UniProtKB - P49959 (MRE11_HUMAN)
Double-strand break repair protein MRE11
MRE11
Functioni
Miscellaneous
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 129 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- 3'-5' exonuclease activity Source: CACAO
- 5'-3' exonuclease activity Source: UniProtKB
- cadherin binding Source: BHF-UCL
- double-stranded DNA binding Source: ProtInc
- endodeoxyribonuclease activity Source: CACAO
- identical protein binding Source: IntAct
- manganese ion binding Source: InterPro
- nuclease activity Source: BHF-UCL
- protein C-terminus binding Source: UniProtKB
- single-stranded DNA endodeoxyribonuclease activity Source: CACAO
GO - Biological processi
- cell population proliferation Source: Ensembl
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA double-strand break processing Source: Reactome
- DNA duplex unwinding Source: BHF-UCL
- DNA recombination Source: ProtInc
- DNA repair Source: ProtInc
- DNA replication Source: Reactome
- DNA strand resection involved in replication fork processing Source: UniProtKB
- double-strand break repair Source: ProtInc
- double-strand break repair via homologous recombination Source: UniProtKB
- double-strand break repair via nonhomologous end joining Source: CACAO
- homologous chromosome pairing at meiosis Source: Ensembl
- intra-S DNA damage checkpoint Source: GO_Central
- meiotic DNA double-strand break formation Source: GO_Central
- mitochondrial double-strand break repair via homologous recombination Source: GO_Central
- mitotic G2 DNA damage checkpoint Source: GO_Central
- negative regulation of apoptotic process Source: BHF-UCL
- positive regulation of kinase activity Source: BHF-UCL
- positive regulation of protein autophosphorylation Source: BHF-UCL
- positive regulation of telomere maintenance Source: BHF-UCL
- positive regulation of type I interferon production Source: Reactome
- reciprocal meiotic recombination Source: ProtInc
- regulation of mitotic recombination Source: ProtInc
- regulation of signal transduction by p53 class mediator Source: Reactome
- sister chromatid cohesion Source: BHF-UCL
- telomere maintenance Source: GO_Central
- telomere maintenance via telomerase Source: ProtInc
- telomeric 3' overhang formation Source: BHF-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Endonuclease, Exonuclease, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repair, Host-virus interaction, Meiosis |
Ligand | Manganese |
Enzyme and pathway databases
PathwayCommonsi | P49959 |
Reactomei | R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5685939, HDR through MMEJ (alt-NHEJ) R-HSA-5685942, HDR through Homologous Recombination (HRR) R-HSA-5693548, Sensing of DNA Double Strand Breaks R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693579, Homologous DNA Pairing and Strand Exchange R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69473, G2/M DNA damage checkpoint R-HSA-912446, Meiotic recombination |
SIGNORi | P49959 |
Names & Taxonomyi
Protein namesi | Recommended name: Double-strand break repair protein MRE11 (EC:3.1.-.-1 Publication)Alternative name(s): Double-strand break repair protein MRE11A Meiotic recombination 11 homolog 1 Short name: MRE11 homolog 1 Meiotic recombination 11 homolog A Short name: MRE11 homolog A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000020922.12 |
HGNCi | HGNC:7230, MRE11 |
MIMi | 600814, gene |
neXtProti | NX_P49959 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- telomere 1 Publication
- Chromosome 2 Publications
Note: Localizes to discrete nuclear foci after treatment with genotoxic agents.3 Publications
Cytosol
- cytosol Source: Reactome
Nucleus
- Mre11 complex Source: MGI
- nuclear chromosome, telomeric region Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: ProtInc
- PML body Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
- replication fork Source: UniProtKB
- site of double-strand break Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Nucleus, TelomerePathology & Biotechi
Involvement in diseasei
Ataxia-telangiectasia-like disorder 1 (ATLD1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008513 | 117 | N → S in ATLD1. 1 PublicationCorresponds to variant dbSNP:rs137852760EnsemblClinVar. | 1 |
