KHK

Functionⁱ

Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.1 Publication

Catalytic activityⁱ

ATP + D-fructose = ADP + D-fructose 1-phosphate.1 Publication

Activity regulationⁱ

Requires potassium. Inhibition by ADP.

Kineticsⁱ

kcat is 7.6 sec(-1).1 Publication

K_M=
0.8 mM for D-fructose (at 25 degrees Celsius)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria."
  Asipu A., Hayward B.E., O'Reilly J., Bonthron D.T.
  Diabetes 52:2426-2432(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: CHARACTERIZATION OF VARIANTS FRUCT ARG-40 AND THR-43, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, CATALYTIC ACTIVITY.
K_M=
0.15 mM for Mg-ATP (at 25 degrees Celsius)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria."
  Asipu A., Hayward B.E., O'Reilly J., Bonthron D.T.
  Diabetes 52:2426-2432(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: CHARACTERIZATION OF VARIANTS FRUCT ARG-40 AND THR-43, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, CATALYTIC ACTIVITY.

Pathwayⁱ: fructose metabolism

This protein is involved in the pathway fructose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway fructose metabolism and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	15	D-fructose	1
Binding siteⁱ	41	D-fructose; via amide nitrogen	1
Binding siteⁱ	42	D-fructose	1
Binding siteⁱ	45	D-fructose	1
Binding siteⁱ	108	ATP	1
Binding siteⁱ	258	D-fructose	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	255 – 258	ATP		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
carbohydrate kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ketohexokinase activity
Source: MGI
Inferred from direct assayⁱ
- 22371574

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
fructose metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of glycogen metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to fructose
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to glucose
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to insulin
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to sucrose
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to zinc ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Carbohydrate metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06437-MONOMER
BRENDAⁱ	2.7.1.3 2681
Reactomeⁱ	R-HSA-5657562 Essential fructosuria R-HSA-70350 Fructose catabolism
SABIO-RKⁱ	P50053
UniPathwayⁱ	UPA00202

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: KetohexokinaseImported (EC:2.7.1.31 Publication) Alternative name(s): Hepatic fructokinase
Gene namesⁱ	Name:KHKImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138030.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6315 KHK
MIMⁱ	614058 gene
neXtProtⁱ	NX_P50053

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Fructosuria (FRUCT)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionBenign defect of intermediary metabolism.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3795
MalaCards human disease database More...MalaCardsⁱ	KHK
MIMⁱ	229800 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000138030
Orphanetⁱ	2056 Essential fructosuria
PharmGKBⁱ	PA30095

Chemistry databases

ChEMBLⁱ	CHEMBL1275212

ChEMBLⁱ

CHEMBL1275212

Polymorphism and mutation databases

BioMutaⁱ	KHK
DMDMⁱ	1730044

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080088	1 – 298	KetohexokinaseAdd BLAST		298

Proteomic databases

EPDⁱ	P50053
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50053
PaxDbⁱ	P50053
PeptideAtlas More...PeptideAtlasⁱ	P50053
PRIDEⁱ	P50053
ProteomicsDBⁱ	56192 56193 [P50053-2]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00029488

REPRODUCTION-2DPAGEⁱ

IPI00029488

PTM databases

iPTMnetⁱ	P50053
PhosphoSitePlusⁱ	P50053

Expressionⁱ

Tissue specificityⁱ

Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000138030 Expressed in 163 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_KHK
ExpressionAtlasⁱ	P50053 baseline and differential
Genevisibleⁱ	P50053 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007040

HPAⁱ

HPA007040

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LHX9	Q9NQ69	3	EBI-12204387,EBI-10175218
PRPS1	P60891-1	4	EBI-12204387,EBI-16205225

Protein-protein interaction databases

BioGridⁱ	109996, 20 interactors
Database of interacting proteins More...DIPⁱ	DIP-50184N
IntActⁱ	P50053, 4 interactors
STRINGⁱ	9606.ENSP00000260598

