIISMYIFV NMFVSLIIGN FSYVYRSGGS RSGINRSEIK KYIEAWSKFD
1810 1820 1830 1840 1850
TDGTGELELS YLPRIMHSFD GPLSFKIWEG RLTIKSLVEN YMEVNPDDPY
1860 1870 1880 1890 1900
DVKIDLIGLN KELNTIDKAK IIQRKLQYRR FVQSIHYTNA YNGCIRFSDL
1910 1920 1930 1940 1950
LLQIPLYTAY SARECLGIDQ YVHHLYILGK VDKYLENQRN FDVLEMVVTR
1960 1970 1980 1990 2000
WKFHCRMKRT IEPEWDVKDP TVSSHISNIN VNLEPAPGIL EREPIATPRM
2010 2020 2030
DYGVNNFMWS PRMNQDSTME PPEEPIDNND DSANDLIDR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1185 | R → Q in CAA61165 (PubMed:9290212).Curated | 1 | |
Sequence conflicti | 1203 | I → N in CAA61165 (PubMed:9290212).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73002 Genomic DNA Translation: CAA97244.1 Z73003 Genomic DNA Translation: CAA97245.1 X87941 Genomic DNA Translation: CAA61165.1 BK006941 Genomic DNA Translation: DAA08311.1 |
PIRi | S64540 |
RefSeqi | NP_011733.3, NM_001181346.3 |
Genome annotation databases
EnsemblFungii | YGR217W_mRNA; YGR217W; YGR217W |
GeneIDi | 853131 |
KEGGi | sce:YGR217W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73002 Genomic DNA Translation: CAA97244.1 Z73003 Genomic DNA Translation: CAA97245.1 X87941 Genomic DNA Translation: CAA61165.1 BK006941 Genomic DNA Translation: DAA08311.1 |
PIRi | S64540 |
RefSeqi | NP_011733.3, NM_001181346.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33470, 166 interactors |
IntActi | P50077, 14 interactors |
MINTi | P50077 |
STRINGi | 4932.YGR217W |
Protein family/group databases
TCDBi | 1.A.1.11.10, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | P50077 |
Proteomic databases
MaxQBi | P50077 |
PaxDbi | P50077 |
PRIDEi | P50077 |
Genome annotation databases
EnsemblFungii | YGR217W_mRNA; YGR217W; YGR217W |
GeneIDi | 853131 |
KEGGi | sce:YGR217W |
Organism-specific databases
SGDi | S000003449, CCH1 |
VEuPathDBi | FungiDB:YGR217W |
Phylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000170242 |
HOGENOMi | CLU_000443_2_0_1 |
InParanoidi | P50077 |
OMAi | CQRIVGP |
Miscellaneous databases
PROi | PR:P50077 |
RNActi | P50077, protein |
Family and domain databases
Gene3Di | 1.20.120.350, 2 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR005821, Ion_trans_dom IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCH1_YEAST | |
Accessioni | P50077Primary (citable) accession number: P50077 Secondary accession number(s): D6VV00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - SIMILARITY comments
Index of protein domains and families - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names