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Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene

ENTPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication, Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.0-7.5 with ATP as substrate, and 7.5-8.0 with ADP as substrate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei174Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: ProtInc
  • cell adhesion Source: ProtInc
  • nucleobase-containing small molecule catabolic process Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06471-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
Short name:
NTPDase 1
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name:
Ecto-ATPDase 1
Short name:
Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen: CD39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENTPD1
Synonyms:CD39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138185.17
HostDB:ENSG00000282889.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3363 ENTPD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49961

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 478ExtracellularSequence analysisAdd BLAST441
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 510CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 64, autosomal recessive (SPG64)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
See also OMIM:615683
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071082210G → R in SPG64. 1 Publication1

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
953

MalaCards human disease database

More...
MalaCardsi
ENTPD1
MIMi615683 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138185

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
401810 Autosomal recessive spastic paraplegia type 64

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27798

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5722

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2888

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENTPD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1705710

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002099021 – 510Ectonucleoside triphosphate diphosphohydrolase 1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi13S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi84 ↔ 108By similarity
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 301By similarity
Disulfide bondi282 ↔ 325By similarity
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi338 ↔ 343By similarity
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi390 ↔ 413By similarity
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Palmitoylated in the N-terminal part.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49961

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49961

PeptideAtlas

More...
PeptideAtlasi
P49961

PRoteomics IDEntifications database

More...
PRIDEi
P49961

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56188
56189 [P49961-2]
56190 [P49961-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1192

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49961

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49961

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P49961

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138185 Expressed in 222 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...
CleanExi
HS_ENTPD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49961 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49961 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002494
HPA014067

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RANBP9Q96S595EBI-8074749,EBI-636085

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107391, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P49961

Protein interaction database and analysis system

More...
IntActi
P49961, 1 interactor

Molecular INTeraction database

More...
MINTi
P49961

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360250

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P49961

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P49961

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49961

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1386 Eukaryota
COG5371 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059572

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018982

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49961

KEGG Orthology (KO)

More...
KOi
K01510

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFCSQPW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05FZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49961

TreeFam database of animal gene trees

More...
TreeFami
TF332859

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000407 GDA1_CD39_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR11782 PTHR11782, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01150 GDA1_CD39, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49961-1) [UniParc]FASTAAdd to basket
Also known as: Vascular

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG
60 70 80 90 100
IVLDAGSSHT SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE
110 120 130 140 150
IGIYLTDCME RAREVIPRSQ HQETPVYLGA TAGMRLLRME SEELADRVLD
160 170 180 190 200
VVERSLSNYP FDFQGARIIT GQEEGAYGWI TINYLLGKFS QKTRWFSIVP
210 220 230 240 250
YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR LYGKDYNVYT
260 270 280 290 300
HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
310 320 330 340 350
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL
360 370 380 390 400
PPLQGDFGAF SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS
410 420 430 440 450
YAGVKEKYLS EYCFSGTYIL SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW
460 470 480 490 500
TLGYMLNLTN MIPAEQPLST PLSHSTYVFL MVLFSLVLFT VAIIGLLIFH
510
KPSYFWKDMV
Length:510
Mass (Da):57,965
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAD87D2499649159
GO
Isoform 2 (identifier: P49961-2) [UniParc]FASTAAdd to basket
Also known as: Placental I

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEDT → MKGTKDLTSQQ

Show »
Length:517
Mass (Da):58,706
Checksum:i3E6C59E474010921
GO
Isoform 3 (identifier: P49961-3) [UniParc]FASTAAdd to basket
Also known as: Placental II

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEDT → MKGTKDLTSQQ
     272-299: VASNEILRDPCFHPGYKKVVNVSDLYKT → ASITQSRPAPFTSAPPAPTSCCFLFQIQ
     300-510: Missing.