Chemistry databases

BindingDBⁱ

P50053

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 10	Combined sources	6
Beta strandⁱ	13 – 22	Combined sources	10
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	33 – 41	Combined sources	9
Helixⁱ	42 – 53	Combined sources	12
Beta strandⁱ	57 – 63	Combined sources	7
Helixⁱ	67 – 78	Combined sources	12
Beta strandⁱ	86 – 88	Combined sources	3
Beta strandⁱ	90 – 92	Combined sources	3
Beta strandⁱ	96 – 102	Combined sources	7
Turnⁱ	103 – 105	Combined sources	3
Beta strandⁱ	108 – 113	Combined sources	6
Helixⁱ	122 – 126	Combined sources	5
Helixⁱ	130 – 132	Combined sources	3
Beta strandⁱ	133 – 139	Combined sources	7
Helixⁱ	143 – 157	Combined sources	15
Helixⁱ	162 – 164	Combined sources	3
Beta strandⁱ	167 – 172	Combined sources	6
Helixⁱ	177 – 184	Combined sources	8
Beta strandⁱ	185 – 191	Combined sources	7
Helixⁱ	193 – 198	Combined sources	6
Helixⁱ	204 – 211	Combined sources	8
Helixⁱ	212 – 214	Combined sources	3
Beta strandⁱ	220 – 224	Combined sources	5
Helixⁱ	226 – 228	Combined sources	3
Beta strandⁱ	230 – 233	Combined sources	4
Beta strandⁱ	239 – 242	Combined sources	4
Helixⁱ	256 – 269	Combined sources	14
Helixⁱ	274 – 289	Combined sources	16
Beta strandⁱ	291 – 294	Combined sources	4
Helixⁱ	295 – 297	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P50053
SMRⁱ	P50053
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P50053

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2947 Eukaryota ENOG4111F4Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007458
HOGENOMⁱ	HOG000212926
HOVERGENⁱ	HBG003335
InParanoidⁱ	P50053
KEGG Orthology (KO) More...KOⁱ	K00846
OMAⁱ	CNKDYPQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EV7
TreeFamⁱ	TF323942

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01939 Ketohexokinase, 1 hit
Gene3Dⁱ	3.40.1190.20, 1 hit
InterProⁱ	View protein in InterPro IPR034093 KHK IPR011611 PfkB_dom IPR029056 Ribokinase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00294 PfkB, 1 hit
SUPFAMⁱ	SSF53613 SSF53613, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform C1 Publication (identifier: P50053-1) [UniParc]FASTA Add to basket

Also known as: Central, hepatic/renal/intestinal1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL 
        60         70         80         90        100
SLLGAPCAFM GSMAPGHVAD FLVADFRRRG VDVSQVAWQS KGDTPSSCCI 
       110        120        130        140        150
INNSNGNRTI VLHDTSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML 
       160        170        180        190        200
QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG 
       210        220        230        240        250
FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV 
       260        270        280        290 
VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Length:298

Mass (Da):32,523

Last modified:April 29, 2015 - v2

Checksum:ⁱBE77FC325CAC5721

GO

Isoform A1 Publication (identifier: P50053-2) [UniParc]FASTA Add to basket

Also known as: Peripheral1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-115: LVADFRRRGV...GNRTIVLHDT → VLDDLRRYSV...GSRTILYYDR

« Hide

        10         20         30         40         50
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL 
        60         70         80         90        100
SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI 
       110        120        130        140        150
INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML 
       160        170        180        190        200
QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG 
       210        220        230        240        250
FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV 
       260        270        280        290 
VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Note: More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1).1 Publication

Show »