Keywords - Diseasei
Ciliopathy, Disease mutationOrganism-specific databases
DisGeNETi | 4361 |
MalaCardsi | MRE11 |
MIMi | 604391, phenotype |
OpenTargetsi | ENSG00000020922 |
Orphaneti | 251347, Ataxia-telangiectasia-like disorder 145, Hereditary breast and ovarian cancer syndrome 240760, Nijmegen breakage syndrome-like disorder |
PharmGKBi | PA30934 |
Miscellaneous databases
Pharosi | P49959, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3308929 |
Polymorphism and mutation databases
BioMutai | MRE11 |
DMDMi | 17380137 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000138672 | 2 – 708 | Double-strand break repair protein MRE11Add BLAST | 707 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Cross-linki | 255 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 275 | PhosphoserineCombined sources | 1 | |
Cross-linki | 416 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 619 | PhosphoserineCombined sources | 1 | |
Cross-linki | 625 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 641 | PhosphoserineBy similarity | 1 | |
Modified residuei | 649 | PhosphoserineCombined sources | 1 | |
Modified residuei | 678 | PhosphoserineCombined sources | 1 | |
Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
Modified residuei | 689 | PhosphoserineCombined sources | 1 | |
Modified residuei | 701 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P49959 |
jPOSTi | P49959 |
MassIVEi | P49959 |
MaxQBi | P49959 |
PaxDbi | P49959 |
PeptideAtlasi | P49959 |
PRIDEi | P49959 |
ProteomicsDBi | 3675 56186 [P49959-1] 56187 [P49959-2] |
PTM databases
iPTMneti | P49959 |
PhosphoSitePlusi | P49959 |
SwissPalmi | P49959 |
Expressioni
Gene expression databases
Bgeei | ENSG00000020922, Expressed in calcaneal tendon and 223 other tissues |
ExpressionAtlasi | P49959, baseline and differential |
Genevisiblei | P49959, HS |
Organism-specific databases
HPAi | ENSG00000020922, Low tissue specificity |
Interactioni
Subunit structurei
Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:10839544, PubMed:26215093). As part of the MRN complex, interacts with MCM9; the interaction recruits the complex to DNA repair sites (PubMed:26215093).
Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (PubMed:10783165).
Found in a complex with TERF2 (PubMed:10888888).
Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo (PubMed:15456891, PubMed:15723659, PubMed:18469862).
Interacts with ATF2 (PubMed:15916964).
Interacts with EXD2 (PubMed:26807646).
Interacts with MRNIP (PubMed:27568553).
Interacts with SAMHD1; leading to stimulate 3'-5' exonuclease activity (PubMed:28834754, PubMed:29670289).
Interacts (when ubiquitinated) with UBQLN4 (via its UBA domain) (PubMed:30612738).
16 Publications(Microbial infection) Interacts with herpes simplex virus 1 protein UL12 (PubMed:20943970).
1 PublicationBinary interactionsi
Hide detailsP49959
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110501, 172 interactors |
ComplexPortali | CPX-4442, MRN complex |
CORUMi | P49959 |
DIPi | DIP-33238N |
IntActi | P49959, 51 interactors |
MINTi | P49959 |
STRINGi | 9606.ENSP00000325863 |
Chemistry databases
BindingDBi | P49959 |
Miscellaneous databases
RNActi | P49959, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P49959 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2310, Eukaryota |
GeneTreei | ENSGT00390000017288 |
HOGENOMi | CLU_009535_3_1_1 |
InParanoidi | P49959 |
OMAi | QWMRPET |
PhylomeDBi | P49959 |
TreeFami | TF101105 |
Family and domain databases
CDDi | cd00840, MPP_Mre11_N, 1 hit |
Gene3Di | 3.30.110.110, 1 hit 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR003701, Mre11 IPR007281, Mre11_DNA-bd IPR038487, Mre11_DNA-bd_sf IPR041796, Mre11_N |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF04152, Mre11_DNA_bind, 1 hit |
PIRSFi | PIRSF000882, DSB_repair_MRE11, 1 hit |
SMARTi | View protein in SMART SM01347, Mre11_DNA_bind, 1 hit |
TIGRFAMsi | TIGR00583, mre11, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN
60 70 80 90 100
EVDFILLGGD LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN
110 120 130 140 150
FGFSKFPWVN YQDGNLNISI PVFSIHGNHD DPTGADALCA LDILSCAGFV
160 170 180 190 200