Show »
Length:306
Mass (Da):34,175
Checksum:iE0D3B642D3A5A6C8
GO
Isoform 4 (identifier: P49961-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:372
Mass (Da):42,731
Checksum:iA8B1DE1366356EE3
GO
Isoform 5 (identifier: P49961-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:402
Mass (Da):46,180
Checksum:iF5CE35BD50FF7DB3
GO
Isoform 6 (identifier: P49961-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MEDTK → MGREELFLTFSFSSGFQ

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,325
Checksum:i5D160D81F02277B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQK8A0A1W2PQK8_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR44A0A0U1RR44_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQZ5A0A0U1RQZ5_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57 – 58SS → G AA sequence (PubMed:9846014).Curated2
Sequence conflicti162D → K AA sequence (PubMed:8529670).Curated1
Sequence conflicti208T → TGET AA sequence (PubMed:9846014).Curated1
Sequence conflicti248V → Y AA sequence (PubMed:9846014).Curated1
Sequence conflicti481M → I in BAG62981 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071082210G → R in SPG64. 1 Publication1
Natural variantiVAR_022099293V → I. Corresponds to variant dbSNP:rs3793744Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442841 – 138Missing in isoform 4. 2 PublicationsAdd BLAST138
Alternative sequenceiVSP_0442831 – 108Missing in isoform 5. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_0460501 – 5MEDTK → MGREELFLTFSFSSGFQ in isoform 6. 1 Publication5
Alternative sequenceiVSP_0036071 – 4MEDT → MKGTKDLTSQQ in isoform 2 and isoform 3. 1 Publication4
Alternative sequenceiVSP_003608272 – 299VASNE…DLYKT → ASITQSRPAPFTSAPPAPTS CCFLFQIQ in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_003609300 – 510Missing in isoform 3. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S73813 mRNA Translation: AAB32152.1
U87967 mRNA Translation: AAB47572.1
AK304836 mRNA Translation: BAG65580.1
AJ133133 mRNA Translation: CAB41886.1
AJ133134 mRNA Translation: CAB41887.1
AK298648 mRNA Translation: BAH12835.1
AK301459 mRNA Translation: BAG62981.1
AK304018 mRNA Translation: BAG64933.1
AK316009 mRNA Translation: BAH14380.1
AL356632 Genomic DNA No translation available.
AL365273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49988.1
CH471066 Genomic DNA Translation: EAW49989.1
CH471066 Genomic DNA Translation: EAW49990.1
BC047664 mRNA Translation: AAH47664.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41554.1 [P49961-2]
CCDS53556.1 [P49961-6]
CCDS53557.1 [P49961-5]
CCDS7444.1 [P49961-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I56242

NCBI Reference Sequences

More...
RefSeqi
NP_001091645.1, NM_001098175.1 [P49961-2]
NP_001157650.1, NM_001164178.1 [P49961-6]
NP_001157653.1, NM_001164181.1 [P49961-5]
NP_001157654.1, NM_001164182.1 [P49961-4]
NP_001157655.1, NM_001164183.1 [P49961-4]
NP_001299583.1, NM_001312654.1 [P49961-5]
NP_001307845.1, NM_001320916.1
NP_001767.3, NM_001776.5 [P49961-1]
XP_011538673.1, XM_011540371.2 [P49961-2]
XP_011538679.1, XM_011540377.2 [P49961-5]
XP_016872448.1, XM_017016959.1 [P49961-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.576612
Hs.722260

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371205; ENSP00000360248; ENSG00000138185 [P49961-1]
ENST00000371207; ENSP00000360250; ENSG00000138185 [P49961-6]
ENST00000453258; ENSP00000390955; ENSG00000138185 [P49961-2]
ENST00000543964; ENSP00000442968; ENSG00000138185 [P49961-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:953