Length:298

Mass (Da):32,730

Checksum:ⁱ1BA47BDC60C1B89F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JDL1	C9JDL1_HUMAN		Ketohexokinase Ketohexokinase	KHK	279	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_006072	40	G → R in FRUCT; loss of ketohexokinase function; insoluble. 2 PublicationsCorresponds to variant dbSNP:rs104893643EnsemblClinVar.	1
Natural variantⁱVAR_006073	43	A → T in FRUCT; no effect on ketohexokinase function; decreases enzyme activity but no effect in substrate affinity; decreases thermal stability. 2 PublicationsCorresponds to variant dbSNP:rs104893644EnsemblClinVar.	1
Natural variantⁱVAR_006074	49	V → I1 PublicationCorresponds to variant dbSNP:rs2304681EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004669	72 – 115	LVADF…VLHDT → VLDDLRRYSVDLRYTVFQTT GSVPIATVIINEASGSRTIL YYDR in isoform A. CuratedAdd BLAST		44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78678 mRNA Translation: CAA55347.1 X78677 mRNA Translation: CAA55346.1 CR456801 mRNA Translation: CAG33082.1 AC013403 Genomic DNA Translation: AAX93167.1 CH471053 Genomic DNA Translation: EAX00643.1 BC006233 mRNA Translation: AAH06233.1 Y09336 Genomic DNA Translation: CAA70516.1 Y09341 Genomic DNA Translation: CAA70522.1 Y09341 Genomic DNA Translation: CAA70523.1 Y09340 Genomic DNA Translation: CAA70521.1 AJ005168 Genomic DNA Translation: CAA06409.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1734.1 [P50053-2] CCDS1735.1 [P50053-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000212.1, NM_000221.2 [P50053-2] NP_006479.1, NM_006488.2 [P50053-1]
UniGeneⁱ	Hs.567297

Genome annotation databases

Ensemblⁱ	ENST00000260598; ENSP00000260598; ENSG00000138030 [P50053-1] ENST00000260599; ENSP00000260599; ENSG00000138030 [P50053-2]
GeneIDⁱ	3795
KEGGⁱ	hsa:3795
UCSC genome browser More...UCSCⁱ	uc002ril.3 human [P50053-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P50053	Ketohexokinase		GORGO		298	UniRef100_P50053
P50053-2	Testicular tissue protein Li 102		HUMAN		298	UniRef100_A0A140VJM6

Protein	Similar proteins		Species	Score	Length	Source
P50053	Ketohexokinase		RAT		298	UniRef90_P50053
Ketohexokinase		MOUSE		298
Ketohexokinase		GORGO		298
Ketohexokinase		CANLF		300
Ketohexokinase (Fragment)		MUSPF		298
+73
P50053-2	KHK isoform 2		PANTR		298	UniRef90_H2QHL3
Uncharacterized protein		PANPA		298
Uncharacterized protein		NOMLE		298
Ketohexokinase isoform a variant (Fragment)		HUMAN		298
Ketohexokinase		SAIBB		298
+16

Protein	Similar proteins		Species	Score	Length	Source
P50053	Ketohexokinase		RAT		298	UniRef50_P50053
Ketohexokinase		MOUSE		298
Ketohexokinase		GORGO		298
Ketohexokinase		CANLF		300
ketohexokinase isoform X3		NEOSC		298
+288

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78678 mRNA Translation: CAA55347.1 X78677 mRNA Translation: CAA55346.1 CR456801 mRNA Translation: CAG33082.1 AC013403 Genomic DNA Translation: AAX93167.1 CH471053 Genomic DNA Translation: EAX00643.1 BC006233 mRNA Translation: AAH06233.1 Y09336 Genomic DNA Translation: CAA70516.1 Y09341 Genomic DNA Translation: CAA70522.1 Y09341 Genomic DNA Translation: CAA70523.1 Y09340 Genomic DNA Translation: CAA70521.1 AJ005168 Genomic DNA Translation: CAA06409.1
CCDSⁱ	CCDS1734.1 [P50053-2] CCDS1735.1 [P50053-1]
RefSeqⁱ	NP_000212.1, NM_000221.2 [P50053-2] NP_006479.1, NM_006488.2 [P50053-1]
UniGeneⁱ	Hs.567297