NHFGRSMSVE KIDISPVLLQ KGSTKIALYG LGSIPDERLY RMFVNKKVTM
210 220 230 240 250
LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL VIWGHEHECK
260 270 280 290 300
IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
310 320 330 340 350
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE
360 370 380 390 400
RLGNSHQPEK PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR
410 420 430 440 450
HREQKEKTGE EINFGKLITK PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT
460 470 480 490 500
ERGMGEAVQE FVDKEEKDAI EELVKYQLEK TQRFLKERHI DALEDKIDEE
510 520 530 540 550
VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF SADDLMSIDL
560 570 580 590 600
AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE
610 620 630 640 650
TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD
660 670 680 690 700
VEEDIFPTTS KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT
SSLRRNRR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W7U8 | F8W7U8_HUMAN | Double-strand break repair protein | MRE11 | 707 | Annotation score: | ||
F5GXT0 | F5GXT0_HUMAN | Double-strand break repair protein ... | MRE11 | 221 | Annotation score: | ||
F5H256 | F5H256_HUMAN | Double-strand break repair protein ... | MRE11 | 127 | Annotation score: | ||
F5H742 | F5H742_HUMAN | Double-strand break repair protein ... | MRE11 | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | V → A in AAC78721 (PubMed:8530104).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011625 | 104 | S → C in cancer. 1 PublicationCorresponds to variant dbSNP:rs748434421EnsemblClinVar. | 1 | |
Natural variantiVAR_008513 | 117 | N → S in ATLD1. 1 PublicationCorresponds to variant dbSNP:rs137852760EnsemblClinVar. | 1 | |
Natural variantiVAR_011626 | 157 | M → V. Corresponds to variant dbSNP:rs147771140EnsemblClinVar. | 1 | |
Natural variantiVAR_036416 | 237 | F → C in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036417 | 302 | H → Y in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_025528 | 305 | R → W in ovarian cancer. 1 PublicationCorresponds to variant dbSNP:rs372000848EnsemblClinVar. | 1 | |
Natural variantiVAR_019288 | 468 | D → G1 PublicationCorresponds to variant dbSNP:rs1805367Ensembl. | 1 | |
Natural variantiVAR_011627 | 503 | R → H in cancer. 1 PublicationCorresponds to variant dbSNP:rs774057024EnsemblClinVar. | 1 | |
Natural variantiVAR_011628 | 572 | R → Q in cancer. 1 PublicationCorresponds to variant dbSNP:rs200085146EnsemblClinVar. | 1 | |
Natural variantiVAR_019289 | 698 | M → V1 PublicationCorresponds to variant dbSNP:rs1805362EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057350 | 1 – 7 | MSTADAL → MNRNISHQKG in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_003262 | 595 – 622 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37359 mRNA Translation: AAC78721.1 AF022778 mRNA Translation: AAD10197.1 AF073362 mRNA Translation: AAC36249.1 AF303395 , AF303379, AF303380, AF303381, AF303382, AF303383, AF303384, AF303385, AF303386, AF303387, AF303388, AF303389, AF303390, AF303391, AF303392, AF303393, AF303394 Genomic DNA Translation: AAK18790.1 AK095388 mRNA Translation: BAG53039.1 AY584241 Genomic DNA Translation: AAS79320.1 AP000765 Genomic DNA No translation available. AP000786 Genomic DNA No translation available. KF455448 Genomic DNA No translation available. BC063458 mRNA Translation: AAH63458.1 |
CCDSi | CCDS8298.1 [P49959-2] CCDS8299.1 [P49959-1] |
RefSeqi | NP_005581.2, NM_005590.3 [P49959-2] NP_005582.1, NM_005591.3 [P49959-1] XP_011541139.1, XM_011542837.2 [P49959-1] XP_016873261.1, XM_017017772.1 [P49959-1] |
Genome annotation databases
Ensembli | ENST00000323929; ENSP00000325863; ENSG00000020922 [P49959-1] ENST00000323977; ENSP00000326094; ENSG00000020922 [P49959-2] ENST00000407439; ENSP00000385614; ENSG00000020922 [P49959-3] |
GeneIDi | 4361 |
KEGGi | hsa:4361 |
UCSCi | uc001peu.4, human [P49959-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