UCSC genome browser

More...
UCSCi
uc001klh.5 human [P49961-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73813 mRNA Translation: AAB32152.1
U87967 mRNA Translation: AAB47572.1
AK304836 mRNA Translation: BAG65580.1
AJ133133 mRNA Translation: CAB41886.1
AJ133134 mRNA Translation: CAB41887.1
AK298648 mRNA Translation: BAH12835.1
AK301459 mRNA Translation: BAG62981.1
AK304018 mRNA Translation: BAG64933.1
AK316009 mRNA Translation: BAH14380.1
AL356632 Genomic DNA No translation available.
AL365273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49988.1
CH471066 Genomic DNA Translation: EAW49989.1
CH471066 Genomic DNA Translation: EAW49990.1
BC047664 mRNA Translation: AAH47664.1
CCDSiCCDS41554.1 [P49961-2]
CCDS53556.1 [P49961-6]
CCDS53557.1 [P49961-5]
CCDS7444.1 [P49961-1]
PIRiI56242
RefSeqiNP_001091645.1, NM_001098175.1 [P49961-2]
NP_001157650.1, NM_001164178.1 [P49961-6]
NP_001157653.1, NM_001164181.1 [P49961-5]
NP_001157654.1, NM_001164182.1 [P49961-4]
NP_001157655.1, NM_001164183.1 [P49961-4]
NP_001299583.1, NM_001312654.1 [P49961-5]
NP_001307845.1, NM_001320916.1
NP_001767.3, NM_001776.5 [P49961-1]
XP_011538673.1, XM_011540371.2 [P49961-2]
XP_011538679.1, XM_011540377.2 [P49961-5]
XP_016872448.1, XM_017016959.1 [P49961-4]
UniGeneiHs.576612
Hs.722260

3D structure databases

ProteinModelPortaliP49961
SMRiP49961
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107391, 2 interactors
CORUMiP49961
IntActiP49961, 1 interactor
MINTiP49961
STRINGi9606.ENSP00000360250

Chemistry databases

BindingDBiP49961
ChEMBLiCHEMBL5722
GuidetoPHARMACOLOGYi2888

PTM databases

GlyConnecti1192
iPTMnetiP49961
PhosphoSitePlusiP49961
SwissPalmiP49961

Polymorphism and mutation databases

BioMutaiENTPD1
DMDMi1705710

Proteomic databases

MaxQBiP49961
PaxDbiP49961
PeptideAtlasiP49961
PRIDEiP49961
ProteomicsDBi56188
56189 [P49961-2]
56190 [P49961-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
953
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371205; ENSP00000360248; ENSG00000138185 [P49961-1]
ENST00000371207; ENSP00000360250; ENSG00000138185 [P49961-6]
ENST00000453258; ENSP00000390955; ENSG00000138185 [P49961-2]
ENST00000543964; ENSP00000442968; ENSG00000138185 [P49961-5]
GeneIDi953
KEGGihsa:953
UCSCiuc001klh.5 human [P49961-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
953
DisGeNETi953
EuPathDBiHostDB:ENSG00000138185.17
HostDB:ENSG00000282889.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENTPD1
HGNCiHGNC:3363 ENTPD1
HPAiCAB002494
HPA014067
MalaCardsiENTPD1
MIMi601752 gene
615683 phenotype
neXtProtiNX_P49961
OpenTargetsiENSG00000138185
Orphaneti401810 Autosomal recessive spastic paraplegia type 64
PharmGKBiPA27798

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1386 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00940000153151
HOGENOMiHOG000059572
HOVERGENiHBG018982
InParanoidiP49961
KOiK01510
OMAiKFCSQPW
OrthoDBiEOG091G05FZ
PhylomeDBiP49961
TreeFamiTF332859

Enzyme and pathway databases

BioCyciMetaCyc:HS06471-MONOMER
ReactomeiR-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ENTPD1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ENTPD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
953

Protein Ontology

More...
PROi
PR:P49961

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138185 Expressed in 222 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ENTPD1
ExpressionAtlasiP49961 baseline and differential
GenevisibleiP49961 HS

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENTP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49961
Secondary accession number(s): A9Z1X8
, B4DWB9, B4E1X1, B7Z599, G3XAF6, Q5T561, Q5T562, Q86VV3, Q9UQQ9, Q9Y3Q9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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