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HLZ	X-ray	1.85	A/B/C/D	5-298	[»]
	2HQQ	X-ray	1.86	A	1-298	[»]
	2HW1	X-ray	2.10	A	1-298	[»]
	3B3L	X-ray	2.90	A/B/C/D	1-298	[»]
	3NBV	X-ray	2.30	A/B	5-298	[»]
	3NBW	X-ray	2.34	A/B	5-298	[»]
	3NC2	X-ray	2.50	A/B	5-298	[»]
	3NC9	X-ray	2.40	A/B	5-298	[»]
	3NCA	X-ray	2.60	A/B	5-298	[»]
	3Q92	X-ray	2.80	A/B	5-298	[»]
	3QA2	X-ray	2.52	A/B	5-298	[»]
	3QAI	X-ray	2.70	A/B	5-298	[»]
	3RO4	X-ray	2.60	A/B	5-298	[»]
	5WBM	X-ray	2.16	A/B	5-298	[»]
	5WBO	X-ray	2.25	A/B	5-298	[»]
	5WBP	X-ray	2.74	A/B	5-298	[»]
	5WBQ	X-ray	2.40	A/B	5-298	[»]
	5WBR	X-ray	2.58	A/B	5-298	[»]
	5WBZ	X-ray	2.40	A/B	5-298	[»]
ProteinModelPortalⁱ	P50053
SMRⁱ	P50053
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109996, 20 interactors
DIPⁱ	DIP-50184N
IntActⁱ	P50053, 4 interactors
STRINGⁱ	9606.ENSP00000260598

Chemistry databases

BindingDBⁱ	P50053
ChEMBLⁱ	CHEMBL1275212

PTM databases

iPTMnetⁱ	P50053
PhosphoSitePlusⁱ	P50053

Polymorphism and mutation databases

BioMutaⁱ	KHK
DMDMⁱ	1730044

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00029488

REPRODUCTION-2DPAGEⁱ

IPI00029488

Proteomic databases

EPDⁱ	P50053
MaxQBⁱ	P50053
PaxDbⁱ	P50053
PeptideAtlasⁱ	P50053
PRIDEⁱ	P50053
ProteomicsDBⁱ	56192 56193 [P50053-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3795
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000260598; ENSP00000260598; ENSG00000138030 [P50053-1] ENST00000260599; ENSP00000260599; ENSG00000138030 [P50053-2]
GeneIDⁱ	3795
KEGGⁱ	hsa:3795
UCSCⁱ	uc002ril.3 human [P50053-1]

Organism-specific databases

CTDⁱ	3795
DisGeNETⁱ	3795
EuPathDBⁱ	HostDB:ENSG00000138030.12
GeneCardsⁱ	KHK
HGNCⁱ	HGNC:6315 KHK
HPAⁱ	HPA007040
MalaCardsⁱ	KHK
MIMⁱ	229800 phenotype 614058 gene
neXtProtⁱ	NX_P50053
OpenTargetsⁱ	ENSG00000138030
Orphanetⁱ	2056 Essential fructosuria
PharmGKBⁱ	PA30095
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2947 Eukaryota ENOG4111F4Q LUCA
GeneTreeⁱ	ENSGT00390000007458
HOGENOMⁱ	HOG000212926
HOVERGENⁱ	HBG003335
InParanoidⁱ	P50053
KOⁱ	K00846
OMAⁱ	CNKDYPQ
OrthoDBⁱ	EOG091G0EV7
TreeFamⁱ	TF323942

Enzyme and pathway databases

UniPathwayⁱ	UPA00202
BioCycⁱ	MetaCyc:HS06437-MONOMER
BRENDAⁱ	2.7.1.3 2681
Reactomeⁱ	R-HSA-5657562 Essential fructosuria R-HSA-70350 Fructose catabolism
SABIO-RKⁱ	P50053

Miscellaneous databases

EvolutionaryTraceⁱ	P50053
GenomeRNAiⁱ	3795
Protein Ontology More...PROⁱ	PR:P50053
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138030 Expressed in 163 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_KHK
ExpressionAtlasⁱ	P50053 baseline and differential
Genevisibleⁱ	P50053 HS

Family and domain databases

CDDⁱ	cd01939 Ketohexokinase, 1 hit
Gene3Dⁱ	3.40.1190.20, 1 hit
InterProⁱ	View protein in InterPro IPR034093 KHK IPR011611 PfkB_dom IPR029056 Ribokinase-like
Pfamⁱ	View protein in Pfam PF00294 PfkB, 1 hit
SUPFAMⁱ	SSF53613 SSF53613, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KHK_HUMAN
Accessionⁱ	P50053Primary (citable) accession number: P50053 Secondary accession number(s): Q6IBK2 , Q99532, Q9BRJ3, Q9UMN1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	April 29, 2015
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50053 (KHK_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Ketohexokinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fructose metabolism

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: fructose metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