MRE11base MRE11A mutation db |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37359 mRNA Translation: AAC78721.1 AF022778 mRNA Translation: AAD10197.1 AF073362 mRNA Translation: AAC36249.1 AF303395 , AF303379, AF303380, AF303381, AF303382, AF303383, AF303384, AF303385, AF303386, AF303387, AF303388, AF303389, AF303390, AF303391, AF303392, AF303393, AF303394 Genomic DNA Translation: AAK18790.1 AK095388 mRNA Translation: BAG53039.1 AY584241 Genomic DNA Translation: AAS79320.1 AP000765 Genomic DNA No translation available. AP000786 Genomic DNA No translation available. KF455448 Genomic DNA No translation available. BC063458 mRNA Translation: AAH63458.1 |
CCDSi | CCDS8298.1 [P49959-2] CCDS8299.1 [P49959-1] |
RefSeqi | NP_005581.2, NM_005590.3 [P49959-2] NP_005582.1, NM_005591.3 [P49959-1] XP_011541139.1, XM_011542837.2 [P49959-1] XP_016873261.1, XM_017017772.1 [P49959-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3T1I | X-ray | 3.00 | A/B/C/D | 1-411 | [»] | |
SMRi | P49959 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110501, 172 interactors |
ComplexPortali | CPX-4442, MRN complex |
CORUMi | P49959 |
DIPi | DIP-33238N |
IntActi | P49959, 51 interactors |
MINTi | P49959 |
STRINGi | 9606.ENSP00000325863 |
Chemistry databases
BindingDBi | P49959 |
ChEMBLi | CHEMBL3308929 |
PTM databases
iPTMneti | P49959 |
PhosphoSitePlusi | P49959 |
SwissPalmi | P49959 |
Polymorphism and mutation databases
BioMutai | MRE11 |
DMDMi | 17380137 |
Proteomic databases
EPDi | P49959 |
jPOSTi | P49959 |
MassIVEi | P49959 |
MaxQBi | P49959 |
PaxDbi | P49959 |
PeptideAtlasi | P49959 |
PRIDEi | P49959 |
ProteomicsDBi | 3675 56186 [P49959-1] 56187 [P49959-2] |
Protocols and materials databases
Antibodypediai | 706, 673 antibodies |
CPTCi | P49959, 1 antibody |
DNASUi | 4361 |
Genome annotation databases
Ensembli | ENST00000323929; ENSP00000325863; ENSG00000020922 [P49959-1] ENST00000323977; ENSP00000326094; ENSG00000020922 [P49959-2] ENST00000407439; ENSP00000385614; ENSG00000020922 [P49959-3] |
GeneIDi | 4361 |
KEGGi | hsa:4361 |
UCSCi | uc001peu.4, human [P49959-1] |
Organism-specific databases
CTDi | 4361 |
DisGeNETi | 4361 |
EuPathDBi | HostDB:ENSG00000020922.12 |
GeneCardsi | MRE11 |
HGNCi | HGNC:7230, MRE11 |
HPAi | ENSG00000020922, Low tissue specificity |
MalaCardsi | MRE11 |
MIMi | 600814, gene 604391, phenotype |
neXtProti | NX_P49959 |
OpenTargetsi | ENSG00000020922 |
Orphaneti | 251347, Ataxia-telangiectasia-like disorder 145, Hereditary breast and ovarian cancer syndrome 240760, Nijmegen breakage syndrome-like disorder |
PharmGKBi | PA30934 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2310, Eukaryota |
GeneTreei | ENSGT00390000017288 |
HOGENOMi | CLU_009535_3_1_1 |
InParanoidi | P49959 |
OMAi | QWMRPET |
PhylomeDBi | P49959 |
TreeFami | TF101105 |
Enzyme and pathway databases
PathwayCommonsi | P49959 |
Reactomei | R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5685939, HDR through MMEJ (alt-NHEJ) R-HSA-5685942, HDR through Homologous Recombination (HRR) R-HSA-5693548, Sensing of DNA Double Strand Breaks R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693579, Homologous DNA Pairing and Strand Exchange R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69473, G2/M DNA damage checkpoint R-HSA-912446, Meiotic recombination |
SIGNORi | P49959 |
Miscellaneous databases
BioGRID-ORCSi | 4361, 305 hits in 852 CRISPR screens |
ChiTaRSi | MRE11A, human |
GeneWikii | MRE11A |
GenomeRNAii | 4361 |
Pharosi | P49959, Tbio |
PROi | PR:P49959 |
RNActi | P49959, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000020922, Expressed in calcaneal tendon and 223 other tissues |
ExpressionAtlasi | P49959, baseline and differential |
Genevisiblei | P49959, HS |
Family and domain databases
CDDi | cd00840, MPP_Mre11_N, 1 hit |
Gene3Di | 3.30.110.110, 1 hit 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR003701, Mre11 IPR007281, Mre11_DNA-bd IPR038487, Mre11_DNA-bd_sf IPR041796, Mre11_N |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF04152, Mre11_DNA_bind, 1 hit |
PIRSFi | PIRSF000882, DSB_repair_MRE11, 1 hit |
SMARTi | View protein in SMART SM01347, Mre11_DNA_bind, 1 hit |
TIGRFAMsi | TIGR00583, mre11, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MRE11_HUMAN | |
Accessioni | P49959Primary (citable) accession number: P49959 Secondary accession number(s): B3KTC7, O43475 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 26, 2001 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations